WO1993000129A1 - Dispositif d'acces implantable - Google Patents

Dispositif d'acces implantable Download PDF

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Publication number
WO1993000129A1
WO1993000129A1 PCT/EP1992/001352 EP9201352W WO9300129A1 WO 1993000129 A1 WO1993000129 A1 WO 1993000129A1 EP 9201352 W EP9201352 W EP 9201352W WO 9300129 A1 WO9300129 A1 WO 9300129A1
Authority
WO
WIPO (PCT)
Prior art keywords
valve
port
catheter
membrane
port according
Prior art date
Application number
PCT/EP1992/001352
Other languages
German (de)
English (en)
Inventor
Zeljko MILOS^¿EVIC
Renate MILOS^¿EVIC
Original Assignee
Milosevic Zeljko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19914120425 external-priority patent/DE4120425A1/de
Priority claimed from DE19924211045 external-priority patent/DE4211045A1/de
Application filed by Milosevic Zeljko filed Critical Milosevic Zeljko
Publication of WO1993000129A1 publication Critical patent/WO1993000129A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0208—Subcutaneous access sites for injecting or removing fluids

Definitions

  • the invention relates to an implantable port with a closed hollow body, the wall delimiting its interior has a wall area formed by a puncturable, elastic membrane and a connection opening into the interior for a catheter, the tip of which faces away from the connection Introduction into a vessel to be catheterized, and with a valve which is closed in its unactuated state serves as a shut-off device on the way from the port interior to the catheter tip.
  • the port is implanted subcutaneously and its one end is connected to the connection opening.
  • This catheter with its tip opposite this end is guided inside the body to the point to which access is required.
  • the tip of the catheter can be placed in an artery, a vein or in the epidural or intrathecal space.
  • the tip of the catheter can also be connected to an occluder, which is arranged on a blood vessel and throttles or closes this blood vessel when pressure medium is applied.
  • the application areas of the ports thus extend in particular to chemotherapy for cancer treatment, the therapy of arterial occlusive diseases, the treatment of pain and the provision of vascular accesses which can be punctured quickly in emergency patients.
  • valve which normally closes the catheter and which is only opened during the puncture procedure by the pressure exerted via the puncture cannula.
  • the valve is immediate arranged on the catheter tip used for insertion into the vessel to be catheterized.
  • the tip of the tube forming the catheter is closed and the tube is provided with lateral, axial slots which are closed due to the elasticity of the tube material and which only open when the agent to be injected is under pressure from the interior by means of the puncture cannula port is fed here.
  • the valve is inserted into the tip of the catheter tube, which is open at its end, and opens when pressure is exerted in the axial direction of the catheter tube. Should . If the valve on the catheter tip is also suitable for removing body fluid, then it has side flaps on the valve body that only open when there is negative pressure. These flaps cannot therefore be reached by rinsing liquid, since they only allow body fluid to wash around the outside of the catheter tip.
  • valve Since in all known embodiments the valve is arranged directly on the tip used for insertion into the vessel and therefore lies inside the vessel when the port is in use, body fluid, in particular venous or arterial blood, is constantly applied to it , so that it can accumulate. In addition, penetration of the body fluid into the valve cannot be reliably ruled out during puncturing. Because of its location on the tip of the catheter, the valve cannot be cleaned by irrigation fluid injected into the port. As a result, the known valves on the catheter tip are themselves susceptible to constipation. In particular, it has been shown that with such valves in arterial vessels, the blockage probability is 50% within six months. With valves inserted into venous vessels, the likelihood of clogging is high somewhat smaller, but by no means negligible.
  • a thrombus always forms on the catheter in the area of these valves, which creates the risk of microembolism. If such a valve finally has to be replaced due to a malfunction that cannot be remedied, a major surgical intervention is always required at the connection point of the catheter to the vessel, usually in the abdominal cavity.
  • the invention has for its object to provide an implantable port of the type mentioned, the functionality of which is ensured for a long time and in addition the risk of thrombosis is considerably reduced.
