WO1995018605A1 - Ultra-micro-emulsions of spontaneously dispersible concentrates with difficultly soluble carotenes - Google Patents

Ultra-micro-emulsions of spontaneously dispersible concentrates with difficultly soluble carotenes Download PDF

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Publication number
WO1995018605A1
WO1995018605A1 PCT/CH1994/000240 CH9400240W WO9518605A1 WO 1995018605 A1 WO1995018605 A1 WO 1995018605A1 CH 9400240 W CH9400240 W CH 9400240W WO 9518605 A1 WO9518605 A1 WO 9518605A1
Authority
WO
WIPO (PCT)
Prior art keywords
carotenes
emulsions
micro
ultra
dispersible concentrates
Prior art date
Application number
PCT/CH1994/000240
Other languages
German (de)
French (fr)
Inventor
Carl Eugster
Conrad Hans Eugster
Walter Haldemann
Giorgio Rivara
Original Assignee
Marigen S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marigen S.A. filed Critical Marigen S.A.
Priority to EP95902737A priority Critical patent/EP0719136A1/en
Publication of WO1995018605A1 publication Critical patent/WO1995018605A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The description relates to spontaneously dispersible concentrates with difficultly soluble carotenes which, when diluted with water or a 5 % glucose solution, give thermodynamically stable ultra-micro-emulsions, the micelles of which have a hydrodynamic radius of 1.5 to 3.0 nm, and their use as medicaments for the treatment of tumours, psoriasis and eczemas.
PCT/CH1994/000240 1994-01-04 1994-12-19 Ultra-micro-emulsions of spontaneously dispersible concentrates with difficultly soluble carotenes WO1995018605A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP95902737A EP0719136A1 (en) 1994-01-04 1994-12-19 Ultra-micro-emulsions of spontaneously dispersible concentrates with difficultly soluble carotenes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH394 1994-01-04
CH3/94-8 1994-01-04

Publications (1)

Publication Number Publication Date
WO1995018605A1 true WO1995018605A1 (en) 1995-07-13

Family

ID=4177217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH1994/000240 WO1995018605A1 (en) 1994-01-04 1994-12-19 Ultra-micro-emulsions of spontaneously dispersible concentrates with difficultly soluble carotenes

Country Status (3)

Country Link
EP (1) EP0719136A1 (en)
CH (1) CH685325A5 (en)
WO (1) WO1995018605A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0800825A1 (en) * 1996-03-11 1997-10-15 Basf Aktiengesellschaft Stable aqueous solutes containing carotenoids and vitamins
WO1998013359A1 (en) * 1996-09-24 1998-04-02 Marigen S.A. Ultramicroemulsion of spontaneously dispersible concentrates of esters of baccatin-iii compounds with antitumor and antiviral effect
WO1998016204A1 (en) * 1996-10-14 1998-04-23 F. Hoffmann-La Roche Ag Process for the manufacture of a pulverous preparation
EP0966960A1 (en) * 1996-11-27 1999-12-29 Dainippon Ink And Chemicals, Inc. Agent for inhibiting carcinogenesis or tumor metastasis
WO2002085328A2 (en) * 2001-02-11 2002-10-31 Aquanova German Solubilisate Technologies (Agt) Gmbh Method for producing an active ingredient concentrate, and an active ingredient concentrate
JP2013513599A (en) * 2009-12-10 2013-04-22 株式会社日健総本社 How to treat psoriasis

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1581390A (en) * 1967-09-20 1969-09-12
FR2187291A1 (en) * 1972-06-07 1974-01-18 Quatrar Sarl Water-sol carotenoid compsns - for poultry food additives or colouring human foodstuffs
JPS58128141A (en) * 1982-01-26 1983-07-30 Sumitomo Chem Co Ltd Production of soft capsule agent containing self- emulsifiable and dispersible type carotenoid
EP0385335A2 (en) * 1989-02-28 1990-09-05 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions
EP0467795A2 (en) * 1990-07-04 1992-01-22 Patrinove Dermatological or cosmetic compositions containing vitamin A derivatives
WO1992021670A1 (en) * 1991-06-04 1992-12-10 Marigen S.A., Riehen New biotenside ester and phosphatide with vitamin d and vitamin e compounds; their preparation and transformation into spontaneously dispersible concentrates and their use for treating tumors
CH683426A5 (en) * 1993-08-24 1994-03-15 Marigen Sa New ester(s) of, e.g., alkenoic acids and di:acids - are useful as soln. aids for compsns. contg. pharmaceutical or cosmetic active agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1581390A (en) * 1967-09-20 1969-09-12
FR2187291A1 (en) * 1972-06-07 1974-01-18 Quatrar Sarl Water-sol carotenoid compsns - for poultry food additives or colouring human foodstuffs
JPS58128141A (en) * 1982-01-26 1983-07-30 Sumitomo Chem Co Ltd Production of soft capsule agent containing self- emulsifiable and dispersible type carotenoid
EP0385335A2 (en) * 1989-02-28 1990-09-05 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions
EP0467795A2 (en) * 1990-07-04 1992-01-22 Patrinove Dermatological or cosmetic compositions containing vitamin A derivatives
WO1992021670A1 (en) * 1991-06-04 1992-12-10 Marigen S.A., Riehen New biotenside ester and phosphatide with vitamin d and vitamin e compounds; their preparation and transformation into spontaneously dispersible concentrates and their use for treating tumors
CH683426A5 (en) * 1993-08-24 1994-03-15 Marigen Sa New ester(s) of, e.g., alkenoic acids and di:acids - are useful as soln. aids for compsns. contg. pharmaceutical or cosmetic active agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8336, Derwent World Patents Index; AN 83-756026 (36) *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0800825A1 (en) * 1996-03-11 1997-10-15 Basf Aktiengesellschaft Stable aqueous solutes containing carotenoids and vitamins
US5891907A (en) * 1996-03-11 1999-04-06 Basf Aktiengesellschaft Stable aqueous solubilizates of carotenoids and vitamins
WO1998013359A1 (en) * 1996-09-24 1998-04-02 Marigen S.A. Ultramicroemulsion of spontaneously dispersible concentrates of esters of baccatin-iii compounds with antitumor and antiviral effect
US6057359A (en) * 1996-09-24 2000-05-02 Marigen S.A. Spontaneously dispersible concentrates comprising esters of baccatin-III compounds having antitumor and antiviral activity
WO1998016204A1 (en) * 1996-10-14 1998-04-23 F. Hoffmann-La Roche Ag Process for the manufacture of a pulverous preparation
EP0966960A1 (en) * 1996-11-27 1999-12-29 Dainippon Ink And Chemicals, Inc. Agent for inhibiting carcinogenesis or tumor metastasis
WO2002085328A2 (en) * 2001-02-11 2002-10-31 Aquanova German Solubilisate Technologies (Agt) Gmbh Method for producing an active ingredient concentrate, and an active ingredient concentrate
WO2002085328A3 (en) * 2001-02-11 2003-11-06 Aquanova Ger Solubilisate Tech Method for producing an active ingredient concentrate, and an active ingredient concentrate
JP2006241167A (en) * 2001-02-11 2006-09-14 Aquanova German Solubilisate Technologies (Agt) Gmbh Method for producing active ingredient concentrate and active ingredient concentrate
JP2013513599A (en) * 2009-12-10 2013-04-22 株式会社日健総本社 How to treat psoriasis
US9180152B2 (en) 2009-12-10 2015-11-10 Nikken Sohonsha Corporation Method for treating psoriasis

Also Published As

Publication number Publication date
CH685325A5 (en) 1995-06-15
EP0719136A1 (en) 1996-07-03

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