UY35687A - Inhibidores de rorc2 y sus métodos de uso - Google Patents

Inhibidores de rorc2 y sus métodos de uso

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Publication number
UY35687A
UY35687A UY35687A UY35687A UY35687A UY 35687 A UY35687 A UY 35687A UY 35687 A UY35687 A UY 35687A UY 35687 A UY35687 A UY 35687A UY 35687 A UY35687 A UY 35687A
Authority
UY
Uruguay
Prior art keywords
methods
rorc2
inhibitors
pharmaceutical compositions
rorc2 inhibitors
Prior art date
Application number
UY35687A
Other languages
English (en)
Inventor
Mente Scot Richard
Blinn James Robert
Flick Andrew Christopher
Göran Mattias Wennerstål
Jones Peter
Kiefer Jr James Richard
Meyers Marvin Jay
Schnute Mark Edward
Thorarensen Atli
Xing Li
Zamaratski Edouard
Zapf Christoph Wolfgang
Ravi G Kurumbail
Kaila Neelu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY35687A publication Critical patent/UY35687A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención proporciona compuestos, composiciones farmacéuticas, métodos para inhibir la actividad de RORy y/o reducir la cantidad de IL-17 en un sujeto, y métodos para tratar los diversos trastornos médicos usando estos compuestos y composiciones farmacéuticas.
UY35687A 2013-08-02 2014-08-01 Inhibidores de rorc2 y sus métodos de uso UY35687A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361861709P 2013-08-02 2013-08-02

Publications (1)

Publication Number Publication Date
UY35687A true UY35687A (es) 2015-02-27

Family

ID=51570793

Family Applications (1)

Application Number Title Priority Date Filing Date
UY35687A UY35687A (es) 2013-08-02 2014-08-01 Inhibidores de rorc2 y sus métodos de uso

Country Status (42)

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US (6) US20160046597A1 (es)
EP (2) EP3428160A1 (es)
JP (1) JP6224832B2 (es)
KR (1) KR101821903B1 (es)
CN (1) CN105492434B (es)
AP (1) AP2016009017A0 (es)
AR (1) AR097199A1 (es)
AU (1) AU2014298017B2 (es)
BR (1) BR112016001781A2 (es)
CA (1) CA2919783C (es)
CL (1) CL2016000235A1 (es)
CR (1) CR20160047A (es)
CU (2) CU24366B1 (es)
CY (1) CY1120751T1 (es)
DK (1) DK3027603T3 (es)
DO (1) DOP2016000039A (es)
EA (1) EA029499B9 (es)
EC (1) ECSP16008797A (es)
ES (1) ES2685839T3 (es)
GE (1) GEP20186876B (es)
GT (1) GT201600027A (es)
HK (1) HK1219093A1 (es)
HR (1) HRP20181291T1 (es)
HU (1) HUE039972T2 (es)
IL (1) IL243728B (es)
LT (1) LT3027603T (es)
MA (1) MA38810B1 (es)
MD (1) MD20160007A2 (es)
MX (1) MX2016001446A (es)
NI (1) NI201600021A (es)
PE (1) PE20160801A1 (es)
PH (1) PH12016500140A1 (es)
PL (1) PL3027603T3 (es)
PT (1) PT3027603T (es)
RS (1) RS57618B1 (es)
SG (1) SG11201600200QA (es)
SI (1) SI3027603T1 (es)
TN (1) TN2016000040A1 (es)
TW (2) TWI652263B (es)
UA (1) UA115908C2 (es)
UY (1) UY35687A (es)
WO (1) WO2015015378A2 (es)

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MA40759A (fr) * 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
WO2016120850A1 (en) * 2015-01-30 2016-08-04 Pfizer Inc. Sulfonamide-subsituted indole modulators of rorc2 and methods of use thereof
CA2975060C (en) * 2015-01-30 2019-09-03 Pfizer Inc. Methoxy-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof
CN104672121B (zh) * 2015-02-16 2017-10-24 上海华默西医药科技有限公司 2r‑(2,5‑二氟苯基)吡咯烷盐酸盐的制备方法
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CN109206401B (zh) * 2017-06-29 2021-03-05 南京柯菲平盛辉制药有限公司 一类甲基-1H-吲唑类RORγ调节剂及其用途
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TW201733998A (zh) 2017-10-01
CU24366B1 (es) 2018-10-04
MD20160007A2 (ro) 2016-06-30
BR112016001781A2 (pt) 2017-08-01
WO2015015378A2 (en) 2015-02-05
GEP20186876B (en) 2018-07-10
MA38810A1 (fr) 2017-10-31
CA2919783C (en) 2018-02-06
CR20160047A (es) 2016-03-03
PH12016500140B1 (en) 2016-04-18
AU2014298017B2 (en) 2018-03-29
US20190144429A1 (en) 2019-05-16
CU20160015A7 (es) 2016-09-30
CU20160145A7 (es) 2017-02-02
HUE039972T2 (hu) 2019-02-28
KR101821903B1 (ko) 2018-01-24
RS57618B1 (sr) 2018-11-30
CN105492434A (zh) 2016-04-13
TW201516041A (zh) 2015-05-01
US20160046597A1 (en) 2016-02-18
CA2919783A1 (en) 2015-02-05
JP2016528226A (ja) 2016-09-15
US20170233371A1 (en) 2017-08-17
EA201690039A1 (ru) 2016-08-31
MA38810B1 (fr) 2018-06-29
DK3027603T3 (en) 2018-09-17
AU2014298017A1 (en) 2016-02-11
US20180282304A1 (en) 2018-10-04
IL243728A0 (en) 2016-04-21
PL3027603T3 (pl) 2019-03-29
PE20160801A1 (es) 2016-08-24
IL243728B (en) 2018-10-31
TN2016000040A1 (fr) 2017-07-05
ES2685839T3 (es) 2018-10-11
LT3027603T (lt) 2018-08-10
UA115908C2 (uk) 2018-01-10
EP3027603A2 (en) 2016-06-08
CY1120751T1 (el) 2019-12-11
CU24398B1 (es) 2019-04-04
EP3027603B1 (en) 2018-07-18
DOP2016000039A (es) 2016-06-15
CN105492434B (zh) 2018-02-16
KR20160037996A (ko) 2016-04-06
ECSP16008797A (es) 2017-08-31
PT3027603T (pt) 2018-10-11
AR097199A1 (es) 2016-02-24
GT201600027A (es) 2019-09-20
WO2015015378A3 (en) 2015-05-14
EA029499B1 (ru) 2018-04-30
HRP20181291T1 (hr) 2018-10-19
TWI652263B (zh) 2019-03-01
AP2016009017A0 (en) 2016-01-31
NI201600021A (es) 2016-03-16
HK1219093A1 (zh) 2017-03-24
US20200039960A1 (en) 2020-02-06
EP3428160A1 (en) 2019-01-16
US20180086736A1 (en) 2018-03-29
CL2016000235A1 (es) 2017-07-07
SG11201600200QA (en) 2016-02-26
MX2016001446A (es) 2016-05-05
PH12016500140A1 (en) 2016-04-18
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JP6224832B2 (ja) 2017-11-01

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