UA98658C2 - Циклічні депсипептиди - Google Patents

Циклічні депсипептиди

Info

Publication number
UA98658C2
UA98658C2 UAA201001638A UAA201001638A UA98658C2 UA 98658 C2 UA98658 C2 UA 98658C2 UA A201001638 A UAA201001638 A UA A201001638A UA A201001638 A UAA201001638 A UA A201001638A UA 98658 C2 UA98658 C2 UA 98658C2
Authority
UA
Ukraine
Prior art keywords
cyclic depsipeptides
depsipeptides
cyclic
kallikrein
inhibitors
Prior art date
Application number
UAA201001638A
Other languages
English (en)
Russian (ru)
Inventor
Філіпп Крастел
Брігітта-Марія Ліехті
Йозеф Готтфрід Меінгасснер
Естер Шмітт
Ервін Пауль Шрайнер
Original Assignee
Новартіс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38805728&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA98658(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартіс Аг filed Critical Новартіс Аг
Publication of UA98658C2 publication Critical patent/UA98658C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Даний винахід належить до циклічних депсипептидів або їх похідних та їх застосування, наприклад, як інгібіторів калікреїну 7 або еластази нейтрофілів людини.
UAA201001638A 2007-08-17 2008-08-14 Циклічні депсипептиди UA98658C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114507 2007-08-17
PCT/EP2008/060689 WO2009024527A1 (en) 2007-08-17 2008-08-14 Cyclic depsipeptides

Publications (1)

Publication Number Publication Date
UA98658C2 true UA98658C2 (uk) 2012-06-11

Family

ID=38805728

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201001638A UA98658C2 (uk) 2007-08-17 2008-08-14 Циклічні депсипептиди

Country Status (30)

Country Link
US (2) US8178650B2 (uk)
EP (1) EP2183273B1 (uk)
JP (1) JP5520824B2 (uk)
KR (2) KR20120123579A (uk)
CN (1) CN103298827B (uk)
AR (1) AR068343A1 (uk)
AU (1) AU2008290567B2 (uk)
BR (1) BRPI0815547B8 (uk)
CA (1) CA2696570C (uk)
CL (1) CL2008002394A1 (uk)
CO (1) CO6260099A2 (uk)
CR (1) CR11251A (uk)
CU (2) CU23943B1 (uk)
EA (1) EA017735B1 (uk)
EC (1) ECSP109968A (uk)
ES (1) ES2632392T3 (uk)
GT (1) GT201000037A (uk)
MA (1) MA31701B1 (uk)
MX (1) MX2010001849A (uk)
MY (1) MY151973A (uk)
NZ (1) NZ583284A (uk)
PE (2) PE20091007A1 (uk)
PL (1) PL2183273T3 (uk)
PT (1) PT2183273T (uk)
SV (1) SV2010003485A (uk)
TN (1) TN2010000074A1 (uk)
TW (1) TW200922613A (uk)
UA (1) UA98658C2 (uk)
WO (1) WO2009024527A1 (uk)
ZA (1) ZA201000776B (uk)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5401459B2 (ja) 2007-08-17 2014-01-29 ノバルティス アーゲー カリクレイン７を阻害するための環状デプシペプチドの使用
PT2183273T (pt) 2007-08-17 2017-05-22 Novartis Ag Depsipéptidos cíclicos
MX2011008542A (es) * 2009-02-13 2011-09-01 Novartis Ag Molecula de acido nucleico de un racimo biosintetico que codifica sintasas peptidicas no ribosomales y usos de la misma.
US8614289B2 (en) * 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) * 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9744148B2 (en) 2014-01-23 2017-08-29 Sixera Pharma Ab Kallikrein 7 inhibitors
WO2015114144A1 (en) * 2014-02-03 2015-08-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of netherton syndrome
CN106029684A (zh) 2014-04-08 2016-10-12 诺华股份有限公司 用于生产大环缩酚酸肽和新中间体的新型缩醛类方法
KR101729848B1 (ko) 2015-06-30 2017-04-24 영남대학교 산학협력단 신규한 해양 바실러스속 균주, 이로부터 분리한 화합물 및 상기 화합물의 약제학적 용도
CN106518868B (zh) * 2015-11-04 2018-02-23 衡阳师范学院 激肽释放酶7小分子抑制剂及其制备方法、用途
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3043252C2 (de) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (de) * 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
JP2000154198A (ja) 1998-11-20 2000-06-06 Nisshin Flour Milling Co Ltd 環状デプシペプチドの固相合成方法及びその中間体
GB0108234D0 (en) 2001-04-02 2001-05-23 Pharma Mar Sa Process for producing trunkamide A compounds
US20040110228A1 (en) 2002-04-01 2004-06-10 Mcalpine Shelli R. Combinatorial organic synthesis of unique biologically active compounds
DE602004025803D1 (de) 2003-06-06 2010-04-15 Arexis Ab Verwendung von kondensierten heterozyklischen verbindungen als scce-hemmern zur behandlung von hautzuständen
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
WO2005075667A1 (en) * 2004-02-03 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
CA2651796A1 (en) * 2006-02-27 2007-09-07 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
JP5401459B2 (ja) * 2007-08-17 2014-01-29 ノバルティス アーゲー カリクレイン７を阻害するための環状デプシペプチドの使用
PT2183273T (pt) 2007-08-17 2017-05-22 Novartis Ag Depsipéptidos cíclicos
US20110112121A1 (en) 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
US20120064013A1 (en) 2010-02-03 2012-03-15 David Marcos Foamable topical composition
KR101004362B1 (ko) 2010-03-19 2010-12-28 가톨릭대학교 산학협력단 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
BR112013018918A2 (pt) 2011-01-24 2016-10-04 Anterios Inc composições de nanopartículas
SG10201804552WA (en) 2011-01-24 2018-07-30 Anterios Inc Nanoparticle compositions, formulations thereof, and uses therefor
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en) 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
CN103298827B (zh) 2017-05-31
JP5520824B2 (ja) 2014-06-11
SV2010003485A (es) 2011-03-23
PT2183273T (pt) 2017-05-22
PL2183273T3 (pl) 2017-09-29
PE20091007A1 (es) 2009-08-14
EP2183273B1 (en) 2017-04-05
CO6260099A2 (es) 2011-03-22
CL2008002394A1 (es) 2009-05-15
ZA201000776B (en) 2010-10-27
CU23943B1 (es) 2013-09-27
BRPI0815547A2 (pt) 2015-02-10
MY151973A (en) 2014-07-31
JP2010536731A (ja) 2010-12-02
CN103298827A (zh) 2013-09-11
EA201000329A1 (ru) 2010-08-30
BRPI0815547B8 (pt) 2021-05-25
TN2010000074A1 (en) 2011-09-26
CA2696570A1 (en) 2009-02-26
KR20100044893A (ko) 2010-04-30
BRPI0815547B1 (pt) 2020-09-15
MX2010001849A (es) 2010-03-10
AR068343A1 (es) 2009-11-11
NZ583284A (en) 2012-04-27
CU20100032A7 (es) 2011-10-05
TW200922613A (en) 2009-06-01
CA2696570C (en) 2020-12-29
PE20141199A1 (es) 2014-09-24
ES2632392T3 (es) 2017-09-12
KR20120123579A (ko) 2012-11-08
CU20130063A7 (es) 2013-06-28
EP2183273A1 (en) 2010-05-12
EA017735B1 (ru) 2013-02-28
KR101227231B1 (ko) 2013-01-28
US9127044B2 (en) 2015-09-08
AU2008290567A1 (en) 2009-02-26
WO2009024527A1 (en) 2009-02-26
CR11251A (es) 2010-03-08
ECSP109968A (es) 2010-03-31
AU2008290567B2 (en) 2011-05-12
MA31701B1 (fr) 2010-09-01
US20120196790A1 (en) 2012-08-02
US8178650B2 (en) 2012-05-15
US20090156472A1 (en) 2009-06-18
GT201000037A (es) 2012-04-30

