US20110319988A1 - Device and System for Transcatheter Mitral Valve Replacement - Google Patents
Device and System for Transcatheter Mitral Valve Replacement Download PDFInfo
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- US20110319988A1 US20110319988A1 US12/963,596 US96359610A US2011319988A1 US 20110319988 A1 US20110319988 A1 US 20110319988A1 US 96359610 A US96359610 A US 96359610A US 2011319988 A1 US2011319988 A1 US 2011319988A1
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- prosthetic heart
- heart valve
- valve
- cuff
- tethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2436—Deployment by retracting a sheath
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2454—Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
- A61F2/2457—Chordae tendineae prostheses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/9522—Means for mounting a stent or stent-graft onto or into a placement instrument
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- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/005—Rosette-shaped, e.g. star-shaped
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0073—Quadric-shaped
- A61F2230/0078—Quadric-shaped hyperboloidal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0069—Sealing means
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
Definitions
- This invention relates to a transcatheter mitral valve replacement and a delivery system therefor.
- Valvular heart disease and specifically aortic and mitral valve disease is a significant health issue in the US Annually approximately 90,000 valve replacements are conducted in the US.
- Traditional valve replacement surgery the orthotopic replacement of a heart valve, is an “open heart” surgical procedure. Briefly, the procedure necessitates surgical opening of the thorax, the initiation of extra-corporeal circulation with a heart-lung machine, stopping and opening the heart, excision and replacement of the diseased valve, and re-starting of the heart.
- valve replacement surgery typically carries a 1-4% mortality risk in otherwise healthy persons, a significantly higher morbidity is associated to the procedure largely due to the necessity for extra-corporeal circulation. Further, open heart surgery is often poorly tolerated in elderly patients.
- the Edwards SAPIEN transcatheter heart valve is currently undergoing clinical trial in patients with calcific aortic valve disease who are considered high-risk for conventional open-heart valve surgery. This valve is deployable via a retrograde transarterial (transfemoral) approach or an antegrade transapical (transventricular) approach.
- a key aspect of the Edwards SAPIEN and other transcatheter aortic valve replacement designs is their dependence on lateral fixation (e.g. tines) that engages the valve tissues as the primary anchoring mechanism.
- Such a design basically relies on circumferential friction around the valve housing or stent to prevent dislodgement during the cardiac cycle. This anchoring mechanism is facilitated by, and may somewhat depend on, a calcified aortic valve annulus. This design also requires that the valve housing or stent have a certain degree of rigidity.
- At least one transcatheter mitral valve design is currently in development.
- the Endovalve uses a folding tripod-like design that delivers a tri-leaflet bioprosthetic valve. It is designed to be deployed from a minimally invasive transatrial approach, and could eventually be adapted to a transvenous atrial septotomy delivery.
- This design uses “proprietary gripping features” designed to engage the valve annulus and leaflets tissues.
- the anchoring mechanism of this device is essentially equivalent to that used by transcatheter aortic valve replacement designs.
- the present invention relates to the design and function of a compressible prosthetic heart valve replacement which can be deployed into a closed beating heart using a transcatheter delivery system.
- the design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure utilizing the intercostal or subxyphoid space for valve introduction.
- the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the target location, for example the mitral or tricuspid valve annulus.
- a prosthetic mitral valve containing a cuff which locally contours to the mitral annulus.
- a prosthetic heart valve with a cuff that has a tissue or synthetic covering.
- a prosthetic heart valve with a cuff that has articulating wire loops of various lengths.
- a prosthetic heart valve containing at least one elastic tether to provide compliance during the physiologic movement or conformational changes associated with heart contraction.
- a prosthetic heart valve having a stent body and cuff that are made from a superelastic metal.
- a prosthetic heart valve having a stent body and cuff that are made from a superelastic metal that is laser cut with predetermined shapes to facilitate collapsing into the catheter delivery system.
- a prosthetic heart valve having a stent body constructed from ductile metal, for example stainless steel, so as to require a balloon for expansion once located at the annulus, but capable of deformation without fracture.
- a prosthetic heart valve constructed from superelastic wire made from a shape memory alloy such as nickel-titanium alloy (Naval Ordinance Lab) NitinolTM.
- a laser cut prosthetic heart valve containing tethers for anchoring.
- valve constructed from wire containing tethers for anchoring.
- valve containing tether which are used to position the valve cuff into the mitral annulus to prevent perivalvular leak.
- tethers that are bioabsorbable and provide temporary anchoring until biological fixation of the prosthesis occurs.
- Biological fixation consisting of fibrous adhesions between the leaflet tissues and prosthesis or compression on the prosthesis by reversal of heart dilation, or both.
- a prosthetic heart valve constructed from wire or laser-formed demonstrating a compliant body and cuff such that the two components accommodate the movement of the heart throughout the cardiac cycle.
- a cuff for a prosthetic heart valve said cuff being covered with tissue.
- a cuff for a prosthetic heart valve said cuff being covered with a synthetic polymer selected from expandable polytetrafluoroethylene (ePTFE) or polyester.
- ePTFE expandable polytetrafluoroethylene
- a prosthetic heart valve that has leaflet material constructed from a material selected from the group consisting of polyurethane, polytetrafluoroethylene, pericardium, and small intestine submucosa.
- a prosthetic heart valve having surfaces that are treated with anticoagulant.
- a prosthetic heart valve having a cuff and containing anchoring tethers which are attached to the cuff
- a prosthetic heart valve having a cuff and containing anchoring tethers which are attached to the cuff and at both commissural tips.
- a prosthetic heart valve having a cuff where the cuff attachment relative to the body is within the angles of about 60 degrees to about 150 degrees.
- a prosthetic heart valve containing a combination of tethers and barbs useful for anchoring the device into the mitral annulus.
- a prosthetic heart valve which comprises an expandable tubular stent having a cuff and an expandable internal leaflet assembly, said leaflet assembly may or may not have a structural wire support, wherein said cuff is comprised of wire covered with stabilized tissue, and wherein said leaflet assembly is disposed within the stent and is comprised of stabilized tissue in the form of leaflets.
- the wire of the cuff is formed as a series of radially extending loops of equal or variable length.
- the cuff extends laterally beyond the expanded tubular stent according to a ratio of the relationship between the height of the expanded deployed stent (h) and the lateral distance that the cuff extends onto the tissue (1).
- the h/1 ratio can range from 1:10 to 10:1, and more preferably includes without limitation 1:3, 1:2, 1:1, 2:1, and fractional ranges there between such as 1.25 : 2.0, 1.5 : 2.0, and so forth. It is contemplated in one non-limiting example that the cuff can extend laterally (1) between about 3 and about 30 millimeters.
- tubular stent has a first end and a second end, wherein the cuff is formed from the stent itself, or in the alternative is formed separately and wherein the cuff is located at the first end of the stent, and the second end of the tubular stent has a plurality of tether attachment structures.
- a feature further comprising a plurality of tethers for anchoring the prosthetic heart valve to tissue and/or for positioning the prosthetic heart valve.
- a feature further comprising an epicardial tether securing device, wherein the tethers extend between about 3 and about 8 cm in length, and are fastened to an epicardial tether securing device.
- a catheter delivery system for delivery of a prosthetic heart valve which comprises a delivery catheter having the prosthetic heart valve disposed therein, and an obturator for expelling the prosthetic heart valve.
