UY31198A1 - Amidas de ácidos benzoicos triazinil sustituidos, composiciones farmacéticas conteniéndolos y aplicaciones. - Google Patents
Amidas de ácidos benzoicos triazinil sustituidos, composiciones farmacéticas conteniéndolos y aplicaciones.Info
- Publication number
- UY31198A1 UY31198A1 UY31198A UY31198A UY31198A1 UY 31198 A1 UY31198 A1 UY 31198A1 UY 31198 A UY31198 A UY 31198A UY 31198 A UY31198 A UY 31198A UY 31198 A1 UY31198 A1 UY 31198A1
- Authority
- UY
- Uruguay
- Prior art keywords
- triazinil
- amidas
- substituted
- applications
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención comprende compuestos de la fórmula general (1) en donden los radicales R1 a R3 y L se definen como en la reivindicación 1, que son apropiados para el tratamiento de enfermedades que se caracterizan por una proliferación celular excesiva o anormal, así como su uso para la preparación de un medicamento con las propiedades previamente mencionadas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07111566 | 2007-07-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31198A1 true UY31198A1 (es) | 2009-01-30 |
Family
ID=38792475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31198A UY31198A1 (es) | 2007-07-02 | 2008-07-01 | Amidas de ácidos benzoicos triazinil sustituidos, composiciones farmacéticas conteniéndolos y aplicaciones. |
Country Status (21)
Country | Link |
---|---|
US (1) | US8889665B2 (es) |
EP (1) | EP2173734B1 (es) |
JP (1) | JP5511658B2 (es) |
KR (1) | KR20100039849A (es) |
CN (1) | CN101796045A (es) |
AR (1) | AR067397A1 (es) |
AU (1) | AU2008270300A1 (es) |
BR (1) | BRPI0814601A2 (es) |
CA (1) | CA2692383A1 (es) |
CL (1) | CL2008001943A1 (es) |
CO (1) | CO6251316A2 (es) |
EA (1) | EA201000105A1 (es) |
EC (1) | ECSP099823A (es) |
IL (1) | IL202625A0 (es) |
MA (1) | MA32120B1 (es) |
MX (1) | MX2009013935A (es) |
PE (1) | PE20090837A1 (es) |
TN (1) | TN2009000551A1 (es) |
TW (1) | TW200911789A (es) |
UY (1) | UY31198A1 (es) |
WO (1) | WO2009003999A2 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2041116A1 (de) | 2006-07-07 | 2009-04-01 | Boehringer Ingelheim International GmbH | Phenyl substituierte heteroaryl-derivate und deren verwendung als antitumormittel |
CA2692379A1 (en) * | 2007-07-02 | 2009-01-08 | Boehringer Ingelheim International Gmbh | Antiproliferative compounds based on 5-membered heterocycles |
PE20090837A1 (es) | 2007-07-02 | 2009-07-24 | Boehringer Ingelheim Int | Nuevos compuestos quimicos |
TW201014860A (en) | 2008-09-08 | 2010-04-16 | Boehringer Ingelheim Int | New chemical compounds |
CN102227421A (zh) | 2008-09-29 | 2011-10-26 | 贝林格尔.英格海姆国际有限公司 | 抗增殖化合物 |
WO2010094695A1 (en) | 2009-02-17 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases |
JP2010235575A (ja) * | 2009-03-09 | 2010-10-21 | Konica Minolta Holdings Inc | 含窒素縮合複素環化合物の製造方法 |
DE102009019962A1 (de) * | 2009-05-05 | 2010-11-11 | Merck Patent Gmbh | 3-([1,2,3]Triazol-4-yl)-pyrrolo[2,3-b]pyridinderivate |
WO2011117382A1 (en) | 2010-03-26 | 2011-09-29 | Boehringer Ingelheim International Gmbh | Pyridyltriazoles |
JP5871896B2 (ja) | 2010-03-26 | 2016-03-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | B−rafキナーゼインヒビター |
UY33817A (es) | 2010-12-21 | 2012-07-31 | Boehringer Ingelheim Int | ?nuevas oxindolpirimidinas bencílicas?. |
US8710055B2 (en) | 2010-12-21 | 2014-04-29 | Boehringer Ingelheim International Gmbh | Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors |
US8889684B2 (en) | 2011-02-02 | 2014-11-18 | Boehringer Ingelheim International Gmbh | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors |
US9156837B2 (en) | 2011-07-29 | 2015-10-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN103172617A (zh) * | 2011-12-20 | 2013-06-26 | 天津市国际生物医药联合研究院 | 1,5-二取代-1,2,3-三氮唑三氟甲基类化合物的应用 |
