Classifications

• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
  • C08K5/00—Use of organic ingredients
  • C08K5/16—Nitrogen-containing compounds
  • C08K5/34—Heterocyclic compounds having nitrogen in the ring
  • C08K5/3412—Heterocyclic compounds having nitrogen in the ring having one nitrogen atom in the ring
  • C08K5/3432—Six-membered rings
  • C08K5/3435—Piperidines
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
  • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
  • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
  • C07D211/74—Oxygen atoms

Definitions

• R represents an alkyl group of 1-18 carbon atoms; a cycloalkyl group which contains or 6 carbon atoms and may be substituted with an alkyl group of 1-4 carbon atoms or hydroxyl group; or the group of the formula -CH R' in which R represents an aryl group which contains 6-10 carbon atoms and may be substituted with an alkyl group of 1-4 carbon atoms, an alkoxy group of 14 carbon atoms, a halogen atom or hydroxyl group in the aryl moiety or a 5- or 6-membered heterocyclic group which contains oxygen atom as a hetero atom and may be substituted with an alkyl group of 1-4 carbon atoms, an alkoxy group of 1-4 carbon atoms, a halogen atom or hydroxyl group.
• piperidone enol ethers are prepared by reacting triacetonamine with an alcohol having the formula wherein R is as defined above in the presence of an acid catalyst. These piperidone enol ethers exhibit a superior stabilizing effect against photoand thermo-deterioration of various synthetic polymers and thus they are useful as a stabilizer for synthetic polymers.
• This invention relates to a new class of piperidone enol ethers, a process for the preparation thereof, as well as their use as a stabilizer for the stabilization of synthetic polymers.
• R represents an alkyl group of 1-18 carbon atoms; a cycloalkyl group which contains 5 or 6 carbon atoms and may be substituted with an alkyl group of l-4 carbon atoms or hydroxyl group; or the group of the formula CH -R in which R represents an aryl group which contains 6-10 carbon atoms and may be substituted with an alkyl group of 1-4 carbon atoms, a halogen atom or hydroxyl group in the aryl moiety or a 5- or 6-membered heterocyclic group which contains oxygen atom as a hetero atom and may be substituted with an alkyl group of 1-4 carbon atoms, an alkoxy group of 1-4 carbon atoms, a halogen atom or hydroxyl group and with a proc- Patented May 16, 1972 ess for the preparation of the piperidone enol ether having the above Formula I. It is also concerned with the stabilization of synthetic polymers against photoand thermodeterioration thereof by having incorporated there
• the group R may be exemplified by methyl, ethyl, n-propyl, n-butyl, n-hexadecyl, stearyl, cyclopentyl, cyclohexyl, 2-methylcyclopentyl, 4- tert.butylcyclopentyl, S-hydroXycycIopentyl, 2- or 4-methylcyclohexyl, 3- or S-terLbutylcycloheXyl, 2- or 4-hydroxycyclohexyl, benzyl, naphthylmethyl, 0-, mor p-methylbenzyl, 0-, mor p-tert.butylbenzyl, 0-, mor p-methoxybenzyl, 0-, mor p-n-butoxybenzyl, o-, mor p-chlorobenzyl, o, mor p-bromobenzyl, o-, mor p-hydroxybenz
• -Polyolefins including homopolymers of olefins such as low-density polyethylene, high-density polyethylene, polypropylene, polystyrene, polybutadiene, polyisoprene and the like, and copolymers of olefins with other ethylenically unsaturated monomers such as ethylene-propylene copolymer, ethylene-butene copolymer, ethylene-vinyl acetate copolymer, styrene-butadiene copolymer, acrylonitrilestyrene copolymer, acrylonitrile-styrene-butadiene copolymer and the like;
• Polyvinyl chlorides and polyvinylidene chlorides including homopolymer of each of vinyl chloride and vinylidene chloride, vinyl chloride-vinylidene chloride copolymer and copolymers of each of vinyl chloride and vinylidene chloride with vinyl acetate or other ethylenically unsaturated monomers;
• Polyesters including polyethylene terephthalate
• Polyacetals including polyoxymethylene and polyoxy ethylene
• Polyamides including 6-nylon, 6,6-nylon, 6,l0-nylon, ll-nylon, 7-nylon, 4-nylon, 12-ny1on and 9-nylon; and
• the piperidone enol ethers (I) of this invention are all new substances undisclosed in the prior art. They exhibit a high degree of stabilizing action on the synthetic polymer, e.g., polyolefins, polyvinylchloride, polyvinylidene chloride, polyesters, polyamides and polyurethanes against the deteriorations thereof.
• Still another object of this invention is to provide a synthetic polymer composition stabilised against photoand thermo-deterioration thereof wherein there is incorporated the piperidone enol ethers of the above Formula I.
• the piperidone enol ethers of the above Formula I can be produced by a process with an alcohol having the formula R-OH (II) wherein R is as defined above in the presence of an acid catalyst.
• the reaction may be suitably effected in the presence or absence of an inert organic solvent.
• inert organic solvents which may be employed in this reaction include aliphatic hydrocarbons, e.g., n-hexane, kerosene, ligroin and the like and aromatic hydrocarbons, e.g., benzene, toluene, xylene and the like.
