WO1994013658A3 - Benzocycloheptenes, benzoxepines et benzothiepines - Google Patents
Benzocycloheptenes, benzoxepines et benzothiepines Download PDFInfo
- Publication number
- WO1994013658A3 WO1994013658A3 PCT/EP1993/003445 EP9303445W WO9413658A3 WO 1994013658 A3 WO1994013658 A3 WO 1994013658A3 EP 9303445 W EP9303445 W EP 9303445W WO 9413658 A3 WO9413658 A3 WO 9413658A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- bond
- compounds
- taken together
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Resins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK94902708T DK0626954T3 (da) | 1992-12-07 | 1993-12-07 | Benzocycloheptener, benzoxepiner og benzothiepiner |
DE69324001T DE69324001T2 (de) | 1992-12-07 | 1993-12-07 | Benzocycloheptine, benzoxepine und benzothiepine |
KR1019940702708A KR100236810B1 (ko) | 1992-12-07 | 1993-12-07 | 벤조사이클로헵텐 |
RU94040853A RU2127268C1 (ru) | 1992-12-07 | 1993-12-07 | Производные бензоциклогептена или бензоксепина, способ их получения, промежуточные соединения и фармацевтическая композиция |
US08/284,454 US5602152A (en) | 1992-12-07 | 1993-12-07 | Benzoxepines |
EP94902708A EP0626954B1 (fr) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines et benzothiepines |
PL93304719A PL174246B1 (pl) | 1992-12-07 | 1993-12-07 | Nowe związki, pochodne benzocykloheptenu, benzoksepiny i benzotiepiny |
CA002129642A CA2129642A1 (fr) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines et benzothiepines |
RO94-01321A RO113040B1 (ro) | 1992-12-07 | 1993-12-07 | Derivati heterociclici de benzocicloheptene, benzoxepine sau benzotiepine, procedeu pentru prepararea acestora, compusi intermediari si compozitie farmaceutica |
SK939-94A SK93994A3 (en) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines and benzothiepines and method their producing |
JP6513771A JPH07503977A (ja) | 1992-12-07 | 1993-12-07 | ベンゾシクロヘプテン,ベンゾキセピンおよびベンゾチエピン |
AU56975/94A AU680856B2 (en) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines and benzothiepines |
LVP-94-154A LV10451B (en) | 1992-12-07 | 1994-08-05 | Benzocycloheptenes, benzoxepines and benzothiepines and methods for preparation thereof |
NO942914A NO942914L (no) | 1992-12-07 | 1994-08-05 | Benzosykloheptener, benzoksepiner og benzotiepiner |
FI943646A FI943646A0 (fi) | 1992-12-07 | 1994-08-05 | Bentsosyklohepteenejä, bentsoksepiinejä bentsotiepiinejä |
GR990401589T GR3030514T3 (en) | 1992-12-07 | 1999-06-15 | Benzocycloheptenes, benzoxepines and benzothiepines. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR92/14720 | 1992-12-07 | ||
FR9214720A FR2698873B1 (fr) | 1992-12-07 | 1992-12-07 | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994013658A2 WO1994013658A2 (fr) | 1994-06-23 |
WO1994013658A3 true WO1994013658A3 (fr) | 1994-08-04 |
Family
ID=9436308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1993/003445 WO1994013658A2 (fr) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines et benzothiepines |
Country Status (29)
Country | Link |
---|---|
US (2) | US5602152A (fr) |
EP (1) | EP0626954B1 (fr) |
JP (1) | JPH07503977A (fr) |
KR (1) | KR100236810B1 (fr) |
CN (1) | CN1050127C (fr) |
AT (1) | ATE177742T1 (fr) |
AU (1) | AU680856B2 (fr) |
CA (1) | CA2129642A1 (fr) |
CZ (1) | CZ184894A3 (fr) |
DE (1) | DE69324001T2 (fr) |
DK (1) | DK0626954T3 (fr) |
ES (1) | ES2132373T3 (fr) |
FI (1) | FI943646A0 (fr) |
FR (1) | FR2698873B1 (fr) |
GR (1) | GR3030514T3 (fr) |
HU (1) | HUT67852A (fr) |
