TW570810B - Skin whitening composition containing bearberry extract and a reducing agent - Google Patents
Skin whitening composition containing bearberry extract and a reducing agent Download PDFInfo
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- TW570810B TW570810B TW088120050A TW88120050A TW570810B TW 570810 B TW570810 B TW 570810B TW 088120050 A TW088120050 A TW 088120050A TW 88120050 A TW88120050 A TW 88120050A TW 570810 B TW570810 B TW 570810B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Description
570810 A7 B7 五、發明説明(i ) 發明背景 本發明係有關包含熊果萃取物及還原劑之外用皮膚美 白組成物’及局部施以含有有效量之包含熊果萃取物及還 原劑之紕成物。 膚色主要係決定於存在於皮膚之黑色素之量。因此, 最近幾年’化妝品組成物已發展出降低皮膚内墨色素含量 ’因而可美白皮膚。此等發展之努力係著眼於抑制酥氨基 酸氧化酵素(其於墨色素之生物合成扮演重要角色)之作用 及活性之美白劑。例如,已提出於化妝品組成物中加入酥 氨基酸氧化酵素活性抑制劑,諸如,氫醍酮、維生素c及 其衍生物、麴酸、谷胱甘、半胱氨酸及桑椹萃取物等。 7 雖然上述化合物於產生皮膚美白之功效,更有效之替 代品仍持續被尋求中。現發現含有熊果之皮膚美白組成物 可藉由添加諸如供應甲醛之化合物之還原劑至組成物而改 良。相信還原劑降低酥氨基酸氧化酵素,其出人意外地產 生組成物美白功效之戲劇性增加之效果。 、此外,相信還原劑能改變某些胺基酸之化學組成,其 數者係黑色素產生方法之關鍵。結果,可獲得增加之皮膚 美白效果。 發明之綜述 本發明之目的係提供包含熊果萃取物及還原劑之組成 物,其適於外用,且避免或抑制皮膚黑色素之生成,因而 可美白皮膚。另一目的係藉由添加諸如重氮啶基尿素之還 原劑而促進及加速藉由熊果萃取物展現之美白及美化效果 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) (請先閲讀背面之注意事項再填寫本頁) •訂 經濟部智慧財產局員工消費合作社印製 -4 570810 五、發明説明(2 ) 之發展。 本發明亦包含-種美白皮廣之方法,其包含於皮膚局 部施用含有熊果萃取物及有效量還原劑之組成物,持續足 以產生可見出之—皮廣美白之時間。於較佳實施例中,還原 劑係提供甲醛之化合物。”提供甲醛之化合物,,一辭係指當 置入化妝品載體内時能提供甲醛部份之化合物。例如,提 供甲醛之化合物可選自甲醛、孓溴1•孓氡基丙烷_丨,3•二醇 、戊二醛、四級鹽-15、聚甲氧基雙環噁唑烷、DM乙内醯 脲、MDM乙内醯脲、DMDM乙内醯脲及尿囊素·甲醛縮合 產物,包含重氮啶基尿素及咪唑啶基尿素及其混合物。於 更佳實施例,中,還原劑係重氮啶基尿素、咪唑啶基尿素或 其混合物/ i In If —- I m (請先閱讀背面之注意事項再填寫本頁) i^i· I - In · -裝· 訂
