UY33299A - DERIVATIVES OF 6- (RENT-O CYCLALQUIL-TRIAZOLOPIRIDACINA-SILFANIL) BENZOTIAZOLES: PREPARATION, APPLICATION AS MEDICATIONS AND USE AS INHIBITORS OF THE MET - Google Patents

DERIVATIVES OF 6- (RENT-O CYCLALQUIL-TRIAZOLOPIRIDACINA-SILFANIL) BENZOTIAZOLES: PREPARATION, APPLICATION AS MEDICATIONS AND USE AS INHIBITORS OF THE MET

Info

Publication number
UY33299A
UY33299A UY0001033299A UY33299A UY33299A UY 33299 A UY33299 A UY 33299A UY 0001033299 A UY0001033299 A UY 0001033299A UY 33299 A UY33299 A UY 33299A UY 33299 A UY33299 A UY 33299A
Authority
UY
Uruguay
Prior art keywords
inhibitors
met
triazolopiridacina
silfanil
cyclalquil
Prior art date
Application number
UY0001033299A
Other languages
Spanish (es)
Inventor
Eric Bacque
Dominique Damour
Conception Nemecek
Sylvie Wentzler
Antonio Ugolini
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1052367A external-priority patent/FR2958292A1/en
Priority claimed from FR1058393A external-priority patent/FR2966151B1/en
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of UY33299A publication Critical patent/UY33299A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La invención se refiere a los nuevos productos de fórmula (I): con R1 que representa alquilo, cicloalquilo o cicloalquilalquilo; Rb representa un átomo de hidrógeno o bien un átomo de flúor W representa H; alquilo, cicloalquilo, heterocicloalquilo o COR con R que representa cicloalquilo, heterocicloalquilo, alquilo; alcoxi, -O-heterocicloalquilo; o NHR2 con R2 que representa H, cicloalquilo, heterocicloalquilo o alquilo; todos sustituidos opcionalmente; estando estos productos en todas las formas isómeras y las sales, a título de medicamentos principalmente como inhibidores de la MET.The invention relates to the new products of formula (I): with R 1 representing alkyl, cycloalkyl or cycloalkylalkyl; Rb represents a hydrogen atom or a fluorine atom W represents H; alkyl, cycloalkyl, heterocycloalkyl or COR with R representing cycloalkyl, heterocycloalkyl, alkyl; alkoxy, -O-heterocycloalkyl; or NHR2 with R2 representing H, cycloalkyl, heterocycloalkyl or alkyl; all optionally substituted; these products being in all isomeric forms and salts, primarily as medicaments as MET inhibitors.

UY0001033299A 2010-03-30 2011-03-30 DERIVATIVES OF 6- (RENT-O CYCLALQUIL-TRIAZOLOPIRIDACINA-SILFANIL) BENZOTIAZOLES: PREPARATION, APPLICATION AS MEDICATIONS AND USE AS INHIBITORS OF THE MET UY33299A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1052367A FR2958292A1 (en) 2010-03-30 2010-03-30 New 6-triazolopyridazine-sulfanyl benzothiazole compounds are met kinase inhibitors useful for treating e.g. metabolic disorders, allergies, asthma, thrombosis, nervous system diseases, retinopathy, psoriasis, diabetes and cancers
FR1058393A FR2966151B1 (en) 2010-10-14 2010-10-14 6- (ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS
FR1151138 2011-02-11

Publications (1)

Publication Number Publication Date
UY33299A true UY33299A (en) 2011-10-31

Family

ID=43996854

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033299A UY33299A (en) 2010-03-30 2011-03-30 DERIVATIVES OF 6- (RENT-O CYCLALQUIL-TRIAZOLOPIRIDACINA-SILFANIL) BENZOTIAZOLES: PREPARATION, APPLICATION AS MEDICATIONS AND USE AS INHIBITORS OF THE MET

Country Status (3)

Country Link
TW (1) TW201202242A (en)
UY (1) UY33299A (en)
WO (1) WO2011121223A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970205B1 (en) 2013-03-14 2019-05-08 Tolero Pharmaceuticals, Inc. Jak2 and alk2 inhibitors and methods for their use
JP7414282B2 (en) 2017-12-07 2024-01-16 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン NSD family inhibitors and methods of treatment using them
CN112512597A (en) 2018-07-26 2021-03-16 大日本住友制药肿瘤公司 Methods for treating diseases associated with aberrant ACVR1 expression and ACVR1 inhibitors useful therefor
JP2022526713A (en) 2019-03-21 2022-05-26 オンクセオ Dbait molecule in combination with a kinase inhibitor for the treatment of cancer
CN114761006A (en) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) Methods of treating cancer resistant to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100457728C (en) 2003-07-24 2009-02-04 麦克公司 Tyrosine kinase inhibitors
PA8792501A1 (en) 2007-08-09 2009-04-23 Sanofi Aventis NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS.
FR2933982A1 (en) 2008-07-18 2010-01-22 Sanofi Aventis NOVEL IMIDAZO-1,2-A! PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS

Also Published As

Publication number Publication date
TW201202242A (en) 2012-01-16
WO2011121223A1 (en) 2011-10-06

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20191217