• Examples of the acid catalysts which may be employed in this reaction include mineral acids, e.g., hydrochloric acid, sulfuric acid, phos-' phoric acid and the like and aromatic sulfonic acids, e.g.-, benzenesulfonc acid, p-toluenesulfonic acid and the like.
• the amount of the reactants to be employed is not critical, but it is usual and preferably to employ triacetonamine and the alcohol (II) in a molar ratio of about 1 to about 1.0-1.5.
• the amount of the acid catalyst to be employed may be of a usual catalytic level.
• the reaction period and temperature are not critical and may be varied mainly depending upon the types of the particular reactants, especially the particular alcohol employed and other factors, but the reaction may be preferably effected at a reflux temperature of the inert organic solvent employed [for about 10-70 hours.
• the reaction in the process of this invention may be most preferably effected by reacting the reactants in the presence of the acid catalyst, while the water formed in situ during the reaction is continuously removed by a conventional means, for example, by forming an azeotropic mixture with the inert organic solvent employed such as benzene.
• the reaction product can be readily recovered and purified from the reaction mixture by a conventional method.
• the reaction mixture is cooled and neutralized by pouring into an ice-cooled aqueous solution of an alkali metal hydroxide, e.g., potassium hydroxide, an organic layer is separated from an aqueous layer and then the separated organic layer is subjected to distillation under reduced pressure to give the desired product.
• an alkali metal hydroxide e.g., potassium hydroxide
• piperidone enol ethers of the above Formula I are to be employed in the synthetic polymer for the purpose of stabilization, they may be readily incorporated into such polymers by various standard procedures commonly utilized in the art.
• the stabilizing piperidone enol ethers (I) of this invention may be incorporated into the synthetic polymers at any desired stage prior to the manufacture of shaped articles therefrom.
• the stabilizer in a form of powder may be admixed with the synthetic polymer or a solution, suspension or emulsion of such a stabilizer may be admixed with a solution, suspension or emulsion of the polymer of this invention.
• the amount of the piperidone enol ethers to be employed in the synthetic polymer in accordance with this invention may be widely varied, depending upon mainly the types, properties and particular use of the polymer to be stabilized.
• the piperidone enol ethers of the Formula I may be added in an amount ranging from 0.01 to 5.0% by weight, based upon the amount of the synthetic polymer, but the practical range is varied depending upon the type of the particular synthetic polymer, that is, 0.01 to 2.0% by weight, preferably 0.02 to 1.0% by weight for polyolefins, 0.01 to 2.0% by weight, preferably 0.02 to 1.0% by weight for polyvinyl chloride and polyvinylidene chloride, 0.01 to 5.0% by weight, preferably 0.02 to 2.0% by weight for polyurethanes and polyamides, and 0.01 to 2.0% by weight, preferably 0.05 to 1% by weight for polyesters and polyacetals.
• the present stabilizers may be used alone or in combination with other known stabilizers, fillers, pigments and the like.
• two or more of the present stabilizers may also be satisfactorily used in admixture.
• Examples 1 through '6 describe the preparation of some of the piperidone enol ethers (I) of this invention.
• Examples 7 through 10 describe some of the stabilized synthetic polymer compositions which contain as a stabilizer the piperidone enol ethers (I) of this invention.
• EXAMPLE 1 4-n-butoxy-2,2,6,G-tetramethyl-A -dehydropiperidine To a solution of 33 g. of triacetonamine in 350 ml. of toluene was added with ice-cooling 37 g. of p-toluenesulfonic acid and then 17 g. of n-butanol with stirring. The resulting mixture was heated under reflux for 20 hours while the water formed in situ during the reaction was continuously removed. After cooling, the reaction mixture was poured into an ice-cooled aqueous potassium hydroxide solution and then aqueous and organic layers were separated. The separated organic layer was washed with water, dried over anhydrous magnesium sulfate and then the solvent was distilled off. The residual liquid was subjected to distillation under reduced pressure to give the desired product as colorless oily subsubstance boiling at -130 C./0.15 mm. Hg.
• EXAMPLE 4 4-cyclohexyloxy-2,2,'6,6-tetramethyl A -dehydropiperidine
• 23.4 g. of triacetonamine and 18.0 g. of cyclohexyl alcohol to give the desired product as colorless oily substance boiling at 84 C./ 3 mm. Hg.
• EXAMPLE -4-(4-hydroxycyclohexyloxy)-2,2,6,6-tetramethyl-A dehydropip eridine The same reaction procedure as in the above Example 2 was repeated except that 29.0 g. of triacetonamine and 8.1 g. of cyclohexane-1,4-diol were employed. After completion of the reaction, the reaction mixture was treated in the same manner as in the above Example 2 except that petroleum ether was added to the residual liquid, the crystalline substance thus separated was recovered by Ifiltration and then recrystallized from benzene to give the desired product as white crystals melting at 130.5- 131.5' C.
• EXAM PIJE 6 4-benzyloxy-2,2,6,6-tetramethyl-A -dehydropiperidine