- an assembly kit for preparing the catheter delivery system which comprises a compression funnel, an introducer, a wire snare, an obturator, a delivery catheter, and a prosthetic heart valve
- the compression funnel has an aperture for attaching to the introducer
- said introducer is comprised of a tube having a diameter that fits within the diameter of the delivery catheter
- said obturator is comprised of a tube fitted with a handle at one end and a cap at the other end, whereinhere said cap has an opening to allow the wire snare to travel therethrough
- said obturator has a diameter that fits within the diameter of the introducer
- said prosthetic heart valve is compressible and fits within the delivery catheter.
- a method of treating mitral regurgitation and/or tricuspid regurgitation in a patient which comprises the step of surgically deploying the prosthetic heart valve into the annulus of the target valve structure, e.g. mitral valve annulus and tricuspid valve annulus of the patient.
- prosthetic heart valve is deployed by directly accessing the heart through an intercostal space, using an apical approach to enter the left (or right) ventricle, and deploying the prosthetic heart valve into the valvular annulus using the catheter delivery system.
- the prosthetic heart valve is deployed by directly accessing the heart through a thoracotomy, sternotomy, or minimally-invasive thoracic, thorascopic, or transdiaphragmatic approach to enter the left (or right) ventricle, and deploying the prosthetic heart valve into the valvular annulus using the catheter delivery system.
- the prosthetic heart valve is deployed by directly accessing the heart through the intercostal space, using a lateral approach to enter the left or right ventricle, and deploying the prosthetic heart valve into the valvular annulus using the catheter delivery system.
- the prosthetic heart valve is deployed by accessing the left heart using either an antegrade-trans(atrial)septal (transvenous-trans(atrial)septal) approach or a retrograde (transarterial-transaortic) catheter approach to enter the left heart, and deploying the prosthetic heart valve into the mitral annulus using the catheter delivery system.
- prosthetic heart valve is deployed into the mitral annulus from a retrograde approach by accessing the left ventricle through the apex of the ventricular septum (transvenous-trans(ventricular)septal approach).
- prosthetic heart valve is deployed into the mitral position using a retrograde transventricular septal approach and the tethers are anchored into or on the right ventricular side of the ventricular septum.
- a feature further comprising tethering the prosthetic heart valve to tissue within the left ventricle.
- prosthetic heart valve is tethered to the apex of the left ventricle using an epicardial tether securing device.
- a retrieval method for quickly removing a prosthetic heart valve having one or more tethers from a patient using minimally invasive cardiac catheter techniques which comprises the steps of, capturing the one or more tethers with a catheter having a snare attachment, guiding the captured tethers into a collapsible funnel attachment connected to the removal catheter, pulling the tethers to conform the prosthetis heart valve into a collapsed, compressed conformation, and pulling the now compressed prosthetic heart valve into the removal catheter for subsequent extraction.
- the retrieval method is contemplated for use for capturing the prosthetic heart valve as described herein or any suitable tethered, collapsible medical device.
- the method is used to extract a prosthetic heart valve from either the left or right ventricle. The method may be particularly useful to extract the prosthetic appliance during an aborted surgical deployment.
- FIG. 1 is a perspective view of one embodiment of a prosthetic valve according to the present invention.
- FIG. 2 A-D is a perspective exploded view of one embodiment of a prosthetic valve according to the present invention that does not use a structural wire support for the valve cusps/leaflets.
- FIG. 3 A-E is a perspective exploded view of one embodiment of a prosthetic valve according to the present invention that incorporates a structural wire support for the valve cusps/leaflets.
- FIG. 4 is a top view of on embodiment of a prosthetic valve according to the present invention and shows a two-leaflet structure.
- FIG. 5 is a side view from slightly below the horizontal plane of one embodiment of a prosthetic valve according to the present invention to show the bottom surface of the cuff.
- FIG. 5 shows the tethers without the structural wire support for the leaflets.
- FIG. 6 is a top view from slightly above the horizontal plane of one embodiment of a prosthetic valve according to the present invention and shows the top surface of the cuff and structural wire support loops extending beyond the length of the stent.
- FIG. 7 is a view of one embodiment of a prosthetic valve according to the present invention showing that the cuff spindles may optionally have variable lengths and sizes.
- FIG. 8 is a view of one embodiment of a prosthetic valve according to the present invention showing that the cuff spindles may optionally have variable lengths and sizes. Here they are shown to create an elongated cuff
- FIG. 9 is a top view of one embodiment of a prosthetic valve according to the present invention showing a three-leaflet structure.
- FIG. 10 A-C is a series of side views of one embodiment of a prosthetic valve according to the present invention illustrating that the cuff may be formed to have an original configuration whereby the cuffs disposition relative to the stent body has an acute, right, or obtuse angle.
- FIG. 11 is a side view of one embodiment of a prosthetic valve according to the present invention illustrating the use of a barb component to assist seating the prosthetic valve in the valvular annulus.
- FIG. 12 A-B is a pair of side views of one embodiment of a prosthetic valve according to the present invention illustrating the use of a barb component which is open but then closes upon or into the annular tissue when the stent body is expanded to assist seating the prosthetic valve in the valvular annulus.
- FIG. 13 is a side view of one embodiment of a prosthetic valve according to the present invention showing tethers attached to the cuff portion in addition to attachment on the stent body.
- FIG. 14 is a drawing of one embodiment of the delivery system equipment according to the present invention used to compress and deploy the prosthetic valve.
- FIG. 15 A-F is a series of drawings of one embodiment of the delivery system according to the present invention.
- FIG. 16 is a detailed sectional view of an embodiment of a delivery catheter, and one embodiment of a compressed prosthetic valve according to the present invention disposed within the delivery catheter.
- FIG. 17 is a cut-away view of a heart with a delivery catheter containing a prosthetic valve according to the present invention and accessing the heart using an apical approach.
- FIG. 17 shows the delivery catheter advanced to through the mitral valve and into the left atrium for deployment of the prosthetic valve.
- FIG. 18 A-D is a series of views of the tip of one embodiment of a delivery catheter according to the present invention containing a pre-loaded prosthetic valve which is being pushed out of the delivery catheter, i.e. by an obturator, starting with (A) the valve completely within the catheter, (B) the cuff portion being in view, (C) the stent body following, and (D) the prosthetic valve with attached tethers for positioning and/or adjustment and/or securing the valve to tissue.
- a pre-loaded prosthetic valve which is being pushed out of the delivery catheter, i.e. by an obturator, starting with (A) the valve completely within the catheter, (B) the cuff portion being in view, (C) the stent body following, and (D) the prosthetic valve with attached tethers for positioning and/or adjustment and/or securing the valve to tissue.
- FIG. 19 is a detailed sectional view of one embodiment of a prosthetic valve according to the present invention deployed within the annulus of the mitral valve of the heart and shows that it is anchored using (a) the atrial cuff and (b) the ventricular tethers connected to the apex, which are shown secured by a securing pledget.
- FIG. 20 is a detailed side-perspective view of one embodiment of a prosthetic valve according to the present invention deployed within the annulus of the mitral valve of the heart and anchored using (a) the atrial cuff and (b) the ventricular tethers connected to papillary muscles and/or ventricular wall and/or septum, which are each secured by one or more securing tissue anchors.
- FIG. 21 A-B is a pair of drawings showing one embodiment of a ventricular tether attachment according to the present invention.
- FIG. 21 A is a detailed drawing of the flexible delivery catheter inserted into the left ventricular apex along with four sutures having partially installed apical-closure/tissue-buttressing material.
- FIG. 21 B is a detailed drawing of the anchoring system of the prosthetic valve in which the ventricular tethers are shown treaded through the left ventricle apex and through a partially installed pledget; also shown are fully installed apical-closure material.
