AR096238A1 - Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo - Google Patents

Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo

Info

Publication number
AR096238A1
AR096238A1 ARP140101884A ARP140101884A AR096238A1 AR 096238 A1 AR096238 A1 AR 096238A1 AR P140101884 A ARP140101884 A AR P140101884A AR P140101884 A ARP140101884 A AR P140101884A AR 096238 A1 AR096238 A1 AR 096238A1
Authority
AR
Argentina
Prior art keywords
compound
formula
oxopropil
propanol
tetrahydrofuran
Prior art date
Application number
ARP140101884A
Other languages
English (en)
Inventor
A Bexrud Jason
Gorin Boris
E S Souza Fabio
Orprecio Ricardo
Original Assignee
Alphora Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphora Res Inc filed Critical Alphora Res Inc
Publication of AR096238A1 publication Critical patent/AR096238A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Se describe un proceso para la preparación de un compuesto de fórmula (1), o un derivado del mismo, en donde PG¹ es un grupo protector de alcohol. También se describen intermediarios y procesos para su preparación. El compuesto de fórmula (1) puede ser útil en la preparación de análogos de halicondrina. Reivindicación 1: Un proceso para la preparación de un compuesto de fórmula (1), o un derivado del mismo, comprendiendo el proceso: reducción del compuesto de fórmula (2), seguido por protección del grupo funcional alcohol resultante, para formar el compuesto de formula (3), y oxidación del compuesto de formula (3) para formar el compuesto de formula (1) en donde PG¹ es un grupo protector de alcohol, y R¹ es H o un grupo hidrocarbonado.
ARP140101884A 2013-05-15 2014-05-09 Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo AR096238A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361823579P 2013-05-15 2013-05-15

Publications (1)

Publication Number Publication Date
AR096238A1 true AR096238A1 (es) 2015-12-16

Family

ID=51897554

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140101884A AR096238A1 (es) 2013-05-15 2014-05-09 Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo

Country Status (8)

Country Link
US (1) US9650397B2 (es)
EP (1) EP2997017B1 (es)
AR (1) AR096238A1 (es)
AU (1) AU2014268086A1 (es)
CA (1) CA2909209A1 (es)
TW (1) TW201514159A (es)
UY (1) UY35567A (es)
WO (1) WO2014183211A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013078559A1 (en) 2011-11-30 2013-06-06 Alphora Research Inc. Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
EP2791123B1 (en) 2011-12-16 2018-07-18 Sandoz AG Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof
EP2797945B1 (en) 2011-12-29 2016-03-16 Alphora Research Inc. 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
JP6531911B2 (ja) 2012-03-30 2019-06-19 サンド アーゲー ハリコンドリンｂの大環状ｃ１−ケト類似体を調製するための合成プロセスおよびそれに有用な中間体
KR101777634B1 (ko) * 2016-01-18 2017-09-12 연성정밀화학(주) 3-((2s,5s)-4-메틸렌-5-(3-옥소프로필)테트라히드로퓨란-2-일)프로판올 유도체의 제조방법 및 이를 위한 중간체
HUE054726T2 (hu) 2016-03-02 2021-09-28 Eisai R&D Man Co Ltd Eribulinalapú antitest-gyógyszer konjugátumok és alkalmazási eljárások
WO2017203459A1 (en) * 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Process for preparation of eribulin and intermediates thereof
CN108341828B (zh) * 2017-01-24 2021-04-06 江苏恒瑞医药股份有限公司 用于制备艾日布林的方法及其中间体
CN108658956B (zh) * 2017-03-28 2021-02-02 上海时莱生物技术有限公司 艾日布林中间体及其制备方法
PL3606928T3 (pl) 2017-04-05 2023-02-06 President And Fellows Of Harvard College Związek makrocykliczny i jego zastosowania
CN115043700A (zh) * 2017-04-11 2022-09-13 上海时莱生物技术有限公司 一种用于制备艾日布林的中间体及其制备方法
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
IL271660B (en) 2017-07-06 2022-09-01 Harvard College Synthesis of the Lichondrins
CN111566113B (zh) 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途
CN111793047B (zh) * 2019-06-13 2023-08-22 南通诺泰生物医药技术有限公司 一种艾日布林中间体的制备方法
CN110981903A (zh) * 2019-11-28 2020-04-10 南京正济医药研究有限公司 一种艾日布林中间体化合物提高光学纯度的精制方法
CN111039787B (zh) * 2019-12-23 2022-04-19 戊言医药科技（上海）有限公司 用于Eribulin-B合成的化合物及其合成方法
CN113372305B (zh) * 2020-03-09 2022-10-18 南京圣鼎医药科技有限公司 一种艾日布林中间体的制备方法
CN116063257A (zh) * 2021-11-02 2023-05-05 中国药科大学 一种抗癌药物中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436238A (en) 1992-03-12 1995-07-25 President And Fellows Of Harvard College Halichondrins and related compounds
US5338865A (en) 1992-03-12 1994-08-16 President And Fellows Of Harvard College Synthesis of halichondrin B and norhalichondrin B
PT1087960E (pt) 1998-06-17 2011-06-17 Eisai R&D Man Co Ltd Análogos macrocíclicos e métodos de sua utilização e preparação
EP2791123B1 (en) 2011-12-16 2018-07-18 Sandoz AG Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof

Also Published As

Publication number Publication date
EP2997017A4 (en) 2017-01-25
US9650397B2 (en) 2017-05-16
US20160090391A1 (en) 2016-03-31
TW201514159A (zh) 2015-04-16
UY35567A (es) 2014-12-31
WO2014183211A1 (en) 2014-11-20
EP2997017B1 (en) 2017-08-09
CA2909209A1 (en) 2014-11-20
AU2014268086A1 (en) 2015-11-05
EP2997017A1 (en) 2016-03-23

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