TWI317738B - Tripeptide and tetrapeptide thioethers - Google Patents
Tripeptide and tetrapeptide thioethersInfo
- Publication number
- TWI317738B TWI317738B TW095100277A TW95100277A TWI317738B TW I317738 B TWI317738 B TW I317738B TW 095100277 A TW095100277 A TW 095100277A TW 95100277 A TW95100277 A TW 95100277A TW I317738 B TWI317738 B TW I317738B
- Authority
- TW
- Taiwan
- Prior art keywords
- tripeptide
- tetrapeptide
- thioethers
- tetrapeptide thioethers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64193205P | 2005-01-06 | 2005-01-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200635948A TW200635948A (en) | 2006-10-16 |
TWI317738B true TWI317738B (en) | 2009-12-01 |
Family
ID=36123437
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095100278A TWI317739B (en) | 2005-01-06 | 2006-01-04 | Tripeptide and tetrapeptide sulfones |
TW095100277A TWI317738B (en) | 2005-01-06 | 2006-01-04 | Tripeptide and tetrapeptide thioethers |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095100278A TWI317739B (en) | 2005-01-06 | 2006-01-04 | Tripeptide and tetrapeptide sulfones |
Country Status (25)
Country | Link |
---|---|
US (2) | US7129215B2 (zh) |
EP (2) | EP1833978B1 (zh) |
JP (2) | JP4903716B2 (zh) |
KR (2) | KR101244609B1 (zh) |
CN (2) | CN101090977B (zh) |
AR (2) | AR051890A1 (zh) |
AT (2) | ATE410520T1 (zh) |
AU (2) | AU2006204022B2 (zh) |
BR (2) | BRPI0606520A2 (zh) |
CA (2) | CA2587284C (zh) |
DE (2) | DE602006003064D1 (zh) |
DK (2) | DK1833978T3 (zh) |
EA (2) | EA200701398A1 (zh) |
ES (2) | ES2314890T3 (zh) |
HK (2) | HK1106778A1 (zh) |
HR (2) | HRP20090128T3 (zh) |
IL (2) | IL182836A (zh) |
MX (2) | MX2007008255A (zh) |
NZ (2) | NZ555362A (zh) |
PL (2) | PL1833978T3 (zh) |
PT (2) | PT1833978E (zh) |
SI (2) | SI1833978T1 (zh) |
TW (2) | TWI317739B (zh) |
WO (2) | WO2006074249A1 (zh) |
ZA (2) | ZA200704487B (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8198247B2 (en) * | 2004-12-21 | 2012-06-12 | Telik, Inc. | Process for and intermediates in the preparation of canfosfamide and its salts |
DE602006003064D1 (en) * | 2005-01-06 | 2008-11-20 | Telik Inc | Tripeptid- und tetrapeptid-thioether |
US20070154963A1 (en) * | 2005-12-30 | 2007-07-05 | Danying Cai | Method to determine whether a compound is a cellular GSTpi inhibitor |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
CN101541743A (zh) | 2006-11-08 | 2009-09-23 | 于崇曦 | 多肽及相关化合物的透皮给药*** |
AU2016213759B2 (en) * | 2006-11-08 | 2018-03-29 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
CN101687792B (zh) | 2007-06-04 | 2016-03-02 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其医药用途 |
CN108191846B (zh) | 2008-12-04 | 2021-08-20 | 于崇曦 | 高穿透性组合物及其应用 |
DE102008060888A1 (de) | 2008-12-09 | 2010-06-10 | Evonik Stockhausen Gmbh | Verfahren zur Herstellung von Acrolein umfassend die Aufarbeitung einer Rohglycerin-Phase |
AU2010244857A1 (en) | 2009-05-08 | 2011-11-10 | Techfields Biochem Co., Ltd. | High penetration prodrug compositions of peptides and peptide-related compounds |
CN102917694A (zh) * | 2010-06-07 | 2013-02-06 | 泰立克公司 | 依泽替米贝的片剂制剂 |
JP2013528214A (ja) | 2010-06-07 | 2013-07-08 | テリック,インコーポレイテッド | 結晶性エザチオスタット塩酸塩非溶媒和物d型の調製 |
US20130035389A1 (en) * | 2011-08-05 | 2013-02-07 | Telik, Inc. | Methods for treating myelodysplastic syndrome with ezatiostat |
JP5970439B2 (ja) * | 2013-09-20 | 2016-08-17 | チョンシー ユー | ペプチド及び関連化合物の経皮送達システム |
CN106146616A (zh) * | 2015-04-03 | 2016-11-23 | 浙江海正药业股份有限公司 | 环肽类化合物及其制备和用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599903A (en) * | 1992-04-03 | 1997-02-04 | Terrapin Technologies, Inc. | Glutathione analogs and paralog panels comprising glutathione mimics |
US5556942A (en) | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
US5786336A (en) | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
US5955432A (en) * | 1992-04-03 | 1999-09-21 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
US5767086A (en) * | 1992-04-03 | 1998-06-16 | Terrapin Technologies, Inc. | Bone marrow stimulation by certain glutathione analogs |
CA2105492C (en) * | 1993-09-03 | 2000-02-01 | Lawrence M. Kauvar | Glutathione analogs and paralog panels comprising glutathione mimics |
US5908919A (en) * | 1993-10-01 | 1999-06-01 | Terrapin Technologies | Urethane mediated, GST specific molecular release systems |
WO1996040205A1 (en) | 1995-06-07 | 1996-12-19 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
