UY36671A - COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO - Google Patents
COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMOInfo
- Publication number
- UY36671A UY36671A UY0001036671A UY36671A UY36671A UY 36671 A UY36671 A UY 36671A UY 0001036671 A UY0001036671 A UY 0001036671A UY 36671 A UY36671 A UY 36671A UY 36671 A UY36671 A UY 36671A
- Authority
- UY
- Uruguay
- Prior art keywords
- factor
- gene
- kng1
- methods
- plasmatic
- Prior art date
Links
- 108010080865 Factor XII Proteins 0.000 title abstract 4
- 102000000429 Factor XII Human genes 0.000 title abstract 3
- 102100034869 Plasma kallikrein Human genes 0.000 title abstract 3
- 108090000113 Plasma Kallikrein Proteins 0.000 title abstract 2
- 108091030071 RNAI Proteins 0.000 title abstract 2
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 2
- 101001091365 Homo sapiens Plasma kallikrein Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000028185 Angioedema Diseases 0.000 abstract 1
- 101150076489 B gene Proteins 0.000 abstract 1
- 101150072419 F12 gene Proteins 0.000 abstract 1
- 101001091590 Homo sapiens Kininogen-1 Proteins 0.000 abstract 1
- 101150017040 I gene Proteins 0.000 abstract 1
- 101150038962 KLKB1 gene Proteins 0.000 abstract 1
- 101150056060 KNG1 gene Proteins 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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- C12N2310/35—Nature of the modification
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- C12N2310/3521—Methyl
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- C12N2310/35—Nature of the modification
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- C12N2310/3533—Halogen
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
La presente invenciôn se relaciona con agentes de ARM, por ejemplo, agentes de ARM de doble hebra, contra el gen de Calicremna B, Plasmática (Factor de Fletcher) I (KLKBI), el gen del Factor XII (Factor de Hageman (F 12), o el gen del Quininogeno I (KNG1), y métodos para usar dichos agentes de ARNi para inhibir La expresión de un gen KLKB1, un gen F12, y/o un gen KNG1, y métodos para tratar sujetos que tienen un angioedema hereditarlo (HAE) y10 untrastorno asociado con la via do activación por contacto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562157890P | 2015-05-06 | 2015-05-06 | |
US201562260887P | 2015-11-30 | 2015-11-30 | |
US201562266958P | 2015-12-14 | 2015-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY36671A true UY36671A (es) | 2016-12-30 |
Family
ID=55971215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001036671A UY36671A (es) | 2015-05-06 | 2016-05-06 | COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO |
Country Status (13)
Country | Link |
---|---|
US (4) | US20180100150A1 (es) |
EP (1) | EP3292201A2 (es) |
JP (4) | JP6695902B2 (es) |
KR (1) | KR20180002688A (es) |
CN (2) | CN115322991A (es) |
AU (3) | AU2016257996A1 (es) |
BR (1) | BR112017021967A2 (es) |
CA (1) | CA2984636A1 (es) |
EA (1) | EA201792444A1 (es) |
HK (1) | HK1249920A1 (es) |
TW (3) | TW202336231A (es) |
UY (1) | UY36671A (es) |
WO (1) | WO2016179342A2 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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MX2017011422A (es) * | 2015-03-17 | 2017-11-10 | Arrowhead Pharmaceuticals Inc | Composiciones y metodos para inhibir la expresion del gen del factor xii. |
AU2016257996A1 (en) | 2015-05-06 | 2017-10-26 | Alnylam Pharmaceuticals, Inc. | Factor XII (Hageman Factor) (F12), Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1), and Kininogen 1 (KNG1) iRNA compositions and methods of use thereof |
