UY36207A - Inhibidores de la syk - Google Patents

Inhibidores de la syk

Info

Publication number
UY36207A
UY36207A UY0001036207A UY36207A UY36207A UY 36207 A UY36207 A UY 36207A UY 0001036207 A UY0001036207 A UY 0001036207A UY 36207 A UY36207 A UY 36207A UY 36207 A UY36207 A UY 36207A
Authority
UY
Uruguay
Prior art keywords
compounds
formula
syk
subject
compound
Prior art date
Application number
UY0001036207A
Other languages
English (en)
Inventor
Peter A Blomgren
Clarke Astrid
Kevin S Currie
Julie Di Paolo
Jeffrey E Kropf
Seung H Lee
Jennifer R Lo
Scott A Mitchell
Aaron C Schmitt
Swaminathan Sundaramoorthi
Jin-Ming Xiong
Xu Jianjun
Zhao Zhongdong
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of UY36207A publication Critical patent/UY36207A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

La presente divulgación se relaciona con compuestos que son inhibidores de Syk y con su uso en el tratamiento de diferentes estados de enfermedad, incluyendo cáncer y condiciones inflamatorias. En realizaciones particulares, la estructura del compuestos está dada por la Formula I:donde R1, R2, R3, y R4 son como se describe aquí. La presente descripción proporciona además composiciones farmacéuticas que incluyen un compuesto de Fórmula I, o sales farmacéuticamente aceptables de los mismos, y métodos de uso de estos compuestos y composiciones para tratar afecciones mediadas por Syk. En ciertas realizaciones, también se describen métodos para el tratamiento de un cáncer en un sujeto (por ejemplo, un humano) que requiera de los mismos, que comprende administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto de Fórmula I, o una sal farmacéuticamente aceptable del mismo, en combinación con un alcaloide de la vinca, o una sal farmacéuticamente aceptable del mismo.
UY0001036207A 2014-07-14 2015-07-08 Inhibidores de la syk UY36207A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462024284P 2014-07-14 2014-07-14

Publications (1)

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UY36207A true UY36207A (es) 2015-09-30

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UY0001036207A UY36207A (es) 2014-07-14 2015-07-08 Inhibidores de la syk

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US (3) US9504684B2 (es)
EP (1) EP3169329A1 (es)
JP (2) JP6292691B2 (es)
KR (1) KR20170023186A (es)
CN (1) CN106572999A (es)
AR (1) AR101177A1 (es)
AU (2) AU2015290041B2 (es)
CA (1) CA2955249A1 (es)
EA (1) EA201790088A1 (es)
MA (1) MA40076A (es)
MX (1) MX2017000612A (es)
NZ (1) NZ726366A (es)
SG (1) SG11201610904UA (es)
TW (1) TW201617074A (es)
UY (1) UY36207A (es)
WO (1) WO2016010809A1 (es)

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MX350010B (es) 2010-03-11 2017-08-23 Gilead Connecticut Inc Inhibidores syk de imidazopiridinas.
US9657023B2 (en) 2013-07-30 2017-05-23 Gilead Connecticut, Inc. Polymorph of Syk inhibitors
EA031601B1 (ru) 2013-07-31 2019-01-31 Джилид Сайэнс, Инк. Ингибиторы syk
PT3076976T (pt) 2013-12-04 2020-12-07 Kronos Bio Inc Métodos para tratar cancros
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
LT3119772T (lt) 2014-03-19 2019-08-26 Boehringer Ingelheim International Gmbh Heteroarilo sik inhibitoriai
EP3169366A1 (en) 2014-07-14 2017-05-24 Gilead Sciences, Inc. Combinations for treating cancers
EA033978B1 (ru) * 2015-09-11 2019-12-16 Бёрингер Ингельхайм Интернациональ Гмбх Пиразолилзамещенные гетероарилы и их применение в качестве лекарственных средств
US10261071B2 (en) * 2016-07-13 2019-04-16 The United States Of America As Represented By The Secretary Of The Navy Volatile organic compounds as diagnostic breath markers for pulmonary oxygen toxicity
WO2018053190A1 (en) * 2016-09-14 2018-03-22 Gilead Sciences, Inc. Syk inhibitors
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
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