TWI618546B

TWI618546B - Emulsified composition

Info

Publication number: TWI618546B
Application number: TW101111543A
Authority: TW
Inventors: Yuko Kishimoto; Koji Okubo; Koji Yokoyama
Original assignee: Kao Corp
Priority date: 2011-03-31
Filing date: 2012-03-30
Publication date: 2018-03-21
Also published as: JP5941732B2; TW201244752A; JP2012214469A; CN102727392A

Abstract

本發明之乳化組合物之製造方法於步驟1後包括步驟2，步驟1係使含有如下成分(A)、(B)、(C)、(D)及(F1)之水相I混合、乳化並進行冷卻：(A)如下通式(1)所表示之化合物0.001~10質量% (Z¹為甘油、山梨糖醇酐、山梨糖醇或蔗糖殘基之具有2個以上羥基之結構，Y¹為酯鍵基或醚鍵基，R為C14~22之烴基，n為1~4之數)、(B)選自C14~22之高級醇及固醇類中的1種以上之化合物0.001~10質量%、(C)通式(2)所表示之化合物0.001~15質量% (R¹為C4~30之烴基；Z為亞甲基、次甲基或O；X¹、X²及X³為H、OH或乙醯氧基，X⁴為H、乙醯基或甘油基；R²及R³為H、OH、羥基甲基或乙醯氧甲基；R⁴為C5~60之烴基；R⁵為H、C1~30之烴基)、(D)陰離子界面活性劑0.00025~10質量%、以及(F1)水；步驟2係進而混合含有如下成分之水相II：(E)選自烷基改性聚丙烯酸系乙烯聚合物及烷基改性多糖類系聚合物中之水溶性高分子0.001~6質量%、以及(F2)水。 The method for producing an emulsified composition of the present invention comprises, after the step 1, a step 2 of mixing and emulsifying the aqueous phase I containing the following components (A), (B), (C), (D) and (F1). And cooling: (A) 0.001 to 10% by mass of the compound represented by the following formula (1) (Z ¹ is a structure having two or more hydroxyl groups of glycerin, sorbitan, sorbitol or sucrose residue, Y ¹ is an ester bond or an ether bond, R is a hydrocarbon group of C14-22, and n is 1~ (4) 0.001 to 10% by mass of (C) one or more compounds selected from the group consisting of higher alcohols and sterols of C14-22, and (C) 0.001 to 15% by mass of the compound represented by the formula (2) (R ¹ is a hydrocarbon group of C4~30; Z is a methylene group, methine group or O; X ¹ , X ² and X ³ are H, OH or ethoxylated groups, and X ⁴ is H, ethyl hydrazine or glycerol R ² and R ³ are H, OH, hydroxymethyl or acetoxymethyl; R ⁴ is a C5-60 hydrocarbon group; R ⁵ is H, C1~30 hydrocarbon group), (D) anionic surfactant 0.00025~10% by mass, and (F1) water; Step 2 further mixes the aqueous phase II containing the following components: (E) is selected from the group consisting of alkyl modified polyacrylic ethylene polymers and alkyl modified polysaccharide polymers The water-soluble polymer in the range is 0.001 to 6% by mass, and (F2) water.

Description

乳化組合物 Emulsified composition

本發明係關於一種乳化組合物。 This invention relates to an emulsified composition.

於皮膚最外層之角質層中存在角質層質細胞及填充其間隙之細胞間脂質。其大部分形成有α-凝膠結構，對皮膚具有如下功能：抑制來自外部之物質之滲入、來自內部之水分蒸發，同時自身保持水分，藉此保持皮膚之柔軟性或光滑之外觀。 There are keratinocytes in the stratum corneum of the outermost layer of the skin and intercellular lipids filling the gap. Most of them are formed with an α-gel structure, and have the following functions on the skin: inhibiting penetration of substances from the outside, evaporation of moisture from the inside, and maintaining moisture by itself, thereby maintaining the softness or smooth appearance of the skin.

通常已知由細胞間脂質、尤其是腦醯胺之減少而引起欠佳之肌膚狀態，可認為外用補充腦醯胺與改善肌膚之功能下降有關。 It is generally known that the skin condition caused by the decrease in intercellular lipids, particularly ceramide, is poor, and it can be considered that topical supplementation of ceramide is associated with a decrease in the function of the skin.

然而，由於腦醯胺熔點高且結晶性較高，難以調配於外用劑等中，故而正對穩定調配進行各種研究。 However, since ceramide has a high melting point and high crystallinity, it is difficult to prepare it in an external preparation or the like, and various studies have been conducted on stable formulation.

例如於專利文獻1中記載有：將腦醯胺類、甘油單脂肪酸酯、及高級醇以特定比例組合而成之乳化組合物可抑制腦醯胺之結晶析出，形成容易保持水分之α-凝膠結構，保濕效果較高。 For example, Patent Document 1 discloses that an emulsified composition obtained by combining ceramide, a monoglyceride, and a higher alcohol in a specific ratio suppresses crystal precipitation of ceramide, and forms α which is easy to retain moisture. The gel structure has a high moisturizing effect.

又，亦研究有：藉由進而組合特定之糖醇或者二糖或三糖，可進一步提高α-凝膠之水分保持能力，使水分長時間殘留於皮膚上，而改善皮膚之狀態(專利文獻2、專利文獻3)。 Further, it has been studied to further improve the moisture retention ability of the α-gel by further combining a specific sugar alcohol or a disaccharide or a trisaccharide, so that the moisture remains on the skin for a long period of time, and the state of the skin is improved (Patent Literature) 2. Patent Document 3).

然而，該等組合物雖形成α-凝膠結構，但黏度低而難以塗佈於皮膚上，因此即便形成具有保濕效果之皮膜，該皮膜亦較為脆弱，無法均勻地覆蓋肌膚，難以發揮充分之水分保持能力。 However, although these compositions form an α-gel structure, they have a low viscosity and are difficult to apply to the skin, so even if a film having a moisturizing effect is formed, the skin The film is also fragile and does not cover the skin evenly, making it difficult to maintain adequate moisture retention.

又，由於皮膜欠缺柔軟性及彈性，故而塗佈後之肌膚上存在特有之摩擦感、粗糙感，無法獲得良好之使用觸感。進而，亦存在如下問題：塗佈後之外觀欠缺光滑度，無法獲得提高肌膚外觀之效果。 Further, since the film lacks flexibility and elasticity, the skin after application has a unique rubbing feeling and a rough feeling, and a good feeling of use cannot be obtained. Further, there is also a problem that the appearance after application lacks smoothness, and the effect of improving the appearance of the skin cannot be obtained.

[先前技術文獻] [Previous Technical Literature] [專利文獻] [Patent Literature]

[專利文獻1]日本專利特開2007-22997號公報 [Patent Document 1] Japanese Patent Laid-Open Publication No. 2007-22997

[專利文獻2]日本專利特開2011-32265號公報 [Patent Document 2] Japanese Patent Laid-Open Publication No. 2011-32265

[專利文獻3]日本專利特開2011-32266號公報 [Patent Document 3] Japanese Patent Laid-Open Publication No. 2011-32266

本發明提供一種乳化組合物之製造方法，其於步驟1後包括步驟2，步驟1係使含有如下成分(A)、(B)、(C)、(D)及(F1)之水相I混合、乳化並進行冷卻：(A)如下通式(1)所表示之化合物0.001~10質量% (式中，Z¹表示甘油、山梨糖醇酐、山梨糖醇或蔗糖殘基之具有2個以上羥基之結構，Y¹表示酯鍵基或醚鍵基，R表示碳數14~22之烴基，n表示1~4之數)、(B)選自碳數14~22之高級醇及固醇類中的1種以上之化合物0.001~10質量%、 (C)通式(2)所表示之化合物0.001~15質量% (式中，R¹表示可經羥基、羰基或胺基取代之碳數4~30之直鏈、支鏈或環狀之飽和或不飽和烴基；Z表示亞甲基、次甲基或氧原子；X¹、X²及X³各自獨立表示氫原子、羥基或乙醯氧基，X⁴表示氫原子、乙醯基或甘油基，或者與鄰接之氧原子一起形成側氧基(但，Z為次甲基時，X¹與X²之任一者為氫原子，另一者不存在。X⁴形成側氧基時，X³不存在)；R²及R³各自獨立表示氫原子、羥基、羥基甲基或乙醯氧甲基；R⁴表示可經羥基、羰基或胺基取代且可於主鏈上具有醚鍵、酯鍵或醯胺鍵之碳數5~60之直鏈、支鏈或環狀之飽和或不飽和烴基；R⁵表示氫原子，或者表示可具有選自羥基、羥基烷氧基、烷氧基及乙醯氧基中之取代基的總碳數1~30之直鏈或支鏈之飽和或不飽和烴基；虛線部表示可為不飽和鍵)、(D)陰離子界面活性劑0.00025~10質量%、(F1)水；步驟2係進而混合含有如下成分之水相II：(E)選自烷基改性聚丙烯酸系乙烯聚合物及烷基改性多糖類系聚合物中之水溶性高分子0.001~6質量%、以及 (F2)水。 The invention provides a method for producing an emulsified composition, which comprises the step 2 after the step 1, the step 1 is to make the water phase I containing the following components (A), (B), (C), (D) and (F1) Mixing, emulsifying, and cooling: (A) 0.001 to 10% by mass of the compound represented by the following formula (1) (wherein Z ¹ represents a structure having two or more hydroxyl groups of glycerin, sorbitan, sorbitol or sucrose residue, Y ¹ represents an ester bond or an ether bond, and R represents a hydrocarbon group having 14 to 22 carbon atoms. (n) is a number of 1 to 4), (B) is 0.001 to 10% by mass of one or more compounds selected from the group consisting of higher alcohols and sterols having a carbon number of 14 to 22, and (C) is represented by the formula (2) 0.001 to 15% by mass of the compound (wherein R ¹ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 4 to 30 carbon atoms which may be substituted by a hydroxyl group, a carbonyl group or an amine group; and Z represents a methylene group, a methine group or an oxygen atom; X ¹ , X ² and X ³ each independently represent a hydrogen atom, a hydroxyl group or an ethoxylated group, and X ⁴ represents a hydrogen atom, an ethenyl group or a glyceryl group, or forms a pendant oxy group together with an adjacent oxygen atom (however, Z is a methine group, X ¹ and X ² according to any one of a hydrogen atom, the other is absent .X ⁴ forming the side group, X ³ does not exist); R ² and R ³ each independently represent a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an ethoxymethyl group; R ⁴ represents a linear chain having a carbon number of 5 to 60 which may be substituted with a hydroxyl group, a carbonyl group or an amine group and may have an ether bond, an ester bond or a guanamine bond in the main chain. a branched or cyclic saturated or unsaturated hydrocarbon group; R ⁵ represents a hydrogen atom, or represents a total carbon number of from 1 to 30 which may have a substituent selected from a hydroxyl group, a hydroxyalkoxy group, an alkoxy group and an ethoxy group. a linear or branched saturated or unsaturated hydrocarbon group; a dotted line indicating that it can be an unsaturated bond), (D) an anionic surfactant 0.00025 to 10% by mass, (F1) water; and a step 2 The aqueous phase of the following components II: (E) is selected from alkyl-modified vinyl polymers and polyacrylic polymers of alkyl-modified polysaccharide-based water-soluble polymer, 0.001 to 6% by mass, and (F2) water.