Similar Documents

Publication Publication Date Title
TN2010000074A1 (en) Cyclic depsipeptides
RS54217B1 (en) SOME TRIAZOLOPIRAZINS, THEIR COMPOSITIONS AND THE METHODS OF USING THEM
MA32776B1 (fr) Inhibiteurs de l'akt et de la p70 s6 kinase
GB0625648D0 (en) Compounds
ES2356883A1 (es) Composicion para el tratamiento del dolor y/o la inflamacion.
CY1110209T1 (el) Υποκατεστημενες ενωσεις βενζο(d)ισοξαζολ-3-υλ-αμινης σαν αναλγητικα
MX343042B (es) Compuestos heteroarilicos biciclicos.
MX2009004707A (es) Piridina carboxamides como inhibidores 11-beta-hsd1.
GEP20146125B (en) Aminopyrimidines as syk inhibitors
MY153915A (en) Organic compounds
EA201070519A1 (ru) Соединения тропана
NO20082120L (no) Behandling og forebyggelse av mikroangiopati
WO2007125103A3 (en) Benzamide glucokinase activators
EA200870514A1 (ru) Ацетиленовые гетероарильные соединения
BRPI1015043A2 (pt) derivados de diazahomoadamantano e métodos de uso dos mesmos
ATE489371T1 (de) Benzamidglucokinaseaktivatoren
EA200870515A1 (ru) Моноциклические гетероарильные соединения
TW200630367A (en) Substituted adenines and the uses thereof
UA102858C2 (uk) Похідні піридинопіридинонів, спосіб їх одержання і застосування в терапії
CL2009000119A1 (es) Compuestos derivados de amino-bencimidazoles sustituidos; composicion farmaceutica; y su uso en el tratamiento del alzheimer.
MX2009013515A (es) Derivados de 7-alquinil-1,8-naftiridonas, su preparacion y su aplicacion en terapeutica.
SG158091A1 (en) Imidazoazepinone compounds
BRPI0807066A8 (pt) Combinações sinergísticas de compostos ativos fungicidas
CL2007000789A1 (es) Compuestos derivados de malonamida, inhibidores de la gamma-secretasa; proceso de preparacion; composicion farmaceutica; y su uso en el tratamiento de la enfermedad de alzheimer.
CL2008003602A1 (es) Compuestos derivados de triazolotriazinas y triazolopirazinas sustituidas; composicion farmaceutica; y su uso en el tratamiento y/o profilaxis de trastornos hematologicos.