US20050055094A1 - Semi-biological intervertebral disc replacement system - Google Patents

Semi-biological intervertebral disc replacement system Download PDF

Info

Publication number
US20050055094A1
US20050055094A1 US10/702,096 US70209603A US2005055094A1 US 20050055094 A1 US20050055094 A1 US 20050055094A1 US 70209603 A US70209603 A US 70209603A US 2005055094 A1 US2005055094 A1 US 2005055094A1
Authority
US
United States
Prior art keywords
promoting material
tissue
tissue promoting
cavity
nuclear replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/702,096
Other languages
English (en)
Inventor
Stephen Kuslich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spineology Inc
Original Assignee
Spineology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spineology Inc filed Critical Spineology Inc
Priority to US10/702,096 priority Critical patent/US20050055094A1/en
Assigned to SPINEOLOGY, INC. reassignment SPINEOLOGY, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KUSLICH, STEPHEN D.
Publication of US20050055094A1 publication Critical patent/US20050055094A1/en
Assigned to MUSCULOSKELETAL TRANSPLANT FOUNDATION, INC. reassignment MUSCULOSKELETAL TRANSPLANT FOUNDATION, INC. SECURITY AGREEMENT Assignors: SPINEOLOGY, INC.
Priority to US12/247,760 priority patent/US8012211B2/en
Priority to US13/226,026 priority patent/US20120116514A1/en
Assigned to SPINEOLOGY, INC. reassignment SPINEOLOGY, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: MUSCULOSKELETAL TRANSPLANT FOUNDATION, INC.
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2/4611—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of spinal prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30075—Properties of materials and coating materials swellable, e.g. when wetted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2002/4625—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
    • A61F2002/4627—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable

Definitions

  • the present invention relates generally to the field of systems adapted to replacing or assisting bone of a natural vertebral column of a living body. More specifically, the present invention relates to a system that surgeons can use to construct a semi-biological nuclear replacement that will replace the diseased nucleus and ultimately function in a manner similar to a natural disc nucleus.
  • the spinal motion segment consists of a unit of spinal anatomy bounded by two vertebral bodies that includes the two vertebral bodies and the interposed intervertebral disc, as well as the attached ligaments, muscles and the facet joints.
  • Degenerative pathology in the spinal motion segment is primarily related to intervertebral disc degeneration.
  • the nucleus (the central cushion of the disc) loses nutritional support, dehydrates, and fragments.
  • the loss in nutritional support causes nuclear tissue necrosis, the cells die.
  • the pH in the nuclear region decreases and highly irritative chemicals form in the disc. Consequently, as the nucleus can no longer support compression loads, the annulus (the fibrous rim of the disc, surrounding the nucleus) is subjected to loading forces, in the form of compression and shear, that the annulus is poorly designed to handle.
  • Nociceptive nerve elements i.e., pain generating, nerve ending afferents in the outer annulus, are stimulated by a combination of chemical and mechanical forces (leakage of irritative chemicals and compression and shear force on the annulus and spinal motion segment).
  • These pain-detecting nerve elements propagate signals in the central and autonomic nervous system pathways, leading to the activation of central pain-modulating and pain-appreciating centers in the spinal cord and brain.
  • the conscious portions of the brain interpret the resultant excitement of certain nerve centers in the spinal cord and brain as somatic and visceral pain.
  • the inventor and his team performed experimental studies directed to the tissue origin of spinal pain.
  • DDD Degenerative Disc Disease
  • the DDD tissue consists of the dead and/or dying fibrocartilogenous remains of the disc nucleus and inner portions of the annulus.
  • Other investigators have described low pH (acidity) of fluids in DDD tissue. These chemicals and fluids leak out through fissures and tears in the annulus and irritate and stimulate the nociceptive nerve endings causing back pain.
  • DDD DDD-related diseases
  • a number of medical and surgical strategies are known to ameliorate symptoms. These include: pain medications that block or modulate pain afferents, or suppress central pain-recognition centers, exercises that promote tissue nutrition, flexibility and muscle strength (exercises also stimulate the release of endorphin, an endogenous morphine-like chemical), braces that restrict motion and reduce forces on tender spinal tissues, anti-inflammatory oral and injectable medications, and surgical procedures designed to remove tissues pressing on nerves, stabilize spinal motion segments and/or replace pathological tissues.
  • Strategies for restabilization are many and include: heating the annular region in an effort to destroy nerve endings and “strengthen” or “heal” the annulus, “fusing” the motion segment by applying bone graft on the sides of the motion segment, or within the disc space, applying rigid or semi-rigid support members on the sides of the motion segment or within the disc space, removing and replacing the entire disc with a non-flexible, articulating artificial device and removing and replacing the nucleus.
  • the currently available devices fall into two general categories: total disc replacements and nuclear replacements.
  • the first category consists of total disc replacements that are made of rigid, inert substances such as metal and plastic. Examples of such devices are the Fernstrom “ball-bearing” and the LINK® and PRODISC® devices.
  • a second class of disc replacement is the nuclear replacement, a form of partial disc replacement.
  • Examples include: the Ray implant (U.S. Pat. No. 4,772,287), the Bao implant (U.S. Pat. No. 5,192,326), and the Sulzer spiral implant (U.S. Pat. No. 5,919,235).
  • These devices are also inert, somewhat flexible, non-biological disc replacements. They involve removal of the nucleus and replacement of the nucleus with a non-biological plastic material that may be flexible and malleable. When these devices are placed in the excavated DDD cavity, they rub against living end-plate cartilage and bone. This rubbing may cause healthy living tissue to erode. This erosion may weaken the living cartilage and bone, resulting in subsidence of the device, fragmentation of the device and perhaps, further vertebral instability. Complete displacement and dislocation of the Ray implant has been reported.
  • This second category of disc replacements is intended to more closely mimic natural disc mechanics.
  • some nuclear replacements utilize the water-containing properties of hydrogel.
  • One embodiment of the Ray implant as described in U.S. Pat. Nos. 4,772,287 and 4,904,260 consists of a block of hydrogel in combination with inert jacket such as a plastic fabric casing.
  • the Bao implant as described in U.S. Pat. No. 5,192,326 consists of hydrogel beads enclosed by a fabric shell.
  • Devices attempting to mimic the mechanics of a natural disc also include such devices as taught in U.S. Pat. No. 6,240,926 to Chin Gan et al.
  • This patent uses a hybrid of cultured intervertebral disc cells and a biodegradable substrate as a nuclear replacement.
  • the device attempts to induce intervertebral disc reformation by regenerating natural disc tissue via the introduction of cultured intervertebral disc cells.
  • Technology such as this is in an early stage of development. Compared to the wide experience with biocompatible materials such as plastics and metals, purely biological replacements may or may not prove to be practical.
  • the present invention is a system for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement.
  • Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth.
  • the fibro-cartilaginous tissue promoting material may be combined with hydrogel or other suitable water-imbibing material.
  • the present invention improves upon current techniques by creating a biological disc replacement that induces living, natural fibrous tissue growth into the DDD cavity. It is believed that living, natural fibrous tissue is preferable to dead and/or dying DDD tissue. First, living natural fibrous tissue does not exhibit acidic properties nor leak chemicals that may cause nerve inflammation and back pain. Second, living natural fibrous tissue offers more support and stability than decaying tissue.
  • Living natural fibrous tissue is also preferable to inert disc replacements. Living natural fibrous tissue will not erode adjacent cartilage or bone. Furthermore, there is less danger to surrounding tissues or nerves should the replaced material extrude from its intended position. Finally, living natural fibrous or fibro-cartilaginous tissue is more likely to mimic the biomechanical and morphologic characteristics of a natural disc.
  • the present invention replaces the dead and/or dying fibro-cartilage of a DDD disc by stimulating living natural fibrous tissue growth with a multiplicity of fibronous pieces, this living natural fibrous tissue fuses with the living tissue of the DDD cavity, forming a partial biological disc replacing the removed DDD tissue.
  • FIG. 1 is a perspective view of bands of fibro-cartilaginous tissue promoting material placed in a disc cavity.
  • FIG. 2 is a perspective view of fibro-cartilaginous tissue promoting material placed in a disc cavity.
  • FIG. 3 is a perspective view of an OPTIMESHTM filled with fibro-cartilaginous tissue promoting material in a disc cavity.
  • FIG. 4 is a cross-sectional view of an OPTIMESHTM filled with fibro-cartilaginous tissue promoting material in a disc cavity.
  • FIG. 5 is a perspective view of a mixture of cotton and hydrogel fibers.
  • FIG. 6 is a cross-sectional depiction of the expansion of the hydrogel as the hydrogel absorbs fluid.
  • FIG. 7 is a perspective of the expansion of the mixture of fibro-cartilaginous tissue promoting material and hydrogel as the hydrogel absorbs fluid.
  • FIG. 8 depicts aliquots of the fibro-cartilaginous tissue promoting material and hydrogel being inserted by a piston through a small diameter tube into the disc cavity.
  • FIG. 9 is a cross-sectional view of the fibro-cartilaginous tissue promoting material and hydrogel being inserted by a piston through a small diameter tube into the disc cavity.
  • FIG. 10 is a cross-sectional view of the bundles of fibro-cartilaginous tissue promoting material and hydrogel expanding as the hydrogel absorbs water.
  • FIG. 1 depicts the device 10 of the present invention embodied in a preparation of multilayered bands of suitable fibrous tissue promoting material piled in a circular configuration 12 formed to fit securely in the DDD cavity 14 .
  • the suitable fibrous tissue promoting material may include, but is not limited to, autograft, allograft or xenograft of fascia lata and/or throraco-lumbar fascia; natural and/or manmade polymeric fiber; fibrous tissue inducers such as: talc, pharmaceuticals and/or minerals; fibrous tissue morphogenic protein produced by recombinant DNA technology and/or notochord cells from stem cell technology and/or any combination thereof.
  • FIG. 2 depicts another embodiment of the device 10 as a tangled knot of suitable fibrous tissue promoting fibers 16 .
  • the device is multiple fabric bands made of suitable fibrous tissue promoting material.
  • the device is any combination of fibers, string, multilayered bands and/or fabric bands made of suitable fibrous tissue promoting material.
  • FIGS. 4 and 5 another embodiment of the device is a preparation of suitable fibrous tissue promoting material in combination with hydrogel chunks and/or fibers 20 .
  • the hydrogel provides water-imbibing qualities similar to a natural disc. The hydrogel thus provides a source of hydration for the device. As the hydrogel absorbs water, the hydrogel and thus the device expands.
  • FIGS. 6 and 7 show the fluid expansion as arrows 22 a and 22 b .
  • the suitable fibrous tissue promoting material induces living, natural fibrous tissue growth.
  • the living, natural fibrous tissue gives stability and cushion to the DDD cavity.
  • the combination of stability, cushioning and hydration allows the device of the present invention to closely mimic the characteristics of a natural disc.
  • FIG. 8 depicts an important feature differentiating the present invention from all of its predecessors; the device is preferably constructed within the nuclear space 24 , in a piecemeal fashion, by pushing small aliquots 26 of the filaments that make up the ultimate device, through a small diameter hollow injection tube 28 .
  • This feature allows the nuclear replacement device 10 to be introduced through a very small portal, with very little damage or removal of the stabilizing annulus.
  • FIG. 9 depicts an embodiment of the invention where the tissue promoting material 32 is at least one strand with a cross-sectional diameter smaller than the diameter of the injection tube 28 .
  • the invention is really a system, therefore, that allows the surgeon to construct a nuclear replacement using minimally invasive techniques.
  • the system consists of a hollow injection tube 28 , a piston 30 , the filaments 26 (cotton or other fibrous tissue stimulating agents with or without hydrogel) and, in at least one embodiment, a fabric or other porous shell 18 that surrounds and contains the filamentous elements.
  • the method of the present invention involves boring a small entrance hole into the DDD cavity 14 .
  • This step can be accomplished using any of several approaches: posterior laminotomy, transforaminal, or any of the anterior or anterior-lateral approaches, including endoscopic approaches.
  • the surgeon then reams the cavity 14 to remove the DDD nucleus and perhaps some of the endplate cartilage and portions of the inner annulus.
  • the cavity 14 is thereby prepared for the optiplasty device insertion.
  • the cavity 14 may be prepared by coating its surface with talc, a pharmaceutical or other suitable fibrous tissue promoting material.
  • the multiplicity of fibronous pieces of fibro-cartilaginous tissue promoting material are then inserted using a piston 30 through a small diameter tube 28 and may or may not be secured within an OptimeshTM, of U.S. Pat. No. 5,571,189 to the applicant, or any other suitable porous bag.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
US10/702,096 2002-11-05 2003-11-05 Semi-biological intervertebral disc replacement system Abandoned US20050055094A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/702,096 US20050055094A1 (en) 2002-11-05 2003-11-05 Semi-biological intervertebral disc replacement system
US12/247,760 US8012211B2 (en) 2002-11-05 2008-10-08 Semi-biological intervertebral disc replacement system
US13/226,026 US20120116514A1 (en) 2002-11-05 2011-09-06 Semi-biological intervertebral disc replacement system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42390002P 2002-11-05 2002-11-05
US10/702,096 US20050055094A1 (en) 2002-11-05 2003-11-05 Semi-biological intervertebral disc replacement system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/247,760 Division US8012211B2 (en) 2002-11-05 2008-10-08 Semi-biological intervertebral disc replacement system

Publications (1)

Publication Number Publication Date
US20050055094A1 true US20050055094A1 (en) 2005-03-10

Family

ID=32312722

Family Applications (3)

Application Number Title Priority Date Filing Date
US10/702,096 Abandoned US20050055094A1 (en) 2002-11-05 2003-11-05 Semi-biological intervertebral disc replacement system
US12/247,760 Expired - Lifetime US8012211B2 (en) 2002-11-05 2008-10-08 Semi-biological intervertebral disc replacement system
US13/226,026 Abandoned US20120116514A1 (en) 2002-11-05 2011-09-06 Semi-biological intervertebral disc replacement system

Family Applications After (2)

Application Number Title Priority Date Filing Date
US12/247,760 Expired - Lifetime US8012211B2 (en) 2002-11-05 2008-10-08 Semi-biological intervertebral disc replacement system
US13/226,026 Abandoned US20120116514A1 (en) 2002-11-05 2011-09-06 Semi-biological intervertebral disc replacement system

Country Status (8)

Country Link
US (3) US20050055094A1 (de)
EP (1) EP1562524A4 (de)
JP (1) JP2006505331A (de)
KR (1) KR20050084658A (de)
AU (2) AU2003290627B2 (de)
CA (3) CA2504591C (de)
NZ (1) NZ539779A (de)
WO (1) WO2004041075A2 (de)

Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
US20050071003A1 (en) * 1999-03-17 2005-03-31 Ku David N. Poly(vinyl alcohol) hydrogel
US20050119754A1 (en) * 2002-09-18 2005-06-02 Trieu Hai H. Compositions and methods for treating intervertebral discs with collagen-based materials
US20050196452A1 (en) * 2004-02-06 2005-09-08 Boyan Barbara D. Surface directed cellular attachment
US20050273169A1 (en) * 2004-02-23 2005-12-08 Thomas Purcell Artificial intervertebral disc assembly
US20050278025A1 (en) * 2004-06-10 2005-12-15 Salumedica Llc Meniscus prosthesis
US20070001981A1 (en) * 2005-06-29 2007-01-04 Nec Electronics Corporation Driver unit including common level shifter circuit for display panel and nonvolatile memory
US20070213824A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070213718A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070213717A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Biological fusion in the vertebral column
US20070227547A1 (en) * 2006-02-14 2007-10-04 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070255406A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US20070255286A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for improved disc augmentation
US20070276496A1 (en) * 2006-05-23 2007-11-29 Sdgi Holdings, Inc. Surgical spacer with shape control
US20070299523A1 (en) * 2006-06-08 2007-12-27 Francis Pflum Sac for use in spinal surgery
US20080004214A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic, Inc Injectable collagen material
US20080004570A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic, Inc. Collagen delivery device
US20080027546A1 (en) * 2006-07-25 2008-01-31 Semler Eric J Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US20080228273A1 (en) * 2005-07-20 2008-09-18 Mcleod Alan Rory Mor Implants
US20080306595A1 (en) * 2004-03-26 2008-12-11 Pearsalls Limited Porous Implant For Spinal Disc Nucleus Replacement
US20080306593A1 (en) * 2004-03-26 2008-12-11 Mcleod Alan Rory Mor Prosthetic Spinal Disc
US20090048677A1 (en) * 2007-08-13 2009-02-19 Nuvasive, Inc. Bioresorbable Spinal Implant and Related Methods
US20090125110A1 (en) * 2002-11-05 2009-05-14 Kuslich Stephen D Semi-biological intervertebral disc replacement system
EP2063808A2 (de) * 2006-09-14 2009-06-03 Spineology, Inc. Saugfähiges faserimplantat
US20090222096A1 (en) * 2008-02-28 2009-09-03 Warsaw Orthopedic, Inc. Multi-compartment expandable devices and methods for intervertebral disc expansion and augmentation
US20090263446A1 (en) * 2004-02-06 2009-10-22 Georgia Tech Research Corporation Method of making load bearing hydrogel implants
US20100076503A1 (en) * 2007-02-07 2010-03-25 N.M.B. Medical Applications Ltd Bone implant
US7713303B2 (en) 2002-09-18 2010-05-11 Warsaw Orthopedic, Inc. Collagen-based materials and methods for augmenting intervertebral discs
US7731981B2 (en) 2002-11-15 2010-06-08 Warsaw Orthopedic, Inc. Collagen-based materials and methods for treating synovial joints
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
US20110054532A1 (en) * 2007-07-03 2011-03-03 Alexandre De Moura Interspinous mesh
US7909873B2 (en) 2006-12-15 2011-03-22 Soteira, Inc. Delivery apparatus and methods for vertebrostenting
US8133279B2 (en) 2006-04-27 2012-03-13 Warsaw Orthopedic, Inc. Methods for treating an annulus defect of an intervertebral disc
US8377135B1 (en) 2008-03-31 2013-02-19 Nuvasive, Inc. Textile-based surgical implant and related methods
US20130282121A1 (en) * 2012-03-22 2013-10-24 Ann Prewett Spinal facet augmentation implant and method
WO2014061005A2 (en) 2012-10-19 2014-04-24 Tsunami S.R.L. Vertebral fusion device and system
US9155543B2 (en) 2011-05-26 2015-10-13 Cartiva, Inc. Tapered joint implant and related tools
US9192397B2 (en) 2006-12-15 2015-11-24 Gmedelaware 2 Llc Devices and methods for fracture reduction
US9480485B2 (en) 2006-12-15 2016-11-01 Globus Medical, Inc. Devices and methods for vertebrostenting
US9668875B2 (en) 1999-03-07 2017-06-06 Nuvasive, Inc. Method and apparatus for computerized surgery
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
US10028776B2 (en) 2010-10-20 2018-07-24 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US10143560B2 (en) 2006-06-08 2018-12-04 Francis Pflum Sac for use in spinal surgery
US10350072B2 (en) 2012-05-24 2019-07-16 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525168B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10758374B2 (en) 2015-03-31 2020-09-01 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
US10857261B2 (en) 2010-10-20 2020-12-08 206 Ortho, Inc. Implantable polymer for bone and vascular lesions
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11351261B2 (en) 2010-10-20 2022-06-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004100841A1 (en) 1999-08-18 2004-11-25 Intrinsic Therapeutics, Inc. Devices and method for augmenting a vertebral disc nucleus
WO2009033100A1 (en) 2007-09-07 2009-03-12 Intrinsic Therapeutics, Inc. Bone anchoring systems
US8323341B2 (en) 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
JP4247519B2 (ja) * 1999-08-18 2009-04-02 イントリンジック セラピューティックス インコーポレイテッド 髄核オーグメンテーションおよび保定のための装置および方法
US7717961B2 (en) 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
EP1623727A1 (de) 2004-07-14 2006-02-08 Bruno Sidler Füllmittel und Zuführvorrichtung zum Ausbilden einer Stützstruktur in einem Knocheninnenraum
US20070042326A1 (en) * 2005-06-01 2007-02-22 Osseous Technologies Of America Collagen antral membrane expander
FR2929502B1 (fr) 2008-04-04 2011-04-08 Clariance Implant nucleique.
US8114156B2 (en) * 2008-05-30 2012-02-14 Edwin Burton Hatch Flexibly compliant ceramic prosthetic meniscus for the replacement of damaged cartilage in orthopedic surgical repair or reconstruction of hip, knee, ankle, shoulder, elbow, wrist and other anatomical joints
WO2010093950A1 (en) * 2009-02-12 2010-08-19 Osteotech, Inc. Delivery system cartridge
WO2010099463A2 (en) 2009-02-27 2010-09-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Joint bioscaffolds
JP2011078745A (ja) * 2009-09-09 2011-04-21 Kinki Univ 骨補填材
WO2013075091A1 (en) * 2011-11-17 2013-05-23 Allosource Multi-piece machine graft systems and methods
EP2877129B1 (de) 2012-07-25 2017-10-11 Spineology, Inc. Netzabstandshalterhybrid
US9433404B2 (en) 2012-10-31 2016-09-06 Suture Concepts Inc. Method and apparatus for closing fissures in the annulus fibrosus
US10786235B2 (en) 2012-10-31 2020-09-29 Anchor Innovation Medical, Inc. Method and apparatus for closing a fissure in the annulus of an intervertebral disc, and/or for effecting other anatomical repairs and/or fixations
US9907654B2 (en) * 2012-12-11 2018-03-06 Dr. H.C. Robert Mathys Stiftung Bone substitute and method for producing the same
US20140277467A1 (en) 2013-03-14 2014-09-18 Spinal Stabilization Technologies, Llc Prosthetic Spinal Disk Nucleus
WO2015024013A2 (en) 2013-08-16 2015-02-19 Suture Concepts Inc. Method and apparatus for closing a fissure in the annulus of an intervertebral disc, and/or for effecting other anatomical repairs and/or fixations
WO2016073587A1 (en) 2014-11-04 2016-05-12 Spinal Stabilization Technologies Llc Percutaneous implantable nuclear prosthesis
CN106999286B (zh) 2014-11-04 2019-08-16 脊柱稳定技术有限责任公司 可经皮植入的髓核假体
KR102607758B1 (ko) 2015-09-01 2023-11-29 스파이널 스태빌라이제이션 테크놀로지스, 엘엘씨 이식 가능한 핵 보철물
WO2018232100A1 (en) 2017-06-14 2018-12-20 Osteoagra Llc Stabilization of vertebral bodies with bone particle slurry
US10806828B2 (en) * 2017-11-15 2020-10-20 De Novo Orthopedics Inc. Methods for reattaching detached tissue to hard tissue using bioinductive patch
JP7457712B2 (ja) 2018-09-04 2024-03-28 スパイナル スタビライゼーション テクノロジーズ リミテッド ライアビリティ カンパニー 植込み可能な髄核補綴物、キット、および関連する方法

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772287A (en) * 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US5192326A (en) * 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5919235A (en) * 1995-11-08 1999-07-06 Sulzer Orthopaedie Ag Intervertebral prosthesis
US6183518B1 (en) * 1999-02-22 2001-02-06 Anthony C. Ross Method of replacing nucleus pulposus and repairing the intervertebral disk
US6240926B1 (en) * 1996-08-08 2001-06-05 The Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US20020026195A1 (en) * 2000-04-07 2002-02-28 Kyphon Inc. Insertion devices and method of use
US20020045942A1 (en) * 2000-10-16 2002-04-18 Ham Michael J. Procedure for repairing damaged discs
US6395034B1 (en) * 1999-11-24 2002-05-28 Loubert Suddaby Intervertebral disc prosthesis
US20020068974A1 (en) * 2000-07-21 2002-06-06 Kuslich Stephen D. Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone
US20020077701A1 (en) * 2000-12-15 2002-06-20 Kuslich Stephen D. Annulus-reinforcing band
US6437018B1 (en) * 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6443988B2 (en) * 1994-05-06 2002-09-03 Disc Dynamics, Inc. Mold apparatus and kit for in situ tissue repair
US20020147496A1 (en) * 2001-04-06 2002-10-10 Integrated Vascular Systems, Inc. Apparatus for treating spinal discs
US20040215343A1 (en) * 2000-02-28 2004-10-28 Stephen Hochschuler Method and apparatus for treating a vertebral body
US20050065609A1 (en) * 2001-11-19 2005-03-24 Douglas Wardlaw Intervertebral disc prosthesis

Family Cites Families (199)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030951A (en) * 1959-04-10 1962-04-24 Michael P Mandarino Methods and materials for orthopedic surgery
CA992255A (en) * 1971-01-25 1976-07-06 Cutter Laboratories Prosthesis for spinal repair
US3875595A (en) * 1974-04-15 1975-04-08 Edward C Froning Intervertebral disc prosthesis and instruments for locating same
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
US5030233A (en) 1984-10-17 1991-07-09 Paul Ducheyne Porous flexible metal fiber material for surgical implantation
US4743260A (en) * 1985-06-10 1988-05-10 Burton Charles V Method for a flexible stabilization system for a vertebral column
US4735625A (en) * 1985-09-11 1988-04-05 Richards Medical Company Bone cement reinforcement and method
US4755184A (en) 1986-01-09 1988-07-05 Mark Silverberg Bone augmentation implant
CH671691A5 (de) * 1987-01-08 1989-09-29 Sulzer Ag
US4863477A (en) 1987-05-12 1989-09-05 Monson Gary L Synthetic intervertebral disc prosthesis
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5108438A (en) * 1989-03-02 1992-04-28 Regen Corporation Prosthetic intervertebral disc
US5282856A (en) * 1987-12-22 1994-02-01 Ledergerber Walter J Implantable prosthetic device
US7534254B1 (en) 1988-06-13 2009-05-19 Warsaw Orthopedic, Inc. Threaded frusto-conical interbody spinal fusion implants
US5609635A (en) * 1988-06-28 1997-03-11 Michelson; Gary K. Lordotic interbody spinal fusion implants
AU624627B2 (en) 1988-08-18 1992-06-18 Johnson & Johnson Orthopaedics, Inc. Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness
GB2254394B (en) 1988-12-21 1993-03-17 Bristol Myers Squibb Co Coupler assembly
US5147359A (en) 1988-12-21 1992-09-15 Zimmer, Inc. Spinal hook body
US4969888A (en) * 1989-02-09 1990-11-13 Arie Scholten Surgical protocol for fixation of osteoporotic bone using inflatable device
US5015255A (en) * 1989-05-10 1991-05-14 Spine-Tech, Inc. Spinal stabilization method
DE3923996A1 (de) * 1989-07-20 1991-01-31 Lutz Biedermann Aufnahmeteil zum gelenkigen verbinden mit einer schraube zum bilden einer pedikelschraube
US5261913A (en) 1989-07-26 1993-11-16 J.B.S. Limited Company Device for straightening, securing, compressing and elongating the spinal column
US4936848A (en) * 1989-09-22 1990-06-26 Bagby George W Implant for vertebrae
EP0423064B1 (de) 1989-10-12 1993-10-20 SULZER Medizinaltechnik AG Hüftgelenksprothesen mit Verankerung durch Gitterflächen
US4932975A (en) * 1989-10-16 1990-06-12 Vanderbilt University Vertebral prosthesis
DE8912648U1 (de) * 1989-10-23 1990-11-22 Mecron Medizinische Produkte Gmbh, 1000 Berlin Wirbelkörperimplantat
US5059193A (en) 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
CA2035348C (fr) * 1990-02-08 2000-05-16 Jean-Louis Vignaud Dispositif de fixation orientable de tiges d'osteosynthese rachidienne
FR2658413B1 (fr) 1990-02-19 1997-01-03 Sofamor Dispositif d'osteosynthese pour la correction des deviations rachidiennes.
FR2659226B1 (fr) * 1990-03-07 1992-05-29 Jbs Sa Prothese pour disques intervertebraux et ses instruments d'implantation.
EP0453393B1 (de) 1990-04-20 1993-10-06 SULZER Medizinaltechnik AG Implantat, insbesondere Zwischenwirbelprothese
CH685850A5 (de) * 1990-11-26 1995-10-31 Synthes Ag Verankerungseinrichtung
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5176678A (en) * 1991-03-14 1993-01-05 Tsou Paul M Orthopaedic device with angularly adjustable anchor attachments to the vertebrae
JP3007903B2 (ja) * 1991-03-29 2000-02-14 京セラ株式会社 人工椎間板
FR2676354B1 (fr) 1991-05-17 1997-11-07 Vignaud Jean Louis Dispositif de liaison verrouillable d'elements d'ancrage d'osteosynthese rachidienne.
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
DE4128332A1 (de) * 1991-08-27 1993-03-04 Man Ceramics Gmbh Wirbelknochenersatz
US5306309A (en) * 1992-05-04 1994-04-26 Calcitek, Inc. Spinal disk implant and implantation kit
US5275600A (en) * 1992-10-05 1994-01-04 Zimmer, Inc. Telescoping rod to rod coupler for a spinal system
JP3012095B2 (ja) 1992-10-08 2000-02-21 京セラ株式会社 多孔質生体補綴部材とそれに弾性付与するための処理方法
US5282801A (en) * 1993-02-17 1994-02-01 Danek Medical, Inc. Top tightening clamp assembly for a spinal fixation system
EP0621020A1 (de) * 1993-04-21 1994-10-26 SULZER Medizinaltechnik AG Zwischenwirbelprothese und Verfahren zum Implantieren einer derartigen Prothese
US7044954B2 (en) * 1994-01-26 2006-05-16 Kyphon Inc. Method for treating a vertebral body
EP1464293B1 (de) * 1994-01-26 2007-05-02 Kyphon Inc. Verbesserte aufblasbare Vorrichtung zur Verwendung in chirurgischen Methoden zur Fixierung von Knochen
US6241734B1 (en) * 1998-08-14 2001-06-05 Kyphon, Inc. Systems and methods for placing materials into bone
CA2180556C (en) 1994-01-26 2007-08-07 Mark A. Reiley Improved inflatable device for use in surgical protocol relating to fixation of bone
US6248110B1 (en) * 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US5503164A (en) * 1994-01-28 1996-04-02 Osteogenics, Inc. Device and method for repair of craniomaxillofacial bone defects including burr holes
US6248131B1 (en) * 1994-05-06 2001-06-19 Advanced Bio Surfaces, Inc. Articulating joint repair
US5888220A (en) * 1994-05-06 1999-03-30 Advanced Bio Surfaces, Inc. Articulating joint repair
US5556429A (en) 1994-05-06 1996-09-17 Advanced Bio Surfaces, Inc. Joint resurfacing system
DE19581655T1 (de) * 1994-05-24 1997-05-28 Smith & Nephew Bandscheibenimplantat
US5562736A (en) * 1994-10-17 1996-10-08 Raymedica, Inc. Method for surgical implantation of a prosthetic spinal disc nucleus
US5634945A (en) * 1995-03-02 1997-06-03 Pernia; Luis R. Biological filler and use of same
US5645597A (en) * 1995-12-29 1997-07-08 Krapiva; Pavel I. Disc replacement method and apparatus
US7069087B2 (en) * 2000-02-25 2006-06-27 Oratec Interventions, Inc. Apparatus and method for accessing and performing a function within an intervertebral disc
US5961554A (en) 1996-12-31 1999-10-05 Janson; Frank S Intervertebral spacer
US7618451B2 (en) * 2001-05-25 2009-11-17 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty
US6127597A (en) 1997-03-07 2000-10-03 Discotech N.V. Systems for percutaneous bone and spinal stabilization, fixation and repair
IL128261A0 (en) * 1999-01-27 1999-11-30 Disc O Tech Medical Tech Ltd Expandable element
US6022376A (en) * 1997-06-06 2000-02-08 Raymedica, Inc. Percutaneous prosthetic spinal disc nucleus and method of manufacture
US6852095B1 (en) * 1997-07-09 2005-02-08 Charles D. Ray Interbody device and method for treatment of osteoporotic vertebral collapse
GB9714580D0 (en) * 1997-07-10 1997-09-17 Wardlaw Douglas Prosthetic intervertebral disc nucleus
WO1999049819A1 (en) * 1998-04-01 1999-10-07 Parallax Medical, Inc. Pressure applicator for hard tissue implant placement
US6224630B1 (en) * 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
ATE484247T1 (de) * 1998-06-01 2010-10-15 Kyphon S Rl Entfaltbare, vorgeformte strukturen zur auffaltung in regionen innerhalb des körpers
US6132465A (en) * 1998-06-04 2000-10-17 Raymedica, Inc. Tapered prosthetic spinal disc nucleus
US6746485B1 (en) * 1999-02-18 2004-06-08 St. Francis Medical Technologies, Inc. Hair used as a biologic disk, replacement, and/or structure and method
US6436143B1 (en) * 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6264659B1 (en) * 1999-02-22 2001-07-24 Anthony C. Ross Method of treating an intervertebral disk
US6770079B2 (en) * 1999-03-16 2004-08-03 American Osteomedix, Inc. Apparatus and method for fixation of osteoporotic bone
US6113639A (en) * 1999-03-23 2000-09-05 Raymedica, Inc. Trial implant and trial implant kit for evaluating an intradiscal space
US6602291B1 (en) * 1999-04-05 2003-08-05 Raymedica, Inc. Prosthetic spinal disc nucleus having a shape change characteristic
US6110210A (en) * 1999-04-08 2000-08-29 Raymedica, Inc. Prosthetic spinal disc nucleus having selectively coupled bodies
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6419704B1 (en) * 1999-10-08 2002-07-16 Bret Ferree Artificial intervertebral disc replacement methods and apparatus
US6969404B2 (en) * 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
US6245107B1 (en) 1999-05-28 2001-06-12 Bret A. Ferree Methods and apparatus for treating disc herniation
US6371990B1 (en) * 1999-10-08 2002-04-16 Bret A. Ferree Annulus fibrosis augmentation methods and apparatus
US6425919B1 (en) 1999-08-18 2002-07-30 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
US7507243B2 (en) * 1999-08-18 2009-03-24 Gregory Lambrecht Devices and method for augmenting a vertebral disc
US7998213B2 (en) * 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
US7553329B2 (en) * 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
US6508839B1 (en) * 1999-08-18 2003-01-21 Intrinsic Orthopedics, Inc. Devices and methods of vertebral disc augmentation
JP4247519B2 (ja) * 1999-08-18 2009-04-02 イントリンジック セラピューティックス インコーポレイテッド 髄核オーグメンテーションおよび保定のための装置および方法
WO2004100841A1 (en) * 1999-08-18 2004-11-25 Intrinsic Therapeutics, Inc. Devices and method for augmenting a vertebral disc nucleus
US6783546B2 (en) * 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6964674B1 (en) * 1999-09-20 2005-11-15 Nuvasive, Inc. Annulotomy closure device
US6264695B1 (en) * 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
US6602261B2 (en) * 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
US7201774B2 (en) * 1999-10-08 2007-04-10 Ferree Bret A Artificial intervertebral disc replacements incorporating reinforced wall sections
US7004970B2 (en) * 1999-10-20 2006-02-28 Anulex Technologies, Inc. Methods and devices for spinal disc annulus reconstruction and repair
US20030153976A1 (en) * 1999-10-20 2003-08-14 Cauthen Joseph C. Spinal disc annulus reconstruction method and spinal disc annulus stent
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
JP4672947B2 (ja) * 1999-12-06 2011-04-20 ウォーソー・オーソペディック・インコーポレーテッド 椎間板の治療装置及び方法
US6558390B2 (en) * 2000-02-16 2003-05-06 Axiamed, Inc. Methods and apparatus for performing therapeutic procedures in the spine
US6332894B1 (en) * 2000-03-07 2001-12-25 Zimmer, Inc. Polymer filled spinal fusion cage
ATE318559T1 (de) * 2000-04-05 2006-03-15 Kyphon Inc Vorrichtungen zur behandlung von gebrochenen und/oder erkrankten knochen
US6869445B1 (en) * 2000-05-04 2005-03-22 Phillips Plastics Corp. Packable ceramic beads for bone repair
WO2004043303A2 (en) * 2002-11-12 2004-05-27 Regenex Ltd. Expandable devices and methods for tissue expansion, regenerationand fixation
DE50106944D1 (de) * 2000-05-26 2005-09-08 Zimmer Gmbh Winterthur Bandscheibenersatz für den Kern einer Bandscheibe
US6533817B1 (en) * 2000-06-05 2003-03-18 Raymedica, Inc. Packaged, partially hydrated prosthetic disc nucleus
US20080086133A1 (en) * 2003-05-16 2008-04-10 Spineology Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone
US20020026244A1 (en) * 2000-08-30 2002-02-28 Trieu Hai H. Intervertebral disc nucleus implants and methods
US6620196B1 (en) * 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
ES2303972T3 (es) * 2000-08-30 2008-09-01 Warsaw Orthopedic, Inc. Implantes de disco intervertebral.
US7503936B2 (en) * 2000-08-30 2009-03-17 Warsaw Orthopedic, Inc. Methods for forming and retaining intervertebral disc implants
WO2002026170A2 (en) * 2000-09-26 2002-04-04 Neurortho Implants Design, Llc Inter-vertebral disc prosthesis for lumbar rachis through posterior surgery thereof
US6733531B1 (en) * 2000-10-20 2004-05-11 Sdgi Holdings, Inc. Anchoring devices and implants for intervertebral disc augmentation
WO2002034111A2 (en) * 2000-10-24 2002-05-02 Cryolife, Inc. In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics
ATE291890T1 (de) * 2000-10-27 2005-04-15 Sdgi Holdings Inc Annulusreparatursystem
US6679914B1 (en) * 2000-11-14 2004-01-20 Shlomo Gabbay Implantable orthopedic support apparatus
JP2006500115A (ja) * 2000-11-16 2006-01-05 マイクロスフエリツクス・エル・エル・シー 密封小線源治療用の可撓性および／または弾性シードまたはストランド
US6375659B1 (en) * 2001-02-20 2002-04-23 Vita Licensing, Inc. Method for delivery of biocompatible material
US7544196B2 (en) * 2001-02-20 2009-06-09 Orthovita, Inc. System and kit for delivery of restorative materials
US6595998B2 (en) * 2001-03-08 2003-07-22 Spinewave, Inc. Tissue distraction device
US6632235B2 (en) * 2001-04-19 2003-10-14 Synthes (U.S.A.) Inflatable device and method for reducing fractures in bone and in treating the spine
AU2002305401A1 (en) * 2001-05-04 2002-11-18 Concentric Medical Hydrogel filament vaso-occlusive device
AU2002318159A1 (en) * 2001-06-29 2003-03-03 The Regents Of The University Of California Biodegradable/bioactive nucleus pulposus implant and method for treating degenerated intervertebral discs
US20030028251A1 (en) * 2001-07-30 2003-02-06 Mathews Hallett H. Methods and devices for interbody spinal stabilization
US7008431B2 (en) * 2001-10-30 2006-03-07 Depuy Spine, Inc. Configured and sized cannula
EP1465521A4 (de) * 2001-11-01 2008-10-08 Spine Wave Inc System und verfahren zur vorbehandlung der endplatten einer bandscheibe
US7004945B2 (en) * 2001-11-01 2006-02-28 Spinewave, Inc. Devices and methods for the restoration of a spinal disc
KR100824440B1 (ko) * 2001-12-05 2008-04-23 신세스 게엠바하 추간 디스크 보철물 또는 세포핵-대체-보철물
US6953465B2 (en) * 2002-03-25 2005-10-11 Concentric Medical, Inc. Containers and methods for delivering vaso-occluding filaments and particles
US20030195630A1 (en) * 2002-04-10 2003-10-16 Ferree Bret A. Disc augmentation using materials that expand in situ
AU2003229045A1 (en) * 2002-05-13 2003-11-11 D. Russell Pflueger Spinal disc therapy system
US7128746B2 (en) * 2002-05-16 2006-10-31 Pmt Corporation Device for treating intervertebral disc herniations
DE10223332A1 (de) * 2002-05-25 2003-12-04 Efmt Entwicklungs Und Forschun Medizinisches Implantat
US7066960B1 (en) * 2002-06-28 2006-06-27 Dickman Curtis A Intervertebral disk replacement
ATE400237T1 (de) * 2002-08-15 2008-07-15 Synthes Gmbh Bandscheibenimplantat
CA2496804A1 (en) * 2002-08-27 2004-03-11 Sdgi Holdings, Inc. Systems and methods for intravertebral reduction
US20040054413A1 (en) * 2002-09-16 2004-03-18 Howmedica Osteonics Corp. Radiovisible hydrogel intervertebral disc nucleus
US20040054414A1 (en) * 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US7309359B2 (en) * 2003-08-21 2007-12-18 Warsaw Orthopedic, Inc. Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs
AU2003276926B2 (en) * 2002-09-18 2009-02-05 Warsaw Orthopedic, Inc. Natural tissue devices and methods of implantation
US6932843B2 (en) * 2002-09-25 2005-08-23 Medicinelodge, Inc. Apparatus and method for the in-situ formation of a structural prosthesis
EP1562524A4 (de) 2002-11-05 2010-12-22 Spineology Inc Semibiologisches bandscheiben-ersatzsystem
US6733533B1 (en) * 2002-11-19 2004-05-11 Zimmer Technology, Inc. Artificial spinal disc
WO2004047689A1 (en) * 2002-11-21 2004-06-10 Sdgi Holdings, Inc. Systems and techniques for intravertebral spinal stablization with expandable devices
JP2006515780A (ja) * 2003-01-17 2006-06-08 プシナーギ コーポレイション 人工髄核およびその注入方法
US7306610B2 (en) * 2003-03-21 2007-12-11 Cana Lab Corporation Method and device for forming a hardened cement in a bone cavity
US20050010297A1 (en) * 2003-05-08 2005-01-13 Kuros Biosurgery Ag Balloon technologies for tissue repair
DE602004019917D1 (de) * 2003-06-02 2009-04-23 Warsaw Orthopedic Inc Bandscheibenimplantate und methoden zu deren herstellung
US20050015150A1 (en) * 2003-07-17 2005-01-20 Lee Casey K. Intervertebral disk and nucleus prosthesis
GB2420502B (en) * 2003-07-25 2007-01-31 Impliant Ltd Elastomeric spinal disc nucleus replacement
US6958077B2 (en) * 2003-07-29 2005-10-25 Loubert Suddaby Inflatable nuclear prosthesis
US7789912B2 (en) * 2004-01-08 2010-09-07 Spine Wave, Inc. Apparatus and method for injecting fluent material at a distracted tissue site
US8029511B2 (en) * 2004-03-22 2011-10-04 Disc Dynamics, Inc. Multi-stage biomaterial injection system for spinal implants
US7465318B2 (en) * 2004-04-15 2008-12-16 Soteira, Inc. Cement-directing orthopedic implants
US20050245938A1 (en) * 2004-04-28 2005-11-03 Kochan Jeffrey P Method and apparatus for minimally invasive repair of intervertebral discs and articular joints
US20050244451A1 (en) * 2004-05-03 2005-11-03 Robert Diaz Method and device for reducing susceptibility to fractures in vertebral bodies
US20080132899A1 (en) * 2004-05-17 2008-06-05 Shadduck John H Composite implant and method for treating bone abnormalities
AU2005245017A1 (en) * 2004-05-21 2005-12-01 Synthes Gmbh Replacement of nucleus pulposus using a hydrogel
US7749268B2 (en) * 2004-05-26 2010-07-06 Warsaw Orthopedic, Inc. Methods for treating the spine
US7722579B2 (en) * 2004-06-29 2010-05-25 Spine Wave, Inc. Devices for injecting a curable biomaterial into a intervertebral space
JP2008508045A (ja) * 2004-07-27 2008-03-21 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 椎間円板の髄核の置換又は補完方法
US7172628B2 (en) * 2004-07-27 2007-02-06 Lonnie Jay Lamprich Spinal disc prosthesis and methods
US8110003B2 (en) * 2004-09-09 2012-02-07 University Of South Florida Prostheses for spine discs having fusion capability
US7682393B2 (en) * 2004-10-14 2010-03-23 Warsaw Orthopedic, Inc. Implant system, method, and instrument for augmentation or reconstruction of intervertebral disc
US8317864B2 (en) * 2004-10-20 2012-11-27 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for posterior dynamic stabilization of the spine
US7799078B2 (en) * 2004-11-12 2010-09-21 Warsaw Orthopedic, Inc. Implantable vertebral lift
CA2588388A1 (en) * 2004-12-01 2006-06-08 The Regents Of The University Of California Systems, devices and methods of treatment of intervertebral disorders
US20060195115A1 (en) * 2005-02-23 2006-08-31 Ferree Bret A Method and apparatus for kyphoplasty
US20060265077A1 (en) * 2005-02-23 2006-11-23 Zwirkoski Paul A Spinal repair
US20060253202A1 (en) * 2005-05-05 2006-11-09 Lipov Eugene G Vertebral disc implant in fiber form
US7628800B2 (en) * 2005-06-03 2009-12-08 Warsaw Orthopedic, Inc. Formed in place corpectomy device
US7988735B2 (en) * 2005-06-15 2011-08-02 Matthew Yurek Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement
US7618457B2 (en) * 2005-08-10 2009-11-17 Zimmer Spine, Inc. Devices and methods for disc nucleus replacement
JP4944111B2 (ja) * 2005-08-16 2012-05-30 ベンベニュー メディカル， インコーポレイテッド 脊柱組織伸延装置
DE602006013649D1 (en) * 2005-08-26 2010-05-27 Synthes Gmbh Hydrogel-ballonprothese für nucleus pulposus
US20070093899A1 (en) * 2005-09-28 2007-04-26 Christof Dutoit Apparatus and methods for treating bone
US7699894B2 (en) * 2005-12-22 2010-04-20 Depuy Spine, Inc. Nucleus pulposus trial device and technique
US20070150059A1 (en) * 2005-12-22 2007-06-28 Depuy Spine, Inc. Methods and devices for intervertebral augmentation using injectable formulations and enclosures
US7645301B2 (en) * 2006-01-13 2010-01-12 Zimmer Spine, Inc. Devices and methods for disc replacement
US7799079B2 (en) * 2006-01-18 2010-09-21 Zimmer Spine, Inc. Vertebral fusion device and method
US7959676B2 (en) * 2006-02-13 2011-06-14 Lanx, Inc. Method and apparatus for intervertebral disc support and repair
US7520888B2 (en) * 2006-02-14 2009-04-21 Warsaw Orthopedic, Inc. Treatment of the vertebral column
US8518098B2 (en) * 2006-02-21 2013-08-27 Cook Medical Technologies Llc Split sheath deployment system
US8133279B2 (en) * 2006-04-27 2012-03-13 Warsaw Orthopedic, Inc. Methods for treating an annulus defect of an intervertebral disc
US8092536B2 (en) * 2006-05-24 2012-01-10 Disc Dynamics, Inc. Retention structure for in situ formation of an intervertebral prosthesis
WO2008013763A2 (en) * 2006-07-25 2008-01-31 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US7758649B2 (en) * 2006-08-04 2010-07-20 Integrity Intellect Inc. Reversibly deformable implant
US20080103505A1 (en) * 2006-10-26 2008-05-01 Hendrik Raoul Andre Fransen Containment device for site-specific delivery of a therapeutic material and methods of use
WO2008088869A1 (en) * 2007-01-19 2008-07-24 Spinemedica Corporation Methods and systems for forming implants with selectively exposed mesh for fixation
EP1961433A1 (de) * 2007-02-20 2008-08-27 National University of Ireland Galway Poröse Substrate zur Implantation
US20080249604A1 (en) * 2007-03-30 2008-10-09 Brian Donovan Apparatus and method for medical procedures within a spine
WO2008137428A2 (en) * 2007-04-30 2008-11-13 Dfine, Inc. Bone treatment systems and methods
US8052728B2 (en) * 2007-07-31 2011-11-08 Zimmer Spine, Inc. Method for stabilizing a facet joint
US8282681B2 (en) * 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US7842095B2 (en) * 2007-09-11 2010-11-30 Howmedica Osteonics Corp. Antibiotic bone cement spacer
US7883511B2 (en) * 2007-09-12 2011-02-08 Fernyhough Jeffrey C Method and composition for use in reinforcing bone
US8226719B2 (en) * 2007-11-14 2012-07-24 Cook Medical Technologies Llc Method and bone cement substitute kit for stabilizing a collapsed vertebra of a patient
US7799056B2 (en) * 2007-12-31 2010-09-21 Warsaw Orthopedic, Inc. Bone fusion device and methods
US7842040B2 (en) * 2008-01-18 2010-11-30 Illuminoss Medical, Inc. Internal bone fixation system with integrated mixer
US9011538B2 (en) * 2009-01-21 2015-04-21 Warsaw Orthopedic, Inc. Methods of spinal nucleus replacemennt
US9192655B2 (en) * 2009-03-12 2015-11-24 New Jersey Institute Of Technology System and method for a hydrogel and hydrogel composite for cartilage repair applications
US20100256646A1 (en) * 2009-04-01 2010-10-07 Frank Pinal Orthobiologics delivery tool

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772287A (en) * 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US4904260A (en) * 1987-08-20 1990-02-27 Cedar Surgical, Inc. Prosthetic disc containing therapeutic material
US5192326A (en) * 1990-12-21 1993-03-09 Pfizer Hospital Products Group, Inc. Hydrogel bead intervertebral disc nucleus
US6443988B2 (en) * 1994-05-06 2002-09-03 Disc Dynamics, Inc. Mold apparatus and kit for in situ tissue repair
US5549679A (en) * 1994-05-20 1996-08-27 Kuslich; Stephen D. Expandable fabric implant for stabilizing the spinal motion segment
US5919235A (en) * 1995-11-08 1999-07-06 Sulzer Orthopaedie Ag Intervertebral prosthesis
US6240926B1 (en) * 1996-08-08 2001-06-05 The Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US6437018B1 (en) * 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6183518B1 (en) * 1999-02-22 2001-02-06 Anthony C. Ross Method of replacing nucleus pulposus and repairing the intervertebral disk
US6395034B1 (en) * 1999-11-24 2002-05-28 Loubert Suddaby Intervertebral disc prosthesis
US20040215343A1 (en) * 2000-02-28 2004-10-28 Stephen Hochschuler Method and apparatus for treating a vertebral body
US20020026195A1 (en) * 2000-04-07 2002-02-28 Kyphon Inc. Insertion devices and method of use
US20020068974A1 (en) * 2000-07-21 2002-06-06 Kuslich Stephen D. Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone
US20020045942A1 (en) * 2000-10-16 2002-04-18 Ham Michael J. Procedure for repairing damaged discs
US20020077701A1 (en) * 2000-12-15 2002-06-20 Kuslich Stephen D. Annulus-reinforcing band
US20020147496A1 (en) * 2001-04-06 2002-10-10 Integrated Vascular Systems, Inc. Apparatus for treating spinal discs
US20050065609A1 (en) * 2001-11-19 2005-03-24 Douglas Wardlaw Intervertebral disc prosthesis