經濟部智慧財產局員工消黄合作社印製 與還原劑混合之熊果萃取物係作為美白劑。其它美白 劑可被包含於皮膚美白組成物内。此等試劑之例子包含酥 氨基酸氧化酵素抑制劑、白由基清除劑及其混合物。一些 酥氨基酸氧化酵素抑制劑包含熊果甘、檸檬萃取物、小黃 瓜萃取物、2-M基琥珀酸、2-酼基葡萄聚糖、麴酸、麴酸 衍生物、維生素C、維生素C之衍生物、氫酕酮、谷胱甘 、半胱胺酸、桑椹萃取物及其衍生物、甘草汁萃取物及 其衍生物及其等之混合物,但不限於此。 於依據本發明之美白組成物中,熊果萃取物及其還原 劑之量不能被絕對特定化,因其係依製備形式而改變。但 是,熊果一般使用量係約0.001%至約99%,較佳係約〇·〇1 % 至約50%,所欲者係約0.1%至約25%,更佳係約0.2%至約 本紙張尺度適用中國國家標準(CNS ) A4規格(210 X 297公釐) 570810 五、發明説明( 經濟部智慧財產局員工消費合作社印製 A7 B7 10%,最佳係約1%至約5%。還原劑一般使用量係約0.001% 至約99%,較佳係約0.01%至約50%,所欲者係約〇1 %至 約25%,更佳係約〇·〇ι%至約100%,最佳係約〇 1〇0/〇至約 0.50% 〇 需注意除非其它表示,說明書及申請專利範圍中所有 百分率係指重量百分率。 較佳實施例之詳細說明 依據本發明,一種皮廣美白組成物被提供,其包含熊 果萃取物及作為活化組份之還原劑。 熊果萃取物係自uva-ursi 萃取出。較佳 者,熊果萃取物係自Pentapharm獲得。其係被標準化至毫 升>50酥氨基酸氧化酵素抑制劑單位(TyiU/ml)之二醇萃 取物。 還原劑係供應甲醛之化合物。供應甲醛之化合物能有 效作為還原劑以還原硫氫官能基及胺官能基。此外,還原 劑作為競爭式地干擾導致自酥氨基酸生成黑色素之氧化反 應。供應曱醛之化合物係選自甲醛、2-溴-2-氡基丙烷-1,3-二醇、戊二醛、四級鹽-15、聚甲氧基雙環噁唑烷、DM乙 内醯腺、MDM乙内醯腺、DMDM乙内醯腺及尿囊素-甲醛 縮合產物,包含重氮啶基尿素及咪唑啶基尿素及其混合物 。於更佳實施例中,還原劑係重氮啶基尿素、咪唑啶基尿 素或其混合物。 相信若依據本發明以還原劑補償,含有熊果萃取物之 皮膚美白組成物可達成更高功效之皮膚美白。結果,更高 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) (請先閲讀背面之注意事項再填寫本頁)
570810 A7 B7
經濟部智慧財產局員工消費合作社印製 五、發明説明(4 ) 程度之皮膚美白活性可以較低含量之熊果萃取物達成。 進一步相信依據本發明之含有熊果萃取物及還原劑之 組成物可藉由促進已知皮膚美白劑之皮膚美白組功效展現 相乘功效。此功效可藉由添加一或多種具有已知美昌功效 之物質而進一步增加。 基於此理由’包含熊果萃取物及還原劑之本發明組成 物較佳係以其它美白劑增加。用於本發明之美白劑被認為 包含已知美白劑及於未來可發展出者。雖然可能無法指出 所有已知之美白劑,下述美白劑被述及且對於本發明之目 的係較佳·穌氨基酸氧化酵素抑制劑、白由基清除劑、整 合劑及其混合物。 一些酥氨基酸氧化酵素抑制劑包含熊果甘、橘子萃取 物、檸檬萃取物、小黃瓜萃取物、2-鲼基琥珀酸、2-巯基 葡萄聚糖、麴酸、麴酸衍生物、維生素C、維生素c之衍 生物、氫酕酮、氫醍酮衍生物、谷胱甘、半胱胺酸及其 衍生物(諸如,N-乙醯基半胱胺酸及描述於美國專利第 5,296,500號案描述者,其相關部份在此被併入以供參考) 、桑椹萃取物及其衍生物、甘草汁萃取物及其衍一物及其 專之混合物,但不限於此。 麴酸或其酯可以下述化學式表式: I---------^------1T------線 (請先閲讀背面之注意事項再填寫本頁)
570810 A 7 B7 五、發明説明(7 ) (請先閲讀背面之注意事項再填寫本頁) 可被用於本發明之另一物質係-2巯基葡萄聚糖。2-巯 基葡萄聚糖係聚硫醇,其可藉由使用例如N-乙醯基同半 胱氨酸硫代己内酮硫化葡萄聚糖化合物而合成。葡萄聚糖 可具有約500至500,000之任何適合之分子量。用於本發明 之2-鲼基葡萄聚糖可依據Eldjarn,L & E. Jellum:有機汞 多糖,用於分離及隔離SH-蛋白質之色層分析材料之方法 ;Acta Chem. Scand·,17:2610-21 (1963)及/或 Jellum,E·,J. Aaseth & L. Eldjarn: 2-巯基葡萄聚糖,高分子量之金屬螯 合及二硫化物還原多硫醇;Biochem. Pharmacol·, 22:1179-88 (1973)製備,二者在此被併入以供參考。另外 ,相信2·巯基葡萄聚糖可藉由葡萄聚與硫衍生物(諸如,2-巯基琥珀酸)之聚合反應製得。於任何情況中,現不相信 製備方法對於施行本發明係重要的。因此,2-巯基葡萄聚 糖可以任何適當方法製備。 經濟部智慧財產局員工消費合作社印製 相信葡萄聚糖可具有約500至約500,000之任何分子量 ,因此,所形成之2-酼基葡萄聚糖亦可具有約500至約 500,000之任何適當之分子量,如此,2-疏基葡萄聚糖展 現酥氨基酸氧化酵素之抑制性。有關於此,相信具有少於 約100,000之分子量之2-酼基葡萄聚糖對於皮渭美白比具 有大於約100,000之分子量者更有效。因此,較佳係使用 具有約1000與100,000之間之分子量之2-M基葡萄聚糖。 於較佳實施例中,Pharmacia Biotech之具有約10,000之分 子量之2-酼基葡萄聚糖係已知有效者。’ 當2-酼基葡萄聚糖與熊果萃取物及其還原劑和其它已 本紙張尺度適用中.國國家標準(.CNS ).A4規格(210X297公釐) 10 經濟部智慧財產局員工消費合作社印製 570810 A? B7 五、發明説明(8 ) 知美白劑混合時,2-巯基葡萄聚糖對熊果萃取物之比例係 約1:100至約100:1,較佳係約1:50至約50:1,更佳係約1:10 至約10:1。最佳者,2-巯基葡萄聚糖對熊果萃取物之比例 係約1:5至約5:1。 本發明組成物可以各種不同形式製得。例如,其可以 化妝品製備形式,諸如,乳化物、軟膏或藥膏乳液、冷霜 (水包油、油包水及數相)、溶液、f懸浮液(無水及以水為 基準者)、無水產物(油及乙二醇為基準者)、凝膠、棒、 界面活性劑系統(清潔劑、洗頭髮、清面劑等)、粉末、面 膜、包裝物或粉末等。 本發明組成物一般包含熊果萃取物、還原劑及化妝品 可接受或藥學可接受之載體。”藥學可接受,,及,,化妝品可 接受”一辭係指適於與水類及較低動物之組織接觸而無不 當之毐性、不相容性、不穩定性、輻射性等且以合理之益 處/危險比例相當者之藥品、藥劑或惰性組份。 化妝品可接受之載劑一般係組成物重量之約1 %至約 99.9%,較佳係約50%至約99%,且在無其它化妝品附屬 品中形成組成物之其餘量。 組成物一般含有各種不同之已知傳統化妝品組份。例 如,諸如醇、脂及油、界面活性劑、脂肪酸、矽酮油、稀 釋劑、濕化劑、黏度改質劑、乳化劑、穩定劑、色劑及香 料之化妝品組份可被包含之。 緩和劑包含硬脂酸基醇、甘油基單’蒽蔴油酯、甘油基 單硬脂酸酯、貂油、十六醇、異丙基異硬脂酸酯、脂肪酸 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) ---------^------1T------0 (請先閲讀背面之注意事項再填寫本頁) -11 570810
五、發明説明( 經濟部智慧財產局員工消費合作社印製 及酯、硬脂酸、異丁基棕櫚酸酯、異十六基硬脂酸酯、油 醯基醇、異丙基月桂酸酯、己基月桂酸酯、癸基油酸酯' 十六基-2-醇、異十六奉醇、脂肪酸,諸如,二十基醇、 二十二烯基醇、十六基棕櫚酸酯、揮發性或非揮發性之矽 酮油諸如,二甲基聚矽酮、二正丁基泌脂酸酯、異丙基 莖蔻酸酯、異丙基棕櫚酸酯、異丙基硬脂酸酯、丁基硬脂 酸§曰、聚乙二醇、三乙二醇、羊毛脂、磷脂、可可亞奶油 、玉米油、棉花籽油、牛脂、豬油、橄欖油、棕櫚核仁油 、紅花子油、待宵草油、黃豆油、葵花籽油、西番蓮油、 酪架/由、撖視油、芝藏籽油、橄子油、花生油、海捏油、 乙醯化羊毛脂醇、原油凝膠、礦物油、丁基莖蔻酸酯、異 硬脂酸、棕7摘酸、異丙基亞麻仁酯、月桂酸基乳酸酯、笪 蔻基乳酸酯、癸基油酸酯、莖蔻基菫蔻酯。 依據本發明之組成物可選擇性地包含一或多者之油或 其它具有油性之物質。適當油之例子包含礦物油及蔬菜油 ,及油材料,諸如,已提出作為緩和劑者。其它之油或油 質材料包含矽酮油(揮發性或非揮發性),諸如,聚二甲基 石夕烧。 當作為形成乳化物而存在時,此等油或油質材料一般 係形成組成物體積之最高達9〇% ,較佳係1〇至8〇%。 依據本發明之組成物亦可選擇性地包含一或多者之乳 化劑,其選擇性一般取決於是否形成油包水及水包油。 备需要油包水時,所選之乳化劑一般需具有丨至6之平 均HLB值。當需要水包油時,所選之乳化物需具有平>6之 i ^1T«^1^ (請先閲讀背面之注意事項再填寫本頁)
570810 A7 A7 ' B7 五、發明説明(10 HLB值 雖然本發明组成物可為無水,其亦可包含水,一般係 以體積計為最高達98%,較佳係5至80%。 除已述及之選擇性乳化劑外,或作為其替代品,本發 明組成物亦可選擇性地包含高分子量之矽酮界面活性劑, 其亦可作為乳化劑。 - 矽酮界面活性劑可為具有l〇,〇(J〇至50 000分子量且具 有下述結構之具有琴氧伸乙基及/或聚氧伸丙基側鍵之二 甲基聚碎綱* — ^-- (請先閱讀背面之注意事項再填寫本頁)
"f3 一 si - 〇 si - 0 L V Si CH3 訂 其中&及^基之每一者係選自-^^以烷基,* 線 -iCH2CH20]K[CH2CHO}Ji ch3 經濟部智慧財產局員工消費合作社印製 - I I— -- I - t具有9至115之值, u具有0至50之值, v具有133至673之值, w具有25至0.25之值, 二甲基聚矽酮聚合物可以於揮發性矽烷内之分散物而 提供,此分散物包含,例如,1至20體積%之聚合物及8〇 至99體積%之揮發性矽烷。理想係分散物由ι〇體積%之聚 ( CNS ) ( 210X297^ ) 13 經濟部智慧財產局員工消費合作社印製 570810 _____B7 .五、發明説明(U ) 合物分散於揮發性矽烷内組成。