CN103539784B (zh) * | 2012-07-09 | 2016-08-17 | 中国科学院广州生物医药与健康研究院 | 杂环苯甲酰胺类化合物、药用组合物及其应用 |
WO2015143653A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
WO2015143654A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
WO2015143652A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
WO2016161572A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
CA2986083A1 (en) | 2015-06-11 | 2016-12-15 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
KR101723881B1 (ko) * | 2016-03-28 | 2017-04-07 | 이화여자대학교 산학협력단 | 신규한 트리아졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 오로라 키나제 관련 약학적 조성물 |
WO2020007729A1 (en) * | 2018-07-04 | 2020-01-09 | Boehringer Ingelheim International Gmbh | Triazole benzamide derivatives as gpr142 agonists |
CN116761801A (zh) * | 2021-03-12 | 2023-09-15 | 四川科伦博泰生物医药股份有限公司 | 具有蛋白激酶抑制活性的杂环化合物、包含其的药物组合物及其制备方法和用途 |
WO2023205703A2 (en) * | 2022-04-19 | 2023-10-26 | Watershed Medical, Inc. | Formulation for treating urinary system disorders |
CN114805334B (zh) * | 2022-05-24 | 2023-06-09 | 深圳大学 | 一种QC和GSK-3β多靶向抑制剂及其制备方法与应用 |
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AU507066B1 (en) | 1977-09-06 | 1980-01-31 | Sumitomo Chemical Company, Limited | 2-Substituted-5-Hydroxy-1h-Imidazole 4-Carbozamide Derivatives |
JPH03174153A (ja) | 1989-09-20 | 1991-07-29 | Fuji Photo Film Co Ltd | カラー画像形成方法 |
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BRPI0414313A (pt) | 2003-09-11 | 2006-11-07 | Kemia Inc | inibidores de citocinas |
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JP4824576B2 (ja) | 2003-12-03 | 2011-11-30 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン生成のインヒビターとしての1,2,3−トリアゾールアミド誘導体 |
CA2557856C (en) | 2004-03-09 | 2010-06-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | 3-'4-heterocyclyl-1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases |
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CA2586870A1 (en) | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Il-12 modulatory compounds |
US7531560B2 (en) * | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
ES2465469T3 (es) * | 2005-01-14 | 2014-06-05 | Gilead Connecticut, Inc. | Diaril ureas 1,3-sustituidas como moduladores de la actividad quinasa |
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WO2007056016A2 (en) | 2005-11-02 | 2007-05-18 | Kemia, Inc. | Bisamide cytokine inhibitors |
WO2007075896A2 (en) | 2005-12-22 | 2007-07-05 | Kemia, Inc. | Heterocyclic cytokine inhibitors |
US20070155746A1 (en) | 2005-12-23 | 2007-07-05 | Kalypsys, Inc. | Novel substituted pyridinyloxy and pyrimidinyloxy amides useful as inhibitors of protein kinases |
US7858804B2 (en) | 2006-04-18 | 2010-12-28 | Boehringer Ingelheim International Gmbh | Process for making cytokine inhibiting compounds containing 4- and 5-imidazolyl rings and the intermediates thereof |
PE20120006A1 (es) | 2006-05-15 | 2012-02-02 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
EP2041138B1 (en) | 2006-07-07 | 2014-06-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
EP2041116A1 (de) | 2006-07-07 | 2009-04-01 | Boehringer Ingelheim International GmbH | Phenyl substituierte heteroaryl-derivate und deren verwendung als antitumormittel |
WO2008008234A1 (en) | 2006-07-07 | 2008-01-17 | Targegen, Inc. | 2-amino-5-substituted pyrimidine inhibitors |
TW200813033A (en) | 2006-07-07 | 2008-03-16 | Schering Corp | 3, 4-di-substituted cyclobutene-1, 2-diones as CXC-chemokine receptor ligands |
PE20080906A1 (es) | 2006-08-17 | 2008-07-05 | Kemia Inc | Derivados heteroarilo como inhibidores de citocina |
WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
WO2008089034A2 (en) | 2007-01-11 | 2008-07-24 | Kemia, Inc. | Cytokine inhibitors |
CA2679659C (en) | 2007-03-01 | 2016-01-19 | Novartis Ag | Pim kinase inhibitors and methods of their use |
