EA201000329A1 - Циклические депсипептиды - Google Patents

Циклические депсипептиды

Info

Publication number
EA201000329A1
EA201000329A1 EA201000329A EA201000329A EA201000329A1 EA 201000329 A1 EA201000329 A1 EA 201000329A1 EA 201000329 A EA201000329 A EA 201000329A EA 201000329 A EA201000329 A EA 201000329A EA 201000329 A1 EA201000329 A1 EA 201000329A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclic depsipeptides
depsipeptides
cyclic
kallikrein
inhibitors
Prior art date
Application number
EA201000329A
Other languages
English (en)
Other versions
EA017735B1 (ru
Inventor
Филипп Крастель
Бригитта-Мария Лихти
Йозеф Готтфрид Майнгасснер
Эстер Шмитт
Эрвин Пол Шрайнер
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38805728&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201000329(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201000329A1 publication Critical patent/EA201000329A1/ru
Publication of EA017735B1 publication Critical patent/EA017735B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Настоящее изобретение относится к циклическим депсипептидам или их производным формулы (I) и их применению, например, в качестве ингибиторов калликреина 7 или эластазы нейтрофилов человека.
EA201000329A 2007-08-17 2008-08-14 Циклические депсипептиды EA017735B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114507 2007-08-17
PCT/EP2008/060689 WO2009024527A1 (en) 2007-08-17 2008-08-14 Cyclic depsipeptides

Publications (2)

Publication Number Publication Date
EA201000329A1 true EA201000329A1 (ru) 2010-08-30
EA017735B1 EA017735B1 (ru) 2013-02-28

Family

ID=38805728

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000329A EA017735B1 (ru) 2007-08-17 2008-08-14 Циклические депсипептиды

Country Status (30)

Country Link
US (2) US8178650B2 (ru)
EP (1) EP2183273B1 (ru)
JP (1) JP5520824B2 (ru)
KR (2) KR20120123579A (ru)
CN (1) CN103298827B (ru)
AR (1) AR068343A1 (ru)
AU (1) AU2008290567B2 (ru)
BR (1) BRPI0815547B8 (ru)
CA (1) CA2696570C (ru)
CL (1) CL2008002394A1 (ru)
CO (1) CO6260099A2 (ru)
CR (1) CR11251A (ru)
CU (2) CU23943B1 (ru)
EA (1) EA017735B1 (ru)
EC (1) ECSP109968A (ru)
ES (1) ES2632392T3 (ru)
GT (1) GT201000037A (ru)
MA (1) MA31701B1 (ru)
MX (1) MX2010001849A (ru)
MY (1) MY151973A (ru)
NZ (1) NZ583284A (ru)
PE (2) PE20091007A1 (ru)
PL (1) PL2183273T3 (ru)
PT (1) PT2183273T (ru)
SV (1) SV2010003485A (ru)
TN (1) TN2010000074A1 (ru)
TW (1) TW200922613A (ru)
UA (1) UA98658C2 (ru)
WO (1) WO2009024527A1 (ru)
ZA (1) ZA201000776B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2183273B1 (en) 2007-08-17 2017-04-05 Novartis AG Cyclic depsipeptides
ES2527298T3 (es) 2007-08-17 2015-01-22 Novartis Ag Uso de depsipéptidos cíclicos para inhibir calicreína 7
CN102369211B (zh) * 2009-02-13 2015-04-29 诺华股份有限公司 编码非核糖体肽合酶的生物合成簇的核酸分子及其用途
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en) * 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
DK3097084T3 (da) 2014-01-23 2020-12-21 Sixera Pharma Ab Nye kallikrein 7-hæmmere
WO2015114144A1 (en) * 2014-02-03 2015-08-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of netherton syndrome
CN106029684A (zh) 2014-04-08 2016-10-12 诺华股份有限公司 用于生产大环缩酚酸肽和新中间体的新型缩醛类方法
KR101729848B1 (ko) 2015-06-30 2017-04-24 영남대학교 산학협력단 신규한 해양 바실러스속 균주, 이로부터 분리한 화합물 및 상기 화합물의 약제학적 용도
CN106518880B (zh) * 2015-11-04 2018-10-19 衡阳师范学院 激肽释放酶7小分子抑制剂及其制备方法与用途
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

