WO2002020736A3 - Proteases - Google Patents

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Publication number
WO2002020736A3
WO2002020736A3 PCT/US2001/028161 US0128161W WO0220736A3 WO 2002020736 A3 WO2002020736 A3 WO 2002020736A3 US 0128161 W US0128161 W US 0128161W WO 0220736 A3 WO0220736 A3 WO 0220736A3
Authority
WO
WIPO (PCT)
Prior art keywords
prts
provides
proteases
polynucleotides
agonists
Prior art date
Application number
PCT/US2001/028161
Other languages
French (fr)
Other versions
WO2002020736A2 (en
WO2002020736A9 (en
Inventor
Stephen Todd
Angelo M Delegeane
Ameena R Gandhi
Danniel B Nguyen
April J A Hafalia
Liam Kearney
Yan Lu
Ernestine A Lee
Original Assignee
Incyte Genomics Inc
Stephen Todd
Angelo M Delegeane
Ameena R Gandhi
Danniel B Nguyen
April J A Hafalia
Liam Kearney
Yan Lu
Ernestine A Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Stephen Todd, Angelo M Delegeane, Ameena R Gandhi, Danniel B Nguyen, April J A Hafalia, Liam Kearney, Yan Lu, Ernestine A Lee filed Critical Incyte Genomics Inc
Priority to CA002421922A priority Critical patent/CA2421922A1/en
Priority to AU2001292594A priority patent/AU2001292594A1/en
Priority to US10/363,937 priority patent/US6927056B2/en
Priority to JP2002525743A priority patent/JP2004523212A/en
Publication of WO2002020736A2 publication Critical patent/WO2002020736A2/en
Publication of WO2002020736A9 publication Critical patent/WO2002020736A9/en
Publication of WO2002020736A3 publication Critical patent/WO2002020736A3/en
Priority to US11/167,040 priority patent/US20050239126A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.
PCT/US2001/028161 2000-09-08 2001-09-06 Proteases WO2002020736A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002421922A CA2421922A1 (en) 2000-09-08 2001-09-06 Proteases
AU2001292594A AU2001292594A1 (en) 2000-09-08 2001-09-06 Proteases
US10/363,937 US6927056B2 (en) 2001-09-06 2001-09-06 Proteases
JP2002525743A JP2004523212A (en) 2000-09-08 2001-09-06 Protease
US11/167,040 US20050239126A1 (en) 2000-09-08 2005-06-27 Proteases

Applications Claiming Priority (12)

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US23103900P 2000-09-08 2000-09-08
US60/231,039 2000-09-08
US23281200P 2000-09-15 2000-09-15
US60/232,812 2000-09-15
US23485000P 2000-09-22 2000-09-22
US60/234,850 2000-09-22
US23650000P 2000-09-29 2000-09-29
US60/236,500 2000-09-29
US23877300P 2000-10-05 2000-10-05
US60/238,773 2000-10-05
US23965800P 2000-10-12 2000-10-12
US60/239,658 2000-10-12

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CA2447935A1 (en) * 2001-06-04 2002-12-12 Curagen Corporation Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
EP1476545A4 (en) * 2002-01-31 2006-11-29 Wyeth Corp Aggrecanase molecules
WO2004104575A2 (en) * 2003-05-23 2004-12-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with x-prolyl aminopeptidase 2 (xpnpep2)
US8729239B2 (en) 2009-04-09 2014-05-20 Nuclea Biotechnologies, Inc. Antibodies against fatty acid synthase
WO2011031517A1 (en) 2009-08-27 2011-03-17 Nuclea Biotechnologies, LLC Method and assay for determining fas expression
WO2013043970A1 (en) * 2011-09-21 2013-03-28 Progenra, Inc. Methods of screening for inhibitors of enzymes
US9056919B2 (en) 2011-10-26 2015-06-16 Nuclea Biotechnologies, Inc. USP2a peptides and antibodies

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US5710014A (en) * 1988-02-11 1998-01-20 The United States Of America As Represented By The Department Of Health And Human Services Cloned cDNA for human procathepsin l.
WO1998044128A1 (en) * 1997-03-31 1998-10-08 Incyte Pharmaceuticals, Inc. Novel human serine carboxypeptidase
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WO2002020736A9 (en) 2002-05-30

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