WO1998054223A3 - Immunological method - Google Patents

Immunological method Download PDF

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Publication number
WO1998054223A3
WO1998054223A3 PCT/GB1998/001382 GB9801382W WO9854223A3 WO 1998054223 A3 WO1998054223 A3 WO 1998054223A3 GB 9801382 W GB9801382 W GB 9801382W WO 9854223 A3 WO9854223 A3 WO 9854223A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
cells
antigen
specific
responded
Prior art date
Application number
PCT/GB1998/001382
Other languages
French (fr)
Other versions
WO1998054223A2 (en
Inventor
Richard Andrew Kay
Original Assignee
Univ Dundee
Richard Andrew Kay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dundee, Richard Andrew Kay filed Critical Univ Dundee
Priority to CA002291004A priority Critical patent/CA2291004A1/en
Priority to JP50035099A priority patent/JP2001517958A/en
Priority to EP98924427A priority patent/EP1017724A2/en
Priority to AU76631/98A priority patent/AU728909B2/en
Publication of WO1998054223A2 publication Critical patent/WO1998054223A2/en
Publication of WO1998054223A3 publication Critical patent/WO1998054223A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)

Abstract

A method of identifying an antigen-responsive T cell within a population of T cells, the method comprising the steps of: (1) obtaining a sample containing T cells which have responded to the antigen; (2) determining individually for each of a plurality of specific T cell receptors, or individually for each of a plurality of subsets of T cell receptors, whether expression of a gene encoding a specific T cell receptor, or whether expression of genes encoding a subset of T cell receptors, has increased per specific T cell receptor-positive T cell or per specific T cell receptor-positive T cell subset compared to the expression of said gene or genes in a sample containing T cells which have not responded to the antigen. The method is useful for identifying antigen-responsive T cells which are associated with a disease state such as rheumatoid arthritis.
PCT/GB1998/001382 1997-05-27 1998-05-27 Immunological method WO1998054223A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002291004A CA2291004A1 (en) 1997-05-27 1998-05-27 Immunological method
JP50035099A JP2001517958A (en) 1997-05-27 1998-05-27 Immunological method
EP98924427A EP1017724A2 (en) 1997-05-27 1998-05-27 Immunological method
AU76631/98A AU728909B2 (en) 1997-05-27 1998-05-27 Immunological method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710820.3A GB9710820D0 (en) 1997-05-27 1997-05-27 Immunological method
GB9710820.3 1997-05-27

Publications (2)

Publication Number Publication Date
WO1998054223A2 WO1998054223A2 (en) 1998-12-03
WO1998054223A3 true WO1998054223A3 (en) 1999-03-04

Family

ID=10813057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001382 WO1998054223A2 (en) 1997-05-27 1998-05-27 Immunological method

Country Status (6)

Country Link
EP (1) EP1017724A2 (en)
JP (1) JP2001517958A (en)
AU (1) AU728909B2 (en)
CA (1) CA2291004A1 (en)
GB (1) GB9710820D0 (en)
WO (1) WO1998054223A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243327A1 (en) * 2001-03-19 2002-09-25 BioChip Technologies GmbH Suface with a pattern of cells and method for its production
GB0128153D0 (en) * 2001-11-23 2002-01-16 Bayer Ag Profiling of the immune gene repertoire
EP2338509B1 (en) 2003-06-27 2014-06-18 International Institute of Cancer Immunology, Inc. Method of selecting patients suitable for WT1 vaccine
EP2857508A3 (en) 2007-03-05 2015-04-15 International Institute of Cancer Immunology, Inc. Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene, and use of them
EP2746393A4 (en) 2011-06-28 2015-06-10 Int Inst Cancer Immunology Inc Receptor gene for peptide cancer antigen-specific t cell

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012260A1 (en) * 1991-01-09 1992-07-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) METHOD OF DESCRIBING REPERTOIRES OF ANTIBODIES (Ab) AND T CELL RECEPTORS (TcR) OF THE IMMUNE SYSTEM OF AN INDIVIDUAL
WO1993004695A1 (en) * 1991-08-28 1993-03-18 The Wistar Institute T cell receptor-based therapy for rheumatoid arthritis
WO1994014067A1 (en) * 1992-12-14 1994-06-23 T Cell Sciences, Inc. Diagnosis and therapy of sarcoidosis
WO1998001738A2 (en) * 1996-06-20 1998-01-15 Cornell Research Foundation, Inc. Identification of abnormalities in the expression of t and b cell antigen receptors as disease indicators

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012260A1 (en) * 1991-01-09 1992-07-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) METHOD OF DESCRIBING REPERTOIRES OF ANTIBODIES (Ab) AND T CELL RECEPTORS (TcR) OF THE IMMUNE SYSTEM OF AN INDIVIDUAL
WO1993004695A1 (en) * 1991-08-28 1993-03-18 The Wistar Institute T cell receptor-based therapy for rheumatoid arthritis
WO1994014067A1 (en) * 1992-12-14 1994-06-23 T Cell Sciences, Inc. Diagnosis and therapy of sarcoidosis
WO1998001738A2 (en) * 1996-06-20 1998-01-15 Cornell Research Foundation, Inc. Identification of abnormalities in the expression of t and b cell antigen receptors as disease indicators

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DADAGLIO G ET AL: "SELECTIVE ANERGY OF VBETA8+ T CELLS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED INDIVIDUALS", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 179, no. 2, February 1994 (1994-02-01), pages 413 - 424, XP000601471 *
DU BOIS R.M. ET AL.,: "T-Lymphocytes that accumulate in the lung in sarcoidosis have evidence of resent stimulation of the T-cell antigen receptor", RESPIRATORY DISEASES, vol. 145, no. 5, May 1992 (1992-05-01), pages 1205 - 1211, XP002086693 *
MAR P. ET AL.,: "Quantitative tracing of mRNAs for T- and B-Lymphocyte receptor genes in individual cells by in situ hybridization with fluorochrome-labeled gene probes. 1:Expression in malignancies carrying B-lineage associated antigens", BLOOD, vol. 74, no. 2, - 1 August 1989 (1989-08-01), pages 638 - 644, XP002086694 *
MARGUERIE C. ET AL.,: "PCR-based analysis of the TCR repertoire in human autoimmune diseases", IMMUNOLOGY TODAY, vol. 13, no. 9, - 1992, pages 336 - 338, XP002086695 *

Also Published As

Publication number Publication date
CA2291004A1 (en) 1998-12-03
AU728909B2 (en) 2001-01-18
GB9710820D0 (en) 1997-07-23
JP2001517958A (en) 2001-10-09
AU7663198A (en) 1998-12-30
WO1998054223A2 (en) 1998-12-03
EP1017724A2 (en) 2000-07-12

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