WO1999012958A3 - Ampullosporin, verfahren zu dessen herstellung und dessen verwendung - Google Patents
Ampullosporin, verfahren zu dessen herstellung und dessen verwendung Download PDFInfo
- Publication number
- WO1999012958A3 WO1999012958A3 PCT/DE1998/002654 DE9802654W WO9912958A3 WO 1999012958 A3 WO1999012958 A3 WO 1999012958A3 DE 9802654 W DE9802654 W DE 9802654W WO 9912958 A3 WO9912958 A3 WO 9912958A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aib
- ampullosporin
- sepedonium
- dsm
- spec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Die Erfindung betrifft eine neue neuroleptisch wirksame Substanz vom Strukturtyp der Peptaibole mit der Bezeichnung Ampullosporin, die aus der Kulturbrühe des Mikroorganismus Sepedonium spec. DSM 10602 erhältlich ist. Acetyl-L-Trp-L-Ala-Aib-Aib-L-Leu-Aib-L-Glu-Aib-Aib-Aib-L-Gln-L-Leu-Aib-L-Gln-L-Leucinol. Zur Herstellung wird der Mikroorganismus Sepedonium spec. DSM 10602 unter emersen, submersen und sterilen Kulturbedingungen angezogen. Das gebildete Ampullosporin wird als einheitliche Komponente aus der Kulturbrühe mit organischen Lösungsmitteln extrahiert und anschließend in reiner Form durch die Anwendung üblicher chromatografischer Reinigungsschritte gewonnen. Ampullosporin besitzt eine starke neuroleptische Wirkung und ist für die Herstellung pharmazeutischer Zubereitungen geeignet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19740030.2 | 1997-09-11 | ||
DE19740030A DE19740030A1 (de) | 1997-09-11 | 1997-09-11 | Ampullosporin, Verfahren zu dessen Herstellung und dessen Verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999012958A2 WO1999012958A2 (de) | 1999-03-18 |
WO1999012958A3 true WO1999012958A3 (de) | 1999-06-10 |
Family
ID=7842070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1998/002654 WO1999012958A2 (de) | 1997-09-11 | 1998-09-08 | Ampullosporin, verfahren zu dessen herstellung und dessen verwendung |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE19740030A1 (de) |
WO (1) | WO1999012958A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19948644A1 (de) * | 1999-10-01 | 2001-04-05 | Knoell Hans Forschung Ev | Neue Peptaibole mit neuroleptischer Wirkung |
DE10061525A1 (de) * | 2000-12-08 | 2002-06-20 | Knoell Hans Forschung Ev | Lipophile Oligopeptide als Carrier für Pharmaka |
DE10222792A1 (de) * | 2002-05-23 | 2003-12-04 | Aventis Pharma Gmbh | Neue Verwendung von Cephaibolen |
US7041649B2 (en) | 2002-05-23 | 2006-05-09 | Sanofi-Aventis Deutschland Gmbh | Method for treating neurological conditions and inducing immunosuppression with cephaibols |
CN1332979C (zh) * | 2004-12-27 | 2007-08-22 | 山东大学 | 新型抗生素肽哌珀霉素及其制备工艺 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0622375A1 (de) * | 1993-02-20 | 1994-11-02 | Hoechst Aktiengesellschaft | Chrysospermine, Peptidwirkstoffe aus Apiocrea chrysosperma mit pharmakologischer Wirkung, ein Verfahren zu Herstellung und Verwendung derselben |
-
1997
- 1997-09-11 DE DE19740030A patent/DE19740030A1/de not_active Withdrawn
-
1998
- 1998-09-08 WO PCT/DE1998/002654 patent/WO1999012958A2/de active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0622375A1 (de) * | 1993-02-20 | 1994-11-02 | Hoechst Aktiengesellschaft | Chrysospermine, Peptidwirkstoffe aus Apiocrea chrysosperma mit pharmakologischer Wirkung, ein Verfahren zu Herstellung und Verwendung derselben |
Non-Patent Citations (4)
Title |
---|
BIOCHIM. BIOPHYS. ACTA (1995), 1237 (1), 1-5 CODEN: BBACAQ;ISSN: 0006-3002 * |
CHEMICAL ABSTRACTS, vol. 123, no. 9, 28 August 1995, Columbus, Ohio, US; abstract no. 102102, GRIGORIEV, PAVEL ET AL: "Formation of membrane channels by chrysospermins, new peptaibol antibiotics" XP002100480 * |
GRIGORIEV, P. A. ET AL: "Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics", BIOELECTROCHEM. BIOENERG. (1997), 44(1), 155-158 CODEN: BEBEBP;ISSN: 0302-4598, XP002100478 * |
RITZAU, MICHAEL ET AL: "Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice", J. ANTIBIOT. (1997), 50(9), 722-728 CODEN: JANTAJ;ISSN: 0021-8820, September 1997 (1997-09-01), XP002100479 * |
Also Published As
Publication number | Publication date |
---|---|
DE19740030A1 (de) | 1999-03-18 |
WO1999012958A2 (de) | 1999-03-18 |
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