- FIG. 22 A-B is a pair of drawings of the lateral deployment of one embodiment of a prosthetic valve according to the present invention.
- FIG. 22B is a detail view of an illustration of the prosthetic valve seated within the mitral annulus and tethered to the papillary muscles of the left ventricle.
- FIG. 23 is a cut-away view of a heart with a delivery catheter containing a prosthetic valve according to the present invention and accessing the right ventricle of the heart using an apical approach.
- FIG. 23 shows the delivery catheter advanced through to the tricuspid valve and into the right atrium for deployment of the prosthetic valve.
- FIG. 24 A-B shows an embodiment of a prosthetic valve having a ring or halo feature.
- FIG. 24A is a bottom view from slightly above the horizontal plane of one embodiment of a prosthetic valve according to the present invention to show the bottom surface of the cuff and the halo feature.
- FIG. 24B is a top view from slightly above the horizontal plane of one embodiment of a prosthetic valve according to the present invention to show the top surface of the cuff
- the present invention provides in one embodiment a prosthetic heart valve that comprises a self-expanding valve assembly that is anchored within the mitral valve of the heart using an integral cuff to anchor the valve and using one or more tethers anchored to the heart. It is contemplated as within the scope of the invention to provide a prosthetic heart valve having as an anchoring system both an integral cuff or collar and one or more tethers for tissue anchoring.
- the prosthetic heart valve comprises a self-expanding tubular stent having a cuff at one end and tether loops for attaching tethers at the other end, and disposed within the tubular stent is a leaflet assembly that contains the valve leaflets, the valve leaflets being formed from stabilized tissue or other suitable biological or synthetic material.
- the leaflet assembly comprises a wire form where a formed wire structure is used in conjunction with stabilized tissue to create a leaflet support structure which can have anywhere from 1, 2, 3 or 4 leaflets, or valve cusps disposed therein.
- the leaflet assembly is wireless and uses only the stabilized tissue and stent body to provide the leaflet support structure, without using wire, and which can also have anywhere from 1, 2, 3 or 4 leaflets, or valve cusps disposed therein.
- the cuff functions in a variety of ways.
- the first function of the cuff is to inhibit perivalvular leak/regurgitation of blood around the prosthesis. By flexing and sealing across the irregular contours of the annulus and atrium, leaking is minimized and/or prevented.
- the second function of the cuff is to provide an adjustable and/or compliant bioprosthetic valve.
- the heart and its structures undergo complex conformational changes during the cardiac cycle.
- the mitral valve annulus has a complex geometric shape known as a hyperbolic parabloid much like a saddle, with the horn being anterior, the seat back being posterior, and the left and right valleys located medially and laterally. Beyond this complexity, the area of the mitral annulus changes over the course of the cardiac cycle.
- the geometry of the tricuspid valve and tricuspid annulus continues to be a topic of research, posing its own particular problems. Accordingly, compliance is a very important but unfortunately often overlooked requirement of cardiac devices.
- Compliance here refers to the ability of the valve to maintain structural position and integrity during the cardiac cycle. Compliance with the motion of the heart is a particularly important feature, especially the ability to provide localized compliance where the underlying surfaces are acting differently from the adjacent surfaces. This ability to vary throughout the cardiac cycle allows the valve to remain seated and properly deployed in a manner not heretofore provided.
- Tether-based compliance may be used alone, or in combination with the cuff-based compliance.
- the third function of the cuff valve is to provide a valve that, during surgery, is able to be seated and be able to contour to the irregular surfaces of the atrium.
- the use of independent tethers allows for side to side fitting of the valve within the annulus. For example, where three tethers are used, they are located circumferentially about 120 degrees relative to each other which allows the surgeon to observe whether or where perivalvular leaking might be occurring and to pull on one side or the other to create localized pressure and reduce or eliminate the leaking.
- the forth function of the cuff is to counter the forces that act to displace the prosthesis toward/into the ventricle (i.e. atrial pressure and flow-generated shear stress) during ventricular filling.
- the cuff functions to strengthen the leaflet assembly/stent combination by providing additional structure. Further, during deployment, the cuff functions to guide the entire structure, the prosthetic valve, into place at the mitral annulus during deployment and to keep the valve in place once it is deployed.
- the cuff is a substantially flat plate that projects beyond the diameter of the tubular stent to form a rim or border.
- the term cuff, flange, collar, bonnet, apron, or skirting are considered to be functionally equivalent.
- the cuff is formed from a stiff, flexible shape-memory material such as the nickel-titanium alloy material NitinolTM wire that is covered by stabilized tissue or other suitable biocompatible or synthetic material.
- the cuff wire form is constructed from independent loops of wire that create lobes or segments extending axially around the circumference of the bend or seam where the cuff transitions to the tubular stent (in an integral cuff) or where the cuff is attached to the stent (where they are separate, but joined components).
- the loops provide the cuff the ability to travel up and down, to articulate, along the longitudinal axis that runs through the center of the tubular stent.
- the individual spindles or loops can independently move up and down, and can spring back to their original position due to the relative stiffness of the wire.
- the tissue or material that covers the cuff wire has a certain modulus of elasticity such that, when attached to the wire of the cuff, is able to allow the wire spindles to move. This flexibility gives the cuff, upon being deployed within a patient's heart, the ability to conform to the anatomical shape necessary for a particular application.
- the cuff is able to conform to the irregularities of the left atrium and shape of the mitral annulus, and to provide a tight seal against the atrial tissue adjacent the mitral annulus and the tissue within the mitral annulus.
- this feature importantly provides a degree of flexibility in sizing the a mitral valve and prevents blood from leaking around the implanted prosthetic heart valve.
- an additional important aspect of the cuff dimension and shape is that, when fully seated and secured, the edge of the cuff preferably should not be oriented laterally into the atrial wall such that it can produce a penetrating or cutting action on the atrial wall.
- the wire spindles of the cuff are substantially uniform in shape and size.
- each loop or spindle may be of varying shapes and sizes.
- the loops may form a pattern of alternating large and small loops, depending on where the valve is being deployed.
- pre-operative imaging may allow for customizing the structure of the cuff depending on a particular patient's anatomical geometry in the vicinity of the mitral annulus.
- the cuff wire form is constructed so as to provide sufficient structural integrity to withstand the intracardiac forces without collapsing.
- the cuff wire form is preferably constructed of a superelastic metal, such as Nitinol (TM)® and is capable of maintaining its function as a sealing collar for the tubular stent while under longitudinal forces that might cause a structural deformation or valve displacement. It is contemplated as within the scope of the invention to optionally use other shape memory alloys such as Cu—Zn—Al—Ni alloys, and Cu—Al—Ni alloys.
- the heart is known to generate an average left atrial pressure between about 8 and 30 mm Hg (about 0.15 to 0.6 psi).
- This left atrial filling pressure is the expected approximate pressure that would be exerted in the direction of the left ventricle when the prosthesis is open against the outer face of the cuff as an anchoring force holding the cuff against the atrial tissue that is adjacent the mitral valve.
- the cuff counteracts this longitudinal pressure against the prosthesis in the direction of the left ventricle to keep the valve from being displaced or slipping into the ventricle.
- left ventricular systolic pressure normally about 120 mm Hg, exerts a force on the closed prosthesis in the direction of the left atrium.
- the tethers counteract this force and are used to maintain the valve position and withstand the ventricular force during ventricular contraction or systole.
- the cuff has sufficient structural integrity to provide the necessary tension against the tethers without being dislodged and pulled into the left ventricle.
