UY37863A - Virus adenoasociado (aav) con dominio de fosfolipasa modificado - Google Patents
Virus adenoasociado (aav) con dominio de fosfolipasa modificadoInfo
- Publication number
- UY37863A UY37863A UY0001037863A UY37863A UY37863A UY 37863 A UY37863 A UY 37863A UY 0001037863 A UY0001037863 A UY 0001037863A UY 37863 A UY37863 A UY 37863A UY 37863 A UY37863 A UY 37863A
- Authority
- UY
- Uruguay
- Prior art keywords
- modified
- aav
- adenoasociated
- virus
- sequence
- Prior art date
Links
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical class CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 241000702421 Dependoparvovirus Species 0.000 abstract 3
- 208000002267 Anti-neutrophil cytoplasmic antibody-associated vasculitis Diseases 0.000 abstract 2
- 102100037611 Lysophospholipase Human genes 0.000 abstract 2
- 108010058864 Phospholipases A2 Proteins 0.000 abstract 2
- 108090000565 Capsid Proteins Proteins 0.000 abstract 1
- 102100023321 Ceruloplasmin Human genes 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14044—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente descripción se refiere en términos generales a virus adenoasociados (AAV) modificados de serotipos distintos del serotipo 2, que tienen una proteína de la cápside vírica con una secuencia de una subunidad 1 (VP1) que está modificada en relación con la secuencia natural correspondiente. En particular, los AAV modificados de la descripción comprenden sustituciones de aminoácidos en sitios específicos dentro del dominio de la fosfolipasa A2 (PLA2) y la secuencia flanqueante en relación con la secuencia natural correspondiente, lo que mejora la funcionalidad de los AAV cuando se los produce en células de insecto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762553028P | 2017-08-31 | 2017-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37863A true UY37863A (es) | 2019-03-29 |
Family
ID=65525064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037863A UY37863A (es) | 2017-08-31 | 2018-08-30 | Virus adenoasociado (aav) con dominio de fosfolipasa modificado |
Country Status (12)
Country | Link |
---|---|
US (1) | US11499141B2 (es) |
EP (1) | EP3676381A4 (es) |
JP (1) | JP7360382B2 (es) |
KR (1) | KR102612563B1 (es) |
CN (1) | CN111183224B (es) |
AU (1) | AU2018323049A1 (es) |
BR (1) | BR112020003976A8 (es) |
CA (1) | CA3074042A1 (es) |
IL (1) | IL272972A (es) |
TW (1) | TWI802584B (es) |
UY (1) | UY37863A (es) |
WO (1) | WO2019043630A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11028131B2 (en) * | 2017-01-30 | 2021-06-08 | Nippon Medical School Foundation | Mutant of adeno-associated virus (AAV) capsid protein |
JP7360382B2 (ja) | 2017-08-31 | 2023-10-12 | ベニテック アイピー ホールディングス インコーポレーテッド | 改変されたホスホリパーゼドメインを含むアデノ随伴ウイルス(aav) |
SG11202108469XA (en) | 2019-02-28 | 2021-09-29 | Benitec Ip Holdings Inc | Compositions and methods for treating oculopharyngeal muscular dystrophy (opmd) |
CN111349148A (zh) * | 2020-03-13 | 2020-06-30 | 辉大(上海)生物科技有限公司 | 一种腺相关病毒载体及其用途 |
CN111825772B (zh) * | 2020-07-30 | 2023-10-20 | 中国科学院精密测量科学与技术创新研究院 | 具有变异衣壳蛋白的腺相关病毒及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005072364A2 (en) * | 2004-01-27 | 2005-08-11 | University Of Florida | A modified baculovirus expression system for production of pseudotyped raav vector |
US8632764B2 (en) | 2008-04-30 | 2014-01-21 | University Of North Carolina At Chapel Hill | Directed evolution and in vivo panning of virus vectors |
CN102071206A (zh) * | 2010-10-22 | 2011-05-25 | 中山大学 | 一种腺相关病毒衣壳蛋白基因、相应的蛋白及其应用 |
JP7360382B2 (ja) | 2017-08-31 | 2023-10-12 | ベニテック アイピー ホールディングス インコーポレーテッド | 改変されたホスホリパーゼドメインを含むアデノ随伴ウイルス(aav) |
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2018
- 2018-08-30 JP JP2020511907A patent/JP7360382B2/ja active Active
- 2018-08-30 BR BR112020003976A patent/BR112020003976A8/pt unknown
- 2018-08-30 AU AU2018323049A patent/AU2018323049A1/en active Pending
- 2018-08-30 KR KR1020207009126A patent/KR102612563B1/ko active IP Right Grant
- 2018-08-30 US US16/642,967 patent/US11499141B2/en active Active
- 2018-08-30 WO PCT/IB2018/056651 patent/WO2019043630A1/en active Application Filing
- 2018-08-30 CA CA3074042A patent/CA3074042A1/en active Pending
- 2018-08-30 TW TW107130363A patent/TWI802584B/zh active
- 2018-08-30 UY UY0001037863A patent/UY37863A/es not_active Application Discontinuation
- 2018-08-30 CN CN201880064732.3A patent/CN111183224B/zh active Active
- 2018-08-30 EP EP18852130.6A patent/EP3676381A4/en active Pending
-
2020
- 2020-02-27 IL IL272972A patent/IL272972A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN111183224B (zh) | 2024-02-23 |
KR20200058427A (ko) | 2020-05-27 |
EP3676381A1 (en) | 2020-07-08 |
US11499141B2 (en) | 2022-11-15 |
AU2018323049A1 (en) | 2020-04-16 |
BR112020003976A2 (pt) | 2020-09-01 |
US20200190481A1 (en) | 2020-06-18 |
TWI802584B (zh) | 2023-05-21 |
KR102612563B1 (ko) | 2023-12-11 |
JP7360382B2 (ja) | 2023-10-12 |
TW201920676A (zh) | 2019-06-01 |
EP3676381A4 (en) | 2021-06-02 |
BR112020003976A8 (pt) | 2023-02-28 |
CN111183224A (zh) | 2020-05-19 |
CA3074042A1 (en) | 2019-03-07 |
WO2019043630A1 (en) | 2019-03-07 |
IL272972A (en) | 2020-04-30 |
JP2020533973A (ja) | 2020-11-26 |
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Effective date: 20231110 |