UA97639C2 - ОКТАГИДРОПИРОЛО[3,4-b]ПИРРОЛЬНЫЕ ПРОИЗВОДНЫЕ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ РЕЦЕПТОРОВ ГИСТАМИНА-3 - Google Patents
ОКТАГИДРОПИРОЛО[3,4-b]ПИРРОЛЬНЫЕ ПРОИЗВОДНЫЕ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ РЕЦЕПТОРОВ ГИСТАМИНА-3Info
- Publication number
- UA97639C2 UA97639C2 UAA200811465A UAA200811465A UA97639C2 UA 97639 C2 UA97639 C2 UA 97639C2 UA A200811465 A UAA200811465 A UA A200811465A UA A200811465 A UAA200811465 A UA A200811465A UA 97639 C2 UA97639 C2 UA 97639C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- ccycloalkyl
- alkoxy
- ris
- octahydro
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
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- Obesity (AREA)
- Hematology (AREA)
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- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Pregnancy & Childbirth (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
Abstract
Раскрыты октагидропирроло[3,4-b]пиррольные производные формулы I и II, пригодные для лечения состояний или расстройств, которые предотвращаются или облегчаются с помощью лигандов рецептора гистамина-3.Раскрыты октагидропирроло[3,4-b]пиррольные соединения, применение таких соединений, композиции, содержащие эти соединения, и способы получения таких соединений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77650906P | 2006-02-24 | 2006-02-24 | |
PCT/US2007/062329 WO2007100990A2 (en) | 2006-02-24 | 2007-02-16 | Octahydro-pyrrolo[3,4-b] pyrrole derivatives and their use as histamine-3 receptor ligands |
Publications (1)
Publication Number | Publication Date |
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UA97639C2 true UA97639C2 (ru) | 2012-03-12 |
Family
ID=38325247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200811465A UA97639C2 (ru) | 2006-02-24 | 2007-02-16 | ОКТАГИДРОПИРОЛО[3,4-b]ПИРРОЛЬНЫЕ ПРОИЗВОДНЫЕ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ РЕЦЕПТОРОВ ГИСТАМИНА-3 |
Country Status (21)
Country | Link |
---|---|
US (2) | US7728031B2 (ru) |
EP (1) | EP2001885A2 (ru) |
JP (1) | JP5463038B2 (ru) |
KR (2) | KR20140097612A (ru) |
CN (2) | CN101415709A (ru) |
AU (1) | AU2007220889B2 (ru) |
BR (1) | BRPI0708258A2 (ru) |
CA (1) | CA2641624A1 (ru) |
CR (2) | CR10287A (ru) |
EC (1) | ECSP088687A (ru) |
GT (1) | GT200800166A (ru) |
IL (1) | IL193270A0 (ru) |
MX (1) | MX2008010805A (ru) |
MY (2) | MY149513A (ru) |
NO (1) | NO20084056L (ru) |
NZ (2) | NZ595275A (ru) |
RU (1) | RU2492172C2 (ru) |
SG (2) | SG188878A1 (ru) |
TW (1) | TWI389910B (ru) |
UA (1) | UA97639C2 (ru) |
WO (1) | WO2007100990A2 (ru) |
Families Citing this family (23)
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EA015252B1 (ru) | 2005-05-10 | 2011-06-30 | Интермьюн, Инк. | Способ модуляции стресс-активированной протеинкиназной системы |
US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
CL2008001671A1 (es) | 2007-06-08 | 2009-07-17 | Janssen Pharmaceutica Nv | Compuestos derivados de piperidina/piperazina inhibidores de dgat1, composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades metabolicas especialmente diabetes. |
US8835437B2 (en) | 2007-06-08 | 2014-09-16 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
CA2687918C (en) | 2007-06-08 | 2016-11-08 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2188288A1 (en) * | 2007-09-11 | 2010-05-26 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole n-oxides |
MX2010005650A (es) * | 2007-11-21 | 2010-06-02 | Abbott Lab | Derivados de diazabicicloalcano substituidos con biarilo. |
US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
EP2296659B1 (en) | 2008-06-05 | 2016-12-21 | Janssen Pharmaceutica, N.V. | Drug combinations comprising a DGAT inhibitor and a PPAR-agonist |
WO2010135470A1 (en) * | 2009-05-19 | 2010-11-25 | Intermune, Inc. | Pifenidone derivatives for treating bronchial asthma |
US8252801B1 (en) | 2009-06-03 | 2012-08-28 | Abbott Laboratories | Treatment of schizophrenia and related disorders |
WO2011068926A1 (en) * | 2009-12-04 | 2011-06-09 | Tetralogic Pharmaceuticals Corp. | Iap inhibitors |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
CN110452216B (zh) | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
GB201416351D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Heterocyclic derivatives |
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