- changes in the geometry of the heart and/or fibrous adhesion between prosthesis and surrounding cardiac tissues may assist or replace the function of the ventricular tethers in resisting longitudinal forces on the valve prosthesis during ventricular contraction.
- superelastic metal wire such as Nitinol (TM) wire
- Nitinol (TM) wire is used for the stent, for the inner wire-based leaflet assembly that is disposed within the stent, and for the cuff wire form.
- other shape memory alloys such as Cu—Zn—Al—Ni alloys, and Cu—Al—Ni alloys.
- the stent may be constructed as a braided stent or as a laser cut stent. Such stents are available from any number of commercial manufacturers, such as Pulse Systems.
- Laser cut stents are preferably made from Nickel-Titanium (Nitinol (TM)), but also without limitation made from stainless steel, cobalt chromium, titanium, and other functionally equivalent metals and alloys, or Pulse Systems braided stent that is shape-set by heat treating on a fixture or mandrel.
- TM Nickel-Titanium
- TM cobalt chromium
- titanium titanium
- Pulse Systems braided stent that is shape-set by heat treating on a fixture or mandrel.
- Nitinol has been found to be especially useful since it can be processed to be austhenitic, martensitic or super elastic. Martensitic and super elastic alloys can be processed to demonstrate the required compression features.
- the stent envisions the laser cutting of a thin, isodiametric Nitinol tube.
- the laser cuts form regular cutouts in the thin Nitinol tube.
- the tube is placed on a mold of the desired shape, heated to the Martensitic temperature and quenched.
- the treatment of the stent in this manner will form a stent or stent/cuff that has shape memory properties and will readily revert to the memory shape at the calibrated temperature.
- a stent can be constructed utilizing simple braiding techniques. Using a Nitinol wire—for example a 0.012′′ wire—and a simple braiding fixture, the wire is wound on the braiding fixture in a simple over/under braiding pattern until an isodiametric tube is formed from a single wire. The two loose ends of the wire are coupled using a stainless steel or Nitinol coupling tube into which the loose ends are placed and crimped. Angular braids of approximately 60 degrees have been found to be particularly useful. Secondarily, the braided stent is placed on a shaping fixture and placed in a muffle furnace at a specified temperature to set the stent to the desired shape and to develop the martensitic or super elastic properties desired.
- the stent as envisioned in one preferred embodiment is designed such that the ventricular aspect of the stent comes to 2-5 points onto which anchoring sutures are affixed.
- the anchoring sutures (tethers) will traverse the ventricle and ultimately be anchored to the epicardial surface of the heart approximately at the level of the apex.
- the tethers when installed under slight tension will serve to hold the valve in place, i.e. inhibit paravalvular leakage during systole.
- the leaflet assembly comprises a leaflet wire support structure to which the leaflets are attached and the entire leaflet assembly is housed within the stent body.
- the assembly is constructed of wire and stabilized tissue to form a suitable platform for attaching the leaflets.
- the wire and stabilized tissue allow for the leaflet structure to be compressed when the prosthetic valve is compressed within the deployment catheter, and to spring open into the proper functional shape when the prosthetic valve is opened during deployment.
- the leaflet assembly may optionally be attached to and housed within a separate cylindrical liner made of stabilized tissue or material, and the liner is then attached to line the interior of the stent body.
- the leaflet wire support structure is constructed to have a collapsible/expandable geometry.
- the structure is a single piece of wire.
- the wireform is, in one embodiment, constructed from a shape memory alloy such as Nitinol.
- the structure may optionally be made of a plurality of wires, including between 2 to 10 wires.
- the geometry of the wire form is without limitation, and may optionally be a series of parabolic inverted collapsible arches to mimic the saddle-like shape of the native annulus when the leaflets are attached. Alternatively, it may optionally be constructed as collapsible concentric rings, or other similar geometric forms that are able to collapse/compress which is followed by an expansion to its functional shape.
- the wire form may be an umbrella-type structure, or other similar unfold-and-lock-open designs.
- a preferred embodiment utilizes super elastic Nitinol wire approximately 0.015′′ in diameter.
- the wire is wound around a shaping fixture in such a manner that 2-3 commissural posts are formed.
- the fixture containing the wrapped wire is placed in a muffle furnace at a pre-determined temperature to set the shape of the wire form and to impart it's super elastic properties.
- the loose ends of the wireform are joined with a stainless steel or Nitinol tube and crimped to form a continuous shape.
- the commissural posts of the wireform are adjoined at their tips by a circular connecting ring, or halo, whose purpose is to minimize inward deflection of the post(s).
- the leaflet assembly is constructed solely of stabilized tissue or other suitable material without a separate wire support structure.
- the leaflet assembly in this embodiment is also disposed within the lumen of the stent and is attached to the stent to provide a sealed joint between the leaflet assembly and the inner wall of the stent.
- any structure made from stabilized tissue and/or wire(s) related to supporting the leaflets within the stent constitute a leaflet assembly.
- stabilized tissue or suitable material may also optionally be used as a liner for the inner wall of the stent and is considered part of the leaflet assembly.
- Liner tissue or biocompatible material may be processed to have the same or different mechanical qualities, e.g. thickness, durability, etc. from the leaflet tissue.
- the prosthetic heart valve is, in one embodiment, apically delivered through the apex of the left ventricle of the heart using a catheter system.
- the catheter system accesses the heart and pericardial space by intercostal delivery.
- the catheter system delivers the prosthetic heart valve using either an antegrade or retrograde delivery approach using a flexible catheter system, and without requiring the rigid tube system commonly used.
- the catheter system accesses the heart via a trans-septal approach.
- the stent body extends into the ventricle about to the edge of the open mitral valve leaflets (approximately 25% of the distance between the annulus and the ventricular apex).
- the open native leaflets lay against the outside stent wall and parallel to the long axis of the stent (i.e. the stent holds the native mitral valve open).
- the diameter should approximately match the diameter of the mitral annulus.
- the valve may be positioned to sit in the mitral annulus at a slight angle directed away from the aortic valve such that it is not obstructing flow through the aortic valve.
- the outflow portion (bottom) of the stent should not be too close to the lateral wall of the ventricle or papillary muscle as this position may interfere with flow through the prosthesis.
- the position of the tricuspid valve may be very similar to that of the mitral valve.
- the prosthetic valve is sized and configured for use in areas other than the mitral annulus, including, without limitation, the tricuspid valve between the right atrium and right ventricle.
- Alternative embodiments may optionally include variations to the cuff structure to accommodate deployment to the pulmonary valve between the right ventricle and pulmonary artery , and the aortic valve between the left ventricle and the aorta.
- the prosthetic valve is optionally used as a venous backflow valve for the venous system, including without limitation the vena cava, femoral, subclavian, pulmonary, hepatic, renal and cardiac.
- the cuff feature is utilized to provide additional protection against leaking
- tethers attached to the prosthetic heart valve that extend to one or more tissue anchor locations within the heart.
- the tethers extend downward through the left ventricle, exiting the left ventricle at the apex of the heart to be fastened on the epicardial surface outside of the heart. Similar anchoring is contemplated herein as it regards the tricuspid, or other valve structure requiring a prosthetic.
- the tethers may optionally be attached to the cuff to provide additional control over position, adjustment, and compliance.
- one or more tethers are optionally attached to the cuff, in addition to, or optionally, in place of, the tethers attached to the stent.
- the operator is able to adjust or customize the tethers to the correct length for a particular patient's anatomy.
- the tethers also allow the operator to tighten the cuff onto the tissue around the valvular annulus by pulling the tethers, which creates a leak-free seal.