Family Cites Families (24)

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DE3043252C2 (de) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (de) * 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
JP2000154198A (ja) 1998-11-20 2000-06-06 Nisshin Flour Milling Co Ltd 環状デプシペプチドの固相合成方法及びその中間体
GB0108234D0 (en) 2001-04-02 2001-05-23 Pharma Mar Sa Process for producing trunkamide A compounds
US20040110228A1 (en) 2002-04-01 2004-06-10 Mcalpine Shelli R. Combinatorial organic synthesis of unique biologically active compounds
ATE459359T1 (de) 2003-06-06 2010-03-15 Arexis Ab Verwendung von kondensierten heterozyklischen verbindungen als scce-hemmern zur behandlung von hautzuständen
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
WO2005075667A1 (en) * 2004-02-03 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
WO2007101227A2 (en) * 2006-02-27 2007-09-07 Arizona Board Of Regents For And On Behalf Of Arizona State University Identification and use of novopeptides for the treatment of cancer
EP2183273B1 (en) 2007-08-17 2017-04-05 Novartis AG Cyclic depsipeptides
ES2527298T3 (es) 2007-08-17 2015-01-22 Novartis Ag Uso de depsipéptidos cíclicos para inhibir calicreína 7
US20110112121A1 (en) 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
US20120064013A1 (en) 2010-02-03 2012-03-15 David Marcos Foamable topical composition
KR101004362B1 (ko) 2010-03-19 2010-12-28 가톨릭대학교 산학협력단 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
KR20140003572A (ko) 2011-01-24 2014-01-09 안테리오스, 인코퍼레이티드 나노입자 조성물
KR20140005998A (ko) 2011-01-24 2014-01-15 안테리오스, 인코퍼레이티드 나노입자 조성물, 이의 제형, 및 그의 용도
US8614289B2 (en) 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
CA2696570C (en) 2020-12-29
BRPI0815547B8 (pt) 2021-05-25
TW200922613A (en) 2009-06-01
WO2009024527A1 (en) 2009-02-26
ZA201000776B (en) 2010-10-27
CU23943B1 (es) 2013-09-27
US20090156472A1 (en) 2009-06-18
AU2008290567A1 (en) 2009-02-26
PE20091007A1 (es) 2009-08-14
TN2010000074A1 (en) 2011-09-26
KR20120123579A (ko) 2012-11-08
CU20100032A7 (es) 2011-10-05
BRPI0815547A2 (pt) 2015-02-10
KR101227231B1 (ko) 2013-01-28
MY151973A (en) 2014-07-31
US9127044B2 (en) 2015-09-08
PE20141199A1 (es) 2014-09-24
CL2008002394A1 (es) 2009-05-15
EP2183273A1 (en) 2010-05-12
ES2632392T3 (es) 2017-09-12
EP2183273B1 (en) 2017-04-05
US20120196790A1 (en) 2012-08-02
AR068343A1 (es) 2009-11-11
MX2010001849A (es) 2010-03-10
CO6260099A2 (es) 2011-03-22
BRPI0815547B1 (pt) 2020-09-15
KR20100044893A (ko) 2010-04-30
MA31701B1 (fr) 2010-09-01
CU20130063A7 (es) 2013-06-28
PT2183273T (pt) 2017-05-22
PL2183273T3 (pl) 2017-09-29
US8178650B2 (en) 2012-05-15
CR11251A (es) 2010-03-08
JP2010536731A (ja) 2010-12-02
CN103298827A (zh) 2013-09-11
NZ583284A (en) 2012-04-27
JP5520824B2 (ja) 2014-06-11
ECSP109968A (es) 2010-03-31
CA2696570A1 (en) 2009-02-26
SV2010003485A (es) 2011-03-23
AU2008290567B2 (en) 2011-05-12
UA98658C2 (ru) 2012-06-11
EA017735B1 (ru) 2013-02-28
GT201000037A (es) 2012-04-30
CN103298827B (zh) 2017-05-31

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