又，本發明提供一種乳化組合物，其含有如下成分(A)、(B)、(C)、(D)、(E)及(F)：(A)甘油單山萮酸酯或甘油單鯨蠟醚0.001~10質量%、(B)鯨蠟醇或硬脂醇0.001~10質量%、(C)通式(3)或通式(4)所表示之腦醯胺類0.001~15質量% (式中，R¹¹表示可經羥基取代之碳數7~19之直鏈、支鏈或環狀之飽和或不飽和烴基；Z₁表示亞甲基或次甲基；X⁵、X⁶及X⁷各自獨立表示氫原子、羥基或乙醯氧基；X⁸表示氫原子，或者與鄰接之氧原子一起形成側氧基(但，Z₁為次甲基時，X⁵與X⁶之任一者為氫原子，另一者不存在。X⁸形成側氧基時，X⁷不存在)；R¹²表示羥基甲基或乙醯氧甲基；R¹³表示氫原子，或者表示碳數1~4之烷基；R¹⁴為可經羥基取代之碳數5~30之直鏈、支鏈或環狀之飽和或不飽和烴基，或者表示於該烷基之ω末端酯鍵結有可經羥基取代之碳數8~22之直鏈或支鏈之飽和或不飽和脂肪酸者；虛線部表示可為不飽和鍵)[化4] (式中，R¹⁵表示可經羥基取代之碳數10~22之直鏈、支鏈或環狀之飽和或不飽和烴基或氫原子；X⁹表示氫原子、乙醯基或甘油基；R¹⁶為可經羥基或胺基取代之碳數5~22之直鏈、支鏈或環狀之飽和或不飽和烴基，或者表示於該烴基之ω末端酯鍵結有可經羥基取代之碳數8~22之直鏈或支鏈之飽和或不飽和脂肪酸者；R¹⁷表示氫原子，或者表示可經羥基、羥基烷氧基、烷氧基或乙醯氧基取代之總碳數1~30之烷基)、(D)硬脂醯基麩胺酸鹽、硬脂醯基甲基牛磺酸鹽或聚氧乙烯硬脂醚磷酸鹽0.00025~10質量%、(E)(丙烯酸/丙烯酸烷基酯(C10-30))共聚物、(丙烯酸烷基酯/甲基丙烯酸硬脂醇聚醚-20)共聚物、月桂醇聚醚-13PG羥基乙基纖維素或硬脂氧基PG羥基乙基纖維素磺酸鈉0.001~6質量%、以及(F)水。 Further, the present invention provides an emulsified composition comprising the following components (A), (B), (C), (D), (E) and (F): (A) glycerol monobehenate or glycerol single Cetyl ether 0.001 to 10% by mass, (B) cetyl alcohol or stearyl alcohol 0.001 to 10% by mass, (C) ceramides represented by the general formula (3) or the general formula (4) 0.001 to 15 mass % (wherein R ¹¹ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms which may be substituted by a hydroxyl group; Z ₁ represents a methylene group or a methine group; X ⁵ and X ⁶ and X ⁷ each independently represents a hydrogen atom, a hydroxyl group or an ethyloxy group; X ⁸ represents a hydrogen atom or forms a pendant oxy group together with an adjacent oxygen atom (however, when Z ₁ is a methine group, X ⁵ and X ^{6 are used} ) One is a hydrogen atom and the other is absent. When X ⁸ forms a pendant oxy group, X ⁷ is absent); R ¹² represents a hydroxymethyl group or an ethoxymethyloxy group; R ¹³ represents a hydrogen atom, or represents a carbon number of 1 Alkyl group of ~4; R ¹⁴ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 30 carbon atoms which may be substituted by a hydroxyl group, or may be represented by an ω terminal ester bond of the alkyl group. A hydroxy group substituted with a linear or branched saturated or unsaturated fatty acid having a carbon number of 8 to 22; a dotted line indicating an unsaturated bond) [Chemical 4] (wherein R ¹⁵ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom which may be substituted with a hydroxyl group and has a carbon number of 10 to 22; X ⁹ represents a hydrogen atom, an ethyl fluorenyl group or a glyceryl group; ¹⁶ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms which may be substituted by a hydroxyl group or an amine group, or a carbon number which may be substituted by a hydroxyl group at the ω terminal ester of the hydrocarbon group a linear or branched saturated or unsaturated fatty acid of 8 to 22; R ¹⁷ represents a hydrogen atom, or represents a total carbon number of 1 to 30 which may be substituted by a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an ethoxy group. Alkyl), (D) stearyl glutamate, stearyl methyl taurate or polyoxyethylene stearyl ether 0.0225 to 10% by mass, (E) (acrylic acid / acrylonitrile) Base (C10-30)) copolymer, (alkyl acrylate / stearyl methacrylate-20) copolymer, laureth-13PG hydroxyethyl cellulose or stearoxy PG hydroxy group B Sodium cellulose sulfonate 0.001 to 6% by mass, and (F) water.

本發明之乳化組合物可獲得高黏度且彈性之液性，使塗膜具有柔軟性及彈性，因此可均勻地覆蓋肌膚，提高水分保持能力，肌膚觸感光滑，且亦可使外觀光滑。 The emulsified composition of the present invention can obtain high viscosity and elastic liquidity, and the coating film has flexibility and elasticity, so that the skin can be uniformly covered, the moisture retaining ability can be improved, the skin feels smooth, and the appearance can be made smooth.

本發明係關於一種塗膜具有柔軟性及彈性，可均勻地覆蓋肌膚，提高水分保持能力，肌膚觸感光滑，且亦可使外觀光滑的乳化組合物。 The present invention relates to a coating film which has flexibility and elasticity and can be uniformly coated. An emulsified composition that covers the skin, improves moisture retention, smoothes the skin, and smoothes the appearance.

本發明者等人發現：藉由對水分保持能力提高之設計之α-凝膠組合特定之水溶性高分子，可獲得高黏度且彈性之液性，使塗膜具有柔軟性及彈性，因此可獲得一種可均勻地覆蓋肌膚，提高水分保持能力，肌膚觸感光滑，且亦可使外觀光滑的乳化組合物。 The present inventors have found that a highly viscous and elastic liquid property can be obtained by combining a specific water-soluble polymer with a designed α-gel having improved water retention ability, so that the coating film has flexibility and elasticity, and thus An emulsified composition is obtained which can uniformly cover the skin, improve the moisture retaining ability, and has a smooth touch and smooth appearance.

本發明中使用之成分(A)係上述通式(1)所表示者。 The component (A) used in the present invention is represented by the above formula (1).

式中，作為R所表示之碳數14~22之烴基，較佳為直鏈烴基，例如可列舉：肉豆蔻基、棕櫚基、硬脂基、山萮基等直鏈烷基；棕櫚醯基、油烯基(oleyl)等。 In the formula, the hydrocarbon group having 14 to 22 carbon atoms represented by R is preferably a linear hydrocarbon group, and examples thereof include a linear alkyl group such as a myristyl group, a palmity group, a stearyl group, and a behenyl group; , oleyl (oleyl) and the like.

作為通式(1)所表示之化合物，可列舉：甘油單脂肪酸酯、山梨糖醇酐單脂肪酸酯、山梨糖醇酐二脂肪酸酯、山梨糖醇單脂肪酸酯、山梨糖醇二脂肪酸酯、蔗糖單脂肪酸酯、甘油單烷基醚等。 Examples of the compound represented by the formula (1) include glycerin mono-fatty acid ester, sorbitan mono-fatty acid ester, sorbitan di-fatty acid ester, sorbitol mono-fatty acid ester, and sorbitol II. Fatty acid esters, sucrose mono-fatty acid esters, glycerol monoalkyl ethers, and the like.

作為成分(A)，較佳為甘油單脂肪酸酯、山梨糖醇酐單脂肪酸酯、甘油單烷基醚。其中，較佳為甘油單棕櫚酸酯、甘油單硬脂酸酯、甘油單山萮酸酯、山梨糖醇酐單硬脂酸酯、甘油單鯨蠟醚、甘油單硬脂醚；進而，就提高下述薄片狀皮膜之形成性、保水性之觀點而言，更佳為甘油單山萮酸酯或甘油單鯨蠟醚。 As the component (A), a glycerin mono-fatty acid ester, a sorbitan mono-fatty acid ester, or a glycerin monoalkyl ether is preferable. Among them, preferred are glycerol monopalmitate, glyceryl monostearate, glycerol monobehenate, sorbitan monostearate, glycerol monocetyl ether, glyceryl monostearyl ether; From the viewpoint of improving the formability and water retention of the following flaky film, glyceryl monobehenate or glycerol monocetyl ether is more preferable.

成分(A)可使用1種以上，於總組成中含有0.001~10質量%，較佳為含有0.05~7質量%，更佳為含有0.25~3質量%。若為該範圍內，則將本發明之乳化組合物塗佈於皮膚上後，於乾燥過程中可於皮膚表面上形成下述成分(B)~(E)所構成之脂質層與水分層交替排列之薄片狀皮膜。其結果，可於層間保持水分故而水分保持能力提高，因此較佳。進而塗膜之使用觸感亦變好，故而較佳。 The component (A) may be used singly or in combination of 0.001 to 10% by mass, preferably 0.05 to 7% by mass, more preferably 0.25 to 3% by mass, based on the total composition. If it is within this range, the emulsified composition of the present invention is applied to the skin. Thereafter, a flaky film in which the lipid layer and the water layer composed of the following components (B) to (E) are alternately arranged is formed on the surface of the skin during the drying process. As a result, it is preferable to retain moisture between the layers and to improve the water retaining ability. Further, the touch feeling of the coating film is also improved, so that it is preferable.

本發明中使用之成分(B)中，高級醇為碳數14~22、較佳為碳數16~18者。例如可列舉：肉豆蔻醇、鯨蠟醇、硬脂醇、山萮醇等。 In the component (B) used in the present invention, the higher alcohol has a carbon number of 14 to 22, preferably a carbon number of 16 to 18. For example, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, etc. are mentioned.

該等之中，較佳為鯨蠟醇、硬脂醇，進而較佳為鯨蠟醇。 Among these, cetyl alcohol and stearyl alcohol are preferable, and cetyl alcohol is further preferable.

又，成分(B)中，作為固醇類，可列舉膽固醇、植物固醇。植物固醇為β-穀固醇、菜油固醇、豆固醇、菜籽固醇等植物固醇之總稱，其組成並無限定。 Further, in the component (B), examples of the sterols include cholesterol and phytosterols. Plant sterols are a general term for plant sterols such as β-sitosterol, rapeseed sterol, soybean sterol, and rapeseed sterol, and the composition thereof is not limited.

成分(B)可使用1種以上，於總組成中含有0.001~10質量%，較佳為含有0.05~7質量%，更佳為含有0.1~3質量%。若為該範圍內，則將本發明之乳化組合物塗佈於皮膚上後，於乾燥過程中可於皮膚表面上形成上述成分(A)、及下述成分(C)~(E)所構成之脂質層及水分層交替排列之薄片狀皮膜。其結果，可於層間保持水分故而水分封鎖性提高，因此較佳。進而塗佈後之肌膚外觀亦提高，故而較佳。 The component (B) may be used singly or in combination of 0.001 to 10% by mass, preferably 0.05 to 7% by mass, more preferably 0.1 to 3% by mass, based on the total composition. If it is in this range, after apply|coating the emulsion composition of this invention on skin, it can comprise the above-mentioned component (A) and the following components (C)- (E) on the skin surface in the drying process. The flaky film in which the lipid layer and the water layer are alternately arranged. As a result, it is preferable to retain moisture between the layers and to improve moisture barrier properties. Further, since the appearance of the skin after application is also improved, it is preferable.

本發明中使用之成分(C)腦醯胺類為上述通式(2)所表示者。 The component (C) ceramide used in the present invention is represented by the above formula (2).

式中，R¹為可經羥基、羰基或胺基取代之碳數4~30、較佳為可經羥基取代之碳數7~22之直鏈、支鏈或環狀之飽和或不飽和烴基，或者氫原子。 Wherein R ¹ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group which may be substituted with a hydroxyl group, a carbonyl group or an amine group and has a carbon number of 4 to 30, preferably a hydroxyl group substituted with a carbon number of 7 to 22; , or a hydrogen atom.

Z表示亞甲基、次甲基或氧原子之任一者。 Z represents either a methylene group, a methine group or an oxygen atom.

X¹、X²及X³各自獨立表示氫原子、羥基或乙醯氧基。較佳為X¹、X²及X³中之0~1個為羥基，其餘為氫原子。Z為次甲基時，X¹與X²僅任一者為氫原子，另一者不存在。又，X⁴較佳為氫原子或甘油基。 X ¹ , X ² and X ³ each independently represent a hydrogen atom, a hydroxyl group or an ethoxy group. Preferably, 0 to 1 of X ¹ , X ² and X ³ are a hydroxyl group, and the balance is a hydrogen atom. When Z is a methine group, only one of X ¹ and X ² is a hydrogen atom, and the other is not present. Further, X ^{4 is} preferably a hydrogen atom or a glyceryl group.

R²及R³表示氫原子、羥基、羥基甲基或乙醯氧甲基，較佳之R²為氫原子或羥基甲基，較佳之R³為氫原子。 R ² and R ³ represent a hydrogen atom, a hydroxyl group, a hydroxymethyl group or an ethoxymethyl group. Preferably, R ² is a hydrogen atom or a hydroxymethyl group, and preferably R ³ is a hydrogen atom.

R⁴表示可經羥基、羧基或胺基取代且可於主鏈上具有醚鍵、酯鍵或醯胺鍵之碳數5~60之直鏈、支鏈或環狀之飽和或不飽和烴基。較佳為列舉可經羥基或胺基取代之碳數5~35之直鏈、支鏈或環狀之飽和或不飽和烴基，或者於該烴基之ω位上酯鍵結或醯胺鍵結有可經羥基取代之碳數8~22之直鏈、分支或環狀之飽和或不飽和脂肪酸者。作為鍵結之脂肪酸，較佳為異硬脂酸、12-羥基硬脂酸或亞麻油酸。 R ⁴ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 60 carbon atoms which may be substituted with a hydroxyl group, a carboxyl group or an amine group and may have an ether bond, an ester bond or a guanamine bond in the main chain. Preferably, a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 35 carbon atoms which may be substituted by a hydroxyl group or an amine group is used, or an ester bond or a guanamine bond is bonded to the ω position of the hydrocarbon group. A linear, branched or cyclic saturated or unsaturated fatty acid having a carbon number of 8 to 22 which may be substituted by a hydroxyl group. As the fatty acid to be bonded, isostearic acid, 12-hydroxystearic acid or linoleic acid is preferred.

R⁵表示氫原子，或者為可具有選自羥基、羥基烷氧基、烷氧基及乙醯氧基中之取代基的總碳數1~30之直鏈或支鏈之飽和或不飽和烴基。R¹為氫原子、Z為氧原子時，R⁵為總碳數10~30之烴基。又，R¹為烴基時，R⁵為總碳數1~8之烴基。該等之中，較佳為氫原子，或者可經選自羥基及羥基烷氧基、烷氧基中之1~3個取代的總碳數1~8之烴基。此處，作為羥基烷氧基及烷氧基，較佳為碳數1~7者。 R ⁵ represents a hydrogen atom, or a may have a group selected from hydroxy, hydroxyalkoxy, alkoxy and substituted acetyl group in the total number of carbons of the saturated straight-chain or branched, of 1 to 30 or unsaturated hydrocarbon chains . When R ¹ is a hydrogen atom and Z is an oxygen atom, R ⁵ is a hydrocarbon group having a total carbon number of 10 to 30. Further, when R ¹ is a hydrocarbon group, R ⁵ is a hydrocarbon group having a total carbon number of 1 to 8. Among these, a hydrogen atom or a hydrocarbon group having a total carbon number of 1 to 8 which is substituted with one to three substituents selected from a hydroxyl group, a hydroxyalkoxy group and an alkoxy group is preferable. Here, as the hydroxyalkoxy group and the alkoxy group, those having 1 to 7 carbon atoms are preferable.

作為通式(2)所表示之化合物，較佳為如下通式(3)或(4)所表示之腦醯胺類。 The compound represented by the formula (2) is preferably a ceramide which is represented by the following formula (3) or (4).

(I)通式(3)所表示之化合物可為源自天然之腦醯胺類或同結構之合成物。 (I) The compound represented by the formula (3) may be derived from natural ceramide or the same a composite of structures.

(式中，R¹¹表示可經羥基取代之碳數7~19之直鏈、支鏈或環狀之飽和或不飽和烴基；Z₁表示亞甲基或次甲基；X⁵、X⁶及X⁷各自獨立表示氫原子、羥基或乙醯氧基；X⁸表示氫原子，或者與鄰接之氧原子一起形成側氧基(但，Z₁為次甲基時，X⁵與X⁶之任一者為氫原子，另一者不存在。X⁸形成側氧基時，X⁷不存在)；R¹²表示羥基甲基或乙醯氧甲基；R¹³表示氫原子，或者表示碳數1~4之烷基；R¹⁴為可經羥基取代之碳數5~30之直鏈、支鏈或環狀之飽和或不飽和烴基，或者表示於該烷基之ω末端酯鍵結有可經羥基取代之碳數8~22之直鏈或支鏈之飽和或不飽和脂肪酸者；虛線部表示可為不飽和鍵) (Wherein, R ¹¹ represents a hydroxyl group may be substituted with a carbon number of 7 to 19 of the straight-chain, branched or cyclic saturated or unsaturated hydrocarbon group of; Z ₁ represents a methylene group or a methine group; X ^5, X ⁶ and X ⁷ each independently represents a hydrogen atom, a hydroxyl group or an ethyloxy group; X ⁸ represents a hydrogen atom or forms a pendant oxy group together with an adjacent oxygen atom (however, when Z ₁ is a methine group, X ⁵ and X ^{6 are used} ) One is a hydrogen atom and the other is absent. When X ⁸ forms a pendant oxy group, X ⁷ is absent); R ¹² represents a hydroxymethyl group or an ethoxymethyloxy group; R ¹³ represents a hydrogen atom, or represents a carbon number of 1 Alkyl group of ~4; R ¹⁴ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 30 carbon atoms which may be substituted by a hydroxyl group, or may be represented by an ω terminal ester bond of the alkyl group. a hydroxy group substituted with a linear or branched saturated or unsaturated fatty acid having a carbon number of 8 to 22; a dotted line indicating an unsaturated bond)

可列舉如下化合物：R¹¹較佳為碳數7~19、更佳為碳數13~15之直鏈烷基；R¹⁴為可經羥基取代之碳數9~27之直鏈烷基或者酯鍵結有亞麻油酸之碳數9~27之直鏈烷基。又，X⁸較佳為表示氫原子，或者與氧原子一起形成側氧基。進而，作為R¹⁴，較佳為二十三烷基、1-羥基十五烷基、1-羥基二十三烷基、十七烷基、1-羥基十一烷基、及於ω位上酯鍵結有亞麻油酸之二十九烷基。 The following compounds may be mentioned: R ^{11 is} preferably a linear alkyl group having a carbon number of 7 to 19, more preferably 13 to 15 carbon atoms; and R ¹⁴ is a linear alkyl group or ester having a carbon number of 9 to 27 which may be substituted by a hydroxyl group. The bond has a linear alkyl group of 9 to 27 carbon atoms of linoleic acid. Further, X ⁸ preferably represents a hydrogen atom or forms a pendant oxy group together with an oxygen atom. Further, as R ¹⁴ , a tetradecyl group, a 1-hydroxypentadecyl group, a 1-hydroxytetracosyl group, a heptadecyl group, a 1-hydroxyundecyl group, and the ω position are preferable. The ester bond is a octadecyl group of linoleic acid.

作為天然型腦醯胺之具體例示，可列舉神經鞘胺醇、二氫神經鞘胺醇、植物神經鞘胺醇或鞘胺二醇經醯胺化之腦醯胺1~7型(例如，J.Lipid Res.,24：759(1983)之圖2及J.Lipid.Res.,35：2069(1994)之圖4中記載的豬及人之腦醯胺類)。 Specific examples of the natural ceramide include sphingosine 1 to 7 which is succinylated by sphingosine, dihydrosphingosine, phytosphingosine or sphingamine diol (for example, J). .Lipid Res., Fig. 2 of 24:759 (1983) and pigs and human ceramides of Fig. 4 of J. Lipid. Res., 35:2069 (1994).

進而亦含有該等之N-烷基體(例如N-甲基體)。 Further, these N-alkyl groups (for example, N-methyl groups) are also contained.

該等腦醯胺可使用天然型(D(-)體)之光學活性體，亦可使用非天然型(L(+)體)之光學活性體，進而可使用天然型與非天然型之混合物。關於上述化合物之相對組態，可為天然型之組態者，亦可為其以外之非天然型之組態者，又可為由該等之混合物形成者。其中，較佳為CERAMIDE 1、CERAMIDE 2、CERAMIDE 3、CERAMIDE 5、CERAMIDE 6II之化合物(以上為INCI(International Nomenclature of Cosmetic Ingredients，化妝品成分之國際命名)名；第8版)及下式所表示者。 These ceramides may be optically active (D(-)), or optically active (L(+)), and a mixture of natural and non-natural. . The relative configuration of the above compounds may be either a natural type configurator, a non-natural type configurator other than the above, or a mixture of such a mixture. Among them, preferred are CERAMIDE 1, CERAMIDE 2, CERAMIDE 3, CERAMIDE 5, CERAMIDE 6II compounds (the above are INCI (International Nomenclature of Cosmetic Ingredients); 8th edition) and the following formula .

該等可為源自天然之萃取物及合成物之任一者，亦可使用市售品。 These may be any of natural extracts and compositions, and commercially available products may also be used.

作為此種天然型腦醯胺之市售品，可列舉：Ceramide I、Ceramide III、Ceramide IIIA、Ceramide IIIB、Ceramide IIIC、Ceramide VI(以上由Cosmofarm公司製造)、Ceramide TIC-001(高砂香料公司)、CERAMIDE II(Quest International公司)、DS-Ceramide VI、DS-CLA-Phytoceramide、C6-Phytoceramide、DS-Ceramide Y3S(DOOSAN公司)、CERAMIDE 2(Sederma公司)。 As a commercial product of such natural ceramide, Ceramide I, Ceramide III, Ceramide IIIA, Ceramide IIIB, Ceramide IIIC, Ceramide VI (above, manufactured by Cosmofarm), and Ceramide TIC-001 (High Sand Spice Co., Ltd.) are mentioned. , CERAMIDE II (Quest International), DS-Ceramide VI, DS-CLA-Phytoceramide, C6-Phytoceramide, DS-Ceramide Y3S (DOOSAN), CERAMIDE 2 (Sederma).

(II)通式(4)所表示之偽型腦醯胺。 (II) pseudo-cerebralamine represented by the formula (4).

(式中，R¹⁵表示可經羥基取代之碳數10~22之直鏈、支鏈或環狀之飽和或不飽和烴基或氫原子；X⁹表示氫原子、乙醯基或甘油基；R¹⁶為可經羥基或胺基取代之碳數5~22之直鏈、支鏈或環狀之飽和或不飽和烴基，或者表示於該烴基之ω末端酯鍵結有可經羥基取代之碳數8~22之直鏈或支鏈之飽和或不飽和脂肪酸者；R¹⁷表示氫原子，或者表示可經羥基、羥基烷氧基、烷氧基或乙醯氧基取代之總碳數1~30之烷基) (wherein R ¹⁵ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom which may be substituted with a hydroxyl group and has a carbon number of 10 to 22; X ⁹ represents a hydrogen atom, an ethyl fluorenyl group or a glyceryl group; ¹⁶ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms which may be substituted by a hydroxyl group or an amine group, or a carbon number which may be substituted by a hydroxyl group at the ω terminal ester of the hydrocarbon group a linear or branched saturated or unsaturated fatty acid of 8 to 22; R ¹⁷ represents a hydrogen atom, or represents a total carbon number of 1 to 30 which may be substituted by a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an ethoxy group. Alkyl)

作為R¹⁶，較佳為壬基、十三烷基、十五烷基、於ω位上酯鍵結有亞麻油酸之十一烷基、於ω位上酯鍵結有亞麻油酸之十五烷基、於ω位上酯鍵結有12-羥基硬脂酸之十五烷基、及於ω位上醯胺鍵結有甲基分支異硬脂酸之十一烷基。 As R ¹⁶ , a decyl group, a tridecyl group, a pentadecyl group, an undecyl group bonded with linoleic acid at the ω position, and an oleic acid at the ω position are bonded thereto. The pentaalkyl group is esterified with a pentadecyl group of 12-hydroxystearic acid at the ω position, and an undecyl group having a methyl branched isostearic acid bonded to the oxime at the ω position.

R¹⁷較佳為：於R¹⁵為氫原子之情形時，其為可經羥基、羥基烷氧基、烷氧基或乙醯氧基取代之總碳數10~30、較佳為總碳數12~20之烷基；於R¹⁵為可經羥基取代之碳數10~22之直鏈、支鏈或環狀之飽和或不飽和烴基之情形時，其表示氫原子，或者表示可經羥基、羥基烷氧基、烷氧基或乙醯氧基取代之總碳數1~8之烷基。作為R¹⁷之羥基烷氧基或烷氧基，較佳為碳數1~7者。 R ^{17 is} preferably a total carbon number of 10 to 30, preferably a total carbon number, which may be substituted by a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an ethoxy group when R ¹⁵ is a hydrogen atom. An alkyl group of 12 to 20; in the case where R ¹⁵ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having a carbon number of 10 to 22 which may be substituted by a hydroxyl group, it represents a hydrogen atom or represents a hydroxyl group. An alkyl group having a total carbon number of 1 to 8 substituted by a hydroxyalkoxy group, an alkoxy group or an ethoxylated group. The hydroxyalkoxy group or alkoxy group of R ¹⁷ is preferably a carbon number of 1 to 7.

作為通式(4)，較佳為R¹⁵為十六烷基、X⁹為氫原子、R¹⁶為十五烷基、R¹⁷為羥基乙基者；R¹⁵為十六烷基、X⁹為氫原子、R¹⁶為壬基、R¹⁷為羥基乙基者；或者R¹⁵為十六烷基、X⁹為甘油基、R¹⁶為十三烷基、R¹⁷為3-甲氧基丙基的偽型腦醯胺類；更佳為通式(4)之R¹⁵為十六烷基、X⁹為氫原子、R¹⁶為十五烷基、R¹⁷為羥基乙基者(N-(十六烷氧基羥基丙基)-N-羥基乙基十六烷醯胺)。 As the general formula (4), R ¹⁵ is a hexadecyl group, X ⁹ is a hydrogen atom, R ¹⁶ is a pentadecyl group, and R ¹⁷ is a hydroxyethyl group; R ¹⁵ is a hexadecyl group, and X ⁹ is a group Is a hydrogen atom, R ¹⁶ is a fluorenyl group, and R ¹⁷ is a hydroxyethyl group; or R ¹⁵ is a hexadecyl group, X ⁹ is a glyceryl group, R ¹⁶ is a tridecyl group, and R ¹⁷ is a 3-methoxy group. a pseudo-cephalamine of the group; more preferably, R ¹⁵ of the formula (4) is a hexadecyl group, X ⁹ is a hydrogen atom, R ¹⁶ is a pentadecyl group, and R ¹⁷ is a hydroxyethyl group (N- (hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecaneamine).

成分(C)化合物可使用1種以上，於總組成中含有 0.001~15質量%，較佳為含有0.05~7質量%，更佳為含有0.5~5質量%。若為該範圍內，則將本發明之乳化組合物塗佈於皮膚上後，於乾燥過程中可於皮膚表面上形成上述成分(A)、(B)、及下述成分(D)~(E)所構成之脂質層與水分層交替排列之薄片狀皮膜。其結果，可於層間保持水分。再者，於本件發明之乳化組合物中及塗佈乾燥後所形成之薄片狀皮膜中，成分(C)不會結晶化。其結果，可使成分(C)高度滲透至皮膚中，因此較佳。進而，與提高塗佈後之肌膚外觀、使用觸感有關，因此較佳。 The compound of the component (C) may be used alone or in combination of the total composition. 0.001 to 15% by mass, preferably 0.05 to 7% by mass, more preferably 0.5 to 5% by mass. Within this range, after the emulsion composition of the present invention is applied to the skin, the above components (A), (B), and the following components (D)~ can be formed on the skin surface during the drying process. E) A flaky film in which the lipid layer and the water layer are alternately arranged. As a result, moisture can be maintained between the layers. Further, in the emulsified composition of the present invention and the flaky film formed after coating and drying, the component (C) does not crystallize. As a result, the component (C) can be highly penetrated into the skin, which is preferable. Further, it is preferable because it improves the appearance of the skin after application and the feeling of use.

作為本發明中使用之成分(D)陰離子界面活性劑，例如可列舉：月桂酸鈉、棕櫚酸鉀、硬脂酸精胺酸等碳數12~24之脂肪酸鹽；月桂基硫酸鈉、月桂基硫酸鉀等烷基硫酸酯鹽；聚氧乙烯月桂基硫酸三乙醇胺等烷基醚硫酸酯鹽；月桂醯基肌胺酸鈉等N-醯基肌胺酸鹽；N-硬脂醯基-N-甲基牛磺酸鈉、N-肉豆蔻醯基-N-甲基牛磺酸鈉等脂肪酸醯胺磺酸鹽；單硬脂基磷酸鈉等烷基磷酸鹽；聚氧乙烯油醚磷酸鈉、聚氧乙烯硬脂醚磷酸鈉等聚氧乙烯烷基醚磷酸鹽；二-2-乙基己基磺基琥珀酸鈉等長鏈磺基琥珀酸鹽；N-月桂醯基麩胺酸單鈉、N-硬脂醯基-L-麩胺酸鈉、N-硬脂醯基-L-麩胺酸精胺酸、N-硬脂醯基麩胺酸鈉、N-肉豆蔻醯基-L-麩胺酸鈉等長鏈N-醯基麩胺酸鹽等。 Examples of the component (D) anionic surfactant used in the present invention include fatty acid salts having a carbon number of 12 to 24 such as sodium laurate, potassium palmitate, and stearic acid; sodium lauryl sulfate and lauryl An alkyl sulfate salt such as potassium sulfate; an alkyl ether sulfate salt such as polyoxyethylene lauryl sulfate triethanolamine; N-mercapto myosamine such as sodium lauryl sarcosinate; N-stearyl sulfhydryl-N - fatty acid decyl sulfonate such as sodium methyl taurate, N-myristyl-N-methyl taurate; alkyl phosphate such as sodium monostearyl phosphate; polyoxyethylene oleate sodium phosphate Polyoxyethylene alkyl ether phosphate such as polyoxyethylene stearyl ether sodium phosphate; long chain sulfosuccinate such as sodium di-2-ethylhexyl sulfosuccinate; N-lauric acid glutamic acid monosodium , N-stearyl-L-glutamate, N-stearyl-L-glutamic acid, N-stearyl glutamate, N-myristyl-L - Long-chain N-mercapto glutamate such as sodium glutamate.

該等之中，較佳為碳數12~24之脂肪酸鹽、烷基硫酸酯鹽、烷基醚硫酸酯鹽、脂肪酸醯胺磺酸鹽、烷基磷酸鹽、聚氧乙烯烷基醚磷酸鹽、長鏈N-醯基麩胺酸鹽。 Among these, a fatty acid salt having 12 to 24 carbon atoms, an alkyl sulfate ester salt, an alkyl ether sulfate salt, a fatty acid decyl sulfonate, an alkyl phosphate, a polyoxyethylene alkyl ether phosphate is preferred. Long chain N-mercapto glutamate.

其中，較佳為硬脂醯基麩胺酸鹽、硬脂醯基甲基牛磺酸鹽、聚氧乙烯硬脂醚磷酸鹽，更佳為硬脂醯基麩胺酸鹽、硬脂醯基甲基牛磺酸鹽，進而較佳為硬脂醯基麩胺酸鹽。 Among them, preferred are stearyl glutamate, stearyl methyl taurate, polyoxyethylene stearyl ether phosphate, more preferably stearyl glutamate, stearyl sulfonate Methyl taurate, and more preferably stearyl glutamate.

作為成分(D)之鹽，較佳為選自鈉鹽、鉀鹽、鹼性胺基酸鹽、及銨中之1種以上，就表現乳化組合物之黏度之觀點而言，較佳為選自鈉鹽、精胺酸鹽中之1種以上。 The salt of the component (D) is preferably one or more selected from the group consisting of a sodium salt, a potassium salt, a basic amino acid salt, and ammonium, and is preferably selected from the viewpoint of exhibiting the viscosity of the emulsified composition. One or more of the sodium salt and the arginine salt.

成分(D)可作為酸而調配，亦可藉由鹼進行中和而以鹽之形式含有。該情形時之中和成分(D)之鹼較佳為選自鹼性胺基酸、氫氧化鈉、氫氧化鉀、三乙醇胺、氫氧化鈣中之1種或2種以上，鹼性胺基酸較佳為選自精胺酸、離胺酸、組胺酸中之1種或2種以上。作為中和成分(D)之鹼，就表現乳化組合物之黏度之觀點而言，較佳為選自精胺酸、氫氧化鈉中之1種或2種；就使用感等方面而言，更佳為精胺酸。 The component (D) may be formulated as an acid or may be neutralized by a base to be contained in the form of a salt. In this case, the base of the component (D) is preferably one or more selected from the group consisting of a basic amino acid, sodium hydroxide, potassium hydroxide, triethanolamine, and calcium hydroxide, and a basic amino group. The acid is preferably one or more selected from the group consisting of arginine, lysine, and histidine. The base of the neutralizing component (D) is preferably one or two selected from the group consisting of arginine and sodium hydroxide from the viewpoint of exhibiting the viscosity of the emulsified composition. More preferably arginine.

成分(D)可使用1種以上，於總組成中含有0.00025~10質量%，較佳為含有0.05~2質量%，更佳為含有0.1~1質量%。若為該範圍內，則可使成分(A)~(C)乳化。進而，將本發明之乳化組合物塗佈於皮膚上後，於乾燥過程中可於皮膚表面上形成由成分(A)~(D)及成分(E)所構成之脂質層與水分層交替排列之薄片狀皮膜。其結果，可於層間保持水分，對提高水分保持能力起作用，因此較佳。 The component (D) may be used alone or in combination, and is contained in an amount of 0.00025 to 10% by mass, preferably 0.05 to 2% by mass, more preferably 0.1 to 1% by mass in the total composition. If it is in this range, component (A)-(C) can be emulsified. Further, after the emulsified composition of the present invention is applied to the skin, a lipid layer composed of the components (A) to (D) and the component (E) and the water layer are alternately arranged on the surface of the skin during the drying process. a flaky film. As a result, it is preferable to retain moisture between the layers and to promote the water retaining ability.

本發明中使用之成分(E)為選自烷基改性聚丙烯酸系聚合物及烷基改性多糖類系聚合物中之水溶性高分子。 The component (E) used in the present invention is a water-soluble polymer selected from the group consisting of an alkyl-modified polyacrylic polymer and an alkyl-modified polysaccharide-based polymer.

例如可列舉：丙烯酸烷基酯共聚物、(甲基)丙烯酸/(甲基)丙烯酸烷基酯共聚物、丙烯酸烷基酯-甲基丙烯酸烷基酯-聚氧乙烯硬脂醚共聚物、多糖衍生物等。 For example, an alkyl acrylate copolymer, (meth)acrylic acid / (A) Alkyl acrylate copolymer, alkyl acrylate-alkyl methacrylate-polyoxyethylene stearyl ether copolymer, polysaccharide derivative, and the like.

更為具體而言，較佳為(丙烯酸/丙烯酸烷基酯(C10-30))共聚物、(丙烯酸烷基酯/甲基丙烯酸硬脂醇聚醚-20)共聚物、月桂醇聚醚-13PG羥基乙基纖維素、硬脂氧基PG羥基乙基纖維素磺酸鈉等。 More specifically, (acrylic acid/alkyl acrylate (C10-30)) copolymer, (alkyl acrylate/stearyl methacrylate-20) copolymer, laureth- 13PG hydroxyethyl cellulose, stearyloxy PG hydroxyethyl cellulose sulfonate, and the like.

作為市售品，例如作為丙烯酸烷基酯聚合物，可列舉Aculyn 33(The Dow Chemical Company)；作為(甲基)丙烯酸/(甲基)丙烯酸烷基酯共聚物，可列舉：Pemulen TR-1、Pemulen TR-2、Carbopol ETD2020(以上由Lubrizol Advanced Materials,Inc.製造)等。又，作為丙烯酸烷基酯-甲基丙烯酸烷基酯-聚氧乙烯硬脂醚共聚物，可列舉：Aculyn 22(The Dow Chemical Company)等。作為多糖衍生物，可列舉：SPS-S-SA、SOFCARE EP-S(以上由花王公司製造)、Natrosol Plus(Hercules-Aqualon)等。 As a commercial item, for example, Aculyn 33 (The Dow Chemical Company) can be cited as the alkyl acrylate polymer, and as a (meth)acrylic acid/alkyl (meth) acrylate copolymer, Pemulen TR-1 can be cited. , Pemulen TR-2, Carbopol ETD2020 (above manufactured by Lubrizol Advanced Materials, Inc.) and the like. Further, examples of the alkyl acrylate-alkyl methacrylate-polyoxyethylene stearyl ether copolymer include Aculyn 22 (The Dow Chemical Company). Examples of the polysaccharide derivative include SPS-S-SA, SOFCARE EP-S (above, manufactured by Kao Corporation), and Natrosol Plus (Hercules-Aqualon).

成分(E)可使用1種以上，於總組成中含有0.001~6質量%，較佳為含有0.05~5質量%，更佳為含有0.1~3質量%。若為該範圍內，則可提高本發明之乳化組合物之保存穩定性。進而，可抑制成分(A)~(D)所構成之脂質混合物之結晶化。其結果，可對塗佈本發明之乳化組合物後於乾燥過程中形成於皮膚表面上之薄片狀皮膜賦予柔軟性。其結果，對水分保持能力/提高使用觸感/提高塗佈後之肌膚外觀起作用，因此較佳。 The component (E) may be used singly or in combination of 0.001 to 6% by mass, preferably 0.05 to 5% by mass, more preferably 0.1 to 3% by mass, based on the total composition. If it is in this range, the storage stability of the emulsified composition of this invention can be improved. Further, crystallization of the lipid mixture composed of the components (A) to (D) can be suppressed. As a result, it is possible to impart flexibility to the flaky film formed on the surface of the skin after drying by applying the emulsified composition of the present invention. As a result, it is preferable because it has a function of retaining moisture, improving the feeling of use, and improving the appearance of the skin after application.

於本發明中，成分(F)水構成各成分之剩餘部分，較佳為於總組成中含有49~85質量%，更佳為含有55~80質量%。 In the present invention, the component (F) water constitutes the remainder of each component, preferably It is contained in the total composition of 49 to 85% by mass, more preferably 55 to 80% by mass.

於本發明中，就獲得高黏度且彈性之液性之方面而言，成分(A)、(B)、(C)、(D)及(E)之質量比例較佳為(E)/((A)+(B)+(C))=0.0025~50，進而較佳為(E)/((A)+(B)+(C))=0.01~3，尤佳為(E)/((A)+(B)+(C))=0.1~1.5。其結果為，塗佈於皮膚上時，可感受到較高之塗佈感，賦予良好之使用感。 In the present invention, the mass ratio of the components (A), (B), (C), (D) and (E) is preferably (E) / (in terms of obtaining high viscosity and elastic liquidity). (A) + (B) + (C)) = 0.0025 to 50, further preferably (E) / ((A) + (B) + (C)) = 0.01 to 3, and particularly preferably (E) / ((A)+(B)+(C))=0.1~1.5. As a result, when applied to the skin, a high coating feeling can be felt, and a good feeling of use can be imparted.

又，為獲得具有柔軟性及彈性之被膜，較佳為(E)/(D)=0.025~100，進而較佳為(E)/(D)=0.14~7.5，尤佳為(E)/(D)=1.2~6。 Further, in order to obtain a film having flexibility and elasticity, it is preferably (E) / (D) = 0.025 to 100, more preferably (E) / (D) = 0.14 to 7.5, and particularly preferably (E) / (D) = 1.2~6.

於本發明中，更佳為組合上述成分各自之較佳成分及較佳含量。 In the present invention, it is more preferred to combine the preferred components and preferred contents of the above components.

進而，於本發明之乳化組合物中，較佳為：成分(A)為甘油單山萮酸酯或甘油單鯨蠟醚，成分(B)為鯨蠟醇或硬脂醇，成分(C)為通式(1)所表示之化合物，成分(D)為硬脂醯基麩胺酸鹽、硬脂醯基甲基牛磺酸鹽或聚氧乙烯硬脂醚磷酸鹽，成分(E)為(丙烯酸/丙烯酸烷基酯(C10-30))共聚物、(丙烯酸烷基酯/甲基丙烯酸硬脂醇聚醚-20)共聚物、月桂醇聚醚-13PG羥基乙基纖維素或硬脂氧基PG羥基乙基纖維素磺酸鈉，成分(F)為水。 Further, in the emulsified composition of the present invention, it is preferred that the component (A) is glycerol monobehenate or glycerin monocetyl ether, and the component (B) is cetyl alcohol or stearyl alcohol, and the component (C) The compound represented by the formula (1), the component (D) is stearyl glutamate, stearyl methyl taurate or polyoxyethylene stearyl ether phosphate, and the component (E) is (acrylic acid/alkyl acrylate (C10-30)) copolymer, (alkyl acrylate/stearyl methacrylate-20) copolymer, laureth-13PG hydroxyethyl cellulose or stearic acid Sodium oxy hydroxyethyl cellulose sulfonate, component (F) is water.

進而，於本發明之乳化組合物，較佳為：成分(A)為甘油單山萮酸酯，成分(B)為鯨蠟醇，成分(C)為通式(1)所表示之化合物，成分(D)為硬脂醯基麩胺酸鹽，成分(E)為(丙烯酸/丙烯酸烷基酯(C10-30))共聚物、(丙烯酸烷基酯/甲基丙烯酸硬脂醇聚醚-20)共聚物、月桂醇聚醚-13PG羥基乙基纖維素或硬脂氧基PG羥基乙基纖維素磺酸鈉，成分(F)為水。 Further, in the emulsified composition of the present invention, it is preferred that: Component (A) is glycerol monobehenate, component (B) is cetyl alcohol, component (C) is a compound represented by the formula (1), and component (D) is stearyl glutamate. Ingredient (E) is (acrylic acid/alkyl acrylate (C10-30)) copolymer, (alkyl acrylate/stearyl methacrylate-20) copolymer, laureth-13PG hydroxyethyl Cellulose or sodium stearyl PG hydroxyethyl cellulose sulfonate, component (F) is water.

於本發明中，以成分(A)~(D)形成乳化物之脂質。該等一旦乾燥，則發生結晶化，形成硬脆之皮膜，而無法獲得保濕性較高之皮膜。然而，已知藉由進而含有成分(E)，可抑制脂質之結晶化，形成含有大量水分，脂質層與水層交替排列之薄片狀之柔軟皮膜。尤其是，若成分(B)使用鯨蠟醇，則皮膜之柔軟性增加，肌膚之外觀及觸感之光滑度提高。進而，可提供用於製造皮膚塗佈劑的本發明之乳化組合物之用途、用於製造皮膚之水分保持劑的本發明之乳化組合物之用途、及用於製造皮膚之塗膜形成劑的本發明之乳化組合物之用途。 In the present invention, the lipids of the emulsion are formed from the components (A) to (D). When these are dried, crystallization occurs to form a hard and brittle film, and a film having a high moisture retention property cannot be obtained. However, it is known that by further containing the component (E), crystallization of the lipid can be suppressed, and a flaky soft film containing a large amount of water and having a lipid layer and an aqueous layer alternately arranged can be formed. In particular, when cetyl alcohol is used as the component (B), the softness of the film is increased, and the smoothness of the appearance and touch of the skin is improved. Further, the use of the emulsified composition of the present invention for producing a skin coating agent, the use of the emulsified composition of the present invention for producing a moisture retaining agent for skin, and the coating film forming agent for producing a skin can be provided. Use of the emulsified composition of the present invention.

本發明之乳化組合物中可進而含有成分(B)及(C)以外之油性成分。例如可列舉：液態石蠟、角鯊烷、凡士林等烴油；鯨蠟基二甲基丁醚、乙二醇二辛醚、甘油單油醚等醚油；肉豆蔻酸辛基十二烷基酯、棕櫚酸異丙酯、硬脂酸丁酯、己二酸二-2-乙基己酯、新戊二醇二癸酸酯、甘油三辛酸酯等酯油；硬脂酸、山萮酸、異肉豆蔻酸等高級脂肪酸；橄欖油等植物油；二甲基聚矽氧烷、環狀二甲基聚矽氧烷、甲基苯基聚矽氧烷、胺基改性聚矽氧、羧基改性聚矽氧、醇改性聚矽氧、烷基改性聚矽氧、聚醚改性聚矽氧、氟改性聚矽氧等聚矽氧油；全氟烷基乙基磷酸、全氟烷基聚氧乙烯磷酸、全氟聚醚、聚四氟乙烯等氟系油等。該等油性成分較佳為於總組成中含有0~20質量%。 The emulsified composition of the present invention may further contain an oil component other than the components (B) and (C). For example, a hydrocarbon oil such as liquid paraffin, squalane or petrolatum; an ether oil such as cetyl dimethyl butyl ether, ethylene glycol dioctyl ether or glycerin monooleate; octyl dodecyl myristate; Isopropyl palmitate, butyl stearate, di-2-ethylhexyl adipate, neopentyl glycol dicaprate, glycerol trioctane Ester oils such as acid esters; higher fatty acids such as stearic acid, behenic acid, isomyristate; vegetable oils such as olive oil; dimethyl polyoxyalkylene, cyclic dimethyl polyoxyalkylene, methyl phenyl poly Alkoxysilane, amine modified polyoxyl, carboxyl modified polyoxyl, alcohol modified polyoxyl, alkyl modified polyoxyl, polyether modified polyoxygen, fluorine modified polyoxyl Oxygenated oil; perfluoroalkylethylphosphoric acid, perfluoroalkyl polyoxyethylene phosphate, perfluoropolyether, polytetrafluoroethylene and other fluorine-based oils. These oily components are preferably contained in an amount of 0 to 20% by mass based on the total composition.

又，本發明之乳化組合物中亦可含有通常之化妝料中使用之有效成分或添加劑，例如抗壞血酸、菸鹼酸醯胺、菸鹼酸等水溶性維生素類；黃柏萃取物、甘草萃取物、蘆薈萃取物、問荊萃取物、茶萃取物、黃瓜萃取物、丁香萃取物、人蔘萃取物、金縷梅萃取液、胎盤萃取物、海藻萃取物、七葉樹萃取物、柚子萃取物、羅漢柏萃取物、蜂王漿萃取物、桉樹萃取物、羅漢柏萃取液等動植物萃取液；氫氧化鉀、氫氧化鈉、三乙醇胺、碳酸鈉等鹼；檸檬酸、酒石酸、乳酸、磷酸、琥珀酸、己二酸等酸等。 Further, the emulsified composition of the present invention may contain an active ingredient or an additive used in a usual cosmetic, such as water-soluble vitamins such as ascorbic acid, niacinamide, niacin, etc.; cork extract, licorice extract, Aloe Vera Extract, Brass Extract, Tea Extract, Cucumber Extract, Clove Extract, Astragalus Extract, Witch Hazel Extract, Placenta Extract, Algae Extract, Buckeye Extract, Grapefruit Extract, Luo Hanbai extract, royal jelly extract, eucalyptus extract, Luo Hanbai extract and other animal and plant extracts; potassium hydroxide, sodium hydroxide, triethanolamine, sodium carbonate and other alkali; citric acid, tartaric acid, lactic acid, phosphoric acid, succinic acid, Acid such as adipic acid.

本發明之乳化組合物之製造方法較佳為於混合含有成分(A)~(D)及成分(F)之一部分(F1)之水相I使其乳化並進行冷卻的步驟1後，包括進而混合含有成分(E)及成分(F)之剩餘部分(F2)之水相成分(水相II)的步驟。根據該方法，藉由在形成α-凝膠結構後使聚合物相互作用，可獲得於較廣溫度範圍內穩定性優異之乳化物，因此較佳。 The method for producing an emulsified composition of the present invention is preferably after the step 1 of mixing the aqueous phase I containing the components (A) to (D) and the component (F) (F1) to be emulsified and cooled, and further comprising The step of mixing the aqueous phase component (aqueous phase II) containing the component (E) and the remainder (F2) of the component (F). According to this method, it is preferred that the polymer is allowed to interact after the formation of the α-gel structure, whereby an emulsion excellent in stability over a wide temperature range can be obtained.

步驟1為形成α-凝膠結構之步驟，較佳為選自以下步驟1A、1B、1C及1D之4個製造步驟中者。就製造性方面而言，較佳為選自包括將未中和之成分(D)藉由鹼進行中和之步驟的步驟1A及步驟1C中者；就表現黏度之觀點而言，較佳為選自將成分(D)混合至油相中之步驟1A及步驟1B中者。如上所述，步驟1較佳為包括選自步驟1A、步驟1B及步驟1C中者，更佳為包括步驟1A或步驟1B，進而較佳為包括步驟1A。 Step 1 is a step of forming an α-gel structure, preferably selected from the following four steps of steps 1A, 1B, 1C and 1D. In terms of manufacturability Preferably, it is selected from the group consisting of the steps 1A and 1C including the step of neutralizing the unneutralized component (D) by a base; and from the viewpoint of exhibiting viscosity, it is preferably selected from the component ( D) Mixing into step 1A and step 1B in the oil phase. As described above, step 1 preferably includes one selected from the group consisting of step 1A, step 1B, and step 1C, and more preferably includes step 1A or step 1B, and further preferably includes step 1A.

步驟1A包括如下步驟：獲得含有成分(A)、(B)、(C)及未中和之成分(D)之油相之混合成分，以及於該油相中混合含有成分(F)之一部分(F1)及鹼之水相I使其乳化並進行冷卻。 Step 1A comprises the steps of: obtaining a mixed component of the oil phase containing the components (A), (B), (C) and the unneutralized component (D), and mixing a portion of the component (F) in the oil phase (F1) and the aqueous phase I of the base are emulsified and cooled.

步驟1B包括如下步驟：獲得含有成分(A)、(B)、(C)及成分(D)之鹽的油相之混合成分，以及於該油相中混合含有成分(F)之一部分(F1)之水相I使其乳化並進行冷卻。 Step 1B includes the steps of: obtaining a mixed component of an oil phase containing a salt of the components (A), (B), (C), and the component (D), and mixing a portion containing the component (F) in the oil phase (F1) The aqueous phase I is emulsified and cooled.

步驟1C包括如下步驟：獲得含有成分(A)、(B)及(C)之油相之混合成分，以及於該油相中混合含有未中和之成分(D)、成分(F)之一部分(F1)及鹼之水相I使其乳化並進行冷卻。 Step 1C includes the steps of: obtaining a mixed component containing the oil phase of the components (A), (B), and (C), and mixing the oil phase with a portion containing the unneutralized component (D) and the component (F) (F1) and the aqueous phase I of the base are emulsified and cooled.

步驟1D包括如下步驟：獲得含有成分(A)、(B)及(C)之油相之混合成分，以及於該油相中混合含有成分(D)之鹽及成分(F)之一部分(F1)之水相I使其乳化並進行冷卻。 Step 1D includes the steps of: obtaining a mixed component containing the oil phases of the components (A), (B), and (C), and mixing the salt containing the component (D) and one of the components (F) in the oil phase (F1) The aqueous phase I is emulsified and cooled.

於該等方法中，將成分(F)水分成(F1)與(F2)進行添加、混合，其質量比例較佳為(F1)/(F2)=0.1~9，進而較佳為0.25~4。 In these methods, the component (F) water is divided into (F1) and (F2) for addition and mixing, and the mass ratio thereof is preferably (F1) / (F2) = 0.1 to 9, and further preferably 0.25 to 4. .

所獲得之乳化組合物為α-凝膠(α型結晶)，可抑制結晶(γ 型結晶)之析出。α-凝膠可藉由X射線之結構分析而確認。α型結構之特徵在於，其為六方晶系，親油基相對於親水基層之面呈直角定向，並於布拉格角21~23°附近出現一個陡峭之繞射波峰。 The obtained emulsified composition is an α-gel (α-form crystal) which inhibits crystallization (γ Precipitation of type crystal). The α-gel can be confirmed by structural analysis of X-rays. The α-type structure is characterized in that it is a hexagonal crystal system, and the lipophilic group is oriented at a right angle with respect to the surface of the hydrophilic base layer, and a steep diffraction peak appears near the Bragg angle of 21 to 23°.

又，乳化組合物之於25℃下之黏度為10~8000 dPa．s，更佳為500~1500 dPa．s，進而較佳為1500~5000 dPa．s。本發明之乳化組合物可藉由組合上述成分而以如此高之黏度且彈性之液性獲得。 Moreover, the viscosity of the emulsified composition at 25 ° C is 10 to 8000 dPa. s, more preferably 500~1500 dPa. s, and further preferably 1500~5000 dPa. s. The emulsified composition of the present invention can be obtained by combining the above components with such a high viscosity and elastic liquidity.

再者，於本發明中，黏度係於25℃下藉由B8R型旋轉黏度計(Rotor C或D，5 r/min，測定1分鐘)而測定者。 Further, in the present invention, the viscosity is measured by a B8R type rotational viscometer (Rotor C or D, 5 r/min, measured for 1 minute) at 25 °C.

又，所獲得之乳化組合物為水中油型乳化組合物，例如適於作為化妝水、乳液、乳霜、凝膠等化妝料，或皮膚外用劑。關於上述實施形態，本發明之乳化組合物進而可用作皮膚塗佈劑、皮膚之水分保持劑、用於皮膚之塗膜形成劑。 Further, the obtained emulsified composition is an oil-in-water emulsion composition, and is suitable, for example, as a cosmetic such as a lotion, an emulsion, a cream, a gel, or an external preparation for skin. In the above embodiment, the emulsified composition of the present invention can be further used as a skin coating agent, a moisture retaining agent for the skin, and a coating film forming agent for the skin.

[實施例] [Examples] 實施例1~10及比較例1~7 Examples 1 to 10 and Comparative Examples 1 to 7

製造表1及表2所示之組成之水中油型乳化組合物，進行黏度及殘存水分量之測定，並且對皮膜進行利用SAXS(Small-angle X-ray scattering，小角度X射線繞射)之薄片狀結構之確認及利用SEM(Scanning Electron Microscope，掃描式電子顯微鏡)之表面狀態之觀察。又，對濕潤之持續性、塗佈後之肌膚之觸感及外觀進行官能評價。將結果一併示於表1及表2中。 The oil-in-water emulsion composition of the composition shown in Tables 1 and 2 was produced, and the viscosity and the residual moisture content were measured, and the film was subjected to SAXS (Small-angle X-ray scattering). Confirmation of the sheet-like structure and observation of the surface state by SEM (Scanning Electron Microscope). Further, the persistence of moistness, the touch of the skin after application, and the appearance were evaluated. The results are shown together in Tables 1 and 2.

(製造方法) (Production method)

將第I相之成分於80~90℃下加熱混合，並於螺旋槳攪拌下(300 rpm)向其中添加加熱至80~90℃之第II相之成分，利用均質攪拌機於7000 rpm、10分鐘之條件下一面施加剪切一面進行乳化，形成α-凝膠。緩緩地冷卻至25℃後，添加第III相之成分，獲得水中油型乳化組合物。 The components of the first phase were heated and mixed at 80 to 90 ° C, and the components of the second phase heated to 80 to 90 ° C were added thereto under stirring by a propeller (300 rpm), and the mixture was stirred at 7000 rpm for 10 minutes using a homomixer. Under the conditions, emulsification was carried out while applying shear to form an α-gel. After gradually cooling to 25 ° C, the component of the third phase was added to obtain an oily emulsified composition in water.

(評價方法) (evaluation method) (1)黏度： (1) Viscosity:

於25℃下，藉由B8R型旋轉黏度計(Rotor C或D，5 r/min，測定1分鐘)而進行測定。 The measurement was carried out at 25 ° C by a B8R type rotational viscometer (Rotor C or D, 5 r/min, measured for 1 minute).

(2)殘存水分量： (2) Residual water content:

於6×6 cm之金屬托盤中，使水中油型乳化組合物1 g以一定厚度均勻地展開，並於20℃、濕度40%之恆溫恆濕下，相對於時間將質量變化繪製成圖。藉由經時形成薄片狀皮膜，而使此後質量變化變得極小。求出質量成為一定值之24小時後之殘存水分量，並根據以下之式求出製劑中相對於固形物成分之水分量。固形物成分中含有成分(A)~(E)所有成分。 In a metal tray of 6 × 6 cm, 1 g of the oil-type emulsified composition in water was uniformly spread at a certain thickness, and the mass change was plotted against time at a constant temperature and humidity of 20 ° C and a humidity of 40%. By forming a flaky film over time, the mass change thereafter becomes extremely small. The amount of residual water after 24 hours from which the mass became a constant value was determined, and the amount of moisture in the preparation relative to the solid content was determined according to the following formula. The solid content component contains all components (A) to (E).

(3)利用SAXS之薄片狀結構之確認： (3) Confirmation of the flaky structure of SAXS:

於人工皮革Supplare(註冊商標)上將水中油型乳化組合物以0.001 g/cm²均勻地抹開並使其乾燥1天後，以Nano- viewer、λCuKα=1.54Å、照射30分鐘、相機長649.5 mm之條件，於2θ=0.2~5°之範圍內測定皮膜表面之狀態。 The oil-in-water emulsion composition was uniformly spread at 0.001 g/cm ² on an artificial leather Supplare (registered trademark) and dried for 1 day, and then irradiated for 30 minutes with a Nano-viewer, λCuKα=1.54Å, and a camera length. Under the condition of 649.5 mm, the state of the surface of the film was measured in the range of 2θ=0.2~5°.

(4)利用SEM之皮膜表面狀態之觀察： (4) Observation of the surface state of the film using SEM:

於人工皮革Supplare(註冊商標)上將水中油型乳化組合物以0.001 g/cm²均勻地抹開並使其乾燥1天後，藉由SEM(掃描式電子顯微鏡)以50倍倍率觀察皮膜表面之狀態。將結果按以下基準表示。 After the oil-in-water emulsion composition was uniformly spread at 0.001 g/cm ² on an artificial leather Supplare (registered trademark) and dried for 1 day, the surface of the film was observed by SEM (scanning electron microscope) at a magnification of 50 times. State. The results are expressed on the following basis.

○：脊表皮、溝表皮之邊界部分光滑。 ○: The boundary between the ridge skin and the groove skin is smooth.

△：脊表皮、溝表皮之邊界部分上捲。 △: The boundary portion of the ridge skin and the groove epidermis is wound up.

×：未形成皮膜。 ×: No film was formed.

(5)濕潤之持續性、塗佈後之肌膚之觸感(光滑度)及外觀(外觀之光滑度)： (5) Moisture persistence, touch (smoothness) and appearance (smoothness of appearance) of the skin after application:

讓12名專業官能檢察員對剛將各水中油型乳化組合物0.4~0.6 g塗佈於面部後之「肌膚之觸感之光滑度」及「肌膚之外觀之光滑度」、進而塗佈經過10小時後之「濕潤之持續性」進行官能評價。將結果以評價為「良好」之官能檢察員之人數來表示。 Let 12 professional functional inspectors apply the "smoothness of the touch of the skin" and the "smoothness of the appearance of the skin" after applying the oil-based emulsified composition of 0.4 to 0.6 g on the face. The "wetness persistence" after 10 hours was evaluated for sensitization. The results are expressed in terms of the number of functional inspectors rated as “good”.

實施例11~29及比較例8~9 Examples 11 to 29 and Comparative Examples 8 to 9

以與實施例1~10相同之方式製造表3~表6所示之組成之水中油型乳化組合物，進行黏度及殘存水分量之測定，並且對皮膜進行利用SAXS之薄片狀結構之確認及利用SEM之表面狀態之觀察。又，對濕潤之持續性、塗佈後肌膚之觸感及外觀進行評價。將結果一併示於表3~表6中。 The oil-in-water emulsion composition of the composition shown in Tables 3 to 6 was produced in the same manner as in Examples 1 to 10, and the viscosity and residual moisture content were measured, and the film was confirmed by the SAXS sheet-like structure. Observe the surface state of the SEM. Moreover, the persistence of moistness, the touch of the skin after application, and the appearance were evaluated. The results are shown together in Tables 3 to 6.

實施例1、30~32 Example 1, 30~32

以與實施例1~10相同之方式製造表7中所示之組成之水中油型乳化組合物，進行黏度及殘存水分量之測定，並且對皮膜進行利用SAXS之薄片狀結構之確認及利用EM之表面狀態之觀察。又，對濕潤之持續性、塗佈後肌膚之觸感及外觀進行評價。將結果一併示於表7中。 The oil-in-water emulsion composition of the composition shown in Table 7 was produced in the same manner as in Examples 1 to 10, and the viscosity and residual moisture content were measured, and the film was confirmed to have a sheet-like structure using SAXS and EM was used. Observation of the surface state. Moreover, the persistence of moistness, the touch of the skin after application, and the appearance were evaluated. The results are shown together in Table 7.