- the tethers are optionally anchored to other tissue locations depending on the particular application of the prosthetic heart valve.
- a mitral valve, or the tricuspid valve there are optionally one or more tethers anchored to one or both papillary muscles, septum, and/or ventricular wall.
- the tethers in conjunction with the cuff, provide for a compliant valve which has heretofore not been available.
- the tethers are made from surgical-grade materials such as biocompatible polymer suture material. Examples of such material include 2-0 exPFTE (polytetrafluoroethylene) or 2-0 polypropylene.
- the tethers are inelastic. It is also contemplated that one or more of the tethers may optionally be elastic to provide an even further degree of compliance of the valve during the cardiac cycle.
- the tethers may be fastened by a suitable mechanism such as tying off to a pledget or similar adjustable button-type anchoring device to inhibit retraction of the tether back into the ventricle. It is also contemplated that the tethers might be bioresorbable/bioabsorbable and thereby provide temporary fixation until other types of fixation take hold such a biological fibrous adhesion between the tissues and prosthesis and/or radial compression from a reduction in the degree of heart chamber dilation.
- the prosthetic heart valve may optionally be deployed with a combination of installation tethers and permanent tethers, attached to either the stent or cuff, or both, the installation tethers being removed after the valve is successfully deployed. It is also contemplated that combinations of inelastic and elastic tethers may optionally be used for deployment and to provide structural and positional compliance of the valve during the cardiac cycle.
- a circular, semi-circular, or multi-part pledget is employed.
- the pledget may be constructed from a semi-rigid material such as PFTE felt.
- the felt Prior to puncturing of the apex by the delivery system, the felt is firmly attached to the heart such that the apex is centrally located.
- the delivery system is introduced through the central area, or orifice as it may be, of the pledget. Positioned and attached in this manner, the pledget acts to control any potential tearing at the apex.
- the valve can be seated within the valvular annulus through the use of tines or barbs. These may be used in conjunction with, or in place of one or more tethers.
- the tines or barbs are located to provide attachment to adjacent tissue.
- the tines are optionally circumferentially located around the bend/transition area between the stent and the cuff. Such tines are forced into the annular tissue by mechanical means such as using a balloon catheter.
- the tines may optionally be semi-circular hooks that upon expansion of the stent body, pierce, rotate into, and hold annular tissue securely.
- tissue and biocompatible material may be used to cover the cuff, to form the valve leaflets, to form a wireless leaflet assembly, and/or to line both the inner and/or outer lateral walls of the stent.
- the leaflet component may be constructed solely from stabilized tissue, without using wire, to create a leaflet assembly and valve leaflets.
- the tissue-only leaflet component may be attached to the stent with or without the use of the wire form. In a preferred embodiment, there can be anywhere from 1, 2, 3 or 4 leaflets, or valve cusps.
- tissue may be used to cover the inside of the stent body, the outside of the stent body, and the top and/or bottom side of the cuff wire form, or any combination thereof
- the tissue used herein is optionally a biological tissue and may be a chemically stabilized valve of an animal, such as a pig.
- the biological tissue is used to make leaflets that are sewn or attached to a metal frame. This tissue is chemically stabilized pericardial tissue of an animal, such as a cow (bovine pericardium) or sheep (ovine pericardium) or pig (porcine pericardium) or horse (equine pericardium).
- the tissue is bovine pericardial tissue.
- suitable tissue include that used in the products Duraguard®, Peri-Guard®, and Vascu-Guard®, all products currently used in surgical procedures, and which are marketed as being harvested generally from cattle less than 30 months old.
- Other patents and publications disclose the surgical use of harvested, biocompatible animal thin tissues suitable herein as biocompatible “jackets” or sleeves for implantable stents, including for example, U.S. Pat. No. 5,554,185 to Block, U.S. Pat. No. 7,108,717 to Design & Performance-Cyprus Limited disclosing a covered stent assembly, U.S. Pat. No. 6,440,164 to Scimed Life Systems, Inc. disclosing a bioprosthetic valve for implantation, and U.S. Pat. No. 5,336,616 to LifeCell Corporation discloses acellular collagen-based tissue matrix for transplantation.
- valve leaflets may optionally be made from a synthetic material such a polyurethane or polytetrafluoroethylene.
- synthetic polymer materials such expanded polytetrafluoroethylene or polyester may optionally be used.
- suitable materials may optionally include thermoplastic polycarbonate urethane, polyether urethane, segmented polyether urethane, silicone polyether urethane, silicone-polycarbonate urethane, and ultra-high molecular weight polyethylene.
- Additional biocompatible polymers may optionally include polyolefins, elastomers, polyethylene-glycols, polyethersulphones , polysulphones, polyvinylpyrrolidones, polyvinylchlorides, other fluoropolymers, silicone polyesters, siloxane polymers and/or oligomers, and/or polylactones, and block co-polymers using the same.
- valve leaflets may optionally have a surface that has been treated with (or reacted with) an anti-coagulant, such as, without limitation, immobilized heparin.
- an anti-coagulant such as, without limitation, immobilized heparin.
- valve leaflets may optionally be made from pericardial tissue or small intestine submucosal tissue.
- ultra-thin vapor-cross linked stabilized bioprosthetic or implant tissue material is contemplated.
- Tissue having a 0.003′ (0.0762 mm) to about 0.010′′ (0.254 mm) may be made using a process comprising the steps of: (a) vapor cross-linking a pre-digested compressed tissue specimen by exposing the tissue specimen to a vapor of a cross-linking agent selected from the group consisting of aldehydes, epoxides, isocyanates, carbodiimides, isothiocyanates, glycidalethers, and acyl azides; and (b) chemically cross-linking the vapor-cross-linked tissue specimen by exposing the vapor-crosslinked tissue specimen to an aqueous crosslinking bath for a predetermined time, such crosslinking bath containing a liquid phase of a crosslinking agent selected from the group consisting of aldehydes, epoxides, isocyanates, carbodi
- tissue may be porcine, ovine, equine or bovine in origin and preferably the initial material is taken from a bovine animal 30 days old or less, although tissue from older animals is contemplated as within the scope of the invention.
- the tissue specimen is subjected to chemical dehydration/compression and mechanical compression before cross-linking
- Pre-digestion is provided by digesting a harvested, cleaned pericardial tissue in a solution containing a surfactant, such as 1% sodium laurel sulfate.
- the chemical dehydration/compression step comprises subjecting the tissue specimen to hyperosmotic salt solution.
- the mechanical compression may be performed by subjecting the tissue specimen to a roller apparatus capable of compressing the tissue specimen to a thickness ranging from about 0.003′ (0.0762 mm) to about 0.010′′ (0.254 mm).
- the animal collagen tissue specimen is then chemically cross-linked first by exposing the tissue to formaldehyde vapor for approximately 10 minutes, and second by immersing the tissue in a glutaraldehyde solution for two consecutive sessions of approximately 24 hours each.
- a retrieval system for quickly removing the prosthetic valve during an aborted surgical deployment using minimally invasive cardiac catheter techniques.
- the tethers would be captured by a catheter having a snare attachment. Once the tethers were captured, an intra-ventricular funnel attachment would guide the prosthetic valve into a collapsed, compressed conformation by pulling on the tethers, thus pulling the compressed prosthetic valve into the removal catheter for subsequent extraction.
- FIG. 1 shows one embodiment of a prosthetic heart valve 110 according to the present invention, comprising tubular stent 112 having tether attachment structures 114 at one end and tubular stent 112 is attached to cuff 116 at the other end.
