UA49838C2 - Спосіб оптичного очищення похідних бензимідазолу, що мають багато енантіомерних форм - Google Patents

Спосіб оптичного очищення похідних бензимідазолу, що мають багато енантіомерних форм

Info

Publication number
UA49838C2
UA49838C2 UA97126300A UA97126300A UA49838C2 UA 49838 C2 UA49838 C2 UA 49838C2 UA 97126300 A UA97126300 A UA 97126300A UA 97126300 A UA97126300 A UA 97126300A UA 49838 C2 UA49838 C2 UA 49838C2
Authority
UA
Ukraine
Prior art keywords
benzimidazole derivatives
optical purification
enantiomers
many
many enantiomers
Prior art date
Application number
UA97126300A
Other languages
English (en)
Russian (ru)
Inventor
УНГЕ Сверкер Вон
Original Assignee
Астразенека Аб
Астра АБ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20397468&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA49838(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб, Астра АБ filed Critical Астразенека Аб
Publication of UA49838C2 publication Critical patent/UA49838C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Спосіб оптичного очищення одиночних енантіомерів деяких похідних 2-сульфініл-1Н-бензимідазолу і іншого структурно спорідненого сульфоксиду з відповідного енантіомерно збагаченого препарату.
UA97126300A 1995-07-03 1996-06-26 Спосіб оптичного очищення похідних бензимідазолу, що мають багато енантіомерних форм UA49838C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9500817 1995-07-03
PCT/SE1996/000841 WO1997002261A1 (en) 1995-07-03 1996-06-26 A process for the optical purification of enantiomerically enriched benzimidazole derivatives

Publications (1)

Publication Number Publication Date
UA49838C2 true UA49838C2 (uk) 2002-10-15

Family

ID=20397468

Family Applications (1)

Application Number Title Priority Date Filing Date
UA97126300A UA49838C2 (uk) 1995-07-03 1996-06-26 Спосіб оптичного очищення похідних бензимідазолу, що мають багато енантіомерних форм

Country Status (37)

Country Link
US (1) US5929244A (uk)
EP (2) EP0836601B1 (uk)
JP (1) JP4195507B2 (uk)
KR (1) KR100451078B1 (uk)
CN (1) CN1098261C (uk)
AT (1) ATE418549T1 (uk)
AU (1) AU698638B2 (uk)
BR (1) BR9609450A (uk)
CA (1) CA2226184C (uk)
CZ (1) CZ295430B6 (uk)
DE (1) DE69637788D1 (uk)
DK (1) DK0836601T3 (uk)
DZ (1) DZ2057A1 (uk)
EE (1) EE03444B1 (uk)
ES (1) ES2318850T3 (uk)
HK (1) HK1010193A1 (uk)
HR (1) HRP960232A2 (uk)
HU (1) HUP9901717A3 (uk)
IL (1) IL122811A (uk)
IS (1) IS2666B (uk)
MA (1) MA23921A1 (uk)
MY (1) MY114018A (uk)
NO (1) NO313008B1 (uk)
NZ (1) NZ311842A (uk)
PL (1) PL186702B1 (uk)
PT (1) PT836601E (uk)
RS (1) RS49826B (uk)
RU (1) RU2144031C1 (uk)
SA (1) SA96170103B1 (uk)
SI (1) SI0836601T1 (uk)
SK (1) SK284780B6 (uk)
TN (1) TNSN96090A1 (uk)
TR (1) TR199701754T1 (uk)
TW (1) TW444010B (uk)
UA (1) UA49838C2 (uk)
WO (1) WO1997002261A1 (uk)
ZA (1) ZA965205B (uk)

