UY35567A - ?derivados de 3-((2s,5s)-4-metilen-5-(3- oxopropil)tetrahidrofuran-2-il)propanol, su preparación e intermediarios útiles para la misma?. - Google Patents

?derivados de 3-((2s,5s)-4-metilen-5-(3- oxopropil)tetrahidrofuran-2-il)propanol, su preparación e intermediarios útiles para la misma?.

Info

Publication number
UY35567A
UY35567A UY0001035567A UY35567A UY35567A UY 35567 A UY35567 A UY 35567A UY 0001035567 A UY0001035567 A UY 0001035567A UY 35567 A UY35567 A UY 35567A UY 35567 A UY35567 A UY 35567A
Authority
UY
Uruguay
Prior art keywords
preparation
oxopropil
methylen
propanol
tetrahydrofuran
Prior art date
Application number
UY0001035567A
Other languages
English (en)
Inventor
Fabio E S Souza
Jason A Bexrud
Orprecio Richard
Gorin Boris
Original Assignee
Alphora Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphora Res Inc filed Critical Alphora Res Inc
Publication of UY35567A publication Critical patent/UY35567A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describe un proceso para la preparación de un compuesto de fórmula 11, o un derivado del mismo, en donde PG1 es un grupo protector de alcohol. También se describen intermediarios y procesos para su preparación. El compuesto de fórmula 11 puede ser útil en la preparación de análogos de halicondrina
UY0001035567A 2013-05-15 2014-05-14 ?derivados de 3-((2s,5s)-4-metilen-5-(3- oxopropil)tetrahidrofuran-2-il)propanol, su preparación e intermediarios útiles para la misma?. UY35567A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361823579P 2013-05-15 2013-05-15

Publications (1)

Publication Number Publication Date
UY35567A true UY35567A (es) 2014-12-31

Family

ID=51897554

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035567A UY35567A (es) 2013-05-15 2014-05-14 ?derivados de 3-((2s,5s)-4-metilen-5-(3- oxopropil)tetrahidrofuran-2-il)propanol, su preparación e intermediarios útiles para la misma?.

Country Status (8)

Country Link
US (1) US9650397B2 (es)
EP (1) EP2997017B1 (es)
AR (1) AR096238A1 (es)
AU (1) AU2014268086A1 (es)
CA (1) CA2909209A1 (es)
TW (1) TW201514159A (es)
UY (1) UY35567A (es)
WO (1) WO2014183211A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500210A (ja) 2011-11-30 2015-01-05 アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． （３ｒ）−２，４−ジ−脱離基−３−メチルブタ−１−エンの調製方法
CN104024237B (zh) 2011-12-16 2016-02-24 阿方拉研究股份有限公司 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体
US9062020B2 (en) 2011-12-29 2015-06-23 Alphora Research Inc. 2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
US9278979B2 (en) 2012-03-30 2016-03-08 Alphora Research Inc. Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein
KR101777634B1 (ko) * 2016-01-18 2017-09-12 연성정밀화학(주) 3-((2s,5s)-4-메틸렌-5-(3-옥소프로필)테트라히드로퓨란-2-일)프로판올 유도체의 제조방법 및 이를 위한 중간체
SG10202007520WA (en) 2016-03-02 2020-09-29 Eisai R&D Man Co Ltd Eribulin-based antibody-drug conjugates and methods of use
US11059799B2 (en) * 2016-05-26 2021-07-13 Dr. Reddy's Laboratories Limited. Process for preparation of eribulin and intermediates thereof
CN108341828B (zh) * 2017-01-24 2021-04-06 江苏恒瑞医药股份有限公司 用于制备艾日布林的方法及其中间体
CN108658956B (zh) * 2017-03-28 2021-02-02 上海时莱生物技术有限公司 艾日布林中间体及其制备方法
JOP20190234B1 (ar) 2017-04-05 2023-09-17 Eisai Randd Man Co Ltd مركب كبير الحلقات واستخداماته
CN115043700A (zh) * 2017-04-11 2022-09-13 上海时莱生物技术有限公司 一种用于制备艾日布林的中间体及其制备方法
KR20220124279A (ko) 2017-07-06 2022-09-13 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 할리콘드린의 합성
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
ES2974243T3 (es) 2017-11-15 2024-06-26 Harvard College Compuestos macrocíclicos y usos de los mismos
CN111793047B (zh) * 2019-06-13 2023-08-22 南通诺泰生物医药技术有限公司 一种艾日布林中间体的制备方法
CN110981903A (zh) * 2019-11-28 2020-04-10 南京正济医药研究有限公司 一种艾日布林中间体化合物提高光学纯度的精制方法
CN111039787B (zh) * 2019-12-23 2022-04-19 戊言医药科技（上海）有限公司 用于Eribulin-B合成的化合物及其合成方法
CN113372305B (zh) * 2020-03-09 2022-10-18 南京圣鼎医药科技有限公司 一种艾日布林中间体的制备方法
CN116063257A (zh) * 2021-11-02 2023-05-05 中国药科大学 一种抗癌药物中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338865A (en) 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
WO1999065894A1 (en) 1998-06-17 1999-12-23 Eisai Co., Ltd. Macrocyclic analogs and methods of their use and preparation
CN104024237B (zh) 2011-12-16 2016-02-24 阿方拉研究股份有限公司 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体

Also Published As

Publication number Publication date
US20160090391A1 (en) 2016-03-31
EP2997017A1 (en) 2016-03-23
AR096238A1 (es) 2015-12-16
EP2997017B1 (en) 2017-08-09
TW201514159A (zh) 2015-04-16
CA2909209A1 (en) 2014-11-20
AU2014268086A1 (en) 2015-11-05
WO2014183211A1 (en) 2014-11-20
US9650397B2 (en) 2017-05-16
EP2997017A4 (en) 2017-01-25

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Effective date: 20211206