- Leaflet assembly 118 (not shown) is disposed within stent 112 and supports leaflets 120 (also not shown).
- Cuff 116 has independent articulating loops of wire 122 and covering 124 .
- tubular stent 112 may be an expandable laser cut stent or an expandable braided stent.
- Tubular stent 112 may be constructed of Martensitic or super elastic metal alloys.
- Tubular stent 112 may be compressed along its longitudinal axis and will fit into a catheter-based stent delivery system. When the tubular stent 112 is delivered to the location where it is to be installed, it is expelled from the catheter by an obturator and deposited at the site where it is to be deployed.
- Tubular stent 112 includes a plurality of tether attachments 114 upon which a tether (not shown) may be connected.
- FIG. 1 shows an embodiment having three tether attachments which are integrated into the distal portion of the stent 112 .
- Leaflet assembly 118 is a separate but integrated structure that is disposed within the stent 112 .
- Leaflet assembly 118 functions to provide the structure upon which the valve leaflets or cusps 120 are located.
- Leaflet assembly 118 may be made entirely of stabilized tissue or it may be a combination wire and tissue structure. Where leaflet assembly 118 is composed entirely of tissue, it is contemplated that the leaflet assembly, leaflet support structure, and leaflets or cusps 120 are made from tissue. It is contemplated as within the scope of the invention that different qualities of stabilized tissue, i.e. thin or thick, structurally rigid or flexible as it may be, may be used for the different components of the cuff covering 124 , the stent covering, the leaflet assembly 118 and the leaflets 120 . Where leaflet assembly 118 is composed of wire and tissue, it contemplated that assembly or support(s), or both, may be made from wire, and the cusps 120 would necessarily be made from tissue.
- Prosthetic heart valve 110 also includes cuff 116 .
- FIG. 1 shows cuff 116 formed from a cuff wire form 122 that is covered by, in one embodiment, stabilized tissue 124 .
- the cuff wire form is an extension of the stent itself, where the stent has been heated and manipulated upon a form to create the extended spindles of the flat, collar plate of the cuff.
- the cuff wire form 122 is made separate from the stent 112 and attached as a flat collar plate constructed to include an inner rim 130 and an outer rim 132 , with independent loops of wire 122 that create lobes or segments extending axially around the circumference of the inner rim, the joint 130 where the cuff 116 meets the tubular stent 112 .
- FIG. 2 an exploded component view is provided that shows cuff covering 124 in FIG. 2A .
- the wire cuff loops, or spindles, 122 is illustrated along with stent body 112 and tether attachments 114 .
- the combination of the stabilized tissue of the cuff covering 124 and wire cuff spindles, make up a cuff structure and provide a semi-rigid form that assists in the sealing of the cuff against the atrial trabeculations and tissue within and adjacent to the mitral annulus.
- the spindles are formed by heating a Nitinol (TM) stent on a mold to create the proper extension and angle necessary to establish the cuff or collar portion.
- TM Nitinol
- the cuff wire form 122 may be manufactured as a unitary laser-cut stent-cuff construction.
- the cuff wire form and the stent are laser cut within the same overall manufacturing process.
- the cuff wire form is made separate from the stent and attached as a flat collar plate, the cuff wire form and stent may be manufactured/laser cut separately and attached using laser weld or other similar technique to create a non-fatiguing elastic stent-cuff joint capable of maintaining elastic compliance while it is deployed.
- the rim may consist of an artificial transition point between the stent and the cuff where the stent has been heated to change the shape and angle of the topmost portion of the stent or the valve has been laser cut to create it's overall wire form, or the rim may consist of a constructed transition point such as a laser welded joint for attaching two component parts.
- the loops 122 provide the cuff 116 the ability to travel or flex up and down, along the longitudinal axis; longitudinal defined by the lengthwise axis of the stent.
- this flexibility or compliance provides the prosthetic heart valve, specifically the cuff, upon being deployed within a patient's heart, the ability to conform to the anatomical shape of the left atrium, maintain the conforming shape during the cardiac cycle, and provide a tight seal against the atrial tissue adjacent the mitral valve aperture. This feature reduces or removes the guesswork that often accompanies the pre-surgical sizing of a mitral valve. By providing a better fit, this necessarily prevents blood from leaking around the implanted prosthetic heart valve.
- the cuff tissue 126 is thin, durable, and may be attached to the top, bottom, or both sides of the cuff 116 .
- FIG. 2C is a stent liner 128 made from tissue and that may optionally function to support the leaflets of the valve.
- This liner is contemplated as being made of tissue or biocompatible material as disclosed herein.
- the stent may also optionally have a inner stent liner and/or an outer (surface) stent liner.
- FIG. 2D is a perspective view of one embodiment of a two-piece structure made of leaflets 120 .
- the leaflet structure is illustrated in a prosthetic heart valve having a mitral valve shape, a “saddle shape” that constitutes a hyperbolic paraboloid to afford one specific form of structural integrity.
- FIG. 3A the cuff covering 124 is shown in FIG. 3A .
- the stent body 112 and cuff spindles 122 are shown in FIG. 3B .
- FIG. 3C shows a stent liner 128 made from tissue and that may optionally function to support the leaflets of the valve.
- FIG. 3D is a perspective view of one embodiment of a two-piece structure made of leaflets 120 , and illustrated in a prosthetic heart valve having a mitral valve shape, a “saddle shape”.
- FIG. 3E shows the use of a structural wire support 126 for the leaflets 120 .
- This leaflet structural wire support also provides spring-like tension to assist in the proper orientation of the leaflets once the prosthetic heart valve is expanded from a compressed stored shape to its final functional shape.
- FIG. 3E shows the three junctions 146 (commissural tips) and the three arched wires 148 (of this embodiment) of the leaflet structural wire support 126 .
- Leaflet wire form is preferably constructed as a single wire that is molded, twisted, and/or manipulated into the final shape.
- the leaflet wire form is series of wires that have been attached, e.g. laser welded.
- the junctions 146 move independently of the stent.
- junction end of the leaflet assembly may not be attached to the stent, but only the upper portion. Having unattached junctions with the ability to flex inward and, more importantly, expand outward, gives the leaflet wire form the structural ability to collapse when compressed and expand when deployed. The ability to compress and expand independently of one another, relieves mechanical stresses on the tissue.
- FIG. 4 shows inner rim 130 and outer rim 132 of cuff 116 .
- Spindles 122 are shown between the outer rim 128 and the inner rim 130 .
- Valve leaflets 120 are shown within the inner rim 130 .
- FIG. 5 shows a side view from slightly below the horizontal plane of one embodiment of a prosthetic valve according to the present invention to show the bottom surface of the cuff.
- FIG. 5 shows stent 112 having three tether attachment structures 114 projecting from the distal end of stent 112 for attaching to tethers 138 .
- FIG. 5 shows an example of an embodiment wherein the cuff 116 is formed from the stent 112 by heating and shaping.
- FIG. 6 shows an example of an embodiment wherein the cuff 116 and stent 112 are formed from two joined pieces.
- FIG. 6 also shows that tethers 138 are not attached to the leaflet assembly or leaflet wire form 148 and 146 (shown for illustration purposes but would not be visible through tissue or synthetic material, e.g. liner), but rather the tethers 138 are contemplated as attaching to the stent 112 , to the base of the cuff 116 , to an upper portion of the cuff 116 , or a combination of the above.
- FIG. 7 shows an example of where the cuff spindles may vary in design size and shape.
- FIG. 7 shows a completely expanded prosthetic valve 110 fully expelled from the flexible delivery catheter, including cuff wire form 122 , cuff tissue covering 124 , tethers 138 , tubular stent 112 , tether attachment 114 , and tethers 138 .