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HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
EP0983263A1 (en) * 1997-05-30 2000-03-08 Dr. Reddy's Research Foundation Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
EP1056456A4 (en) * 1998-01-30 2006-10-25 Sepracor Inc R-LANSOPRAZOL COMPOSITIONS AND TREATMENTS THEREFOR
SE9900274D0 (sv) 1999-01-28 1999-01-28 Astra Ab New compound
TWI289557B (en) 1999-06-17 2007-11-11 Takeda Chemical Industries Ltd A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
PT1191025E (pt) 1999-06-30 2005-09-30 Takeda Pharmaceutical Cristais de lansoprazol
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
ES2521690T3 (es) * 2000-05-15 2014-11-13 Takeda Pharmaceutical Company Limited Procedimiento para producir un cristal de (R)-2-[[[3-metil-4-(2,2,2-trifluoroetoxi)-2-piridil]metil]sulfinil]-bencimidazol
US7271182B2 (en) 2000-08-04 2007-09-18 Takeda Pharmaceutical Company Limited Salts of benzimidazole compound and use thereof
PT1337525E (pt) 2000-12-01 2011-09-01 Takeda Pharmaceutical Processo para a cristalização de (r)- ou (s)-lansoprazole
KR100433735B1 (ko) * 2001-06-27 2004-06-04 주식회사 씨트리 결정형 ⅰ을 갖는 란소프라졸의 제조방법
SE0104295D0 (sv) * 2001-12-18 2001-12-18 Astrazeneca Ab New process
JP2005521662A (ja) * 2002-01-25 2005-07-21 サンタラス インコーポレイティッド プロトンポンプ阻害剤の経粘膜送達
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
EP2596792A1 (en) 2002-10-16 2013-05-29 Takeda Pharmaceutical Company Limited Stable solid preparations
DE10254167A1 (de) 2002-11-20 2004-06-09 Icon Genetics Ag Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen
BRPI0310118B1 (pt) 2002-12-06 2015-10-20 Altana Pharma Ag processo para a preparação de inibidores de bomba de próton (ppi) opticamente puro possuindo uma estrutura de sulfinila
KR101169471B1 (ko) 2002-12-06 2012-07-30 니코메드 게엠베하 (ｓ)-판토프라졸의 제조 방법
JP2006518751A (ja) * 2003-02-20 2006-08-17 サンタラス インコーポレイティッド 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物
EP1606279A1 (en) * 2003-02-28 2005-12-21 Ranbaxy Laboratories, Ltd. Polymorphs of s-omeprazole
US20050031700A1 (en) * 2003-07-18 2005-02-10 Sanatarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US7005732B2 (en) * 2003-10-21 2006-02-28 Honeywell International Inc. Methods and systems for providing MEMS devices with a top cap and upper sense plate
FR2863609A1 (fr) * 2003-12-15 2005-06-17 Isochem Sa Procede d'enrichissement enantiomerique d'un melange d'enantiomeres d'alpha-aminoacides
SE0400410D0 (sv) * 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1768668A2 (en) 2004-06-16 2007-04-04 Tap Pharmaceutical Products, Inc. Multiple ppi dosage form
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
US7553857B2 (en) 2005-12-23 2009-06-30 Lek Pharmaceuticals D.D. S-omeprazole magnesium
US7786309B2 (en) * 2006-06-09 2010-08-31 Apotex Pharmachem Inc. Process for the preparation of esomeprazole and salts thereof
FR2909380B1 (fr) * 2006-12-04 2009-02-20 Sidem Pharma Sa Sa Conglomerats de sels de potassium de tenatoprazole
EP1947099A1 (en) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Process for solvent removal from omeprazole salts
CN101323609B (zh) * 2007-06-15 2013-05-01 成都福瑞生物工程有限公司 不对称氧化硫醚成亚砜合成对映体含量高的苯并咪唑衍生物的方法
BRPI0813191B1 (pt) * 2007-06-15 2021-09-08 Emcure Pharmaceuticals Limited Processo de sulfoxidação de compostos biologicamente ativos
FR2920428B1 (fr) * 2007-08-29 2012-06-15 Univ Rouen Procede de dedoublement de sels de l'omeprazole
PT2262790T (pt) 2008-03-10 2017-07-18 Takeda Pharmaceuticals Co Cristal de composto de benzimidazole
WO2010058409A2 (en) 2008-11-18 2010-05-27 Hetero Research Foundation Optical purification of esomeprazole
KR101001646B1 (ko) * 2008-12-12 2010-12-17 한미약품 주식회사 (ｒ)-(+)-란소프라졸의 제조방법 및 이에 사용되는 중간체
WO2011004387A2 (en) 2009-06-18 2011-01-13 Matrix Laboratories Ltd Process for the preparation of dexlansoprazole polymorphic forms
EP2499125B1 (en) 2009-11-12 2016-01-27 Hetero Research Foundation Process for the resolution of omeprazole
CA2788147A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited Process for the preparation of crystalline forms of dexlansoprazole
DK3176164T3 (da) 2014-07-30 2019-10-28 Aetas Pharma Co Ltd Optisk isomer af 1,4-benzothiazepin-1-oxidderivat og farmaceutisk sammensætning fremstillet ved anvendelse deraf
ES2615637T3 (es) * 2015-03-06 2017-06-07 F.I.S.- Fabbrica Italiana Sintetici S.P.A. Procedimiento mejorado para la purificación óptica del esomeprazol

