WO2000079272A2 - Verfahren und vorrichtung zur testung der steifigkeit biologischer gewebe - Google Patents
Verfahren und vorrichtung zur testung der steifigkeit biologischer gewebe Download PDFInfo
- Publication number
- WO2000079272A2 WO2000079272A2 PCT/DE2000/001977 DE0001977W WO0079272A2 WO 2000079272 A2 WO2000079272 A2 WO 2000079272A2 DE 0001977 W DE0001977 W DE 0001977W WO 0079272 A2 WO0079272 A2 WO 0079272A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- measuring
- test
- cartilage
- rigidity
- pressure
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
- A61B5/4514—Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/40—Investigating hardness or rebound hardness
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
- A61B5/4528—Joints
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/003—Generation of the force
- G01N2203/0042—Pneumatic or hydraulic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/003—Generation of the force
- G01N2203/0042—Pneumatic or hydraulic means
- G01N2203/0048—Hydraulic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0089—Biorheological properties
Definitions
- the invention relates to a method and a device for contactless determination of the mechanical stiffness of biological tissues in body cavities (also arthroscopically) under a defined liquid jet. It is suitable for measuring the mechanical stiffness of native cartilage, joint cartilage replacement, cartilage defect fillings as well as all other biological tissues.
- the mechanical quality of the biological materials can be compared to the native raw material by comparative measurements.
- the properties of articular cartilage can be determined optically (arthroscopy), histologically and with the help of imaging methods (magnetic resonance). These methods make it possible to distinguish damaged cartilage from intact areas. In addition, these procedures are used to assess the quality of healing cartilage defects or defect functions postoperatively. Since articular cartilage is exposed to high loads, its mechanical suitability is an essential criterion for the long-term function of the tissue and the entire joint. Tissue engineering of articular cartilage depends on the determination of the mechanical suitability of the defect. The basic suitability of the replacement materials can be determined preoperatively in pure in vitro tests, but the decisive factor is the mechanical property of the defect filling in a postoperative situation.
- a disadvantage of these devices and methods is that relatively high forces are required to determine the mechanical stiffness of the articular cartilage. Due to the direct mechanical contact of the test devices with the gel cartilage, the regenerates can easily be damaged, particularly in the case of reconstructed articular surfaces. Previous devices do not take into account that measurement inaccuracies can easily occur in manual use due to different test positions or pressure forces. The existing methods therefore do not exclude inter-individual variations in the measured values.
- the invention had for its object to develop a method and a test device with which the mechanical properties of biological materials (eg articular cartilage) can be determined without causing damage to the biological tissue and without showing strong user-dependent variations in the measurement signal.
- the object was achieved in that biological samples in body cavities, in particular cartilage, are deformed by a liquid jet and this deformation is optically recorded.
- the distance between the measuring device and the measuring surface was measured continuously in a predetermined measuring range in a method and by means of a device using an optical method. If this falls below a predetermined value, a clear liquid jet with a defined pressure is directed through the supply pipe onto the measuring surface.
- the deformation of the measurement object by the liquid jet is detected and evaluated as a change in distance by the optical distance measuring system.
- the device according to the invention allows the iterative increase in the load up to a defined, maximum permissible deformation of the sample surface. Damage to the test specimen (eg the joint surface) is to be avoided by this procedure.
- the stiffness of the cartilage is determined from the pressure of the liquid jet, the tube diameter and the deformation of the joint surface (change in distance) and displayed online to the user.
- the mechanical stiffness of biological tissues e.g. articular cartilage
- body cavities e.g. arthroscopically
- the invention enables the contactless and user-independent measurement of biological tissues.
- the device according to the invention is easy to use, flexible to use and easy to use. Due to the safe function, there is no direct or indirect risk for the patient or the user due to the measurement.
- the device according to the invention is composed of an optical distance measuring system (FIG. 1: change in distance) and pressurization by means of a clear liquid (FIG. 1: pressure).
- the optical distance measuring system consists of a light guide cable (1) (supply and discharge), a light source (2) and a detector (3).
- the pressurization by means of clear liquid consists of a pressure vessel (4) with an electrical pressure measuring sensor (5), a control device (6) and a supply hose (7) and a feed pipe (8).
- the data acquisition and evaluation takes place via an output unit (9) (FIG. 1).
- the method and the device according to the invention are suitable for measuring the stiffness of biological samples in body cavities (e.g. arthroscopic measurement of the stiffness of articular cartilage and cartilage regenerates).
- the individual components of the device ( Figure 1) work together in the following way:
- the device according to the invention consists of a combination of known elements and a new evaluation method (the combination of an optical path measurement and a load from a liquid jet), which influence each other and in their new Overall effect a use advantage (synergistic effect) and the desired success, which lies in the fact that contactless and user-independent measurement of the mechanical stiffness of biological materials is now possible.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Dentistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Prostheses (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/018,948 US6783503B1 (en) | 1999-06-21 | 2000-06-20 | Method and device for testing the rigidity of biological tissue |
EP00949113A EP1194776A2 (de) | 1999-06-21 | 2000-06-20 | Verfahren und vorrichtung zur testung der steifigkeit biologischer gewebe |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19929578.6 | 1999-06-21 | ||
DE19929578A DE19929578C2 (de) | 1999-06-21 | 1999-06-21 | Verfahren und Vorrichtung zur Knorpel-Testung |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000079272A2 true WO2000079272A2 (de) | 2000-12-28 |
WO2000079272A3 WO2000079272A3 (de) | 2001-08-09 |
Family
ID=7912822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2000/001977 WO2000079272A2 (de) | 1999-06-21 | 2000-06-20 | Verfahren und vorrichtung zur testung der steifigkeit biologischer gewebe |
Country Status (4)
Country | Link |
---|---|
US (1) | US6783503B1 (de) |
EP (1) | EP1194776A2 (de) |
DE (1) | DE19929578C2 (de) |
WO (1) | WO2000079272A2 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002043588A1 (de) * | 2000-12-02 | 2002-06-06 | Universitätsklinikum Charite Medizinische Fakultät Der Humboldt-Universität Zu Berlin | Force-feedback-system |
CN102353589A (zh) * | 2011-07-11 | 2012-02-15 | 天津理工大学 | 一种在软骨力学性能测试中运用数字图像相关技术的方法 |
CN107072975A (zh) * | 2014-09-09 | 2017-08-18 | 洛桑联邦理工学院 | 用于造血干细胞药物中的方法和化合物 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10212057A1 (de) * | 2002-03-19 | 2003-10-02 | Tesa Ag | Vorrichtung und Verfahren zur Bestimmung Inhomogenitäten in Materialbahnen |
US7124636B2 (en) * | 2004-09-30 | 2006-10-24 | The Hong Kong Polytechnic University | Non-contact measurement of material property |
US20110082389A1 (en) * | 2009-10-07 | 2011-04-07 | The Regents Of The University Of California | Apparatus and method for assessing condition of articular cartilage |
CN112535481B (zh) * | 2020-11-24 | 2022-11-01 | 华中科技大学 | 一种基于近红外光的关节接触力测量方法及装置 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2173896A (en) * | 1985-04-12 | 1986-10-22 | Oreal | Investigation of the properties of a surface e.g. the elasticity of skin |
EP0362616A1 (de) * | 1988-09-26 | 1990-04-11 | COURAGE + KHAZAKA ELECTRONIC GmbH | Vorrichtung und Verfahren zur Messung der elastischen und viskoelastischen Verformbarkeit der Haut |
WO1993020752A1 (en) * | 1992-04-21 | 1993-10-28 | Board Of Regents, The University Of Texas System | Arthroscopic indenter and method for using the same |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2191006A (en) * | 1986-05-22 | 1987-12-02 | Rolls Royce Plc | Testing physical properties of materials e.g. cartilage |
DE3840998A1 (de) * | 1988-12-06 | 1990-06-07 | Battelle Institut E V | Vorrichtung zum zerstoerungsfreien aufspueren von inhomogenitaeten in elastischen werkstoffen |
US5564435A (en) * | 1989-01-23 | 1996-10-15 | Steinberg; Bruce | Noninvasive compartment measurement device |
US5003982A (en) * | 1989-07-28 | 1991-04-02 | Johns Hopkins University | Dynamic indentation system |
US5107837A (en) * | 1989-11-17 | 1992-04-28 | Board Of Regents, University Of Texas | Method and apparatus for measurement and imaging of tissue compressibility or compliance |
US5293870A (en) * | 1989-11-17 | 1994-03-15 | Board Of Regents The University Of Texas System | Method and apparatus for elastographic measurement and imaging |
US5247937A (en) * | 1989-11-17 | 1993-09-28 | Board Of Regents, The University Of Texas System | Transaxial compression technique for sound velocity estimation |
US5474070A (en) * | 1989-11-17 | 1995-12-12 | The Board Of Regents Of The University Of Texas System | Method and apparatus for elastographic measurement and imaging |
US5246013A (en) * | 1989-12-22 | 1993-09-21 | Massachusetts Institute Of Technology | Probe, system and method for detecting cartilage degeneration |
DK94990A (da) * | 1990-04-17 | 1991-10-18 | Skintech Holdings Aps | Fremgangsmaade samt apparat til indtraengningsfri maaling af mindst en mekanisk egenskab for bloede biologiske vaev |
JP2001519674A (ja) * | 1991-05-10 | 2001-10-23 | ボード、オブ、リージェンツ、ザ、ユニバーシティー、オブ、テキサス、システム | エラストグラフィー測定および撮像法およびこの方法を実施する装置 |
FI90616C (fi) * | 1991-08-01 | 1994-03-10 | Ilkka Kiviranta | Jäykän kudoksen jäykkyysmittauslaite ja mittausmenetelmä |
US5503162A (en) * | 1992-04-21 | 1996-04-02 | Board Of Regents, University Of Texas System | Arthroscopic cartilage evaluator and method for using the same |
US5673708A (en) * | 1992-04-21 | 1997-10-07 | Board Of Regents, The University Of Texas System | Articular cartilage evaluator and method for using the same |
US5265612A (en) * | 1992-12-21 | 1993-11-30 | Medical Biophysics International | Intracavity ultrasonic device for elasticity imaging |
US5701913A (en) | 1995-02-03 | 1997-12-30 | University Technologies International Inc. | Tissue softness probe |
WO1997005825A1 (es) * | 1995-08-03 | 1997-02-20 | Asociacion Instituto De Biomecanica De Valencia Y Fundacion Mapfre Medicina | Instrumento para la medicion de la rigidez del cartilago articular |
DE69733261T2 (de) * | 1996-08-23 | 2006-01-19 | Osteobiologics, Inc., San Antonio | Tragbares materialprüfgerät |
DE19650992C2 (de) * | 1996-11-26 | 1998-11-12 | Machui Oliver Dipl Ing Fh | Verfahren und Vorrichtung zur Bestimmung von mechanischen Eigenschaften elastischer Materialien |
US6527716B1 (en) * | 1997-12-30 | 2003-03-04 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
US5779651A (en) * | 1997-02-07 | 1998-07-14 | Bio Syntech | Medical apparatus for the diagnosis of cartilage degeneration via spatial mapping of compression-induced electrical potentials |
DE19711516C2 (de) * | 1997-03-19 | 1999-09-09 | Kosmann | Vorrichtung zum Erfassen eines Knorpelschadens |
US6585666B2 (en) * | 1998-10-13 | 2003-07-01 | The Administrators Of The Tulane Educational Fund | Arthroscopic diagnostic probe to measure mechanical properties of articular cartilage |
-
1999
- 1999-06-21 DE DE19929578A patent/DE19929578C2/de not_active Expired - Fee Related
-
2000
- 2000-06-20 US US10/018,948 patent/US6783503B1/en not_active Expired - Fee Related
- 2000-06-20 EP EP00949113A patent/EP1194776A2/de not_active Withdrawn
- 2000-06-20 WO PCT/DE2000/001977 patent/WO2000079272A2/de active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2173896A (en) * | 1985-04-12 | 1986-10-22 | Oreal | Investigation of the properties of a surface e.g. the elasticity of skin |
EP0362616A1 (de) * | 1988-09-26 | 1990-04-11 | COURAGE + KHAZAKA ELECTRONIC GmbH | Vorrichtung und Verfahren zur Messung der elastischen und viskoelastischen Verformbarkeit der Haut |
WO1993020752A1 (en) * | 1992-04-21 | 1993-10-28 | Board Of Regents, The University Of Texas System | Arthroscopic indenter and method for using the same |
Non-Patent Citations (1)
Title |
---|
See also references of EP1194776A2 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002043588A1 (de) * | 2000-12-02 | 2002-06-06 | Universitätsklinikum Charite Medizinische Fakultät Der Humboldt-Universität Zu Berlin | Force-feedback-system |
CN102353589A (zh) * | 2011-07-11 | 2012-02-15 | 天津理工大学 | 一种在软骨力学性能测试中运用数字图像相关技术的方法 |
CN107072975A (zh) * | 2014-09-09 | 2017-08-18 | 洛桑联邦理工学院 | 用于造血干细胞药物中的方法和化合物 |
Also Published As
Publication number | Publication date |
---|---|
DE19929578C2 (de) | 2001-06-07 |
WO2000079272A3 (de) | 2001-08-09 |
DE19929578A1 (de) | 2001-01-11 |
EP1194776A2 (de) | 2002-04-10 |
US6783503B1 (en) | 2004-08-31 |
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