WO1996018733A3 - Inactivation induite par ribozyme de l'arn associe a la leucemie - Google Patents
Inactivation induite par ribozyme de l'arn associe a la leucemie Download PDFInfo
- Publication number
- WO1996018733A3 WO1996018733A3 PCT/US1995/016451 US9516451W WO9618733A3 WO 1996018733 A3 WO1996018733 A3 WO 1996018733A3 US 9516451 W US9516451 W US 9516451W WO 9618733 A3 WO9618733 A3 WO 9618733A3
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- WIPO (PCT)
- Prior art keywords
- associated rna
- leukemia
- rna
- ribozyme
- mediated inactivation
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/126—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes involving RNAse P
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3527—Other alkyl chain
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne la construction de molécules d'ARN, y compris de ribozymes, de séquences guides externes pour la ribonucléase P et d'oligonucléotides antisens, lesquelles molécules, suivant le cas, favorisent la coupure par ribozymes d'ARN spécifiques de cancers, ou en bloquent la transcription. Ces ARN sont notamment l'ARN de la leucémie promyéloleucocytaire aiguë, l'ARN du lymphome folliculaire, et l'ARN de la leucémie myéloloïde chronique. L'invention concerne également des procédés de production et d'utilisation de telles molécules d'ARN.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU49619/96A AU4961996A (en) | 1994-12-14 | 1995-12-14 | Ribozyme-mediated inactivation of leukemia-associated rna |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35495694A | 1994-12-14 | 1994-12-14 | |
US354,956 | 1994-12-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996018733A2 WO1996018733A2 (fr) | 1996-06-20 |
WO1996018733A3 true WO1996018733A3 (fr) | 1996-12-12 |
Family
ID=23395618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/016451 WO1996018733A2 (fr) | 1994-12-14 | 1995-12-14 | Inactivation induite par ribozyme de l'arn associe a la leucemie |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4961996A (fr) |
WO (1) | WO1996018733A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
US5683873A (en) * | 1995-01-13 | 1997-11-04 | Innovir Laboratories, Inc. | EGS-mediated inactivation of target RNA |
US6057153A (en) * | 1995-01-13 | 2000-05-02 | Yale University | Stabilized external guide sequences |
US20020081733A1 (en) * | 1995-11-14 | 2002-06-27 | Catherine M. Verfaillie | Method to prepare drug-resistant, non-malignant hematopoietic cells |
US5877162A (en) * | 1996-03-14 | 1999-03-02 | Innovir Laboratories, Inc. | Short external guide sequences |
WO1998006837A1 (fr) * | 1996-08-16 | 1998-02-19 | Yale University | Transformation du phenotype de bacteries chimio-resistantes en phenotype chimio-sensible |
AU737190B2 (en) * | 1996-12-06 | 2001-08-09 | Niels Pallisgaard | Detection of chromosomal abnormalities |
US6013447A (en) * | 1997-11-21 | 2000-01-11 | Innovir Laboratories, Inc. | Random intracellular method for obtaining optimally active nucleic acid molecules |
EP1032707A2 (fr) * | 1997-11-21 | 2000-09-06 | Yale University | Procede d'identification et d'inhibition de molecules fonctionnelles d'acide nucleique dans des cellules |
US6248525B1 (en) | 1998-03-30 | 2001-06-19 | Yale University | Method for identifying essential or functional genes |
EP1860188B1 (fr) | 1999-07-07 | 2011-05-04 | ZymoGenetics, Inc. | Récepteur de cytokine humain |
US20030153083A1 (en) | 2000-01-31 | 2003-08-14 | Alexei Shir | Selective killing of cells by activation of double-stranded rna dependent protein kniase-pkr |