IL (1) | IL107891A0 (fr) |
LT (1) | LT3167B (fr) |
LV (1) | LV10451B (fr) |
NO (1) | NO942914L (fr) |
NZ (1) | NZ258896A (fr) |
PL (1) | PL174246B1 (fr) |
RO (1) | RO113040B1 (fr) |
RU (1) | RU2127268C1 (fr) |
SI (1) | SI9300632A (fr) |
SK (1) | SK93994A3 (fr) |
TW (1) | TW276255B (fr) |
WO (1) | WO1994013658A2 (fr) |
ZA (1) | ZA939127B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
JP3304093B2 (ja) * | 1994-09-13 | 2002-07-22 | モンサント カンパニー | 回腸の胆汁酸輸送及びタウロコール酸塩吸収の阻害活性を有する新規ベンゾチエピン類 |
US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US5952326A (en) * | 1997-12-10 | 1999-09-14 | Pfizer Inc. | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases |
US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
ES2203239T3 (es) | 1998-12-23 | 2004-04-01 | G.D. Searle Llc | Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de agentes secuestrantes de acidos biliares para indicaciones cardiovasculares. |
US6489366B1 (en) | 1998-12-23 | 2002-12-03 | G. D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
AU776664B2 (en) | 1998-12-23 | 2004-09-16 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
NZ512536A (en) | 1998-12-23 | 2003-11-28 | G | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
IL143947A0 (en) * | 1998-12-23 | 2002-04-21 | Searle Llc | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
JP2002533414A (ja) * | 1998-12-23 | 2002-10-08 | ジー.ディー.サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ |
US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
WO2000038725A1 (fr) * | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinaisons utilisees dans le cadre de troubles cardio-vasculaires |
US20020061888A1 (en) * | 2000-03-10 | 2002-05-23 | Keller Bradley T. | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
US6794544B2 (en) | 2000-03-10 | 2004-09-21 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
JP2005518347A (ja) * | 2001-11-02 | 2005-06-23 | ジー.ディー. サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送(asbt)およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
MXPA04006255A (es) | 2002-01-17 | 2004-09-27 | Pharmacia Corp | Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. |
KR102051030B1 (ko) | 2011-10-28 | 2019-12-02 | 루메나 파마수티컬즈, 인코포레이티드 | 소아 담즙울체성 간 질환 치료용 담즙산 재순환 억제제 |
WO2013152170A1 (fr) | 2012-04-04 | 2013-10-10 | Catylix, Inc. | Modulateurs sélectifs de récepteur d'androgène |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3509142A (en) * | 1967-04-28 | 1970-04-28 | Mcneilab Inc | 4-piperidino,pyrrolidino and morpholino methyl - 2,3 - dihydro - 5 - phenyl-1-benzothiepins |
DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
BE832726A (fr) * | 1974-08-26 | 1976-02-25 | Derives du benzocycloheptene | |
FR2356647A1 (fr) * | 1976-07-01 | 1978-01-27 | Syntex Inc | Derives 3-aldehyde et 3-acetals de la 6,11-dihydro-dibenzo(b.e.)-thiepinne-11-one et procedes d'obtention |
EP0088066A1 (fr) * | 1982-02-01 | 1983-09-07 | Monsanto Company | L'acide 3,5-(trifluorométhyl)-phénoxycarboxyliques et leurs dérivés |
EP0116373A1 (fr) * | 1983-02-15 | 1984-08-22 | Merrell Dow Pharmaceuticals Inc. | Dérivés de la 2H-(1)benzoxépino(5,4-b)-1,4-oxazine |
WO1989011477A1 (fr) * | 1988-05-28 | 1989-11-30 | Beecham Group Plc | Benzoxepine et composes apparentes |
EP0360131A1 (fr) * | 1988-09-17 | 1990-03-28 | Hoechst Aktiengesellschaft | 2,3,4,5-Tétrahydro 1-benzoxépines, procédé pour leur préparation, leur utilisation et compositions pharmaceutiques à base de ces esters |
