BRPI0413923A - composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo - Google Patents

composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo

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Publication number
BRPI0413923A
BRPI0413923A BRPI0413923-2A BRPI0413923A BRPI0413923A BR PI0413923 A BRPI0413923 A BR PI0413923A BR PI0413923 A BRPI0413923 A BR PI0413923A BR PI0413923 A BRPI0413923 A BR PI0413923A
Authority
BR
Brazil
Prior art keywords
edg
binding
compound
pharmaceutical use
compound capable
Prior art date
Application number
BRPI0413923-2A
Other languages
English (en)
Inventor
Shinji Nakade
Hirotaka Mizuno
Takeji Ono
Masashi Minami
Hiroshi Saga
Hiroshi Hagiya
Takaki Komiya
Himoru Habashita
Haruto Kurata
Kazuhiro Ohtsuki
Kensuke Kusumi
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of BRPI0413923A publication Critical patent/BRPI0413923A/pt

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    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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Abstract

"COMPOSTO CAPAZ DE LIGAR O RECEPTOR DE S1P E USO FARMACêUTICO DO MESMO". Um composto capaz de ligar os receptores de S1P (especialmente EDG-6, preferivelmente EDG-1 e EDG-6). Por exemplo, um composto da fórmula geral (I), o seu sal ou solvato, ou um pró-medicamento do mesmo é capaz de ligar os receptores de S1P (especialmente EDG-6, preferivelmente EDG-1 e EDG-6) e é, desse modo, útil na prevenção e/ou no tratamento de reação imunológica ao transplante, doença do enxerto versus hospedeiro, doença auto-imune, alergose, etc. (I) (em que o anel A é um grupo cíclico; o anel B é um grupo cíclico opcionalmente substituído; X é um espaçador com uma cadeia principal de 1 a 8 átomos, etc.; Y é um espaçador com uma cadeia principal de 1 a 10 átomos, etc. ; e n é 0 ou 1, desde que quando n for 0, m seja 1 e R¬ 1¬ seja um átomo de hidrogênio ou um substituinte, e que quando n for 1, m seja 0 ou um número inteiro de 1 a 7 e R¬ 1¬ seja um substituinte, em que quando m for 2 ou mais, os R¬ 1¬s podem ser idênticos ou diferentes um dos outros).
BRPI0413923-2A 2003-08-29 2004-08-27 composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo BRPI0413923A (pt)

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JP2004198523 2004-07-05
PCT/JP2004/012768 WO2005020882A2 (ja) 2003-08-29 2004-08-27 Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途