- FIG. 7 illustrates where every other spindle is longer that the adjacent showing an alternating pattern.
- FIG. 7 also shows that tethers 138 are not attached in this embodiment to the leaflet assembly or leaflet wire form 148 and 146 (shown for illustration purposes but would not be visible through tissue or synthetic material, e.g. liner)
- FIG. 8 shows another variation of one preferred embodiment of the present invention where the spindles do not alternate, but rather two spindles on either side create an elongated cuff for a prosthetic valve where this provides an advantage.
- FIG. 9 shows a top view of a three-leaflet structure 156 as though from inside the left atrium looking down toward the left ventricle, and shows the completely expanded prosthetic heart valve 110 seated and adjusted to form a tight seal within the mitral annulus.
- FIG. 9 also shows valve leaflets 120 , cuff 116 , and independent loops of wire 122 .
- FIG. 10 there is provided an illustration of how the cuff and stent body may be formed in such a manner to create various positions, e.g. angles, for the cuff.
- the angular relationship between the cuff 116 and the stent 112 function to seal the prosthetic heart valve against the mitral valve aperture and prevent leaking
- the angle of the cuff may also include a more acute inverted-funnel shaped angle. Although not limiting, in one example, the angle is 60 degrees.
- FIG. 10B illustrates the angle of an approximately perpendicular angle.
- FIG. 10C illustrates a more obtuse funnel-shaped angle, e.g. 150 degrees, in relation to the longitudinal axis of the stent.
- FIG. 11 shows how tines or barbs can facilitate the attachment to the tissue, such as the mitral annulus or the tricuspid, annulus.
- FIG. 11 shows cuff 116 attached to stent body 112 where barbs 158 have been attached at the neck of the prosthetic valve where the cuff meets or transitions to the stent body.
- FIG. 12 A-B illustrates a specific form of hooked barb 158 where the hooked barb is adjusted to provide an opening between the barb and the stent body where an operator would direct the annular tissue to assist with seating the valve.
- a balloon catheter or other expansion means is inserted into the stent 112 to expand the internal diameter, thus causing the hooked barbs 158 to rotate back inwards toward the stent 112 , thus capturing and locking the annular tissue to the stent body.
- FIG. 13 shows a prosthetic valve according to the present invention showing tethers 160 attached to the cuff portion 116 with optional cuff-tether attachments 162 in addition to attachment 114 of the tethers 138 on the stent body.
- FIG. 14 this is a drawing of one preferred embodiment of equipment as claimed herein that is used to compress the prosthetic valve and insert the prosthetic valve into the heart.
- FIG. 14 shows funnel compressor 142 , introducer 144 , snare 150 , flexible deployment catheter 134 , catheter insert 152 , and obturator 136 , the implementation of which is further described in FIG. 15 .
- FIGS. 15A-F is a series of drawings of one embodiment of the assembly of a delivery system for a prosthetic valve according to the present invention.
- FIGS. 15A-F show the preparation of the prosthetic valve for implantation into the heart by showing how the prosthetic valve is loaded into the flexible delivery catheter.
- FIG. 15A shows the initial step of attaching the introducer 144 to the compression funnel 142 .
- FIG. 15B shows the snare 150 pulling tethers 138 into compression funnel 142 and threading through introducer 144 .
- FIG. 15C shows the prosthetic valve 110 just prior to being drawn into the compression funnel 142 as it is pulled rear-ward using tethers 138 into the introducer 144 .
- FIG. 15D shows the prosthetic valve 110 (not shown) inserted into the introducer 144 with the anchoring tethers 138 extending from the rear of the introducer 144 .
- FIGS. 15E and 15F show the flexible delivery catheter 132 being attached to the introducer 144 to introduce, or insert, the compressed prosthetic valve 110 (not shown) into the flexible delivery catheter 132 .
- FIG. 15 shows prosthetic valve 110 with tethers 138 that have been threaded, using a snare 150 , through the funnel compressor 142 which is attached to introducer 144 . Upon pulling the tethers 138 , the prosthetic valve 110 is mechanically compressed by the funnel 142 and inserted into the introducer 144 .
- the introducer 144 is then inserted into the delivery catheter 132 in preparation for loading the delivery catheter.
- the obturator 136 having diameter slightly less than the introducer and the delivery catheter, is then inserted into the rear portion of the introducer and to pushes the compressed and tethered prosthetic valve into the delivery catheter. It is contemplated that this process will be performed in the operating room just prior to installing the valve in the patient.
- a ready-made pre-filled catheter/valve delivery system is provided.
- FIG. 16 is a detailed sectional view of the catheter delivery system 132 , which includes the compressed prosthetic valve 110 according to the present invention disposed within the delivery catheter 134 .
- FIG. 16 shows prosthetic valve 110 having cuff 116 attached to stent 112 , which further has tethers 138 leading away from the compressed valve 110 .
- FIG. 17 is a cut-away view of a heart with a delivery catheter containing a prosthetic heart valve according to the present invention and accessing the heart using an apical approach. It is contemplated that other surgical approaches to the heart, and valves in addition to the mitral valve, are within the scope of the inventive subject matter claimed herein.
- FIG. 17 shows the delivery catheter 134 advanced to through the mitral valve and into the left atrium for deployment of the prosthetic valve 110 .
- FIG. 18 A-D is a series of drawings of the deployment of one embodiment of a prosthetic valve according to the present invention.
- FIG. 18 A-D is a series of views of the tip of one embodiment of a delivery catheter according to the present invention containing a pre-loaded prosthetic valve which is being pushed out of the delivery catheter, i.e. by an obturator, starting with (A) the valve completely within the catheter, (B) the cuff portion being in view, (C) the stent body following, and (D) the prosthetic valve with attached tethers for positioning and/or adjustment and/or securing the valve to tissue.
- FIGS. 18A-D shows how the prosthetic valve 110 is deployed from flexible deployment catheter 134 .
- FIG. 18B shows the cuff 116 emerging from the catheter 134 .
- FIG. 18C shows the cuff 116 and stent 112 partially expelled from the delivery catheter 134 .
- FIG. 18D shows the prosthetic valve completely expelled from the delivery catheter 134 with tethers 138 attached to the stent body and trailing behind into the catheter.
- FIG. 18D further shows tethers 138 attached to the stent 112 , with prosthetic valve 110 now expanded and delivered (but not positioned or adjusted), as the delivery catheter 134 is withdrawn away from the target location, e.g. atrium.
- FIG. 19 shows a depiction of a fully deployed prosthetic heart valve 110 installed in the left mitral valve of the heart having the tethers 138 attached to the left ventricle apex of the heart.
- Tethers 138 in this embodiment extend through the heart muscle and are attached to securing device 140 , here shown as a pledget placed on the epicardial surface and having tethers fastened thereto.
- the pledget 140 performs the function of an anchor to which the tethers 138 are attached. Tethers 138 are strung through the left ventricle apex and pulled downward to seat prosthetic valve 110 in the atrial valve area. The completely installed prosthetic valve is held in the left atrium by the cuff 116 and secured to the apex of the heart by tethers 138 .
- the tethers may be held in place by a securing device which in this aspect of the invention is a pledget 140 that the tethers are threaded through and secured against, i.e. by tying a knot or using a cinching feature.