CA2692379A1 (en) | 2007-07-02 | 2009-01-08 | Boehringer Ingelheim International Gmbh | Antiproliferative compounds based on 5-membered heterocycles |
PE20090837A1 (es) | 2007-07-02 | 2009-07-24 | Boehringer Ingelheim Int | Nuevos compuestos quimicos |
US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
BRPI0916356B1 (pt) | 2008-07-24 | 2022-08-23 | Nerviano Medical Sciences S.R.L | 3,4-diaril pirazois como inibidores da proteína quinase |
TW201014860A (en) | 2008-09-08 | 2010-04-16 | Boehringer Ingelheim Int | New chemical compounds |
CN102227421A (zh) | 2008-09-29 | 2011-10-26 | 贝林格尔.英格海姆国际有限公司 | 抗增殖化合物 |
WO2010094695A1 (en) | 2009-02-17 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases |
JP5871896B2 (ja) | 2010-03-26 | 2016-03-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | B−rafキナーゼインヒビター |
WO2011117382A1 (en) | 2010-03-26 | 2011-09-29 | Boehringer Ingelheim International Gmbh | Pyridyltriazoles |
US8710055B2 (en) | 2010-12-21 | 2014-04-29 | Boehringer Ingelheim International Gmbh | Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors |
US20130023531A1 (en) | 2011-01-27 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors |
US8889684B2 (en) | 2011-02-02 | 2014-11-18 | Boehringer Ingelheim International Gmbh | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors |
-
2008
- 2008-06-30 PE PE2008001114A patent/PE20090837A1/es not_active Application Discontinuation
- 2008-06-30 CL CL2008001943A patent/CL2008001943A1/es unknown
- 2008-07-01 AU AU2008270300A patent/AU2008270300A1/en not_active Abandoned
- 2008-07-01 AR ARP080102852A patent/AR067397A1/es unknown
- 2008-07-01 BR BRPI0814601A patent/BRPI0814601A2/pt not_active IP Right Cessation
- 2008-07-01 TW TW097124780A patent/TW200911789A/zh unknown
- 2008-07-01 US US12/665,769 patent/US8889665B2/en active Active
- 2008-07-01 EP EP08774579.0A patent/EP2173734B1/en active Active
- 2008-07-01 EA EA201000105A patent/EA201000105A1/ru unknown
- 2008-07-01 MX MX2009013935A patent/MX2009013935A/es not_active Application Discontinuation
- 2008-07-01 CA CA002692383A patent/CA2692383A1/en not_active Abandoned
- 2008-07-01 JP JP2010513966A patent/JP5511658B2/ja active Active
- 2008-07-01 WO PCT/EP2008/058433 patent/WO2009003999A2/en active Application Filing
- 2008-07-01 UY UY31198A patent/UY31198A1/es not_active Application Discontinuation
- 2008-07-01 KR KR1020107001120A patent/KR20100039849A/ko not_active Application Discontinuation
- 2008-07-01 CN CN200880105329A patent/CN101796045A/zh active Pending
-
2009
- 2009-12-09 IL IL202625A patent/IL202625A0/en unknown
- 2009-12-21 EC EC2009009823A patent/ECSP099823A/es unknown
- 2009-12-28 CO CO09148258A patent/CO6251316A2/es not_active Application Discontinuation
- 2009-12-30 MA MA32465A patent/MA32120B1/fr unknown
- 2009-12-31 TN TNP2009000551A patent/TN2009000551A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
US8889665B2 (en) | 2014-11-18 |
WO2009003999A3 (en) | 2009-07-16 |
CL2008001943A1 (es) | 2009-09-11 |
US20110183952A1 (en) | 2011-07-28 |
CO6251316A2 (es) | 2011-02-21 |
MA32120B1 (fr) | 2011-03-01 |
AU2008270300A1 (en) | 2009-01-08 |
IL202625A0 (en) | 2010-06-30 |
MX2009013935A (es) | 2010-01-28 |
EA201000105A1 (ru) | 2010-06-30 |
TW200911789A (en) | 2009-03-16 |
JP5511658B2 (ja) | 2014-06-04 |
KR20100039849A (ko) | 2010-04-16 |
CA2692383A1 (en) | 2009-01-08 |
EP2173734A2 (en) | 2010-04-14 |
WO2009003999A2 (en) | 2009-01-08 |
PE20090837A1 (es) | 2009-07-24 |
EP2173734B1 (en) | 2016-03-23 |
CN101796045A (zh) | 2010-08-04 |
ECSP099823A (es) | 2010-01-29 |
AR067397A1 (es) | 2009-10-07 |
BRPI0814601A2 (pt) | 2019-09-24 |
JP2010531851A (ja) | 2010-09-30 |
TN2009000551A1 (fr) | 2011-03-31 |
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