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Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1644367B1 (en) * 2003-05-19 2015-10-14 Novartis AG Immunosuppressant compounds and compositions
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
ES2754221T3 (es) * 2003-08-29 2020-04-16 Ono Pharmaceutical Co Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo
TW200538433A (en) * 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
JP5315611B2 (ja) * 2004-06-23 2013-10-16 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその用途
ATE541830T1 (de) 2004-12-13 2012-02-15 Ono Pharmaceutical Co Aminocarbonsäurederivat und dessen medizinische verwendung
RU2412179C2 (ru) * 2005-03-23 2011-02-20 Актелион Фармасьютиклз Лтд Гидрированные производные бензо[с]тиофена в качестве иммуномодуляторов
BRPI0607742A2 (pt) * 2005-03-31 2009-09-29 Janssen Pharmaceutica Nv moduladores de fenil e piridil lta4h
MX2007016505A (es) * 2005-06-24 2008-03-07 Actelion Pharmaceuticals Ltd Nuevos derivados de tiofeno.
AR057894A1 (es) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
JP2009520688A (ja) * 2005-11-23 2009-05-28 エピックス デラウェア， インコーポレイテッド Ｓ１ｐ受容体調節化合物およびそれらの使用
US7919519B2 (en) 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
CA2646469A1 (en) 2006-03-21 2007-09-27 Epix Delaware, Inc. S1p receptor modulating compounds
WO2007129473A1 (ja) * 2006-05-09 2007-11-15 Daiichi Sankyo Company, Limited 二環性アリール誘導体
US20090324581A1 (en) 2006-05-09 2009-12-31 Daiichi Sankyo Company Limited Heteroarylamide lower carboxylic acid derivative
NZ574012A (en) 2006-08-08 2012-02-24 Kyorin Seiyaku Kk Aminoalcohol derivative and immunosuppressant containing the same as active ingredient
CN101501049B (zh) 2006-08-08 2013-04-24 杏林制药株式会社 氨基磷酸酯衍生物以及将它们作为有效成分的s1p受体调节剂
EP1923054A1 (en) * 2006-09-26 2008-05-21 Novartis AG Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
EP1923055A1 (en) * 2006-09-26 2008-05-21 Novartis AG Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
EP1923058A1 (en) * 2006-09-26 2008-05-21 Novartis AG Coated pharmaceutical composition comprising an S1P agonist or modulator
PL3103448T3 (pl) 2006-09-26 2019-12-31 Novartis Ag Kompozycje farmaceutyczne zawierające modulator S1P
AU2007227278B2 (en) * 2007-03-21 2014-09-11 Epix Pharmaceuticals, Inc. SIP receptor modulating compounds and use thereof
AU2008240679A1 (en) * 2007-04-23 2008-10-30 Novartis Ag Phthalazine and isoquinoline derivatives with SLP receptor modulating activities
MX2010002885A (es) * 2007-09-20 2010-04-01 Amgen Inc Derivados de acido 1-(4-(bencilbenzamido)-bencil)-azetidin-3-carbo xilico y compuestos relacionados como moduladores de receptores de s1p para el tratamiento de trastornos inmunitarios.
CA2701116C (en) * 2007-10-05 2013-02-05 Acucela Inc. Alkoxy compounds for disease treatment
JP5452237B2 (ja) 2008-02-07 2014-03-26 杏林製薬株式会社 アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
EP2326621B1 (en) 2008-07-23 2016-06-08 Arena Pharmaceuticals, Inc. SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
RS54970B1 (sr) 2008-08-27 2016-11-30 Arena Pharm Inc Supstituisani triciklični derivati kiselina kao s1p1 receptor agonisti korisni pri lečenju autoimunih i upalnih poremećaja
NZ592748A (en) 2008-10-17 2013-01-25 Akaal Pharma Pty Ltd 2-Amino-(oxadiazol-3-yl)-benzofuran derivatives and their use as S1P receptor modulators