JPH03251586A (ja) * | 1990-01-24 | 1991-11-11 | Yoshitomi Pharmaceut Ind Ltd | 光学活性なベンゾチエピノピリダジン化合物の製造法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0076075B1 (fr) | 1981-09-25 | 1986-11-20 | Beecham Group Plc | Dérivés de benzopyranes pharmacologiquement actifs |
AU597671B2 (en) * | 1986-06-20 | 1990-06-07 | Suntory Limited | 2-Phenylbenzoxepin derivative |
DE3726261A1 (de) | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
US4971982A (en) | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
DE3922392A1 (de) * | 1989-07-07 | 1991-01-17 | Merck Patent Gmbh | Chromanderivate |
-
1992
- 1992-12-07 FR FR9214720A patent/FR2698873B1/fr not_active Expired - Fee Related
-
1993
- 1993-12-03 SI SI9300632A patent/SI9300632A/sl unknown
- 1993-12-03 LT LTIP1525A patent/LT3167B/lt not_active IP Right Cessation
- 1993-12-06 CN CN93120135A patent/CN1050127C/zh not_active Expired - Fee Related
- 1993-12-06 ZA ZA939127A patent/ZA939127B/xx unknown
- 1993-12-06 IL IL10789193A patent/IL107891A0/xx unknown
- 1993-12-07 EP EP94902708A patent/EP0626954B1/fr not_active Expired - Lifetime
- 1993-12-07 US US08/284,454 patent/US5602152A/en not_active Expired - Fee Related
- 1993-12-07 ES ES94902708T patent/ES2132373T3/es not_active Expired - Lifetime
- 1993-12-07 TW TW082110417A patent/TW276255B/zh active
- 1993-12-07 HU HU9402302A patent/HUT67852A/hu unknown
- 1993-12-07 JP JP6513771A patent/JPH07503977A/ja active Pending
- 1993-12-07 WO PCT/EP1993/003445 patent/WO1994013658A2/fr not_active Application Discontinuation
- 1993-12-07 RU RU94040853A patent/RU2127268C1/ru active
- 1993-12-07 AU AU56975/94A patent/AU680856B2/en not_active Ceased
- 1993-12-07 PL PL93304719A patent/PL174246B1/pl unknown
- 1993-12-07 RO RO94-01321A patent/RO113040B1/ro unknown
- 1993-12-07 AT AT94902708T patent/ATE177742T1/de not_active IP Right Cessation
- 1993-12-07 CA CA002129642A patent/CA2129642A1/fr not_active Abandoned
- 1993-12-07 NZ NZ258896A patent/NZ258896A/en unknown
- 1993-12-07 KR KR1019940702708A patent/KR100236810B1/ko not_active IP Right Cessation
- 1993-12-07 DE DE69324001T patent/DE69324001T2/de not_active Expired - Fee Related
- 1993-12-07 CZ CZ941848A patent/CZ184894A3/cs unknown
- 1993-12-07 DK DK94902708T patent/DK0626954T3/da active
- 1993-12-07 SK SK939-94A patent/SK93994A3/sk unknown
-
1994
- 1994-08-05 LV LVP-94-154A patent/LV10451B/en unknown
- 1994-08-05 NO NO942914A patent/NO942914L/no unknown
- 1994-08-05 FI FI943646A patent/FI943646A0/fi unknown
-
1995
- 1995-06-05 US US08/460,866 patent/US5652252A/en not_active Expired - Fee Related
-
1999
- 1999-06-15 GR GR990401589T patent/GR3030514T3/el unknown
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
US3509142A (en) * | 1967-04-28 | 1970-04-28 | Mcneilab Inc | 4-piperidino,pyrrolidino and morpholino methyl - 2,3 - dihydro - 5 - phenyl-1-benzothiepins |
BE832726A (fr) * | 1974-08-26 | 1976-02-25 | Derives du benzocycloheptene | |
DE2536509A1 (de) * | 1974-08-26 | 1976-03-18 | Takeda Chemical Industries Ltd | Benzocycloheptenderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
FR2356647A1 (fr) * | 1976-07-01 | 1978-01-27 | Syntex Inc | Derives 3-aldehyde et 3-acetals de la 6,11-dihydro-dibenzo(b.e.)-thiepinne-11-one et procedes d'obtention |
EP0088066A1 (fr) * | 1982-02-01 | 1983-09-07 | Monsanto Company | L'acide 3,5-(trifluorométhyl)-phénoxycarboxyliques et leurs dérivés |
EP0116373A1 (fr) * | 1983-02-15 | 1984-08-22 | Merrell Dow Pharmaceuticals Inc. | Dérivés de la 2H-(1)benzoxépino(5,4-b)-1,4-oxazine |
WO1989011477A1 (fr) * | 1988-05-28 | 1989-11-30 | Beecham Group Plc | Benzoxepine et composes apparentes |
EP0360131A1 (fr) * | 1988-09-17 | 1990-03-28 | Hoechst Aktiengesellschaft | 2,3,4,5-Tétrahydro 1-benzoxépines, procédé pour leur préparation, leur utilisation et compositions pharmaceutiques à base de ces esters |
JPH03251586A (ja) * | 1990-01-24 | 1991-11-11 | Yoshitomi Pharmaceut Ind Ltd | 光学活性なベンゾチエピノピリダジン化合物の製造法 |
Non-Patent Citations (2)
Title |
---|
CHEMICAL ABSTRACTS, vol. 93, no. 1, 7 July 1980, Columbus, Ohio, US; abstract no. 7854k * |
DATABASE WPI Week 9151, Derwent World Patents Index; AN 91-373587 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1994013658A3 (fr) | Benzocycloheptenes, benzoxepines et benzothiepines | |
NZ297661A (en) | Hindered N-oxide esters of rapamycin and pharmaceutical compositions | |
CA2036304A1 (fr) | Derives de la pyrimidinedione; preparation et utilisation | |
MX9606331A (es) | Nuevos compuestos, procesos para la preparacion de los mismos y agentes antitumor. | |
DE3474444D1 (en) | 1,3,4,5-tetrahydrobenzo(c,d)indoles, process for their preparation and their uses | |
TW256835B (fr) | ||
ZA889597B (en) | Macrocyclic chelating agents and chelates thereof | |
MY117092A (en) | Chemotherapeutic pyrrolocarbazole derivatives | |
HUT60232A (en) | Process for producing diiododiethylether derivatives | |
NZ333798A (en) | Arylcycloalkane carboxylic esters, their use for the treatment of urinary incontinence or irritable bowel syndrome, and method of manufacture. | |
MY131762A (en) | Pharmaceutical compounds | |
TW427993B (en) | New cephem compounds | |
EP0791589A4 (fr) | ||
TW372964B (en) | Substituted 2-phenylpyridines, compositions containing same, processes for preparing same and their uses | |
TH16053A (fr) | ||
GR3017838T3 (en) | Amines showing fungicidal activity. | |
MY131175A (en) | Heterocyclic compounds | |
JO1832B1 (en) | Therapeutic agents | |
JO1755B1 (en) | Therapeutic agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AT AU BB BG BR CA CH CZ DE DK ES FI GB HU JP KP KR LK LU LV MG MN MW NL NO NZ PL PT RO RU SD SE SK UA US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: PV1994-1848 Country of ref document: CZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1994902708 Country of ref document: EP Ref document number: 94-01321 Country of ref document: RO |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AT AU BB BG BR CA CH CZ DE DK ES FI GB HU JP KP KR LK LU LV MG MN MW NL NO NZ PL PT RO RU SD SE SK UA US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 258896 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 93994 Country of ref document: SK Ref document number: 08284454 Country of ref document: US Ref document number: 943646 Country of ref document: FI Ref document number: 2129642 Country of ref document: CA |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWP | Wipo information: published in national office |
Ref document number: 1994902708 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: PV1994-1848 Country of ref document: CZ |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 1994902708 Country of ref document: EP |
|
WWR | Wipo information: refused in national office |
Ref document number: PV1994-1848 Country of ref document: CZ |