UY29824A1 - Preparación de derivados de quinazolinas o sales de los mismos, intermedios utilizados en su preparación y preparación de dichos derivados utilizando esos intermedios - Google Patents

Preparación de derivados de quinazolinas o sales de los mismos, intermedios utilizados en su preparación y preparación de dichos derivados utilizando esos intermedios

Info

Publication number
UY29824A1
UY29824A1 UY29824A UY29824A UY29824A1 UY 29824 A1 UY29824 A1 UY 29824A1 UY 29824 A UY29824 A UY 29824A UY 29824 A UY29824 A UY 29824A UY 29824 A1 UY29824 A1 UY 29824A1
Authority
UY
Uruguay
Prior art keywords
preparation
derivatives
intermediates
manufacture
salts
Prior art date
Application number
UY29824A
Other languages
English (en)
Inventor
Jorgen Blixt
Michael David Golden
Philip John Hogan
David Michael Glanville Martin
Francis Joseph Montgomery
John David Pittam
George Joseph Sependa
Christopher John Squire
Nicholas Cartwright Ale Wright
Zakariya Patel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35395001&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY29824(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY29824A1 publication Critical patent/UY29824A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a procedimientos químicos para la fabricación de ciertos derivados de quinazolina, o sales farmacéuticamente aceptables de los mismos. La invención también se refiere un procedimientos para la fabricación de ciertos compuestos intermedios útiles en la fabricación de los derivados de quinazolina y un procedimientos para la fabricación de los derivados de quinazolina utilizando dichos compuestos intermedios. En particular, la presente invención se refiere un procedimientos químicos y compuestos intermedios útiles en la fabricación del compuesto 4-(4-bromo-2-fluoroanilino)-6-metoxi-7-(1-metilpiperidin-4-ilmetoxi)quinazolina.
UY29824A 2005-09-30 2006-09-29 Preparación de derivados de quinazolinas o sales de los mismos, intermedios utilizados en su preparación y preparación de dichos derivados utilizando esos intermedios UY29824A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0519879.1A GB0519879D0 (en) 2005-09-30 2005-09-30 Chemical process

Publications (1)

Publication Number Publication Date
UY29824A1 true UY29824A1 (es) 2007-04-30

Family

ID=35395001

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29824A UY29824A1 (es) 2005-09-30 2006-09-29 Preparación de derivados de quinazolinas o sales de los mismos, intermedios utilizados en su preparación y preparación de dichos derivados utilizando esos intermedios

Country Status (32)

Country Link
US (8) US8163926B2 (es)
EP (2) EP1943240B1 (es)
JP (2) JP5213715B2 (es)
KR (1) KR101307641B1 (es)
CN (3) CN101277948B (es)
AR (1) AR055671A1 (es)
AT (2) ATE481399T1 (es)
AU (1) AU2006296367B2 (es)
BR (1) BRPI0616715A2 (es)
CA (2) CA2745829C (es)
CY (2) CY1110275T1 (es)
DE (2) DE602006017004D1 (es)
DK (2) DK1943240T3 (es)
ES (2) ES2350513T3 (es)
GB (1) GB0519879D0 (es)
HK (2) HK1122553A1 (es)
HR (2) HRP20100019T1 (es)
IL (2) IL190172A (es)
ME (2) ME01466B (es)
MY (2) MY149834A (es)
NO (1) NO342152B1 (es)
NZ (2) NZ566566A (es)
PL (2) PL2053048T3 (es)
PT (2) PT1943240E (es)
RS (2) RS51515B (es)
RU (1) RU2448102C2 (es)
SG (1) SG165416A1 (es)
SI (2) SI2053048T1 (es)
TW (2) TWI424991B (es)
UY (1) UY29824A1 (es)
WO (1) WO2007036713A2 (es)
ZA (1) ZA200802416B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268230B2 (en) * 2002-02-01 2007-09-11 Astrazeneca Ab Quinazoline compounds
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
CL2007003158A1 (es) * 2006-11-02 2008-05-16 Astrazeneca Ab Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion.
EP2404595B1 (de) * 2011-09-01 2015-08-05 Symrise AG Verfahren zur Herstellung von Indanon-Derivaten
US9273001B2 (en) * 2012-08-15 2016-03-01 Glaxo Group Limited Chemical process
CN104098544A (zh) * 2013-04-07 2014-10-15 浙江九洲药物科技有限公司 一种凡德他尼的制备方法
CN106397401B (zh) * 2016-08-30 2018-11-13 山东罗欣药业集团股份有限公司 一种抗癌药物的晶体化合物及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870083A (en) * 1987-11-24 1989-09-26 Merrell Dow Pharmaceuticals Inc. 1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants
JP2829744B2 (ja) 1989-05-31 1998-12-02 川研ファインケミカル株式会社 ピペリジンカルボン酸類の製造方法
WO1992006086A1 (en) 1990-10-01 1992-04-16 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
BR9205811A (pt) 1991-03-28 1994-06-28 Pfizer Derivados heterociclicos de aminas ciclicas
CA2102780C (en) 1991-05-10 2007-01-09 Alfred P. Spada Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
WO1994019342A1 (en) 1993-02-18 1994-09-01 Kyowa Hakko Kogyo Co., Ltd. Adenosine incorporation inhibitor
EP0700383B1 (en) 1993-05-26 1998-09-23 Syntex (U.S.A.) Inc. Novel 1-phenylalkanone 5-ht 4? receptor ligands
DE4326344A1 (de) 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU685212B2 (en) * 1994-01-13 1998-01-15 Merck Sharp & Dohme Limited Gem-disubstituted azacyclic tachykinin antagonists
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
WO1997032856A1 (en) 1996-03-05 1997-09-12 Zeneca Limited 4-anilinoquinazoline derivatives
WO1998010767A2 (en) 1996-09-13 1998-03-19 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
IL149034A0 (en) 1999-11-05 2002-11-10 Astrazeneca Ab Quinazoline derivatives as vegf inhibitors
GB0126879D0 (en) 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
EP1467995B1 (en) 2001-12-20 2010-05-19 OSI Pharmaceuticals, Inc. Pyrrolopyrimidine a2b selective antagonist compounds, their synthesis and use
US7268230B2 (en) 2002-02-01 2007-09-11 Astrazeneca Ab Quinazoline compounds
JP4389205B2 (ja) 2002-02-06 2009-12-24 宇部興産株式会社 ４−アミノキナゾリン化合物の製法
JP2006502132A (ja) 2002-08-09 2006-01-19 アストラゼネカ アクチボラグ 癌の治療における血管内皮細胞増殖因子受容体の阻害薬ｚｄ６４７４と放射線療法との併用
GB0218526D0 (en) 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
CA2514227C (en) 2003-02-13 2011-08-09 Astrazeneca Ab Combination therapy of zd6474 with 5-fu or/and cpt-11
KR20060033782A (ko) 2003-07-10 2006-04-19 아스트라제네카 아베 백금 화합물 및 임의적으로 이온화 방사능과 조합된퀴나졸린 유도체 ｚｄ6474의 혈관신생 및/또는 증가된 혈관투과성 관련 질환 치료 용도
GB0318423D0 (en) 2003-08-06 2003-09-10 Astrazeneca Ab Chemical compounds
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process

Also Published As

Publication number Publication date
TW201018660A (en) 2010-05-16
JP2013063998A (ja) 2013-04-11
CN102503898B (zh) 2015-03-25
RS51263B (sr) 2010-12-31
US20220033377A1 (en) 2022-02-03
NZ593930A (en) 2013-02-22
ES2335435T3 (es) 2010-03-26
CY1110887T1 (el) 2015-06-10
RS51515B (en) 2011-06-30
CN102503898A (zh) 2012-06-20
AR055671A1 (es) 2007-08-29
US10344015B2 (en) 2019-07-09
PT1943240E (pt) 2010-01-11
DK1943240T3 (da) 2010-03-01
DK2053048T3 (da) 2010-11-29
DE602006010428D1 (de) 2009-12-24
HK1122553A1 (en) 2009-05-22
ES2350513T3 (es) 2011-01-24
NO342152B1 (no) 2018-04-03
CA2745829C (en) 2013-07-02
EP1943240A2 (en) 2008-07-16
ATE481399T1 (de) 2010-10-15
US20120095229A1 (en) 2012-04-19
WO2007036713A3 (en) 2007-06-14
US20180118716A1 (en) 2018-05-03
CN101277948B (zh) 2013-03-13
SI2053048T1 (sl) 2010-12-31
IL227574A (en) 2015-08-31
CA2745829A1 (en) 2007-04-05
US20240150317A1 (en) 2024-05-09
MY149834A (en) 2013-10-31
US8865899B2 (en) 2014-10-21
HRP20100620T1 (hr) 2010-12-31
KR101307641B1 (ko) 2013-09-12
US8163926B2 (en) 2012-04-24
CN101277948A (zh) 2008-10-01
IL190172A0 (en) 2008-08-07
DE602006017004D1 (de) 2010-10-28
TWI424991B (zh) 2014-02-01
HRP20100019T1 (hr) 2010-02-28
MY145540A (en) 2012-02-29
IL190172A (en) 2014-05-28
CN102503933B (zh) 2014-06-25
CN102503933A (zh) 2012-06-20
NO20081267L (no) 2008-04-30
KR20080049114A (ko) 2008-06-03
SG165416A1 (en) 2010-10-28
NZ566566A (en) 2011-08-26
EP2053048B1 (en) 2010-09-15
US20140378684A1 (en) 2014-12-25
TW200745036A (en) 2007-12-16
ZA200802416B (en) 2009-01-28
WO2007036713A2 (en) 2007-04-05
ATE448218T1 (de) 2009-11-15
ME01531B (me) 2014-04-20
GB0519879D0 (en) 2005-11-09
ME01466B (me) 2014-04-20
RU2448102C2 (ru) 2012-04-20
CA2624045A1 (en) 2007-04-05
PL1943240T3 (pl) 2010-04-30
US20190263782A1 (en) 2019-08-29
AU2006296367B2 (en) 2011-08-11
RU2008116573A (ru) 2009-11-10
PL2053048T3 (pl) 2011-03-31
CA2624045C (en) 2012-05-22
JP5213715B2 (ja) 2013-06-19
JP2009510039A (ja) 2009-03-12
SI1943240T1 (sl) 2010-02-26
TWI328580B (en) 2010-08-11
EP2053048A1 (en) 2009-04-29
EP1943240B1 (en) 2009-11-11
US20090203905A1 (en) 2009-08-13
US9815816B2 (en) 2017-11-14
PT2053048E (pt) 2010-11-10
EP2053048B8 (en) 2011-09-21
BRPI0616715A2 (pt) 2011-06-28
CY1110275T1 (el) 2015-01-14
HK1130478A1 (en) 2009-12-31
US20160185754A1 (en) 2016-06-30
AU2006296367A1 (en) 2007-04-05
JP5654546B2 (ja) 2015-01-14

Similar Documents

Publication Publication Date Title
UY29824A1 (es) Preparación de derivados de quinazolinas o sales de los mismos, intermedios utilizados en su preparación y preparación de dichos derivados utilizando esos intermedios
TW200833667A (en) Chemical process
AR059027A1 (es) Administracion de inhibidores de dipeptidil peptidasa
CL2008003691A1 (es) Compuestos derivados de 4-(fenil o piridin) pirimidina, inhibidores de la elastasa neutrofila humana; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento y/o la prevencion de hipertension arterial pulmonar, epoc, enfisema pulmonar, entre otras.
UY30779A1 (es) Derivados de dihidropiridina de utilidad como inhibidores de la proteina quinasa
ECSP11011469A (es) Sales de disacarina, ácido difumárico, ácido di-1-hidroxi-2-naftoico y ácido monobenzoico del 2-(4-((2-amino-4-metil-6-(pentilamino)pirimidin-5-il)metil)fenil)acetato de 4-(dimetilamino)butilo
PA8680701A1 (es) Derivados de oxindol
ECSP077271A (es) Derivados de pirimidina
NO20081893L (no) 4-(3-aminopyrazol)pyrimidinderivater til anvendelse som tyrosin-kinaseinhibitorer i behandling av kreft
UY32848A (es) Compuestos heterocíclicos de oxima
BR122019010008B8 (pt) derivados de pirimidina, seu uso, e composição e combinação farmacêuticas
ECSP078030A (es) Formas cristalinas y otras formas de las sales de ácido láctico de 4-amino-5-fluoro-3-[6-(4-metilpiperazin -1-il)-1h-bencimidazol-2 -il]-1h-quinolin-2-ona
CL2011002925A1 (es) Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1.
BRPI0817843B8 (pt) inibidores da quinase c-fms, composição farmacêutica que os compreende e processo para a fabricação da dita composição
UY29648A1 (es) Derivados de piridopirimidina, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones
ECSP109890A (es) Particulas de un antagonista de crth2
DE502005008057D1 (de) Substituierte cyclopenten-verbindungen
UA113658C2 (xx) Кристалічна форма і дималеатного інгібітору тирозинкінази і способи її одержання
ECSP088700A (es) Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1
CR20110369A (es) Derivados de quinazolinona útiles como antagonistas de vanilloides
ATE481972T1 (de) Chinazolinon-derivate als vanilloid-antagonisten
NZ703549A (en) Benzodioxole derivative and preparation method and use thereof
EA201001517A1 (ru) Замещенные пиперидины в качестве терапевтических соединений
UY30652A1 (es) N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-ilideno)metil)benzamida
UY32333A (es) Derivados cuaternarios de piridina y utilización de los mismos

Legal Events

Date Code Title Description
DESI Application deemed to be withdrawn

Effective date: 20120515