US9181182B2 (en) 2008-10-17 2015-11-10 Akaal Pharma Pty Ltd S1P receptors modulators
RU2490266C2 (ru) * 2008-12-05 2013-08-20 Астеллас Фарма Инк. Соединение 2н-хромена и его производное
WO2011003103A2 (en) 2009-07-02 2011-01-06 Acucela, Inc. Pharmacology of visual cycle modulators
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
AR077969A1 (es) * 2009-08-31 2011-10-05 Abbott Healthcare Products Bv Derivados de (tio)morfolina comomoduladores de s1p
KR20120098796A (ko) * 2009-11-24 2012-09-05 알러간, 인코포레이티드 치료적 유용성을 지니는 수용체 조절제로서의 신규한 화합물
EP3378854B1 (en) 2010-01-27 2022-12-21 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
CA2789480A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
CN109745313A (zh) 2010-08-11 2019-05-14 德雷克塞尔大学 治疗帕金森病中运动障碍的d3多巴胺受体激动剂
UA113507C2 (xx) 2011-02-07 2017-02-10 Модулятори s1p
MX2013011979A (es) * 2011-04-14 2014-02-06 Allergan Inc Derivados de metilamina biciclica de fenilo como moduladores de los receptores de la esfingosina-1 fosfato.
SG194209A1 (en) * 2011-04-18 2013-11-29 Allergan Inc Substituted bicyclic methyl amine derivatives as sphingosine-1-phosphate receptors modulators
DK2762466T3 (en) 2011-09-29 2017-09-18 Ono Pharmaceutical Co phenyl derivative
US9447078B2 (en) 2012-01-20 2016-09-20 Acucela Inc. Substituted heterocyclic compounds for disease treatment
AU2013295594B2 (en) 2012-07-27 2018-03-29 Biogen Ma Inc. Compounds that are S1P modulating agents and/or ATX modulating agents
EP2925721B1 (en) * 2012-11-20 2017-06-07 Biogen MA Inc. S1p and/or atx modulating agents
CA2899322A1 (en) * 2013-01-29 2014-08-07 Biogen Ma Inc. S1p modulating agents
PT2980072T (pt) 2013-03-26 2018-06-06 Ono Pharmaceutical Co Derivado de fenilo
JP6294872B2 (ja) 2013-04-26 2018-03-14 国立大学法人京都大学 脳動脈瘤の形成および／または増大の抑制若しくは縮小用医薬組成物
JP6673218B2 (ja) * 2014-12-04 2020-03-25 小野薬品工業株式会社 ジヒドロナフタレン誘導体
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
SI3310760T1 (sl) 2015-06-22 2023-02-28 Arena Pharmaceuticals, Inc. Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1
US10556907B2 (en) * 2015-08-28 2020-02-11 AbbVie Deutschland GmbH & Co. KG Fused heterocyclic compounds as S1P modulators
CN108884079B (zh) * 2016-02-15 2021-03-05 赛诺菲 作为***受体调节剂的6，7-二氢-5h-苯并[7]轮烯衍生物
MA47503A (fr) 2017-02-16 2021-04-21 Arena Pharm Inc Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
NZ766972A (en) * 2018-02-22 2024-02-23 Ono Pharmaceutical Co Compounds having s1p5 receptor agonistic activity
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
CA3150303A1 (en) 2019-08-20 2021-02-25 Ono Pharmaceutical Co., Ltd. Salt and crystal form of compound having agonistic activity to s1p5 receptor
AR121276A1 (es) 2020-02-06 2022-05-04 Mitsubishi Tanabe Pharma Corp Agente terapéutico para la encefalomielitis miálgica / síndrome de fatiga crónica
EP4136971A4 (en) * 2020-03-31 2023-11-22 Lg Chem, Ltd. ISLAND TRANSPLANT PROTECTION COMPOSITION
CA3201000A1 (en) * 2020-11-09 2022-05-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
WO2022220610A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조방법
CN117177964A (zh) * 2021-04-14 2023-12-05 株式会社Lg化学 制备鞘氨醇-1-磷酸酯受体激动剂的新方法
EP4306516A1 (en) * 2021-04-14 2024-01-17 Lg Chem, Ltd. Novel method for preparing sphingosine-1-phosphate receptor agonist
WO2024025862A1 (en) * 2022-07-28 2024-02-01 The Board Of Regents Of The University Of Oklahoma Agonists of peroxisome proliferator-activated receptor alpha (ppara) and methods of use

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE555319A (pt) 1956-03-21 1900-01-01
US3095355A (en) 1961-10-12 1963-06-25 Revlon Aerosol composition
JPS58162949A (ja) * 1982-03-20 1983-09-27 Konishiroku Photo Ind Co Ltd ハロゲン化銀カラ−写真感光材料
DE3508398A1 (de) * 1985-03-08 1986-11-06 Hoechst Ag, 6230 Frankfurt Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung
EP0411751A1 (en) * 1989-06-06 1991-02-06 Beecham Group p.l.c. Renin inhibitory peptides
EP0466254A1 (en) * 1990-07-11 1992-01-15 Merck & Co. Inc. 2-naphthyl-carbapenems
ATE172711T1 (de) 1992-10-21 1998-11-15 Yoshitomi Pharmaceutical 2-amino-1, 3- propandiolverbindung und immunosuppressium
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
CN1167485A (zh) * 1994-11-01 1997-12-10 泰尔茂株式会社 四氢异喹啉衍生物和含有它们的药物制剂
DE19527568A1 (de) * 1995-07-28 1997-01-30 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US6310107B1 (en) 1997-02-27 2001-10-30 Takeda Chemical Industries, Ltd. Amine compounds, their production and use as amyloid-β production inhibitors
WO1999065867A1 (en) 1998-06-17 1999-12-23 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
WO2001021577A2 (en) 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
US6458822B2 (en) * 2000-03-13 2002-10-01 Pfizer Inc. 2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
CA2420869A1 (en) 2000-08-29 2002-03-07 Allergan, Inc. Compounds having activity as inhibitors of cytochrome p450rai
JP2004521079A (ja) * 2000-08-29 2004-07-15 ファルマシア・コーポレーション アルファーｖベータ３アンタゴニストとして有用な二環式環系を含有する化合物
US6410733B1 (en) * 2000-09-11 2002-06-25 Genentech, Inc. Amidine inhibitors of serine proteases
JP2004509867A (ja) * 2000-09-19 2004-04-02 サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） Ｈｉｖ阻害特性を有するピリジノンおよびピリジンチオン誘導体
IL155125A0 (en) 2000-10-05 2003-10-31 Bayer Ag Propionic acid derivatives with ppar-alpha activating properties
JP4378597B2 (ja) 2001-05-10 2009-12-09 小野薬品工業株式会社 カルボン酸誘導体化合物およびそれらを有効成分とする薬剤
US20050143372A1 (en) * 2001-10-30 2005-06-30 Shomir Ghosh Compounds, pharmaceutical compositions and methods of use therefor
US20040058894A1 (en) * 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists
JP4430941B2 (ja) 2002-01-18 2010-03-10 メルク エンド カムパニー インコーポレーテッド Ｅｄｇ受容体作動薬
US7351725B2 (en) * 2002-01-18 2008-04-01 Merck & Co., Inc. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists
AU2003216054B2 (en) 2002-01-18 2007-01-04 Merck & Co., Inc. Selective S1P1/Edg1 receptor agonists
PT1501804E (pt) 2002-04-26 2009-10-29 Hoffmann La Roche Derivados de isoquinolina
EP1549640A4 (en) * 2002-06-17 2008-08-06 Merck & Co Inc 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) AZETIDINE-3-CARBOXYLATE AND 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) PYRROLIDIN-3-CARBOXYLATE AS EDG RECEPTOR AGONISTS
ES2305491T3 (es) * 2002-09-19 2008-11-01 Eli Lilly And Company Eteres de diarilo como antagonistas de receptores de opioides.
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
AU2003297232B2 (en) 2002-12-20 2010-02-04 Merck Sharp & Dohme Corp. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles
JP2006512417A (ja) * 2002-12-24 2006-04-13 ニューロケム （インターナショナル） リミテッド β−アミロイド関連疾患の治療のための治療用製剤
MY150088A (en) * 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
CA2524054C (en) * 2003-05-19 2012-04-24 Irm Llc Immunosuppressant compounds and compositions
AU2004251146A1 (en) * 2003-05-19 2005-01-06 Irm, Llc Immunosuppressant compounds and compositions
EP1644367B1 (en) * 2003-05-19 2015-10-14 Novartis AG Immunosuppressant compounds and compositions
DE10335092B3 (de) 2003-08-01 2005-02-03 Aventis Pharma Deutschland Gmbh Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
ES2754221T3 (es) * 2003-08-29 2020-04-16 Ono Pharmaceutical Co Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo
CN101407471A (zh) * 2003-08-29 2009-04-15 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途

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IL173973A (en) 2011-04-28
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EP1661881A2 (en) 2006-05-31
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US8791159B2 (en) 2014-07-29
US20140288034A1 (en) 2014-09-25
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JP4947406B2 (ja) 2012-06-06
EP2883865A1 (en) 2015-06-17
ES2754221T3 (es) 2020-04-16
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