UA112565C2 - Біциклічні похідні дигідроізохінолін-1-ону - Google Patents
Біциклічні похідні дигідроізохінолін-1-онуInfo
- Publication number
- UA112565C2 UA112565C2 UAA201407120A UAA201407120A UA112565C2 UA 112565 C2 UA112565 C2 UA 112565C2 UA A201407120 A UAA201407120 A UA A201407120A UA A201407120 A UAA201407120 A UA A201407120A UA 112565 C2 UA112565 C2 UA 112565C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- dihydroisoquinoline
- bicyclic derivatives
- cyp11b1
- cyp11b2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
У винаході запропоновані нові сполуки, що мають загальну формулу (І), (I)у яких R, R, R, R, R, R, А, А, А, А, Ата n є такими, як визначено в даному винаході, композиції, що містять ці сполуки, та способи застосування цих сполук як інгібіторів альдостеронсинтази (CYP11B2 або CYP11B1) для лікування або профілактики хронічного захворювання нирок, застійної серцевої недостатності, гіпертензії, первинного гіперальдостеронізму та синдрому Кушинга.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011083229 | 2011-11-30 | ||
| PCT/EP2012/073653 WO2013079452A1 (en) | 2011-11-30 | 2012-11-27 | New bicyclic dihydroisoquinoline-1-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA112565C2 true UA112565C2 (uk) | 2016-09-26 |
Family
ID=47297189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201407120A UA112565C2 (uk) | 2011-11-30 | 2012-11-27 | Біциклічні похідні дигідроізохінолін-1-ону |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9133158B2 (uk) |
| EP (2) | EP2785695B1 (uk) |
| JP (1) | JP6382108B2 (uk) |
| KR (1) | KR102089927B1 (uk) |
| AR (1) | AR088989A1 (uk) |
| AU (1) | AU2012344041B2 (uk) |
| BR (1) | BR112014013136B1 (uk) |
| CA (1) | CA2850700C (uk) |
| CL (1) | CL2014001389A1 (uk) |
| CO (1) | CO6920296A2 (uk) |
| CR (1) | CR20140229A (uk) |
| DK (1) | DK2785695T3 (uk) |
| EA (1) | EA035454B1 (uk) |
| ES (1) | ES2811806T3 (uk) |
| HR (1) | HRP20201277T1 (uk) |
| HU (1) | HUE050431T2 (uk) |
| IL (1) | IL232570B (uk) |
| LT (1) | LT2785695T (uk) |
| MA (1) | MA35664B1 (uk) |
| MX (1) | MX350717B (uk) |
| MY (1) | MY178867A (uk) |
| PE (1) | PE20141283A1 (uk) |
| PH (1) | PH12014501179A1 (uk) |
| PL (1) | PL2785695T3 (uk) |
| PT (1) | PT2785695T (uk) |
| RS (1) | RS60660B1 (uk) |
| SG (1) | SG11201402199QA (uk) |
| SI (1) | SI2785695T1 (uk) |
| TW (1) | TWI583678B (uk) |
| UA (1) | UA112565C2 (uk) |
| WO (1) | WO2013079452A1 (uk) |
| ZA (1) | ZA201402908B (uk) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR092742A1 (es) * | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP2989082A1 (en) * | 2013-04-23 | 2016-03-02 | LEK Pharmaceuticals d.d. | Novel synthetic process to 8-chloro-1-methyl-benzo[d]azepine, novel intermediates and the production thereof |
| EP2997032B1 (en) * | 2013-05-17 | 2018-07-25 | F.Hoffmann-La Roche Ag | 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| RU2689421C2 (ru) * | 2013-05-27 | 2019-05-28 | Ф.Хоффманн-Ля Рош Аг | Новые 3,4-дигидро-2н-изохинолин-1-оны и 2,3-дигидро-изоиндол-1-оны |
| MY176401A (en) | 2014-04-24 | 2020-08-05 | Mitsubishi Tanabe Pharma Corp | Novel disubstituted 1,2,4-triazine compound |
| CN106852142B (zh) | 2014-10-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 作为醛固酮合酶抑制剂的螺二胺衍生物 |
| ES2724555T3 (es) * | 2014-10-15 | 2019-09-12 | Boehringer Ingelheim Int | Inhibidores de la aldosterona sintasa |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| WO2016089800A1 (en) * | 2014-12-02 | 2016-06-09 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
| JP6314196B2 (ja) * | 2015-10-22 | 2018-04-18 | 田辺三菱製薬株式会社 | 医薬組成物 |
| JP6545275B2 (ja) * | 2015-10-23 | 2019-07-17 | 田辺三菱製薬株式会社 | 新規含窒素芳香族複素環化合物 |
| CA3228632A1 (en) | 2015-12-24 | 2017-06-29 | Kyowa Kirin Co., Ltd. | .alpha.,.beta.-unsaturated amide compound |
| WO2018049324A1 (en) * | 2016-09-12 | 2018-03-15 | Numerate, Inc. | Monocyclic compounds useful as gpr120 modulators |
| EP3509588B1 (en) | 2016-09-12 | 2023-06-07 | Integral Health,Inc. | Bicyclic compounds useful as gpr120 modulators |
| WO2018133865A1 (zh) * | 2017-01-22 | 2018-07-26 | 福建广生堂药业股份有限公司 | Ask1抑制剂及其制备方法和应用 |
| KR20200019979A (ko) | 2017-06-23 | 2020-02-25 | 쿄와 기린 가부시키가이샤 | α, β 불포화 아미드 화합물 |
| EP3655392A1 (en) | 2017-07-17 | 2020-05-27 | Abbvie Deutschland GmbH & Co. KG | 1,2,3,4-substituted quinoline compounds as s1p modulators |
| CN109810171B (zh) * | 2017-11-21 | 2020-12-01 | 首都医科大学 | 二氢异喹啉-3-甲酰-LARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
| US11434249B1 (en) | 2018-01-02 | 2022-09-06 | Seal Rock Therapeutics, Inc. | ASK1 inhibitor compounds and uses thereof |
| CA3115900A1 (en) * | 2018-06-26 | 2020-01-02 | Zhejiang Vimgreen Pharmaceuticals, Ltd | Triazolotriazine derivatives as a2a receptor antagonists |
| WO2020223267A1 (en) | 2019-05-01 | 2020-11-05 | Boehringer Ingelheim International Gmbh | (r)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate |
| WO2021224818A1 (en) * | 2020-05-08 | 2021-11-11 | Pfizer Inc. | Isoindolone compounds as hpk1 inhibitors |
| WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| WO2024061371A1 (zh) * | 2022-09-23 | 2024-03-28 | 广州威诺森医药科技有限公司 | 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT79699B (en) | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| ES2338534T3 (es) * | 2001-02-27 | 2010-05-10 | The Governement Of The Usa, Represented By The Secretary Department Of Health And Human Services | Analogos de talidomina como inhibidores de la angiogenesis. |
| AU2007234968A1 (en) * | 2006-03-29 | 2007-10-18 | Novartis Ag | Organic compounds |
| JP5241834B2 (ja) * | 2007-07-19 | 2013-07-17 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼ阻害剤としての複素環アミド化合物 |
| TW200918062A (en) * | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| CA2761858A1 (en) * | 2009-05-15 | 2010-11-18 | Novartis Ag | 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or cyp11b1 |
| WO2012035078A1 (en) * | 2010-09-16 | 2012-03-22 | Novartis Ag | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS |
-
2012
- 2012-11-27 JP JP2014543854A patent/JP6382108B2/ja active Active
- 2012-11-27 AR ARP120104439A patent/AR088989A1/es active IP Right Grant
- 2012-11-27 PL PL12797817T patent/PL2785695T3/pl unknown
- 2012-11-27 AU AU2012344041A patent/AU2012344041B2/en not_active Ceased
- 2012-11-27 EP EP12797817.9A patent/EP2785695B1/en active Active
- 2012-11-27 ES ES12797817T patent/ES2811806T3/es active Active
- 2012-11-27 PT PT127978179T patent/PT2785695T/pt unknown
- 2012-11-27 MY MYPI2014701399A patent/MY178867A/en unknown
- 2012-11-27 MX MX2014005833A patent/MX350717B/es active IP Right Grant
- 2012-11-27 HU HUE12797817A patent/HUE050431T2/hu unknown
- 2012-11-27 KR KR1020147018023A patent/KR102089927B1/ko active IP Right Grant
- 2012-11-27 LT LTEP12797817.9T patent/LT2785695T/lt unknown
- 2012-11-27 CA CA2850700A patent/CA2850700C/en active Active
- 2012-11-27 PE PE2014000766A patent/PE20141283A1/es active IP Right Grant
- 2012-11-27 RS RS20200979A patent/RS60660B1/sr unknown
- 2012-11-27 WO PCT/EP2012/073653 patent/WO2013079452A1/en active Application Filing
- 2012-11-27 SI SI201231822T patent/SI2785695T1/sl unknown
- 2012-11-27 EP EP19187075.7A patent/EP3587401A1/en active Pending
- 2012-11-27 SG SG11201402199QA patent/SG11201402199QA/en unknown
- 2012-11-27 BR BR112014013136-8A patent/BR112014013136B1/pt active IP Right Grant
- 2012-11-27 EA EA201491018A patent/EA035454B1/ru not_active IP Right Cessation
- 2012-11-27 UA UAA201407120A patent/UA112565C2/uk unknown
- 2012-11-27 DK DK12797817.9T patent/DK2785695T3/da active
- 2012-11-29 US US13/688,373 patent/US9133158B2/en active Active
- 2012-11-29 TW TW101144851A patent/TWI583678B/zh active
-
2014
- 2014-03-31 CO CO14068498A patent/CO6920296A2/es active IP Right Grant
- 2014-04-22 ZA ZA2014/02908A patent/ZA201402908B/en unknown
- 2014-05-12 IL IL232570A patent/IL232570B/en active IP Right Grant
- 2014-05-15 CR CR20140229A patent/CR20140229A/es unknown
- 2014-05-26 PH PH12014501179A patent/PH12014501179A1/en unknown
- 2014-05-27 CL CL2014001389A patent/CL2014001389A1/es unknown
- 2014-05-27 MA MA37074A patent/MA35664B1/fr unknown
-
2020
- 2020-08-13 HR HRP20201277TT patent/HRP20201277T1/hr unknown
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