揮發性矽烷(其間可分散 聚矽烷聚合物者)之例子包含聚二甲基矽烷(五聚物及/或 .六聚物)。矽酮之界面活性劑之例子係環甲酮及二甲酮共 多元醇,諸如,得自D0W CORNING之DC 3225C Formulation Aid。另一者係月桂基甲酮共多元醇,諸如〇(: Q2-5200 ’ 亦得自 d〇w Corning。… 當存在於組成物時,矽酮界面‘性劑之量一般係乳化 物之最高達25重量。/〇,較佳係〇·5至15重量%。 可選擇性被使用之傳統附屬物之例子包含稀釋劑,諸 如,甘油、清涼茶醇、2-咣咯酮羧酸酯、二丁基酞酸 醋、膠、聚乙烯、二醇,較佺係PEG 200-600 ;緩衝液, 諸如與鹼(4如三乙醇胺或氫氧化鈉)一起之乳酸;界面活 性劑,諸如,甘油醚;蠟,諸如蜂蠟、石蠟、植物萃取物 ,諸如,Aloe vera、矢車菊、金纓梅、接骨木花,增稠 劑,諸如,xanthan膠,活性促進劑;色料、香料;及防 曬物質,諸如,超細二氧化鈦及有機防曬物,諸如,對_ 胺基笨曱酸及其酯、乙基己基對-曱氧基肉桂酸酯、孓乙 氧基乙基對-甲氧基肉桂酸酯及丁基甲氧基二笨甲基甲烷 及皮膚有利試劑,諸如,維生素八酸、維生素A、維生素 AS旨;抗發炎試劑,諸如,水揚酸;及其混合物。 諸如α -及万-羥基酸之皮膚滲透組份亦可被包含之。 諸如油脂、神經醯胺、神經氨基醇、神經氨基脂、假神經 酿胺、磷基脂及乙二醇脂之改質劑亦可★被包含之。此等改 質劑可作為改質組成物中之一或多種物質之刺激作用。此 本紙張U適用中國國家蘇7^ )从胁(210X297公釐)-------- ----------—ΦΦ------IT—----费· (請先閲讀背面之注意事項再填寫本頁) 14 570810 A7 B7 經濟部智慧財產局員工涓黄合作社印製 五、發明説明(12 ) 外’其可助於避免及修護皮膚之障避功能β改質劑可與固 醇(諸如,膽固醇及膽固醇硫酸鹽)及脂肪酸(較佳係可於 皮膚及頭髮内發現者,諸如,C10-C30之脂肪酸)混合。 於本聲明組成物之另一方面,其提供一種含熊果之皮 膚美白組成物,其中該改良處包含添加有效量之還原劑以 增加熊果萃取物之皮膚美白效用。還原劑包含上述之甲搭 化合物。 > 於依據本發明之美白組成物及方法中,熊果萃取物及 其還原劑之量不可被絕對特定化,因其依製備形式而改變 。但是,熊果一般使用量係約〇·〇〇 1%至約99%,較佳係約 0.01 %至約50%,所欲者係約0.1%至約25%,更佳係約0.2% 至約10%,最佳係約1%至約5%,其係以美白組成物之總 重量為基準。 還原劑一般使用量係約0.001%至約99%,較佳係約 ^ 0.01%至約50%,所欲者係約0.1%至約25%,更佳係約0.01% 至約1.00%,最佳係約0.10%至約0.50%,其係以美白組成 物之總重量為基準。 於此等範圍内,熊果萃取物對還原劑之比例係約 1:1000至約1000:1,較佳係約1:100至約100:1,更佳係約 1:10 至 10:1。 於本發明組成物之另一方面,組成物包含熊果萃取物 及還原劑,其中該還原劑之存在量係能有效增加熊果萃取 物之皮膚美白功效者。再者,還原劑包含上述之甲醛化合 物0 本紙張尺度適用中國國家標準(CNS ) A4規格(2l〇X297公嫠) 裝------訂------線 (請先閱讀背面之注意事項再填寫本頁) 15 [570810 A7 B7 五、發明説明(13 ) 本發明亦意欲一種視學上美白人類皮膚之方法,包含 於皮廣施用含有熊果萃取物及有效量之還原劑之組成物, 其中該組成物係以足以視覺上美白皮膚之量及時間施用之 ^較佳者’此方法包含局部於皮廣施用包含熊果萃取物、 還原劑及藥學可接受載體或化妝品可接受載體之組成物。 