FR2832154B1 (fr) | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
EP1356820A1 (fr) * | 2002-04-26 | 2003-10-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vaccin ADN combiné avec un inducteur de l'apoptose de cellules tumorales |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993023057A1 (fr) * | 1992-05-14 | 1993-11-25 | Ribozyme Pharmaceuticals, Inc. | Procede et reactif destines a empecher l'evolution du cancer |
WO1995023225A2 (fr) * | 1994-02-23 | 1995-08-31 | Ribozyme Pharmaceuticals, Inc. | Procede et reactif inhibiteur de l'expression de genes concernant une affection |
-
1995
- 1995-12-14 WO PCT/US1995/016451 patent/WO1996018733A2/fr active Application Filing
- 1995-12-14 AU AU49619/96A patent/AU4961996A/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993023057A1 (fr) * | 1992-05-14 | 1993-11-25 | Ribozyme Pharmaceuticals, Inc. | Procede et reactif destines a empecher l'evolution du cancer |
WO1995023225A2 (fr) * | 1994-02-23 | 1995-08-31 | Ribozyme Pharmaceuticals, Inc. | Procede et reactif inhibiteur de l'expression de genes concernant une affection |
Non-Patent Citations (11)
Title |
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37TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY, SEATTLE, WASHINGTON, USA, DECEMBER 1-5, 1995. * |
85TH ANN.MEET. AM.ASSOC. CANCER RES.; SAN FRANCISCO, 10 April 1994 (1994-04-10) - 13 April 1994 (1994-04-13) * |
DE TH, H. ET AL.: "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promylocytic leukemia encods a functionally altered RAR", CELL, vol. 66, 23 August 1991 (1991-08-23), NA US, pages 675 - 684, XP002008608 * |
KEYSTONE SYMPOSIUM ON RIBOZYMES: BASIC SCIENCE AND THERAPEUTIC APPLICATIONS, BRECKENRIDGE, COLORADO, USA, 15 January 1995 (1995-01-15) - 21 January 1995 (1995-01-21) * |
NASON-BURCHENAL, K. ET AL.: "Over-expression of ribozymes cleaving PML-RAR-alpha in vitro is cytotoxic to acute promyelocytic leukemia cells in vivo.", BLOOD 86 (10 SUPPL. 1). PAGE 263A, ABSTRACT 1037, 15 November 1995 (1995-11-15), XP002008611 * |
NORDSTROM, J. ET AL.: "External guide sequences that direct human ribonuclease P to cleave the fusion junction of the PML-RAR-alpha RNA of acute promyelocytic leukemia.", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT 0 (19A).1995. PAGE 223, ABSTRACT A6-317, XP002008610 * |
PACE, U. ET AL.: "A ribozyme which discriminates in vitro between PML/RAR alpha, the t(15;17)-associated fusion RNA of acute promyelocytic leukemia, and PML and RAR alpha, the transcripts from the nonrearranged alleles.", CANCER RESEARCH, (1994 DEC 15) 54 (24) 6365-9., XP002008609 * |
PACE, U. ET AL.: "A ribozyme which discriminates in vitro between the acute promyelocytic leukemia t(15;17) fusion RNA, PML/RAR alpha, and the normal transcripts from the non-rearranged alleles.", PROC ANNU MEET AM ASSOC CANCER RES, VOL. 35, PAGE 206, ABSTRACT #1227, March 1994 (1994-03-01), XP002008607 * |
PAOLELLA, G. ET AL.: "NUCLEASE RESISTANT RIBOZYMES WITH HIGH CATALYTIC ACTIVITY", EMBO JOURNAL, vol. 11, no. 5, 1 May 1992 (1992-05-01), pages 1913 - 1919, XP000268586 * |
ROSSI, J. ET AL.: "RNA ENZYMES (RIBOZYMES) AS ANTIVIRAL THERAPEUTIC AGENTS", TRENDS IN BIOTECHNOLOGY, vol. 8, no. 7, 1 July 1990 (1990-07-01), pages 179 - 183, XP000133090 * |
SYMONS, R. H.: "RIBOZYMES", CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 4, no. 3, 1 June 1994 (1994-06-01), pages 322 - 330, XP000523747 * |
Also Published As
Publication number | Publication date |
---|---|
WO1996018733A2 (fr) | 1996-06-20 |
AU4961996A (en) | 1996-07-03 |
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