  • this object is achieved in that the valve is arranged at a distance from the tip which is used for insertion into the vessel to be catheterized.
  • the tip used for insertion into the vessel to be catheterized is therefore completely open and free of opening and closing obstacles in the tip of the catheter to be inserted into the vessel. Because of this fluid dynamically favorable conditions in the region lying in the vascular region of the catheter occur there no disturbances and / or deposits, "in particular of blood, whereby a Thrombusgefahr is excluded.
  • valve As a result of its functional reliability, the time interval between rinses can also be considerably increased.
  • Another advantage of arranging the valve at a point in the system that is moved away from the tip used for insertion is that, in the event of a malfunction, it is not necessary to intervene surgically at the connection point between the catheter and the vessel, but rather the intervention in the position area of the valve itself which is expediently chosen in an easily accessible place ...
  • valve is close to that .; Connection is arranged. Since the hollow body of the port is implanted subcutaneously at an easily accessible location on the body, the valve located near the connection provided on the wall area of the hollow body is then easily accessible and can be operated without major intervention, possibly together with the hollow body , be replaced. This is made even easier if the valve is arranged in a pluggable adapter.
  • a particularly advantageous embodiment consists in the valve being arranged in the connection.
  • the valve and the hollow body form a unit.
  • the valve can be arranged inside the wall, which at this point of the connection for establishing the connection between the interior and the catheter to be connected externally is broken through in a channel-like manner.
  • valve is arranged in the interior.
  • the valve can be accommodated in the interior of the hollow body without any appreciable enlargement of the port.
  • the catheter then extends freely from the connection to its open tip without any flow obstacles being present in the catheter itself or in the region of its connection to the hollow body.
  • the valve which is self-closing in its non-actuated state is opened by the pressure acting on the valve of the agent supplied during the puncture by means of the puncture cannula.
  • These embodiments are therefore particularly suitable for applications in which the port is connected to an arterial vessel, as for example in the regional chemotherapy of the liver or intraarterial Prostaglandintherapie on 'the common femoral artery of the case.
  • only one agent is injected into the vessel at a time via the port system, while aspiration for the purpose of removing body fluid via the port system is not necessary.
  • valve has an actuating element arranged opposite to the membrane for transferring it into its open position.
  • the valve can thus be brought mechanically into its open position completely independently of the pressure conditions in the port system and the vessel connected to it, also by means of the puncture needle, so that, in particular, blood sampling is also possible.
  • This possibility of mechanically opening the valve exists in addition to the purely pressure-dependent opening possibility, because in the case of injection, the pressure built up in the hollow body also acts independently of a mechanical contact on the actuating element and thereby brings about the opening of the valve.
  • the actuating element has a platform facing the membrane.
  • the platform which advantageously extends along the entire area occupied by the membrane surface, ensures that the cannula Punk ⁇ tion independent of .; their puncture site and their puncture angle securely and thus transfers the actuation movement of the puncture cannula to the actuation element of the valve under all circumstances. Because the platform retracts when its actuation movement counter to the closing force of the valve, the puncture needle is decelerated in their soft impact, so-that damage to the Kanü- be prevented lenspitze '. This is particularly advantageous for an injury-free withdrawal of the puncture cannula from the elastic membrane.
  • FIG. 1 shows a first embodiment of a port in perspective, partially cutaway view
  • FIG. 2 shows a section through the port of FIG. 1, 3 shows a sectional view of the port corresponding to FIG. 2 when puncturing,
  • FIG. 4 shows a sectional view corresponding to the representation of FIG. 2 of a slightly modified second embodiment
  • FIG. 5 shows a sectional view corresponding to the representation of FIG. 2 of a slightly modified third embodiment
  • Fig. 6 is a view of Fig. 2 corresponding sectional view of a somewhat more
  • FIG. 7 is a sectional view corresponding to the representation of FIG. 2 of a fifth embodiment
  • Fig. 8 is a sectional view corresponding to the representation of Fig. 2. heavily modified sixth embodiment,
  • FIG. 9 is a sectional view corresponding to the position of FIG. 2 of a seventh embodiment modified further from FIG. 8, and
  • an implantable port 1 has an axially symmetrical hollow body 2, the axis of symmetry of which is denoted by A in FIGS. 2 to 8.
  • Hollow bodies 2 are made of a plastic, for example, while the upper wall area 5 opposite the lower wall area 3 and extending transversely to the axis of symmetry A is formed by a membrane made of a puncturable, elastic material, for example silicone.
  • the latter is clamped at its edge in an annular groove 7 running around the inside of the lateral wall area 4.
  • the axial dimension of the annular groove 7 is selected to be significantly smaller than the axial thickness of the membrane 5 in the ⁇ tne-clamped state, so that the membrane 5 thickens axially towards the central axis of symmetry A.
  • the axial thickness of the membrane 5 in the area of the annular groove 7 which clamps it in is 6 mm, while the thickness increases to 9 mm towards the center of the membrane.
  • the lower wall area 3 has a flat surface on its outside and is provided with fastening holes 8 on its edge which is radially widened compared to the upper area having the membrane 5.
  • the port 1 is implanted subcutaneously with its lower wall area 3 pointing towards the body and is fixed, for example, by non-absorbable surgical suture material with the aid of the fastening holes 8. In this position, the membrane 5 is removed from the body skin covered and can be pierced through it by means of a puncture cannula 9 shown in FIG. 3.
  • a valve provided in the hollow body 1 in the exemplary embodiments of FIGS. 1 to 6 has a piston 10, the two end faces 11 and 12 of which extend radially, that is to say transversely to the axis of symmetry A. Furthermore, in the exemplary embodiments from FIGS. 2 to 6, an annular groove 13, which is coaxial with the axis of symmetry A, is formed in the piston 10 from the lower end face 12, which has an annular web 14 which is complementary thereto and which is located on the inside of the lower wall area 3 is formed, is in sliding engagement, whereby the piston 10 is guided free of tilting or radial deviations along the direction of the axis of symmetry A.
  • the piston 10 is loaded in the axial direction towards the membrane 5 by an elastic element, which in the embodiments shown in FIGS. 1 to 6 is formed by a centrally and axially extending coil spring 15. This is in its upper region in a central bore 16 which is open on the lower end face 12 of the piston 10 and on the upper closed end face of which the upper end of the helical spring 15 is supported. The opposite lower end of the helical spring 15 is supported on the lower wall area 3.
  • Variations not shown in the drawing for the guidance of the piston 10 relative to the hollow body 2 and the support and guidance of the helical spring 15 consist, for example, of the helical spring 15 alternatively on a mandrel formed on the supporting end face 12 of the piston 10 or in an in to guide the lower wall area 3 formed recess. Furthermore, a mandrel formed on the lower end face 12 of the piston 10 could instead be in a on the lower wall region 3 trained cylindrical projection be slidably guided, the helical spring 15 then being able to be guided on the outer surface of the cylindrical projection.
  • the piston 10 is designed in the form of a truncated cone converging towards the membrane 5.
  • the extending between the upper and lower end faces 11 and 12 of the outer surface of the piston 10 forms a sealing surface 17, which has been conically formed in the interior 6 to form a counter-sealing surface 18 by the axial action of the piston 10 by means of the helical spring 15 ⁇ lichen wall area 4 is sealingly held in system.
  • the "area 19 of the interior 6 adjacent to the membrane 5 is opposite one another due to the sealing seat between the sealing surface 17 of the piston 10 and the counter-sealing surface 18 of the wall area 4 in the side wall area 4 provided opening of a connection 20, which opens into the interior 6 near the lower wall area 3, because the connection 20 in the sealing position of the piston 10 shown in FIGS. 2, 4 and 5 lies below the lower end face 12 of the piston 10.
  • FIG. 4 shows a modification in that the surface line of the sealing surface 17 is convex and that of the counter-sealing surface 18 is concavely curved.
  • the piston 10 stands with a cylindrical jacket region 21 extending from its lower end face 12, with a conical truncated jacket area 22, an adjoining radial shoulder surface 23 and an adjoining further cylindrical jacket area 24 of smaller diameter in contact with the inside of the lateral wall area 4 complementarily shaped to the shape of these jacket areas.
  • the actual sealing surfaces are formed by the radial shoulder surface 23 and the complementary counter surface 25 of the side wall area 4, between which a radially annular elastic seal 26 is arranged.
  • the opening of the connection 20 opens into the complementary frustoconical shell region 27 of the lateral wall region 4 into the interior and is thus closer to the membrane 5 than is the case with the embodiments shown in FIGS. 1 to 5 and 7 .
  • the radial shoulder surface 23 acting as a sealing surface, the complementary counter surface 25 and the gasket 26 arranged between them are located between the opening of the connection 20 and the region 19 of the interior 6 adjacent to the membrane 5, so that the connection between the opening of the connection 20 and the membrane 5 in the normal position of the piston 10 shown in FIG. 6 is interrupted.
  • a flat radial plate 10 ' which is fixed immovably with respect to the side wall area 4, separates the area 19 of the interior 6 adjacent to the membrane 5 from the area of the interior 6 adjacent to the connection 20 in a sealing manner .
  • the lower end face 12 'of the plate 10' lies axially with the lower wall area 3
  • a bore 16 is formed in the valve body 34 from its end face facing the lower wall region 3, in which a helical spring 15 which acts on the valve body 34 in the direction of the membrane 5 is supported. The other end of the coil spring 15 is supported on the lower wall area 3.
  • the tapered end of the valve body 34 is adjoined by an axial connecting region 31, which at its end facing the membrane 5 has a related radial platform 30, which has a slight radial play with respect to the wall region 4 and, moreover, approximately occupies the entire radial surface of the membrane 5.
  • the piston 10 thus forms, through the interaction of its sealing surface 17 with the counter-sealing surface 18 of the lateral wall region 4, a valve 19 separating the region 19 of the interior 6 adjacent to the membrane 5 from the connection opening 20.
  • the valve separating the area 19 from the connection opening 20 is formed by the valve body 34 which interacts with the plate 10 'and whose conical-shaped sealing surface 17 seals the complementary counter-sealing surface 18 of the plate 11 'cooperates.
  • the valve 32 is in the connection 20 and in. the area of a catheter 28 connected to the connection 20 is arranged close to the port 1.
  • FIG. 8 and 9 the valve 32 is in the connection 20 and in. the area of a catheter 28 connected to the connection 20 is arranged close to the port 1.
  • the opening 33 of the connection 20 passing through the side wall region 4 is flared from the interior 6 to the exterior of the port 1, a conical valve body 34 having a complementary shape being mounted in this conical extension.
  • the valve body 34 is by means of one of its Coil spring 35 determining the closing pressure is biased from its conically widened end face into the conically widened opening 33, so that the valve 32 is held in its closed position by the helical spring 35.
  • the flared opening 33 with the valve body 34 held by the helical spring 35 in the closed position is arranged in an intermediate piece 36 which is separate from port 1 and which is close to port 1 in the catheter 28 connected to port 20 is inserted.
  • connection 20 is used for connection to the catheter 28 schematically indicated in the drawing, the tip of which, facing away from the connection opening 20, is connected, for example, to a venous or arterial vessel or connected to an occluder (not shown ) .
  • occluders are arranged on a blood vessel and, when a pressure medium is supplied through the catheter 28, cause the blood flow to be throttled or closed. In this way, e.g. B. Temporary desarterializations of the hepatic aorta. performed for cancer therapy.
  • the port 1 serves to supply agents for chemotherapy and, in the case of venous vessels, alternatively also for taking blood. , '
  • the sealing surface 17 is lifted from the counter-sealing surface 18 or in FIG. 6 the radial shoulder 23, which for example carries the seal 26, from the counter-surface 25 and the connection between the connection opening 20 and that to the membrane 5 adjacent area 19 of the interior 6 released.
  • Air or liquid can thus both be injected into the catheter 28 and removed from the catheter 28 through the puncture cannula 9.
  • the valve is closed again by the force of the coil spring 15.
  • the membrane 5 is then completely decoupled from the pressure conditions prevailing in the catheter 28 and is therefore stress-free.
  • the tightness of port 1 is therefore ensured even after a great number of punctures, which can ultimately lead to fatigue despite the pretensioning of membrane 5 mentioned at the outset.
  • the piston 10 thus acts simultaneously as a closure body and actuating member of the valve, while in the embodiment of FIG. 7 the actuating member through the platform 30 and the connection region 31 that actuates it with the valve body is formed.
  • the membrane 5 in the puncture area of the puncture cannula 9 only an actuating member which comes into contact with the cannula tip 29 could be arranged, the movement of which is transmitted as an opening movement to a valve arranged separately in the hollow body 2.
  • the puncturing process described above is therefore based on a mechanical contact between the puncture cannula 9 and the piston 10 or the platform 30 serving as an actuating element.
  • valve can always be opened regardless of the pressure conditions, especially in the If the catheter 28 is connected to a venous system, blood is drawn after the valve has been opened by suction. If such a removal is not intended, however, contact with the cannula tip 29 is not required. Rather, the pressure of the injection means supplied through the puncture cannula 9 is sufficient to move the piston 10 or the valve body 34 into its open position.
  • the sixth and seventh embodiments shown in FIGS. 8 and 9 are based on such pressure actuation by the injector supplied. As can be seen from FIGS.
  • the injection agent supplied by the puncture cannula 9 acts in the interior 6 of the port 1, the pressure building up against the force of the spring 35 on the valve body 34 in the sense of a displacement of the valve body 3.4 into the 'open position.
  • the connection between the interior 6 and the tip of the catheter 28 is established solely by exerting pressure, while the embodiments of FIGS. 1 to 7 actuate the valve both by mechanical contact with the puncture cannula 9 and also alone enable by exerting pressure.
  • FIG. 10 shows an adapter 37 which can be inserted into the catheter 28, for example, in the manner of the valve 32 in FIG. 9 * .
  • the adapter 37 is also expediently arranged directly on the hollow body 2 of the implanted port 1.
  • the special valve according to FIG. 10 explained in the following consists of two opening in the opposite direction and in the immediate spatial vicinity of valves arranged next to one another can also be arranged in the interior 6 of the hollow body 2 of the port.
  • Cavity the volume of which is kept as small as possible by appropriate shaping.
  • A sits in the center of the expansion 38.
  • Central body 39 which forms the valve seats in the manner shown.
  • the valve 32 can be recognized again. This opens automatically in the manner described above when an overpressure is generated on its left side in FIG. 10 by an injection means injected into the port 1.
  • the injection agent can thus be passed on to the catheter tip in the manner already explained.
  • the valve 32 is again provided with a truncated cone-shaped valve body and has on its rear side a blind hole in which the helical spring 15 holding the valve is mounted at one end, the other end of which rests on a guide pin 40 which is axially parallel to one of the two ⁇ the half body forming the adapter 37 protrudes into the line 38 on.
  • the truncated cone-shaped valve body has an additional rubber seal adapted to it in its jacket. This either results in the higher sealing effect or permits production with the same sealing effect . lower precision requirements.
  • a nozzle 42 is arranged in parallel in the immediate vicinity in the same flow space and opens in the opposite direction. It is obvious that the opening pressures of valve 32 and nozzle valve 42 can be freely selected as required by appropriate selection of the springs acting on them or their corresponding preload can. As is clearly shown in FIG. 10, the nozzle valve 42 is constructed in the same way as the valve 32 through which the injection liquid is pressed. It is arranged in the central body 39 of the adapter 37 only in the opposite direction.
  • the dispensing valve 42 allows the removal of body fluid present to the right of the two valves in FIG. 10 with the aid. a negative pressure that is generated in the interior 6 of the port 1 with the aid of a puncture cannula 9. It can be clearly seen from the figure that the vacuum opening the nozzle valve 42 presses the valve 32 even more firmly into its valve seat and keeps it closed, while conversely the injection pressure opening the valve 32 presses the nozzle valve 42 into its valve seat and closes holds.
  • valve is not important in detail. Any other valve, which can be arranged in the interior 6 of the port, in the connection 20, in the catheter 28 or in the adapter 37 and which has the closing and opening functions described above, could equally well be used. List of reference symbols

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Dans un dispositif d'accès implantable (1) raccordé à un cathéter (28), la communication entre l'intérieur (6) du dispositif d'accès (1) et la pointe du cathéter (28) qui lui est raccordé est coupée par une soupape (32; 10, 17, 18) qui soit s'ouvre toute seule pendant le ponctionnement sous la pression du milieu injecté soit est ouverte par contact mécanique avec une canule de ponctionnement. Afin d'empêcher le système d'accès de se boucher et d'éviter la formation de thromboses, la soupape est montée en un point du système d'accès tel que la pointe du cathéter (28) introduite dans le vaisseau à cathéteriser reste en tout cas ouverte et ne contient aucun élément de soupape.
PCT/EP1992/001352 1991-06-20 1992-06-15 Dispositif d'acces implantable WO1993000129A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19914120425 DE4120425A1 (de) 1991-06-20 1991-06-20 Implantierbarer port
DEP4120425.5 1991-06-20
DE19924211045 DE4211045A1 (de) 1992-04-02 1992-04-02 Implantierbarer Port
DEP4211045.9 1992-04-02

Publications (1)

Publication Number Publication Date
WO1993000129A1 true WO1993000129A1 (fr) 1993-01-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1992/001352 WO1993000129A1 (fr) 1991-06-20 1992-06-15 Dispositif d'acces implantable

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WO (1) WO1993000129A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4243935A1 (de) * 1992-12-23 1994-07-07 Renate Milosevic Ventilanordnung zwischen einem zum Injizieren dienenden Port und einem Katheter
WO1998031416A2 (fr) * 1997-01-21 1998-07-23 Vasca, Inc. Chambre et procede d'acces vasculaire
EP0968027A2 (fr) * 1997-01-21 2000-01-05 Vasca, Inc. Procedes et systemes d'acces vasculaire
US6238369B1 (en) 1997-01-21 2001-05-29 Vasco, Inc. Method and systems for establishing vascular access
US6258079B1 (en) 1997-01-21 2001-07-10 Vasca, Inc. Method and systems for establishing vascular access
EP1154810A1 (fr) * 1999-01-28 2001-11-21 Vasca, Inc. Procede et appareil permettant d'acceder par voie percutanee a un orifice implante commande par la pression
US6929631B1 (en) 1994-01-18 2005-08-16 Vasca, Inc. Method and apparatus for percutaneously accessing a pressure activated implanted port
US7056316B1 (en) 1997-01-21 2006-06-06 Vasca, Inc. Valve port and method for vascular access
WO2007008197A1 (fr) * 2005-07-08 2007-01-18 Longbrook Company, L.L.C. Vanne pour un acces transcutane aux vaisseaux sanguins ou fistules existants
US8608728B2 (en) 2004-03-01 2013-12-17 Smiths Medical Asd, Inc. Delivery system and method
CN106535792A (zh) * 2014-04-10 2017-03-22 健康网络大学 用于将医用装置连接至生物***的套管
CN107376043A (zh) * 2017-08-24 2017-11-24 范朕 一种可植入皮下的血管通路穿刺阀
EP3501593A1 (fr) * 2017-12-22 2019-06-26 Roche Diabetes Care GmbH Agencement de septum

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983000367A1 (fr) * 1981-07-16 1983-02-03 Trawöger, Werner Soupape servant a l'adduction, au controle et au prelevement d'un milieu contenu dans un recipient implante
US4557722A (en) * 1983-04-13 1985-12-10 Cordis Corporation Fill port for an implantable dispensing system
GB2192338A (en) * 1986-07-07 1988-01-13 Bristol Myers Co Septum
DE3710794A1 (de) * 1987-03-31 1988-11-17 Medinorm Ag Implantierbare, in den blutstrom einschaltbare kapsel, in die transcutan stoffe oder lebende zellen eingebracht werden koennen, die mit dem blut mittels membranen bestimmter porengroesse im austausch stehen
WO1989002764A1 (fr) * 1987-10-05 1989-04-06 Heimhilcher Guenter Agencement de clapet antiretour
US4846806A (en) * 1987-10-06 1989-07-11 501 Regents Of University Of Minnesota Implantable intravascular access system

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983000367A1 (fr) * 1981-07-16 1983-02-03 Trawöger, Werner Soupape servant a l'adduction, au controle et au prelevement d'un milieu contenu dans un recipient implante
US4557722A (en) * 1983-04-13 1985-12-10 Cordis Corporation Fill port for an implantable dispensing system
GB2192338A (en) * 1986-07-07 1988-01-13 Bristol Myers Co Septum
DE3710794A1 (de) * 1987-03-31 1988-11-17 Medinorm Ag Implantierbare, in den blutstrom einschaltbare kapsel, in die transcutan stoffe oder lebende zellen eingebracht werden koennen, die mit dem blut mittels membranen bestimmter porengroesse im austausch stehen
WO1989002764A1 (fr) * 1987-10-05 1989-04-06 Heimhilcher Guenter Agencement de clapet antiretour
US4846806A (en) * 1987-10-06 1989-07-11 501 Regents Of University Of Minnesota Implantable intravascular access system

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4243935A1 (de) * 1992-12-23 1994-07-07 Renate Milosevic Ventilanordnung zwischen einem zum Injizieren dienenden Port und einem Katheter
US6929631B1 (en) 1994-01-18 2005-08-16 Vasca, Inc. Method and apparatus for percutaneously accessing a pressure activated implanted port
EP0968027A4 (fr) * 1997-01-21 2000-03-29 Vasca Inc Procedes et systemes d'acces vasculaire
US7056316B1 (en) 1997-01-21 2006-06-06 Vasca, Inc. Valve port and method for vascular access
EP0968027A2 (fr) * 1997-01-21 2000-01-05 Vasca, Inc. Procedes et systemes d'acces vasculaire
WO1998031416A3 (fr) * 1997-01-21 1998-11-12 Vasca Inc Chambre et procede d'acces vasculaire
US6238369B1 (en) 1997-01-21 2001-05-29 Vasco, Inc. Method and systems for establishing vascular access
US6258079B1 (en) 1997-01-21 2001-07-10 Vasca, Inc. Method and systems for establishing vascular access
US6007516A (en) * 1997-01-21 1999-12-28 Vasca, Inc. Valve port and method for vascular access
WO1998031416A2 (fr) * 1997-01-21 1998-07-23 Vasca, Inc. Chambre et procede d'acces vasculaire
EP1154810A4 (fr) * 1999-01-28 2003-01-02 Vasca Inc Procede et appareil permettant d'acceder par voie percutanee a un orifice implante commande par la pression
EP1154810A1 (fr) * 1999-01-28 2001-11-21 Vasca, Inc. Procede et appareil permettant d'acceder par voie percutanee a un orifice implante commande par la pression
US8608728B2 (en) 2004-03-01 2013-12-17 Smiths Medical Asd, Inc. Delivery system and method
US8608727B2 (en) 2004-03-01 2013-12-17 Smiths Medical Asd, Inc. Delivery system and method
WO2007008197A1 (fr) * 2005-07-08 2007-01-18 Longbrook Company, L.L.C. Vanne pour un acces transcutane aux vaisseaux sanguins ou fistules existants
CN106535792A (zh) * 2014-04-10 2017-03-22 健康网络大学 用于将医用装置连接至生物***的套管
US11045633B2 (en) 2014-04-10 2021-06-29 University Health Network Cannula for connecting medical devices to biological systems
CN107376043A (zh) * 2017-08-24 2017-11-24 范朕 一种可植入皮下的血管通路穿刺阀
EP3501593A1 (fr) * 2017-12-22 2019-06-26 Roche Diabetes Care GmbH Agencement de septum
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