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SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
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FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
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HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds

Also Published As

Publication number Publication date
IS2666B (is) 2010-08-15
HUP9901717A2 (hu) 2000-04-28
EE9700368A (et) 1998-06-15
RU2144031C1 (ru) 2000-01-10
CZ421197A3 (cs) 1998-06-17
MX9800160A (es) 1998-03-31
PL186702B1 (pl) 2004-02-27
MY114018A (en) 2002-07-31
EP1498416A1 (en) 2005-01-19
CA2226184A1 (en) 1997-01-23
HRP960232A2 (en) 1998-02-28
SI0836601T1 (sl) 2009-04-30
HK1010193A1 (en) 1999-06-17
CZ295430B6 (cs) 2005-08-17
ES2318850T3 (es) 2009-05-01
EP0836601B1 (en) 2008-12-24
EE03444B1 (et) 2001-06-15
NO976030L (no) 1998-02-09
JPH11508590A (ja) 1999-07-27
US5929244A (en) 1999-07-27
WO1997002261A1 (en) 1997-01-23
ATE418549T1 (de) 2009-01-15
SK179397A3 (en) 1998-09-09
TW444010B (en) 2001-07-01
DZ2057A1 (fr) 2002-10-20
PL324394A1 (en) 1998-05-25
CN1193971A (zh) 1998-09-23
NO976030D0 (no) 1997-12-22
SA96170103B1 (ar) 2006-07-30
AU6324096A (en) 1997-02-05
CA2226184C (en) 2008-08-05
HUP9901717A3 (en) 2002-03-28
PT836601E (pt) 2009-02-17
YU37696A (sh) 1999-03-04
TR199701754T1 (xx) 1998-04-21
SK284780B6 (sk) 2005-11-03
BR9609450A (pt) 1999-03-02
CN1098261C (zh) 2003-01-08
NO313008B1 (no) 2002-07-29
IS4638A (is) 1997-12-22
JP4195507B2 (ja) 2008-12-10
DE69637788D1 (de) 2009-02-05
TNSN96090A1 (fr) 2005-03-15
EP0836601A1 (en) 1998-04-22
IL122811A (en) 2000-11-21
ZA965205B (en) 1997-01-03
KR19990028631A (ko) 1999-04-15
NZ311842A (en) 1998-12-23
AU698638B2 (en) 1998-11-05
IL122811A0 (en) 1998-08-16
MA23921A1 (fr) 1996-12-31
DK0836601T3 (da) 2009-03-16
RS49826B (sr) 2008-08-07
KR100451078B1 (ko) 2004-11-16

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