- FIG. 20 is a detailed cross-sectional view (of the heart) of one embodiment of a prosthetic heart valve according to the present invention deployed within the mitral valve aperture of the heart and anchored, in an alternative embodiment, between (A) where it is seated or lodged by the atrial cuff and (B) the ventricular tethers connected to papillary muscles 166 and/or ventricular wall and/or tether(s) attached to septum 164 , which are each secured by one or more securing tissue anchors, anchoring devices, or anchoring methods.
- FIG. 21A-B shows how the tethers 138 are tied off at the apex of the heart after deployment of the prosthetic valve 110 .
- FIG. 21A shows the flexible delivery catheter 134 inserted into the left ventricular apex along with a suture 156 having partially installed apical-closure/tissue-buttressing material 158 .
- FIG. 21B shows the anchoring system of the prosthetic valve in which the ventricular tethers 138 are shown treaded through the left ventricle apex and through a partially installed pledget 140 ; also shown are fully installed apical suture-closure material 156 / 158 .
- Tissue buttressing material may optionally be in one embodiment a pledget felt.
- FIGS. 22 A-B is a pair of drawings of the lateral deployment of one embodiment of a prosthetic valve according to the present invention and shows a prosthetic valve delivery catheter that has accessed the left atrium via the left ventricle by way of a lateral trans-ventricular wall approach through the lateral wall of the left ventricle of the heart.
- FIGS. 22 A-B is a pair of drawings of the lateral deployment of one embodiment of a prosthetic valve according to the present invention and shows a prosthetic valve delivery catheter that has accessed the left atrium via the left ventricle by way of a lateral trans-ventricular wall approach through the lateral wall of the left ventricle of the heart.
- FIGS. 22 A-B is a pair of drawings of the lateral deployment of one embodiment of a prosthetic valve according to the present invention and shows a prosthetic valve delivery catheter that has accessed the left atrium via the left ventricle by way of a lateral trans-ventricular wall approach through the lateral wall of the left ventricle of the heart.
- FIG. 22 A-B show a prosthetic valve delivery catheter that (A) has accessed the left atrium via the left ventricle by way of a lateral trans-ventricular wall approach through the lateral wall of the left ventricle of the heart, to bedeposited the prosthetic valve into the left atrium, twhich will be withdrawn the delivery catheter for adjustment of the tethers, and (B) that has the valve adjusted and deployed within the mitral annulus.
- FIG. 22B is an illustration of the prosthetic heart valve 110 seated within the mitral annulus and, in this embodiment, having papillary muscle tethers 166 within the left ventricle.
- FIG. 22B also shows annulus barbs 158 , here shown optionally at both the transition point from the stent to the cuff 158 and elsewhere on the cuff itself 168 .
- FIG. 23 is a cut-away view of a heart with a delivery catheter containing a prosthetic heart valve according to the present invention and accessing the right ventricle of the heart using an apical approach.
- FIG. 23 shows the delivery catheter advanced through to the tricuspid valve and into the right atrium for deployment of the prosthetic heart valve.
- FIGS. 24 A-B show an embodiment of a prosthetic valve 110 having a ring or halo feature 154 .
- FIG. 24A is a bottom view from slightly above the horizontal plane of one embodiment of a prosthetic valve according to the present invention to show the bottom surface of the cuff 116 and the halo feature 154 .
- FIG. 24B is a top view from slightly above the horizontal plane of one embodiment of a prosthetic valve according to the present invention to show the top surface of the cuff 116 .
- FIGS. 24 A-B show an embodiment of a prosthetic valve having a ring or halo feature 154 attached to the junctions 146 of the arched wires 148 of leaflet assembly 118 .
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- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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US12/963,596 US20110319988A1 (en) | 2009-12-08 | 2010-12-08 | Device and System for Transcatheter Mitral Valve Replacement |
US13/425,712 US20120179244A1 (en) | 2009-12-08 | 2012-03-21 | Device and System for Transcatheter Mitral Valve Replacement |
US15/163,228 US11179236B2 (en) | 2009-12-08 | 2016-05-24 | Device and system for transcatheter mitral valve replacement |
US17/458,745 US20210386542A1 (en) | 2009-12-08 | 2021-08-27 | Device And System For Transcatheter Mitral Valve Replacement |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US26773909P | 2009-12-08 | 2009-12-08 | |
US12/963,596 US20110319988A1 (en) | 2009-12-08 | 2010-12-08 | Device and System for Transcatheter Mitral Valve Replacement |
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US13/425,712 Continuation-In-Part US20120179244A1 (en) | 2009-12-08 | 2012-03-21 | Device and System for Transcatheter Mitral Valve Replacement |
US13/425,712 Continuation US20120179244A1 (en) | 2009-12-08 | 2012-03-21 | Device and System for Transcatheter Mitral Valve Replacement |
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US20110319988A1 true US20110319988A1 (en) | 2011-12-29 |
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Application Number | Title | Priority Date | Filing Date |
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US12/963,596 Abandoned US20110319988A1 (en) | 2009-12-08 | 2010-12-08 | Device and System for Transcatheter Mitral Valve Replacement |
US13/425,712 Abandoned US20120179244A1 (en) | 2009-12-08 | 2012-03-21 | Device and System for Transcatheter Mitral Valve Replacement |
US15/163,228 Active 2032-04-22 US11179236B2 (en) | 2009-12-08 | 2016-05-24 | Device and system for transcatheter mitral valve replacement |
US17/458,745 Pending US20210386542A1 (en) | 2009-12-08 | 2021-08-27 | Device And System For Transcatheter Mitral Valve Replacement |
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Application Number | Title | Priority Date | Filing Date |
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US13/425,712 Abandoned US20120179244A1 (en) | 2009-12-08 | 2012-03-21 | Device and System for Transcatheter Mitral Valve Replacement |
US15/163,228 Active 2032-04-22 US11179236B2 (en) | 2009-12-08 | 2016-05-24 | Device and system for transcatheter mitral valve replacement |
US17/458,745 Pending US20210386542A1 (en) | 2009-12-08 | 2021-08-27 | Device And System For Transcatheter Mitral Valve Replacement |
Country Status (7)
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US (4) | US20110319988A1 (fr) |
EP (4) | EP3838223A1 (fr) |
JP (2) | JP2013512765A (fr) |
AU (1) | AU2010328106A1 (fr) |
CA (1) | CA2783282C (fr) |
ES (1) | ES2870080T3 (fr) |
WO (1) | WO2011072084A2 (fr) |
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Also Published As
Publication number | Publication date |
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WO2011072084A3 (fr) | 2011-10-20 |
EP3300695A1 (fr) | 2018-04-04 |
JP2013512765A (ja) | 2013-04-18 |
JP6157564B2 (ja) | 2017-07-05 |
ES2870080T3 (es) | 2021-10-26 |
EP3300695B1 (fr) | 2023-05-24 |
JP2016028762A (ja) | 2016-03-03 |
EP3838223A1 (fr) | 2021-06-23 |
EP3649985B8 (fr) | 2021-04-21 |
EP2509538A4 (fr) | 2015-01-21 |
CA2783282C (fr) | 2018-04-03 |
EP2509538B1 (fr) | 2017-09-20 |
WO2011072084A2 (fr) | 2011-06-16 |
US20120179244A1 (en) | 2012-07-12 |
US20210386542A1 (en) | 2021-12-16 |
US20160262881A1 (en) | 2016-09-15 |
EP3649985A1 (fr) | 2020-05-13 |
CA2783282A1 (fr) | 2011-06-16 |
US11179236B2 (en) | 2021-11-23 |
EP3649985B1 (fr) | 2021-03-17 |
AU2010328106A1 (en) | 2012-07-05 |
EP2509538A2 (fr) | 2012-10-17 |
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