DK1943240T3 - Kemisk fremgangsmåde - Google Patents

Kemisk fremgangsmåde

Info

Publication number
DK1943240T3
DK1943240T3 DK06794582.4T DK06794582T DK1943240T3 DK 1943240 T3 DK1943240 T3 DK 1943240T3 DK 06794582 T DK06794582 T DK 06794582T DK 1943240 T3 DK1943240 T3 DK 1943240T3
Authority
DK
Denmark
Prior art keywords
chemical process
chemical
Prior art date
Application number
DK06794582.4T
Other languages
English (en)
Inventor
Joergen Blixt
Michael David Golden
Philip John Hogan
David Michael Glanville Martin
Francis Joseph Montgomery
Zakariya Patel
John David Pittam
George Joseph Sependa
Christopher John Squire
Nicholas Cartwright Alexander Wright
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35395001&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1943240(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1943240T3 publication Critical patent/DK1943240T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK06794582.4T 2005-09-30 2006-09-27 Kemisk fremgangsmåde DK1943240T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0519879.1A GB0519879D0 (en) 2005-09-30 2005-09-30 Chemical process
PCT/GB2006/003587 WO2007036713A2 (en) 2005-09-30 2006-09-27 Chemical process

Publications (1)

Publication Number Publication Date
DK1943240T3 true DK1943240T3 (da) 2010-03-01

Family

ID=35395001

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09152654.1T DK2053048T3 (da) 2005-09-30 2006-09-27 Fremgangsmåde til in situ kemisk sulfonering
DK06794582.4T DK1943240T3 (da) 2005-09-30 2006-09-27 Kemisk fremgangsmåde

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK09152654.1T DK2053048T3 (da) 2005-09-30 2006-09-27 Fremgangsmåde til in situ kemisk sulfonering

Country Status (32)

Country Link
US (8) US8163926B2 (da)
EP (2) EP1943240B1 (da)
JP (2) JP5213715B2 (da)
KR (1) KR101307641B1 (da)
CN (3) CN102503898B (da)
AR (1) AR055671A1 (da)
AT (2) ATE481399T1 (da)
AU (1) AU2006296367B2 (da)
BR (1) BRPI0616715A2 (da)
CA (2) CA2624045C (da)
CY (2) CY1110275T1 (da)
DE (2) DE602006017004D1 (da)
DK (2) DK2053048T3 (da)
ES (2) ES2335435T3 (da)
GB (1) GB0519879D0 (da)
HK (2) HK1122553A1 (da)
HR (2) HRP20100019T1 (da)
IL (2) IL190172A (da)
ME (2) ME01466B (da)
MY (2) MY149834A (da)
NO (1) NO342152B1 (da)
NZ (2) NZ566566A (da)
PL (2) PL1943240T3 (da)
PT (2) PT1943240E (da)
RS (2) RS51515B (da)
RU (1) RU2448102C2 (da)
SG (1) SG165416A1 (da)
SI (2) SI1943240T1 (da)
TW (2) TWI424991B (da)
UY (1) UY29824A1 (da)
WO (1) WO2007036713A2 (da)
ZA (1) ZA200802416B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003064413A1 (en) * 2002-02-01 2003-08-07 Astrazeneca Ab Quinazoline compounds
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
CL2007003158A1 (es) * 2006-11-02 2008-05-16 Astrazeneca Ab Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion.
ES2547902T3 (es) * 2011-09-01 2015-10-09 Symrise Ag Procedimiento para la preparación de derivados de indanona
US9273001B2 (en) * 2012-08-15 2016-03-01 Glaxo Group Limited Chemical process
CN104098544A (zh) * 2013-04-07 2014-10-15 浙江九洲药物科技有限公司 一种凡德他尼的制备方法
CN106397401B (zh) * 2016-08-30 2018-11-13 山东罗欣药业集团股份有限公司 一种抗癌药物的晶体化合物及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870083A (en) 1987-11-24 1989-09-26 Merrell Dow Pharmaceuticals Inc. 1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants
JP2829744B2 (ja) 1989-05-31 1998-12-02 川研ファインケミカル株式会社 ピペリジンカルボン酸類の製造方法
AU8506791A (en) 1990-10-01 1992-04-28 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
JP2659107B2 (ja) 1991-03-28 1997-09-30 エーザイ株式会社 複素環式―環式アミン誘導体
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
CA2102780C (en) 1991-05-10 2007-01-09 Alfred P. Spada Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5624926A (en) 1993-02-18 1997-04-29 Kyowa Hakko Kogyo Co., Ltd. Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors
AU680004B2 (en) * 1993-05-26 1997-07-17 Syntex (U.S.A.) Inc. Novel 1-phenylalkanone 5-HT4 receptor ligands
DE4326344A1 (de) 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0739336B1 (en) * 1994-01-13 1998-08-26 MERCK SHARP & DOHME LTD. Gem-disubstituted azacyclic tachykinin antagonists
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
DE69709319T2 (de) 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
CA2265630A1 (en) 1996-09-13 1998-03-19 Gerald Mcmahon Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
PT1676845E (pt) * 1999-11-05 2008-08-05 Astrazeneca Ab Novos derivados de quinazolina
GB0126879D0 (en) 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
AU2002366801B8 (en) 2001-12-20 2009-05-21 Osi Pharmaceuticals, Inc. Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
WO2003064413A1 (en) 2002-02-01 2003-08-07 Astrazeneca Ab Quinazoline compounds
ATE533750T1 (de) 2002-02-06 2011-12-15 Ube Industries Verfahren zur herstellung einer 4- aminochinazolinverbindung
JP2006502132A (ja) 2002-08-09 2006-01-19 アストラゼネカ アクチボラグ 癌の治療における血管内皮細胞増殖因子受容体の阻害薬zd6474と放射線療法との併用
GB0218526D0 (en) 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
EP1592423B1 (en) 2003-02-13 2011-04-20 AstraZeneca AB Combination therapy of zd6474 with 5-fu and/or cpt-11
DE602004028834D1 (de) 2003-07-10 2010-10-07 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
GB0318423D0 (en) 2003-08-06 2003-09-10 Astrazeneca Ab Chemical compounds
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process

Also Published As

Publication number Publication date
JP5213715B2 (ja) 2013-06-19
US20160185754A1 (en) 2016-06-30
IL190172A0 (en) 2008-08-07
MY149834A (en) 2013-10-31
NZ593930A (en) 2013-02-22
US20180118716A1 (en) 2018-05-03
RU2448102C2 (ru) 2012-04-20
EP1943240B1 (en) 2009-11-11
HK1130478A1 (en) 2009-12-31
CA2624045A1 (en) 2007-04-05
US20240150317A1 (en) 2024-05-09
KR20080049114A (ko) 2008-06-03
TWI424991B (zh) 2014-02-01
SI2053048T1 (sl) 2010-12-31
PT1943240E (pt) 2010-01-11
GB0519879D0 (en) 2005-11-09
AR055671A1 (es) 2007-08-29
CN102503898A (zh) 2012-06-20
HK1122553A1 (en) 2009-05-22
CN102503933B (zh) 2014-06-25
AU2006296367B2 (en) 2011-08-11
ZA200802416B (en) 2009-01-28
PL2053048T3 (pl) 2011-03-31
CA2745829A1 (en) 2007-04-05
EP1943240A2 (en) 2008-07-16
US20120095229A1 (en) 2012-04-19
RS51263B (sr) 2010-12-31
ES2350513T3 (es) 2011-01-24
US20190263782A1 (en) 2019-08-29
IL190172A (en) 2014-05-28
SI1943240T1 (sl) 2010-02-26
CY1110887T1 (el) 2015-06-10
TW200745036A (en) 2007-12-16
WO2007036713A2 (en) 2007-04-05
EP2053048A1 (en) 2009-04-29
PL1943240T3 (pl) 2010-04-30
CN101277948A (zh) 2008-10-01
TWI328580B (en) 2010-08-11
JP5654546B2 (ja) 2015-01-14
KR101307641B1 (ko) 2013-09-12
JP2009510039A (ja) 2009-03-12
EP2053048B1 (en) 2010-09-15
DE602006017004D1 (de) 2010-10-28
US9815816B2 (en) 2017-11-14
ME01466B (me) 2014-04-20
US20140378684A1 (en) 2014-12-25
RS51515B (en) 2011-06-30
TW201018660A (en) 2010-05-16
HRP20100620T1 (hr) 2010-12-31
MY145540A (en) 2012-02-29
CA2624045C (en) 2012-05-22
NO20081267L (no) 2008-04-30
DE602006010428D1 (de) 2009-12-24
JP2013063998A (ja) 2013-04-11
ATE481399T1 (de) 2010-10-15
US20090203905A1 (en) 2009-08-13
HRP20100019T1 (hr) 2010-02-28
UY29824A1 (es) 2007-04-30
CN102503898B (zh) 2015-03-25
US8163926B2 (en) 2012-04-24
PT2053048E (pt) 2010-11-10
US8865899B2 (en) 2014-10-21
ATE448218T1 (de) 2009-11-15
IL227574A (en) 2015-08-31
ES2335435T3 (es) 2010-03-26
CA2745829C (en) 2013-07-02
NO342152B1 (no) 2018-04-03
ME01531B (me) 2014-04-20
CN102503933A (zh) 2012-06-20
CY1110275T1 (el) 2015-01-14
WO2007036713A3 (en) 2007-06-14
DK2053048T3 (da) 2010-11-29
CN101277948B (zh) 2013-03-13
BRPI0616715A2 (pt) 2011-06-28
RU2008116573A (ru) 2009-11-10
US10344015B2 (en) 2019-07-09
AU2006296367A1 (en) 2007-04-05
EP2053048B8 (en) 2011-09-21
NZ566566A (en) 2011-08-26
SG165416A1 (en) 2010-10-28
US20220033377A1 (en) 2022-02-03

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