AU4124697A (en) * | 1996-09-02 | 1998-03-26 | Manchester Metropolitan University, The | S-blocked glutathiones |
DE69925824D1 (de) | 1998-04-16 | 2005-07-21 | Teijin Ltd | Glutathionderivate und dazugehörige dosisformen |
ATE286741T1 (de) * | 1999-01-27 | 2005-01-15 | Telik Inc | Glutathioneanaloge enthaltende therapeutische zusammensetzungen |
US7029695B2 (en) * | 2001-07-10 | 2006-04-18 | Telik, Inc. | Therapeutic compositions containing glutathione analogs |
TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
DE602006003064D1 (en) | 2005-01-06 | 2008-11-20 | Telik Inc | Tripeptid- und tetrapeptid-thioether |
-
2006
- 2006-01-04 DE DE602006003064T patent/DE602006003064D1/de active Active
- 2006-01-04 JP JP2007550441A patent/JP4903716B2/ja not_active Expired - Fee Related
- 2006-01-04 AT AT06717426T patent/ATE410520T1/de active
- 2006-01-04 PL PL06717426T patent/PL1833978T3/pl unknown
- 2006-01-04 EP EP06717426A patent/EP1833978B1/en active Active
- 2006-01-04 DK DK06717426T patent/DK1833978T3/da active
- 2006-01-04 ES ES06717426T patent/ES2314890T3/es active Active
- 2006-01-04 WO PCT/US2006/000219 patent/WO2006074249A1/en active Application Filing
- 2006-01-04 PT PT06717426T patent/PT1833978E/pt unknown
- 2006-01-04 NZ NZ555362A patent/NZ555362A/en not_active IP Right Cessation
- 2006-01-04 BR BRPI0606520-1A patent/BRPI0606520A2/pt not_active IP Right Cessation
- 2006-01-04 SI SI200630153T patent/SI1833978T1/sl unknown
- 2006-01-04 MX MX2007008255A patent/MX2007008255A/es active IP Right Grant
- 2006-01-04 TW TW095100278A patent/TWI317739B/zh not_active IP Right Cessation
- 2006-01-04 TW TW095100277A patent/TWI317738B/zh not_active IP Right Cessation
- 2006-01-04 CN CN2006800014949A patent/CN101090977B/zh not_active Expired - Fee Related
- 2006-01-04 KR KR1020077018022A patent/KR101244609B1/ko not_active IP Right Cessation
- 2006-01-04 AU AU2006204022A patent/AU2006204022B2/en not_active Ceased
- 2006-01-04 CA CA2587284A patent/CA2587284C/en not_active Expired - Fee Related
- 2006-01-04 US US11/325,846 patent/US7129215B2/en not_active Expired - Fee Related
- 2006-01-04 EA EA200701398A patent/EA200701398A1/ru unknown
- 2006-01-05 AR ARP060100042A patent/AR051890A1/es not_active Application Discontinuation
- 2006-01-05 PT PT06717699T patent/PT1833842E/pt unknown
- 2006-01-05 JP JP2007550515A patent/JP4903717B2/ja not_active Expired - Fee Related
- 2006-01-05 ES ES06717699T patent/ES2314891T3/es active Active
- 2006-01-05 CA CA2587310A patent/CA2587310C/en not_active Expired - Fee Related
- 2006-01-05 SI SI200630154T patent/SI1833842T1/sl unknown
- 2006-01-05 PL PL06717699T patent/PL1833842T3/pl unknown
- 2006-01-05 DE DE602006003063T patent/DE602006003063D1/de active Active
- 2006-01-05 AR ARP060100041A patent/AR051889A1/es not_active Application Discontinuation
- 2006-01-05 DK DK06717699T patent/DK1833842T3/da active
- 2006-01-05 WO PCT/US2006/000532 patent/WO2006074409A1/en active Application Filing
- 2006-01-05 KR KR1020077012531A patent/KR20070091611A/ko not_active Application Discontinuation
- 2006-01-05 EP EP06717699A patent/EP1833842B1/en active Active
- 2006-01-05 AT AT06717699T patent/ATE410440T1/de active
- 2006-01-05 AU AU2006203901A patent/AU2006203901B2/en not_active Ceased
- 2006-01-05 MX MX2007008254A patent/MX2007008254A/es active IP Right Grant
- 2006-01-05 BR BRPI0606396-9A patent/BRPI0606396A2/pt not_active IP Right Cessation
- 2006-01-05 EA EA200701399A patent/EA200701399A1/ru unknown
- 2006-01-05 US US11/326,975 patent/US7192918B2/en not_active Expired - Fee Related
- 2006-01-05 NZ NZ555361A patent/NZ555361A/en not_active IP Right Cessation
- 2006-01-05 CN CNA2006800013664A patent/CN101080418A/zh active Pending
-
2007
- 2007-04-26 IL IL182836A patent/IL182836A/en not_active IP Right Cessation
- 2007-05-10 IL IL183107A patent/IL183107A/en not_active IP Right Cessation
- 2007-05-20 ZA ZA200704487A patent/ZA200704487B/xx unknown
- 2007-05-30 ZA ZA200704488A patent/ZA200704488B/xx unknown
- 2007-12-21 HK HK07114049A patent/HK1106778A1/xx not_active IP Right Cessation
- 2007-12-21 HK HK07114048A patent/HK1106796A1/xx not_active IP Right Cessation
-
2009
- 2009-03-03 HR HR20090128T patent/HRP20090128T3/xx unknown
- 2009-03-06 HR HR20090134T patent/HRP20090134T3/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |