AU4595399A - Antisense oligonucleotide constructs based on beta-arabinofuranose and its analogues - Google Patents

Antisense oligonucleotide constructs based on beta-arabinofuranose and its analogues

Info

Publication number
AU4595399A
AU4595399A AU45953/99A AU4595399A AU4595399A AU 4595399 A AU4595399 A AU 4595399A AU 45953/99 A AU45953/99 A AU 45953/99A AU 4595399 A AU4595399 A AU 4595399A AU 4595399 A AU4595399 A AU 4595399A
Authority
AU
Australia
Prior art keywords
relates
arabinofuranose
analogues
beta
antisense oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU45953/99A
Inventor
Dominique Arion
Gadi Borkow
Massad Jose Damha
Anne M. Noronha
Michael A. Parniak
Christopher Wilds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McGill University
Original Assignee
McGill University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McGill University filed Critical McGill University
Publication of AU4595399A publication Critical patent/AU4595399A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

Abstract

The present invention relates to modified oligonucleotide therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention relates to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues. More particularly this invention relates to the use of antisense oligonucleotides having arabinose sugars to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc.
AU45953/99A 1998-06-19 1999-06-17 Antisense oligonucleotide constructs based on beta-arabinofuranose and its analogues Abandoned AU4595399A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA2241361 1998-06-19
CA2241361 1998-06-19
PCT/CA1999/000571 WO1999067378A1 (en) 1998-06-19 1999-06-17 ANTISENSE OLIGONUCLEOTIDE CONSTRUCTS BASED ON β-ARABINOFURANOSE AND ITS ANALOGUES

Publications (1)

Publication Number Publication Date
AU4595399A true AU4595399A (en) 2000-01-10

Family

ID=4162575

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45953/99A Abandoned AU4595399A (en) 1998-06-19 1999-06-17 Antisense oligonucleotide constructs based on beta-arabinofuranose and its analogues

Country Status (6)

Country Link
US (1) US20090105467A1 (en)
EP (1) EP1088066B1 (en)
AT (1) ATE346918T1 (en)
AU (1) AU4595399A (en)
DE (1) DE69934227T2 (en)
WO (1) WO1999067378A1 (en)

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AU2001259706A1 (en) * 2000-05-09 2001-11-20 Reliable Biopharmaceutical, Inc. Polymeric compounds useful as prodrugs
CA2419563C (en) * 2000-09-06 2018-03-20 Mcgill University Chimeric antisense of arabinofuranose analogue and deoxyribose nucleotides
MXPA04000162A (en) 2001-07-06 2006-05-22 Topigen Pharma Inc Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals.
US7132529B2 (en) * 2001-07-30 2006-11-07 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
US20050043256A1 (en) 2001-07-30 2005-02-24 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
ATE416183T1 (en) * 2002-02-01 2008-12-15 Univ Mcgill OLIGONUCLEOTIDES WITH ALTERNATE SEGMENTS AND USES THEREOF
US7381820B2 (en) 2003-10-24 2008-06-03 Yamasa Corporation α-1-phosphorylated-2-deoxy-2-fluoroarabinoside and process for producing 2′-deoxy-2′-fluoro-β-d-arabinonucleoside
BRPI0517387A8 (en) 2004-10-29 2017-07-11 Topigen Pharmaceuticals Inc ANTI-SENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF ALLERGY AND NEOPLASTIC CELL PROLIFERATION
EP1971371B1 (en) 2005-12-01 2015-08-05 Pronai Therapeutics, Inc. Cancer therapies and pharmaceutical compositions used therein
WO2007134451A1 (en) 2006-05-19 2007-11-29 Topigen Pharmaceuticals Inc. Oligonucleotides affecting expression of phosphodiesterases
EP2285961A4 (en) 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc Oligonucleotides for treating inflammation and neoplastic cell proliferation
JP2013520395A (en) * 2009-02-22 2013-06-06 ケムジーンズ コーポレーション Synthesis of ara-2'-O-methyl-nucleosides, phosphoramidites and oligonucleotides incorporating novel modifications for biological applications such as therapeutics, diagnostics, G-tetradogenic oligonucleosides and aptamers
AU2011325956B2 (en) 2010-11-12 2016-07-14 The General Hospital Corporation Polycomb-associated non-coding RNAs
PT2739311T (en) 2011-08-04 2018-03-26 Amgen Inc Method for treating bone gap defects
CA2848753C (en) 2011-09-14 2022-07-26 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
EP2797953B1 (en) 2011-12-28 2020-06-03 Amgen Inc. Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
CN104583398A (en) 2012-05-16 2015-04-29 Rana医疗有限公司 Compositions and methods for modulating gene expression
CA2873794A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating smn gene family expression
WO2013184209A1 (en) 2012-06-04 2013-12-12 Ludwig Institute For Cancer Research Ltd. Mif for use in methods of treating subjects with a neurodegenerative disorder
JP2016509572A (en) 2012-11-05 2016-03-31 プロナイ セラピューティクス インコーポレイテッド Methods of using biomarkers for the treatment of cancer by modulating BCL2 expression
EP3161159B1 (en) 2014-06-25 2020-08-05 The General Hospital Corporation Targeting human satellite ii (hsatii)
DE102014221734A1 (en) * 2014-10-24 2016-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Measuring device and system for melting curve analysis of a DNA microarray, and use of a fluorescence detector array for analysis
WO2018013525A1 (en) 2016-07-11 2018-01-18 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
US10954255B2 (en) 2017-08-03 2021-03-23 Karl-Franzens-Universitaet Graz Phospholipid analogues
CN112969799A (en) * 2018-09-26 2021-06-15 奥姆生命科技公司 2' FANA modified FOXP3 antisense oligonucleotides and methods of use thereof
WO2021142245A1 (en) 2020-01-10 2021-07-15 Translate Bio, Inc. Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003370A1 (en) * 1988-09-28 1990-04-05 Microprobe Corporation DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE
JP3739785B2 (en) * 1991-11-26 2006-01-25 アイシス ファーマシューティカルズ，インコーポレイティド Enhanced triple and double helix shaping using oligomers containing modified pyrimidines
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
US5795726A (en) * 1996-11-12 1998-08-18 Millennium Pharmaceuticals, Inc. Methods for identifying compounds useful in treating type II diabetes
US5739119A (en) * 1996-11-15 1998-04-14 Galli; Rachel L. Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
CA2419563C (en) * 2000-09-06 2018-03-20 Mcgill University Chimeric antisense of arabinofuranose analogue and deoxyribose nucleotides
ATE416183T1 (en) * 2002-02-01 2008-12-15 Univ Mcgill OLIGONUCLEOTIDES WITH ALTERNATE SEGMENTS AND USES THEREOF

Also Published As

Publication number Publication date
US20090105467A1 (en) 2009-04-23
DE69934227D1 (en) 2007-01-11
ATE346918T1 (en) 2006-12-15
WO1999067378A1 (en) 1999-12-29
EP1088066A1 (en) 2001-04-04
DE69934227T2 (en) 2007-10-04
EP1088066B1 (en) 2006-11-29

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase