UA75647C2 - Mercaptoacetylamide derivatives, a process for their preparation, pharmaceutical composition based thereon and a process for preparation of intermediate compound - Google Patents

Mercaptoacetylamide derivatives, a process for their preparation, pharmaceutical composition based thereon and a process for preparation of intermediate compound Download PDF

Info

Publication number: UA75647C2
Authority: UA; Ukraine
Prior art keywords: aryl; alkyl; compound; formula; compound according
Prior art date: 2001-04-12

Application number

UA20031110184A

Other languages

English (en)

Ukrainian (uk)

Inventor

Garya Flynn

Roger Koehl

Ann Anderson

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-03-04

Publication date

2006-05-15

2002-03-04 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2002-04-03 Priority claimed from PCT/EP2002/003668 external-priority patent/WO2002083671A1/en

2006-05-15 Publication of UA75647C2 publication Critical patent/UA75647C2/uk

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 98
238000000034 method Methods 0.000 title claims abstract description 31
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 11
GYXHHICIFZSKKZ-UHFFFAOYSA-N 2-sulfanylacetamide Chemical class NC(=O)CS GYXHHICIFZSKKZ-UHFFFAOYSA-N 0.000 title abstract description 3
238000002360 preparation method Methods 0.000 title description 15
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206010007559 Cardiac failure congestive Diseases 0.000 claims abstract description 7
206010020772 Hypertension Diseases 0.000 claims abstract description 3
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims abstract 2
-1 methylenedioxy Chemical group 0.000 claims description 41
125000003118 aryl group Chemical group 0.000 claims description 34
239000001257 hydrogen Substances 0.000 claims description 23
229910052739 hydrogen Inorganic materials 0.000 claims description 23
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
PVQATPQSBYNMGE-UHFFFAOYSA-N [benzhydryloxy(phenyl)methyl]benzene Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)OC(C=1C=CC=CC=1)C1=CC=CC=C1 PVQATPQSBYNMGE-UHFFFAOYSA-N 0.000 claims description 12
238000006243 chemical reaction Methods 0.000 claims description 12
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UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims description 10
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125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 3
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VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 3
KOUKXHPPRFNWPP-UHFFFAOYSA-N pyrazine-2,5-dicarboxylic acid;hydrate Chemical compound O.OC(=O)C1=CN=C(C(O)=O)C=N1 KOUKXHPPRFNWPP-UHFFFAOYSA-N 0.000 description 3
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

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UA20031110184A 2001-04-12 2002-03-04 Mercaptoacetylamide derivatives, a process for their preparation, pharmaceutical composition based thereon and a process for preparation of intermediate compound UA75647C2 (en)

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US28330501P	2001-04-12	2001-04-12
PCT/EP2002/003668 WO2002083671A1 (en)	2001-04-12	2002-04-03	Mercaptoacetylamide derivatives, a process for their preparation and their use

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UA20031110184A UA75647C2 (en)	2001-04-12	2002-03-04	Mercaptoacetylamide derivatives, a process for their preparation, pharmaceutical composition based thereon and a process for preparation of intermediate compound

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US (1)	US6602866B2 (zh)
KR (1)	KR100910929B1 (zh)
AR (1)	AR034307A1 (zh)
CR (1)	CR7074A (zh)
DK (1)	DK1381605T3 (zh)
EC (1)	ECSP034782A (zh)
GB (1)	GB0119305D0 (zh)
GT (1)	GT200200069A (zh)
IL (1)	IL158289A (zh)
MY (1)	MY128226A (zh)
PE (1)	PE20021079A1 (zh)
RS (1)	RS50919B (zh)
TN (1)	TNSN03083A1 (zh)
TW (1)	TWI319764B (zh)
UA (1)	UA75647C2 (zh)
UY (1)	UY27255A1 (zh)
ZA (1)	ZA200307096B (zh)

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2001
- 2001-08-08 GB GBGB0119305.1A patent/GB0119305D0/en not_active Ceased
2002
- 2002-03-04 UA UA20031110184A patent/UA75647C2/uk unknown
- 2002-04-03 RS YUP-787/03A patent/RS50919B/sr unknown
- 2002-04-03 DK DK02732549T patent/DK1381605T3/da active
- 2002-04-03 KR KR1020037013181A patent/KR100910929B1/ko not_active IP Right Cessation
- 2002-04-08 US US10/118,179 patent/US6602866B2/en not_active Expired - Lifetime
- 2002-04-10 AR ARP020101321A patent/AR034307A1/es active IP Right Grant
- 2002-04-10 UY UY27255A patent/UY27255A1/es not_active Application Discontinuation
- 2002-04-10 MY MYPI20021326A patent/MY128226A/en unknown
- 2002-04-10 TW TW091107133A patent/TWI319764B/zh not_active IP Right Cessation
- 2002-04-10 PE PE2002000294A patent/PE20021079A1/es not_active Application Discontinuation
- 2002-04-10 GT GT200200069A patent/GT200200069A/es unknown
2003
- 2003-07-08 TN TNPCT/EP2002/003668A patent/TNSN03083A1/en unknown
- 2003-09-11 ZA ZA200307096A patent/ZA200307096B/en unknown
- 2003-09-12 CR CR7074A patent/CR7074A/es not_active Application Discontinuation
- 2003-09-26 EC EC2003004782A patent/ECSP034782A/es unknown
- 2003-10-07 IL IL158289A patent/IL158289A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6602866B2 (en)	2003-08-05
UY27255A1 (es)	2002-07-31
GB0119305D0 (en)	2001-10-03
MY128226A (en)	2007-01-31
DK1381605T3 (da)	2005-05-09
ZA200307096B (en)	2004-09-06
TNSN03083A1 (en)	2005-12-23
RS50919B (sr)	2010-08-31
KR20040008153A (ko)	2004-01-28
IL158289A (en)	2010-11-30
US20020193589A1 (en)	2002-12-19
CR7074A (es)	2007-12-04
GT200200069A (es)	2002-12-17
ECSP034782A (es)	2003-12-01
PE20021079A1 (es)	2003-02-19
KR100910929B1 (ko)	2009-08-06
TWI319764B (en)	2010-01-21
AR034307A1 (es)	2004-02-18
YU78703A (sh)	2006-05-25

Publication	Publication Date	Title
UA75647C2 (en)	2006-05-15	Mercaptoacetylamide derivatives, a process for their preparation, pharmaceutical composition based thereon and a process for preparation of intermediate compound
DE69333062T2 (de)	2004-05-06	4-mercaptoacetylamino-[2]benzazepinon(3)- derivate, und verwendung als enkephalinase-inhibitoren
KR100271239B1 (ko)	2001-02-01	엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 2-치환인단-2-메르캅토아세틸아미드 유도체
EP0481522B1 (en)	1997-12-29	Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
KR0128158B1 (ko)	1998-04-04	설프하이드릴 함유 트리사이클릭 락탐 및 이의 중간체
CA2183315C (en)	1999-08-31	Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
KR100220879B1 (ko)	2000-03-15	안지오텐신 전환 효소 억제제로서 유용한 신규 아미노 및 니트로 함유 트리시클릭 화합물
EP0031741A1 (fr)	1981-07-08	Nouveaux iminoacides substitués, leurs procédés de préparation et leur emploi comme inhibiteurs d'enzymes
IE56230B1 (en)	1991-05-22	New derivatives of tricyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
RU2286346C2 (ru)	2006-10-27	Производные меркаптоацетиламида, способ их получения, фармацевтическая композиция на их основе, способ ее получения и способ лечения сердечно-сосудистого болезненного состояния
AU2002304804A1 (en)	2003-04-10	Mercaptoacetylamide derivatives, a process for their preparation and their use
JP3310687B2 (ja)	2002-08-05	キノン誘導体
US5491143A (en)	1996-02-13	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
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WO2012105573A1 (ja)	2012-08-09	環状スルホニウム塩、その製造方法およびそれを用いたα－グルコシダーゼ阻害剤