US10883107B2 (en) | 2016-01-08 | 2021-01-05 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting factor XII (hageman factor) (F12) and methods of use thereof |
AU2018213379A1 (en) * | 2017-01-30 | 2019-07-18 | Arrowhead Pharmaceuticals Inc. | Compositions and methods for inhibition of factor XII gene expression |
WO2018191278A2 (en) | 2017-04-11 | 2018-10-18 | Arbutus Biopharma Corporation | Targeted compositions |
EP3649243A1 (en) * | 2017-07-07 | 2020-05-13 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing contact-activation pathway-associated diseases using irna compositions targeting factor xii (hageman factor) (f12) |
WO2019105414A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
EP3719127A4 (en) | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
JP7273417B2 (ja) | 2017-12-01 | 2023-05-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
CN110997919B (zh) | 2017-12-01 | 2024-04-02 | 苏州瑞博生物技术股份有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
JP7436030B2 (ja) | 2017-12-29 | 2024-02-21 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 複合体及びその調製方法と使用 |
CN111655849B (zh) | 2018-08-21 | 2024-05-10 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的药物组合物和缀合物及其用途 |
CN111655297A (zh) | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
CN113330117B (zh) * | 2019-01-18 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
EP3974529A4 (en) * | 2019-05-22 | 2024-02-07 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PROCESS OF PREPARATION AND USE |
US20220315929A1 (en) * | 2019-05-24 | 2022-10-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate, preparation method therefor and use thereof |
MX2022009658A (es) * | 2020-02-07 | 2022-10-27 | Intellia Therapeutics Inc | Composiciones y metodos para la edicion de genes de calicreina (klkb1). |
EP4127173A4 (en) * | 2020-03-27 | 2024-07-17 | Alnylam Pharmaceuticals Inc | IGG FC FRAGMENT RECEIVER AND TRANSPORTER (FCGRT) ARNI COMPOSITIONS AND METHODS OF USE THEREOF |
TW202242111A (zh) | 2020-12-18 | 2022-11-01 | 美商Ionis製藥公司 | 用於調節因子xii之化合物及方法 |
BR112024001923A2 (pt) * | 2021-08-13 | 2024-04-30 | Alnylam Pharmaceuticals Inc | Composições de irna de fator xii (f12) e métodos de usos das mesmas |
TW202346586A (zh) * | 2022-01-28 | 2023-12-01 | 大陸商上海舶望製藥有限公司 | 用於抑制前激肽釋放酶(pkk)蛋白表達的組合物和方法 |
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HK1249920A1 (zh) | 2018-11-16 |
JP2022141707A (ja) | 2022-09-29 |
EA201792444A1 (ru) | 2018-06-29 |
AU2024200717A1 (en) | 2024-04-18 |
WO2016179342A3 (en) | 2017-01-12 |
US20200131513A1 (en) | 2020-04-30 |
CN108271386A (zh) | 2018-07-10 |
AU2021258003A1 (en) | 2021-11-25 |
US20240076664A1 (en) | 2024-03-07 |
TWI806034B (zh) | 2023-06-21 |
JP6695902B2 (ja) | 2020-05-20 |
US20210246447A1 (en) | 2021-08-12 |
JP2020188756A (ja) | 2020-11-26 |
JP2018519797A (ja) | 2018-07-26 |
KR20180002688A (ko) | 2018-01-08 |
CN115322991A (zh) | 2022-11-11 |
TWI727948B (zh) | 2021-05-21 |
EP3292201A2 (en) | 2018-03-14 |
CA2984636A1 (en) | 2016-11-10 |
BR112017021967A2 (pt) | 2018-07-31 |
TW202130811A (zh) | 2021-08-16 |
TW201704472A (zh) | 2017-02-01 |
AU2016257996A1 (en) | 2017-10-26 |
WO2016179342A9 (en) | 2016-12-08 |
CN108271386B (zh) | 2022-07-15 |
TW202336231A (zh) | 2023-09-16 |
US20180100150A1 (en) | 2018-04-12 |
US10934544B2 (en) | 2021-03-02 |
JP2024037849A (ja) | 2024-03-19 |
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