實施例1、30係藉由製造步驟1A所製造，實施例31係藉由製造步驟1C所製造，實施例32係藉由製造步驟1D所製造。於油相中調配未中和之成分(D)而藉由製造步驟1A所製造的實施例1及實施例30可獲得如下結果：塗佈後肌膚觸感之光滑度之評價較高，腦醯胺之結晶析出受到抑制而確認到薄片狀結構，保濕效果較高，且獲得較高之黏度。 Examples 1 and 30 were produced by the manufacturing step 1A, Example 31 was produced by the manufacturing step 1C, and Example 32 was produced by the manufacturing step 1D. By disposing the unneutralized component (D) in the oil phase, the following results were obtained by the production of Example 1 and Example 30 produced in the step 1A: the smoothness of the touch of the skin after application was evaluated, and the cerebral palsy was high. The precipitation of the crystal of the amine is suppressed, and the flaky structure is confirmed, the moisturizing effect is high, and a high viscosity is obtained.

Claims

一種乳化組合物之製造方法，其於步驟1後包括步驟2，且形成α-凝膠結構，步驟1係使含有如下成分(A)、(B)、(C)、(D)及(F1)之水相I混合、乳化並進行冷卻：(A)甘油脂肪酸酯或甘油單烷基醚0.001~10質量%、(B)選自碳數14~22之高級醇及固醇類中的1種以上之化合物0.001~10質量%、(C)通式(3)或通式(4)所表示之化合物0.001~15質量%(式中，R¹¹表示可經羥基取代之碳數7~19之直鏈、支鏈或環狀之飽和或不飽和烴基；Z₁表示亞甲基或次甲基；X⁵、X⁶及X⁷各自獨立表示氫原子、羥基或乙醯氧基；X⁸表示氫原子，或者與鄰接之氧原子一起形成側氧基(但，Z₁為次甲基時，X⁵與X⁶之任一者為氫原子，另一者不存在，X⁸形成側氧基時，X⁷不存在)；R¹²表示羥基甲基或乙醯氧甲基；R¹³表示氫原子，或者表示碳數1~4之烷基；R¹⁴為可經羥基取代之碳數5~30之直鏈、支鏈或環狀之飽和或不飽和烴基，或者表示於該烷基之ω末端酯鍵結有可經羥基取代之碳數8~22之直鏈或支鏈之飽和或不飽和脂肪酸者；虛線部表示可為不飽和鍵)(式中，R¹⁵表示可經羥基取代之碳數10~22之直鏈、支鏈或環狀之飽和或不飽和烴基或氫原子；X⁹表示氫原子、乙醯基或甘油基；R¹⁶為可經羥基或胺基取代之碳數5~22之直鏈、支鏈或環狀之飽和或不飽和烴基，或者表示於該烴基之ω末端酯鍵結有可經羥基取代之碳數8~22之直鏈或支鏈之飽和或不飽和脂肪酸者；R¹⁷表示氫原子，或者表示可經羥基、羥基烷氧基、烷氧基或乙醯氧基取代的總碳數1~30之烷基)、(D)陰離子界面活性劑0.00025~10質量%、(F1)水；步驟2係進而混合含有如下成分之水相II：(E)選自烷基改性聚丙烯酸系乙烯聚合物及烷基改性多糖類系聚合物中之水溶性高分子0.001~6質量%、及(F2)水。A method for producing an emulsified composition, comprising the step 2 after the step 1, and forming an α-gel structure, the step 1 comprising the following components (A), (B), (C), (D) and (F1) The aqueous phase I is mixed, emulsified and cooled: (A) glycerin fatty acid ester or glycerol monoalkyl ether 0.001 to 10% by mass, (B) selected from higher alcohols and sterols having a carbon number of 14 to 22 0.001 to 10% by mass of one or more kinds of compounds, and 0.001 to 15% by mass of the compound represented by the formula (3) or the formula (4) (wherein R ¹¹ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 7 to 19 carbon atoms which may be substituted by a hydroxyl group; Z ₁ represents a methylene group or a methine group; X ⁵ and X ⁶ and X ⁷ each independently represents a hydrogen atom, a hydroxyl group or an ethyloxy group; X ⁸ represents a hydrogen atom or forms a pendant oxy group together with an adjacent oxygen atom (however, when Z ₁ is a methine group, X ⁵ and X ^{6 are used} ) when one of them is a hydrogen atom, the other is not present, X ⁸ forming the side group, X ⁷ does not exist); R ¹² represents a hydroxyl group or acetyl oxymethyl; R ¹³ represents a hydrogen atom, or a C 1 Alkyl group of ~4; R ¹⁴ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 30 carbon atoms which may be substituted by a hydroxyl group, or may be represented by an ω terminal ester bond of the alkyl group. a hydroxy group substituted with a linear or branched saturated or unsaturated fatty acid having a carbon number of 8 to 22; a dotted line indicating an unsaturated bond) (wherein R ¹⁵ represents a linear, branched or cyclic saturated or unsaturated hydrocarbon group or a hydrogen atom which may be substituted with a hydroxyl group and has a carbon number of 10 to 22; X ⁹ represents a hydrogen atom, an ethyl fluorenyl group or a glyceryl group; ¹⁶ is a linear, branched or cyclic saturated or unsaturated hydrocarbon group having 5 to 22 carbon atoms which may be substituted by a hydroxyl group or an amine group, or a carbon number which may be substituted by a hydroxyl group at the ω terminal ester of the hydrocarbon group a linear or branched saturated or unsaturated fatty acid of 8 to 22; R ¹⁷ represents a hydrogen atom, or represents a total carbon number of 1 to 30 which may be substituted by a hydroxyl group, a hydroxyalkoxy group, an alkoxy group or an ethoxy group. Alkyl), (D) anionic surfactant 0.00025 to 10% by mass, (F1) water; Step 2 is further mixed with an aqueous phase II containing: (E) selected from alkyl-modified polyacrylic ethylene polymerization And the water-soluble polymer in the alkyl-modified polysaccharide-based polymer is 0.001 to 6% by mass, and (F2) water.

如請求項1之乳化組合物之製造方法，其中步驟1為步驟1A或步驟1B，步驟1A包括如下步驟：獲得含有成分(A)、(B)、(C)及未中和之成分(D)之油相之混合成分，以及於該油相中混合含有(F1)及鹼之水相I使其乳化並進行冷卻；步驟1B包括如下步驟：獲得含有成分(A)、(B)、(C)及成分(D)之鹽之油相之混合成分，以及於該油相中混合含有(F1)之水相I使其乳化並進行冷卻。The method for producing an emulsified composition according to claim 1, wherein the step 1 is the step 1A or the step 1B, and the step 1A comprises the step of obtaining the component (A), (B), (C) and the unneutralized component (D). a mixed component of the oil phase, and an aqueous phase I containing (F1) and a base mixed in the oil phase to be emulsified and cooled; the step 1B includes the following steps: obtaining the component (A), (B), C) and a mixed component of the oil phase of the salt of the component (D), and the aqueous phase I containing (F1) is mixed in the oil phase to be emulsified and cooled.

如請求項1之乳化組合物之製造方法，其中步驟1為步驟1C或步驟1D，步驟1C包括如下步驟：獲得含有成分(A)、(B)及(C)之油相之混合成分，以及於該油相中混合含有未中和之成分(D)、(F1)及鹼之水相I使其乳化並進行冷卻；步驟1D包括如下步驟：獲得含有成分(A)、(B)及(C)之油相之混合成分，以及於該油相中混合含有成分(D)之鹽及(F1)之水相I使其乳化並進行冷卻。The method for producing an emulsified composition according to claim 1, wherein the step 1 is the step 1C or the step 1D, and the step 1C comprises the steps of: obtaining a mixed component containing the oil phase of the components (A), (B) and (C), and The aqueous phase is mixed with the aqueous phase I containing the unneutralized components (D), (F1) and alkali to be emulsified and cooled; the step 1D includes the following steps: obtaining the components (A), (B) and The mixed component of the oil phase of C), and the salt phase containing the component (D) and the aqueous phase I of (F1) are mixed in the oil phase to be emulsified and cooled.

如請求項1之乳化組合物之製造方法，其中成分(A)、(B)、(C)、(D)及(E)之質量比例為(E)/((A)+(B)+(C))=0.0025~50，且(E)/(D)=0.025~100。The method for producing an emulsified composition according to claim 1, wherein the mass ratio of the components (A), (B), (C), (D) and (E) is (E) / ((A) + (B) + (C)) = 0.0025 to 50, and (E) / (D) = 0.025 to 100.

如請求項1之乳化組合物之製造方法，其中成分(D)為選自碳數12~24之脂肪酸鹽、烷基硫酸酯鹽、烷基醚硫酸鹽、脂肪酸醯胺磺酸鹽、烷基磷酸鹽、聚氧乙烯烷基醚磷酸鹽及長鏈N-醯基麩胺酸鹽中者。The method for producing an emulsified composition according to claim 1, wherein the component (D) is a fatty acid salt selected from the group consisting of carbon atoms 12 to 24, an alkyl sulfate salt, an alkyl ether sulfate, a fatty acid decyl sulfonate, and an alkyl group. Among phosphates, polyoxyethylene alkyl ether phosphates and long chain N-mercapto glutamate.

如請求項1之乳化組合物之製造方法，其中乳化組合物之於25℃下之黏度為10~8000dPas。The method for producing an emulsified composition according to claim 1, wherein the emulsified composition has a viscosity of from 10 to 8000 dPas at 25 °C.

如請求項1之乳化組合物之製造方法，其中乳化組合物中含有成分(A)0.05~7質量%、成分(B)0.05~7質量%、成分(C)0.05~7質量%、成分(D)0.05~2質量%、及成分(E)0.05~5質量%。The method for producing an emulsified composition according to claim 1, wherein the emulsified composition contains the component (A) 0.05 to 7 mass%, the component (B) 0.05 to 7 mass%, the component (C) 0.05 to 7 mass%, and the component ( D) 0.05 to 2% by mass, and component (E) 0.05 to 5% by mass.

如請求項1之乳化組合物之製造方法，其中成分(A)、(B)、(C)、(D)及(E)之質量比例為(E)/((A)+(B)+(C))=0.01~3。The method for producing an emulsified composition according to claim 1, wherein the mass ratio of the components (A), (B), (C), (D) and (E) is (E) / ((A) + (B) + (C)) = 0.01~3.

如請求項1之乳化組合物之製造方法，其中藉由步驟1而形成α-凝膠結構。The method for producing an emulsified composition according to claim 1, wherein the α -gel structure is formed by the step 1.

如請求項2或3之乳化組合物之製造方法，其中水相I中所含之鹼為選自精胺酸及氫氧化鈉中之1種或2種。The method for producing an emulsified composition according to claim 2, wherein the base contained in the aqueous phase I is one or two selected from the group consisting of arginine and sodium hydroxide.