WO2001096547A3 - Human kinases - Google Patents

Human kinases Download PDF

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Publication number
WO2001096547A3
WO2001096547A3 PCT/US2001/019444 US0119444W WO0196547A3 WO 2001096547 A3 WO2001096547 A3 WO 2001096547A3 US 0119444 W US0119444 W US 0119444W WO 0196547 A3 WO0196547 A3 WO 0196547A3
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WO
WIPO (PCT)
Prior art keywords
pkin
human kinases
provides
kinases
polynucleotides
Prior art date
Application number
PCT/US2001/019444
Other languages
French (fr)
Other versions
WO2001096547A2 (en
Inventor
Henry Yue
Preeti Lal
Olga Bandman
Mark L Borowsky
Janice Au-Young
Yan Lu
Ameena R Gandhi
Catherine M Tribouley
Narinder K Walia
Monique G Yao
Dyung Aina M Lu
Original Assignee
Incyte Genomics Inc
Henry Yue
Preeti Lal
Olga Bandman
Mark L Borowsky
Janice Au-Young
Yan Lu
Ameena R Gandhi
Catherine M Tribouley
Narinder K Walia
Monique G Yao
Dyung Aina M Lu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Henry Yue, Preeti Lal, Olga Bandman, Mark L Borowsky, Janice Au-Young, Yan Lu, Ameena R Gandhi, Catherine M Tribouley, Narinder K Walia, Monique G Yao, Dyung Aina M Lu filed Critical Incyte Genomics Inc
Priority to EP01946479A priority Critical patent/EP1290187A2/en
Priority to CA002410610A priority patent/CA2410610A1/en
Priority to US10/311,034 priority patent/US20040023242A1/en
Priority to JP2002510666A priority patent/JP2004522409A/en
Priority to AU2001268525A priority patent/AU2001268525A1/en
Publication of WO2001096547A2 publication Critical patent/WO2001096547A2/en
Publication of WO2001096547A3 publication Critical patent/WO2001096547A3/en

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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Abstract

The invention provides human kinases (PKIN) and polynucleotides which identify and encode PKIN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or prevention disorders associated with aberrant expression of PKIN.
PCT/US2001/019444 2000-06-15 2001-06-14 Human kinases WO2001096547A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01946479A EP1290187A2 (en) 2000-06-15 2001-06-14 Humain kinases
CA002410610A CA2410610A1 (en) 2000-06-15 2001-06-14 Human kinases
US10/311,034 US20040023242A1 (en) 2001-06-14 2001-06-14 Human kinases
JP2002510666A JP2004522409A (en) 2000-06-15 2001-06-14 Human kinase
AU2001268525A AU2001268525A1 (en) 2000-06-15 2001-06-14 Human kinases

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US21207300P 2000-06-15 2000-06-15
US60/212,073 2000-06-15
US21346700P 2000-06-23 2000-06-23
US60/213,467 2000-06-23
US21565100P 2000-06-30 2000-06-30
US60/215,651 2000-06-30
US21660500P 2000-07-07 2000-07-07
US60/216,605 2000-07-07
US21837200P 2000-07-13 2000-07-13
US60/218,372 2000-07-13
US22805600P 2000-08-25 2000-08-25
US60/228,056 2000-08-25

Publications (2)

Publication Number Publication Date
WO2001096547A2 WO2001096547A2 (en) 2001-12-20
WO2001096547A3 true WO2001096547A3 (en) 2002-08-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019444 WO2001096547A2 (en) 2000-06-15 2001-06-14 Human kinases

Country Status (5)