Cited By (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9668875B2 (en) 1999-03-07 2017-06-06 Nuvasive, Inc. Method and apparatus for computerized surgery
US20050071003A1 (en) * 1999-03-17 2005-03-31 Ku David N. Poly(vinyl alcohol) hydrogel
US20050106255A1 (en) * 1999-03-17 2005-05-19 Ku David N. Poly(vinyl alcohol) hydrogel
US20050119754A1 (en) * 2002-09-18 2005-06-02 Trieu Hai H. Compositions and methods for treating intervertebral discs with collagen-based materials
US7713303B2 (en) 2002-09-18 2010-05-11 Warsaw Orthopedic, Inc. Collagen-based materials and methods for augmenting intervertebral discs
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
US20120116514A1 (en) * 2002-11-05 2012-05-10 Kuslich Stephen D Semi-biological intervertebral disc replacement system
US20090125110A1 (en) * 2002-11-05 2009-05-14 Kuslich Stephen D Semi-biological intervertebral disc replacement system
US8012211B2 (en) 2002-11-05 2011-09-06 Spineology, Inc. Semi-biological intervertebral disc replacement system
US7731981B2 (en) 2002-11-15 2010-06-08 Warsaw Orthopedic, Inc. Collagen-based materials and methods for treating synovial joints
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
US20080279943A1 (en) * 2004-02-06 2008-11-13 Georgia Tech Research Corporation Method of making hydrogel implants
US20090263446A1 (en) * 2004-02-06 2009-10-22 Georgia Tech Research Corporation Method of making load bearing hydrogel implants
US8486436B2 (en) 2004-02-06 2013-07-16 Georgia Tech Research Corporation Articular joint implant
US8142808B2 (en) 2004-02-06 2012-03-27 Georgia Tech Research Corporation Method of treating joints with hydrogel implants
US8895073B2 (en) 2004-02-06 2014-11-25 Georgia Tech Research Corporation Hydrogel implant with superficial pores
US8002830B2 (en) 2004-02-06 2011-08-23 Georgia Tech Research Corporation Surface directed cellular attachment
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
US7682540B2 (en) 2004-02-06 2010-03-23 Georgia Tech Research Corporation Method of making hydrogel implants
US20050196452A1 (en) * 2004-02-06 2005-09-08 Boyan Barbara D. Surface directed cellular attachment
US8318192B2 (en) 2004-02-06 2012-11-27 Georgia Tech Research Corporation Method of making load bearing hydrogel implants
US7485145B2 (en) * 2004-02-23 2009-02-03 Alphatec Spine, Incorporated Artificial intervertebral disc assembly
US20050273169A1 (en) * 2004-02-23 2005-12-08 Thomas Purcell Artificial intervertebral disc assembly
US20080306595A1 (en) * 2004-03-26 2008-12-11 Pearsalls Limited Porous Implant For Spinal Disc Nucleus Replacement
US20080306593A1 (en) * 2004-03-26 2008-12-11 Mcleod Alan Rory Mor Prosthetic Spinal Disc
US20050278025A1 (en) * 2004-06-10 2005-12-15 Salumedica Llc Meniscus prosthesis
US7879103B2 (en) 2005-04-15 2011-02-01 Musculoskeletal Transplant Foundation Vertebral disc repair
US20070001981A1 (en) * 2005-06-29 2007-01-04 Nec Electronics Corporation Driver unit including common level shifter circuit for display panel and nonvolatile memory
US20080228273A1 (en) * 2005-07-20 2008-09-18 Mcleod Alan Rory Mor Implants
US8163018B2 (en) * 2006-02-14 2012-04-24 Warsaw Orthopedic, Inc. Treatment of the vertebral column
US20070227547A1 (en) * 2006-02-14 2007-10-04 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070213718A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070213717A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Biological fusion in the vertebral column
US20070213823A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070213824A1 (en) * 2006-02-14 2007-09-13 Sdgi Holdings, Inc. Treatment of the vertebral column
US20070255406A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US8157863B2 (en) 2006-04-27 2012-04-17 Warsaw Orthopedic, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US20090275913A1 (en) * 2006-04-27 2009-11-05 Warsaw Orthopedic, Inc. Devices, apparatus, and methods for bilateral approach to disc augmentation
US20070255286A1 (en) * 2006-04-27 2007-11-01 Sdgi Holdings, Inc. Devices, apparatus, and methods for improved disc augmentation
US8133279B2 (en) 2006-04-27 2012-03-13 Warsaw Orthopedic, Inc. Methods for treating an annulus defect of an intervertebral disc
US20070276496A1 (en) * 2006-05-23 2007-11-29 Sdgi Holdings, Inc. Surgical spacer with shape control
US20070299523A1 (en) * 2006-06-08 2007-12-27 Francis Pflum Sac for use in spinal surgery
US8226722B2 (en) * 2006-06-08 2012-07-24 Francis Pflum Sac for use in spinal surgery
US10143560B2 (en) 2006-06-08 2018-12-04 Francis Pflum Sac for use in spinal surgery
US8118779B2 (en) 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US20080004214A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic, Inc Injectable collagen material
US20080004570A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic, Inc. Collagen delivery device
US8399619B2 (en) 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US20080027546A1 (en) * 2006-07-25 2008-01-31 Semler Eric J Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US7959683B2 (en) 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
EP2063808A4 (de) * 2006-09-14 2012-06-13 Spineology Inc Saugfähiges faserimplantat
EP2063808A2 (de) * 2006-09-14 2009-06-03 Spineology, Inc. Saugfähiges faserimplantat
US7909873B2 (en) 2006-12-15 2011-03-22 Soteira, Inc. Delivery apparatus and methods for vertebrostenting
US9480485B2 (en) 2006-12-15 2016-11-01 Globus Medical, Inc. Devices and methods for vertebrostenting
US9237916B2 (en) 2006-12-15 2016-01-19 Gmedeleware 2 Llc Devices and methods for vertebrostenting
US8623025B2 (en) 2006-12-15 2014-01-07 Gmedelaware 2 Llc Delivery apparatus and methods for vertebrostenting
US9192397B2 (en) 2006-12-15 2015-11-24 Gmedelaware 2 Llc Devices and methods for fracture reduction
US20100076503A1 (en) * 2007-02-07 2010-03-25 N.M.B. Medical Applications Ltd Bone implant
US20110054532A1 (en) * 2007-07-03 2011-03-03 Alexandre De Moura Interspinous mesh
US8540752B2 (en) 2007-07-03 2013-09-24 Spine Tek, Inc. Interspinous mesh
US20090048677A1 (en) * 2007-08-13 2009-02-19 Nuvasive, Inc. Bioresorbable Spinal Implant and Related Methods
US8282681B2 (en) 2007-08-13 2012-10-09 Nuvasive, Inc. Bioresorbable spinal implant and related methods
US20090222096A1 (en) * 2008-02-28 2009-09-03 Warsaw Orthopedic, Inc. Multi-compartment expandable devices and methods for intervertebral disc expansion and augmentation
US8377135B1 (en) 2008-03-31 2013-02-19 Nuvasive, Inc. Textile-based surgical implant and related methods
US9687255B2 (en) 2008-06-17 2017-06-27 Globus Medical, Inc. Device and methods for fracture reduction
US10588646B2 (en) 2008-06-17 2020-03-17 Globus Medical, Inc. Devices and methods for fracture reduction
US10525168B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10857261B2 (en) 2010-10-20 2020-12-08 206 Ortho, Inc. Implantable polymer for bone and vascular lesions
US11850323B2 (en) 2010-10-20 2023-12-26 206 Ortho, Inc. Implantable polymer for bone and vascular lesions
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10028776B2 (en) 2010-10-20 2018-07-24 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11351261B2 (en) 2010-10-20 2022-06-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10517654B2 (en) 2010-10-20 2019-12-31 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10376368B2 (en) 2011-05-26 2019-08-13 Cartiva, Inc. Devices and methods for creating wedge-shaped recesses
US11944545B2 (en) 2011-05-26 2024-04-02 Cartiva, Inc. Implant introducer
US9155543B2 (en) 2011-05-26 2015-10-13 Cartiva, Inc. Tapered joint implant and related tools
US9526632B2 (en) 2011-05-26 2016-12-27 Cartiva, Inc. Methods of repairing a joint using a wedge-shaped implant
US11278411B2 (en) 2011-05-26 2022-03-22 Cartiva, Inc. Devices and methods for creating wedge-shaped recesses
US20130282121A1 (en) * 2012-03-22 2013-10-24 Ann Prewett Spinal facet augmentation implant and method
US10350072B2 (en) 2012-05-24 2019-07-16 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US10159580B2 (en) * 2012-10-19 2018-12-25 Tsunami S.R.L. Vertebral fusion device and system
WO2014061005A2 (en) 2012-10-19 2014-04-24 Tsunami S.R.L. Vertebral fusion device and system
US20150282944A1 (en) * 2012-10-19 2015-10-08 Giancarlo Guizzardi Vertebral fusion device and system
US10973644B2 (en) 2015-03-31 2021-04-13 Cartiva, Inc. Hydrogel implants with porous materials and methods
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
US11717411B2 (en) 2015-03-31 2023-08-08 Cartiva, Inc. Hydrogel implants with porous materials and methods
US11839552B2 (en) 2015-03-31 2023-12-12 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
US10758374B2 (en) 2015-03-31 2020-09-01 Cartiva, Inc. Carpometacarpal (CMC) implants and methods
US11020231B2 (en) 2015-04-14 2021-06-01 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US11701231B2 (en) 2015-04-14 2023-07-18 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
US10952858B2 (en) 2015-04-14 2021-03-23 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods

Also Published As

Publication number Publication date
AU2009202358A1 (en) 2009-07-02
KR20050084658A (ko) 2005-08-26
US20120116514A1 (en) 2012-05-10
WO2004041075A3 (en) 2005-01-13
EP1562524A4 (de) 2010-12-22
US8012211B2 (en) 2011-09-06
CA2504591A1 (en) 2004-05-21
CA2504591C (en) 2011-09-13
NZ539779A (en) 2009-01-31
AU2003290627A1 (en) 2004-06-07
US20090125110A1 (en) 2009-05-14
JP2006505331A (ja) 2006-02-16
AU2003290627B2 (en) 2009-03-19
CA2735324A1 (en) 2004-05-21
EP1562524A2 (de) 2005-08-17
CA2735334A1 (en) 2004-05-21
WO2004041075A2 (en) 2004-05-21

Similar Documents

Publication Publication Date Title
US8012211B2 (en) Semi-biological intervertebral disc replacement system
KR100403310B1 (ko) 척추운동체절의안정화를위한팽창가능한직물삽입기구
AU768415B2 (en) Prosthetic spinal disc nucleus having selectively coupled bodies
US7267690B2 (en) Interlocked modular disc nucleus prosthesis
AU743053B2 (en) Prosthetic spinal disc nucleus
EP0786963B1 (de) Zwischenwirbel-discuspulposus-prothese
US6764514B1 (en) Prosthetic apparatus and method
US20070233259A1 (en) Intervertebral disc prosthesis and methods of implantation
JP2008531140A (ja) 椎間板修復
JPH02111359A (ja) 治療用物質を含むプロテーゼの円板
JP2004516904A (ja) 髄核オーグメンテーションおよび保定のための装置および方法
CN101500513B (zh) 基于导轨的模块化盘髓核假体
Ray Lumbar interbody threaded prostheses

Legal Events

Date Code Title Description
AS Assignment

Owner name: SPINEOLOGY, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KUSLICH, STEPHEN D.;REEL/FRAME:015112/0916

Effective date: 20040204

AS Assignment

Owner name: MUSCULOSKELETAL TRANSPLANT FOUNDATION, INC., NEW J

Free format text: SECURITY AGREEMENT;ASSIGNOR:SPINEOLOGY, INC.;REEL/FRAME:018563/0350

Effective date: 20061130

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION

AS Assignment

Owner name: SPINEOLOGY, INC., MINNESOTA

Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:MUSCULOSKELETAL TRANSPLANT FOUNDATION, INC.;REEL/FRAME:027805/0445

Effective date: 20120131