• 23.4 g. of triacetonamine and 17.6 g. of benzyl alcohol were employed to give the desired product as colorless oily substance boiling at 117 C./ 2 mm. Hg. This substance crystallized upon cooling to give white crystals melting at 37.5-38.5 C.
• EXAMPLE 7 Into parts of polypropylene [Noblen JHH G, trade name, available from Mitsui Toatsu Chemicals Inc., Japan, employed after twice recrystallizations from monochlorobenzene] was incorporated 0.25 part of each of the test compounds of this invention indicated in the following Table 1. The resulting mixture was uniformly mixed and melted and then molded into a sheet having a thickness of 0.5 mm. under heating and pressure.
• the polypropylene sheet was prepared in a similar manner to that described above without addition of any of stabilizers for comparative purpose.
• test compound 1
• the number of the test compound is the same as specified hereinabove.
• EXAMPLE 8 Into 100 parts of polyvinyl chloride [Geon 103 EP, trade name, available from The Japanese Geon Co. Ltd., Japan] were incorporated 0.5 part of barium stearate, 0.5 part of cadmium stearate and 0.2 part of each of the test compounds of this invention indicated in the following Tables 2 and 3. The resulting mixture was blended and kneaded for 4 minutes on a kneading roll at 180 C. and formed into a sheet having a thickness of about 0.5 mm. The sheet was tested for the discoloration degree thereof by the aging test method set forth below.
• test compound is the same as specified hereiuabove.
• test compound is the same as specified hereinabove.
• EXAMPLE 9 Into 100 parts of 6-nylon [CM 1011, trade name, available from Toyo Rayon Co. Ltd., Japan, containing no stabilizer] was incorporated 0.25 part of each of the test compounds of this invention indicated in the following Table 4. The resulting mixture was heated and melted and then molded into a film having a thickness of about 0.1 mm. under pressure. The film thus formed was exposed to ultraviolet ray irradiation in the fade meter prescribed in the above Example 7 at 45 C. for 300 hours. Thereafter, the exposed sheet was subjected to a standard tensile test to determine retentions of tensile strength and elongation.
• CM 1011 trade name, available from Toyo Rayon Co. Ltd., Japan
• test compound is the same as specified hereinabove.
• EXAMPLE 10 Into 100 parts of polyurethane prepared from polycaprolactone [E-5080, trade name, available from The Nippon Elastollan Industries Ltd., Japan] was incorporated 0.5 part of each of the test compounds of this invention indicated in the following Table 5. The resulting mixture was heated and melted and then molded into a sheet having a thickness of about 0.5 mm. The sheet thus formed was subjected to the exposure to ultraviolet ray irradiation in the fade meter prescribed in the above Example 7 at 45 C. for hours and then tested for retentions of elongation and tensile strength as in the above Example 9.
• test compound is the same as specified herelnabove.
• a compound having the formula E30 CH wherein R represents an alkyl group of 1-18 carbon atoms; a cycloalkyl group which contains 5 or 6 carbon atoms and may be substituted with an alkyl group of 1-4 carbon atoms or hydroxyl group; or the group of the formula -CH R' in which R represents an aryl group which contains 6-10 carbon atoms and may be substituted with an alkyl group of 1-4 carbon atoms, an alkoxy group of 1-4 carbon atoms, a halogen atom or hydroxyl group in the aryl moiety or a 5- or 6-membered heterocyclic group which contains oxygen atom as a hetero atom and may be substituted with an alkyl group of 1-4 carbon atoms, an alkoxy group of 1-4 carbon atoms, a halogen atom or hydroxyl group.
• R represents an alkyl group of 1-18 carbon atoms; a cycloalkyl group which contains 5 or 6 carbon atoms and may be substituted with an alkyl group of 1-4 carbon atoms or hydroxy group; or the group of the formula CH R in which R represents an aryl group which contains 6-10 carbon atoms and may be substituted with an alkyl group of l--4 carbon atoms, an alkoxy group of 1-4 carbon atoms, a halogen atom or hydroxyl group in the aryl moiety or a 5- or fi-membercd heterocyclic group which contains oxygen atom as a hetero atom and may be substituted with an alkyl group of 1-4 carbon atoms, an alkoxy group of 1-4 carbon atoms, a halogen atom or hydroxyl group which comprises reacting triacetonamine with a compound having the formula 3,381,013 4/1968 Minor 260-297R ALAN L. ROTMAN, Primary Examiner US. Cl. X.R.

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• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Health & Medical Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Medicinal Chemistry (AREA)
• Polymers & Plastics (AREA)
• Hydrogenated Pyridines (AREA)
• Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

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• 1970
  • 1970-09-15 US US72522A patent/US3663558A/en not_active Expired - Lifetime
  • 1970-09-22 DE DE2047846A patent/DE2047846C3/de not_active Expired
  • 1970-09-22 NL NL7013976A patent/NL7013976A/xx unknown
  • 1970-09-25 FR FR7034764A patent/FR2064827A5/fr not_active Expired
  • 1970-09-25 GB GB45865/70A patent/GB1284069A/en not_active Expired
  • 1970-09-28 CH CH1433570A patent/CH547803A/de not_active IP Right Cessation

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