Country Link
EP (1) EP1290187A2 (en)
JP (1) JP2004522409A (en)
AU (1) AU2001268525A1 (en)
CA (1) CA2410610A1 (en)
WO (1) WO2001096547A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787345B1 (en) 2000-11-15 2004-09-07 Millennium Pharmaceuticals, Inc. 55053, a novel human eukaryotic kinase and uses therefor
US20040058355A1 (en) 1998-09-30 2004-03-25 Millennium Pharmaceuticals, Inc. Novel 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, H1983, M1983, 38555 or 593 molecules and uses therefor
US20030198953A1 (en) * 2000-03-30 2003-10-23 Spytek Kimberly A. Novel proteins and nucleic acids encoding same
US20040175815A1 (en) * 2000-05-26 2004-09-09 Yonghong Xiao Regulation of human p78-like serube/threonine kinase
JP2004520805A (en) * 2000-07-28 2004-07-15 カイロン コーポレイション Isolation of Drosophila and human polynucleotides encoding PAR-1 kinase, polypeptides encoded by the polynucleotides, and methods utilizing the polynucleotides and polypeptides
WO2002024889A2 (en) * 2000-09-12 2002-03-28 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Optimized cardiac contraction through differential phosphorylation of myosin
AU2001297794A1 (en) 2000-10-19 2002-12-03 Millenium Pharmaceuticals, Inc. Methods and compositions of human proteins and uses thereof.
US6638745B1 (en) * 2001-03-13 2003-10-28 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
JP2005501528A (en) 2001-06-05 2005-01-20 エクセリクシス・インコーポレイテッド GFATs as p53 pathway modifiers and methods of use
AU2002317860A1 (en) * 2001-07-02 2003-01-21 Bayer Aktiengesellschaft Regulation of human citron rho/rac-interacting kinase-short kinase
AU2002324058A1 (en) * 2001-08-21 2003-03-10 Bayer Healthcare Ag Regulation of human g protein-couple receptor kinase
WO2003042371A2 (en) * 2001-11-15 2003-05-22 Millennium Pharmaceuticals, Inc. 55053, a novel human eukaryotic kinase and uses therefor
WO2003044196A1 (en) * 2001-11-20 2003-05-30 Daiichi Pharmaceutical Co.,Ltd. Postsynaptic proteins
AU2003226973A1 (en) * 2002-02-04 2003-09-02 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Proteins involved in the regulation of energy homeostatis
US7326781B2 (en) 2002-04-12 2008-02-05 Bristol-Myers Squibb Company Polynucleotides encoding the human citron kinase polypeptide, BMSNKC—0020/0021
NZ574520A (en) * 2002-11-27 2011-02-25 Dmi Biosciences Inc Use of casein which is at least 10% dephosphorylated for the treatment of diseases and conditions mediated by increased phosphorylation
US20070292349A1 (en) * 2004-01-28 2007-12-20 Exelixis, Inc. Itpks as Modifiers of the Igfr Pathway and Methods of Use
EP2486130A1 (en) * 2009-10-06 2012-08-15 Tallinn University Of Technology Inhibition or activation of serine/threonine ulk3 kinase activity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817479A (en) * 1996-08-07 1998-10-06 Incyte Pharmaceuticals, Inc. Human kinase homologs
WO2000015770A2 (en) * 1998-09-16 2000-03-23 Incyte Pharmaceuticals, Inc. Human serine/threonine protein kinases
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
WO2001085921A2 (en) * 2000-05-12 2001-11-15 Merck Patent Gmbh Human serine-threonine kinase-4

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817479A (en) * 1996-08-07 1998-10-06 Incyte Pharmaceuticals, Inc. Human kinase homologs
WO2000015770A2 (en) * 1998-09-16 2000-03-23 Incyte Pharmaceuticals, Inc. Human serine/threonine protein kinases
WO2000073469A2 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
WO2001085921A2 (en) * 2000-05-12 2001-11-15 Merck Patent Gmbh Human serine-threonine kinase-4

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIELKE W ET AL.: "Characterization of a novel murine testis-specific serine/threonine kinase", GENE, vol. 139, no. 2, 1994, pages 235 - 239, XP002174517, ISSN: 0378-1119 *
DATABASE EM_EST EMBL; 12 July 1999 (1999-07-12), NCI-CGAP: "wj59g02.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE:2407154 3' similar to TR:O54863 O54863 TESTIS SPECIFIC SERINE/ THREONINE KINASE 2 ;, mRNA sequence.", XP002192989 *
DATABASE EM_EST EMBL; 13 July 1999 (1999-07-13), NCI-CGAP: "wh84b11.x1 NCI_CGAP_CLL1 Homo sapiens cDNA clone IMAGE:2387421 3' similar to TR:P97417 P97417 SERINE THREONINE KINASE. ;, mRNA sequence.", XP002192990 *
DATABASE EM_HUM EMBL; 2 May 2001 (2001-05-02), SPIRIDONOV N A ET AL.: "Homo sapiens serine/threonine protein kinase SSTK (SSTK) mRNA, complete cds.", XP002192992 *
DATABASE EM_HUM EMBL; 8 October 1999 (1999-10-08), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 19 clone CTC-260F20, complete sequence.", XP002192991 *

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