UA104746C2 - Замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина как модуляторы гамма-секретазы - Google Patents

Замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина как модуляторы гамма-секретазы

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Publication number
UA104746C2
UA104746C2 UAA201108570A UAA201108570A UA104746C2 UA 104746 C2 UA104746 C2 UA 104746C2 UA A201108570 A UAA201108570 A UA A201108570A UA A201108570 A UAA201108570 A UA A201108570A UA 104746 C2 UA104746 C2 UA 104746C2
Authority
UA
Ukraine
Prior art keywords
oxazolopyridine
benzimidazole
gamma secretase
secretase modulators
imidazopyridine derivatives
Prior art date
Application number
UAA201108570A
Other languages
English (en)
Ukrainian (uk)
Inventor
Хенрікус Якобус Марія Гійсен
Франсуа Пол Бішофф
Вей Жуанг
Брандт Свен Францискус Анна Ван
Мішель Суркін
Мірко Зайя
Дідьє Жан-Клод Бертело
Клейн Мішель Анна Жозеф де
Грегор Джеймс Макдональд
Даніель Ульріх
Original Assignee
Янссен Фармасьютикелз, Инк
Селлзом Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармасьютикелз, Инк, Селлзом Лимитед filed Critical Янссен Фармасьютикелз, Инк
Priority claimed from PCT/EP2010/051843 external-priority patent/WO2010094647A1/en
Publication of UA104746C2 publication Critical patent/UA104746C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Данное изобретение касается новых замещенных производных бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина формулы (I), где R1, R2, R3, R4, X, А1, A2, A3, A4, Y1, Y2, Y3 и Z имеют указанные в формуле изобретения значения. Соединения, согласно данному изобретению, пригодны как модуляторы гамма-секретазы. Изобретение также касается способов получения таких новых соединений, фармацевтических композиций, содержащих указанные соединения в качестве активного ингредиента, а также применения указанных соединений как лекарственных средств. EMBED ISISServer (I)
UAA201108570A 2009-02-19 2010-02-15 Замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина как модуляторы гамма-секретазы UA104746C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09153188 2009-02-19
PCT/EP2010/051843 WO2010094647A1 (en) 2009-02-19 2010-02-15 Novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
UA104746C2 true UA104746C2 (ru) 2014-03-11

Family

ID=40688503

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201108570A UA104746C2 (ru) 2009-02-19 2010-02-15 Замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина как модуляторы гамма-секретазы

Country Status (1)

Country Link
UA (1) UA104746C2 (ru)

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