本發明亦意欲一種增加含有熊果萃取物之皮膚美白組 成物之皮廣美白功效之方法,該方法包含添加有效量之還 原劑。組成物係以足以視覺上美白皮唐之量及時間施用之 m n I- n —I- » ϋ I— 1„J (請先閲讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 為證實依據本發明之含有熊果萃取物及還原劑之皮膚 美白組成物之功效,下列測試被進行之。 範例1 含有2.00%熊果萃取物之二皮膚美白劑被施用於含有 培養之黑素細胞之有蓋玻璃碟子48小時。一美白劑含有 0 · 3 0 %之還原劑*一偶氣咬基尿素,另一者則不含。當以眼 睛觀察時,相較於被塗覆以不含還原劑之美白劑者,被以 含,有還原劑之美白劑塗覆之樣品驚人地變白。 範例2 下述者係依據本發明之水包油乳化組成物。 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) 訂 16 570810 五、發明説明(14 ) A7 B7 原料 % 純化過之水 85.2 Xanthan 勝 0.5 甘油 4.8 二氧化鈦 0.2 鯊烷 3.0 黃豆油 < 1.0 硬脂酸及二十二碳基醇及甘油基硬脂酸酯及順丁烯 二酸酯黃豆油及磷脂及C12_16之醇及棕櫚酸 0.5 Acerola櫻桃發酵物 0.3 橘子萃取物 1.0 檸檬萃取物&木黃瓜萃取物&檸檬酸鈉 0.5 熊果萃取物 2.0 還原劑(丙—醇及二偶氮咬基尿素及甲基paraben及丙 基paraben 1.0 總量 100.0 裝-- (請先閱讀背面之注意事項再填寫本頁) 、^1 線 需瞭解寬範圍之變化及改質可對上述實施例為之。因 此,前述係用以例示本發明而非用以限制本發明,且下述 申請專利範圍(包含其等化物)係用以界定本發明。 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準(CNS ) Α4規格(210X297公釐) 17
Claims (1)
- 570810 /Λ.Β8 C8 申請專利範圍 第088120050號專利再審查案申請專利範圍修正本 修正日期:92年10月 1 ·種具有對黑色素合成具抑制活性之局部使用之組成 物’忒組成物包含衍生自加冲咖__之熊果萃取 物及還原劑,該還原劑為一可提供甲醛之化合物,其中 該還原劑係以0.001至99重量百分之能有效增加該熊果 萃取物之皮膚美白功效之量存在。 2 ·如申印專利範圍第1項之組成物,其中該提供甲醛之化 合物係選自甲醛、2_溴_2-氡基丙烷_丨,3_二醇、戊二醛 、四級鹽-1 5、聚甲氧基雙環噁唑烷、DM乙内醯脲、 MDM乙内醯脲、DMDM乙内醯脲及尿囊素-甲醛縮合產 物及其混合物。 3·如申請專利範圍第1項之組成物,其中該組成物包含約 〇·001重量%至約99重量%之熊果萃取物。 •如申明專利範圍第1項之組成物,其中該組成物係選自 冷霜、藥膏、發泡體、乳液、膏藥、錠、顆粒及乳化物 之製備形式。 5 ·如申請專利範圍第1項之組成物,其進一步包含皮膚美 白劑,其係選自酥氨基酸氧化酵素抑制劑、自由基清除 劑、螯合劑及其混合物。 6·如申請專利範圍第5項之組成物,其中該#氨基酸氧化 酵素之抑制劑係選自熊果苷、檸檬萃取物、小黃瓜萃取 物、2-巯基琥珀酸、2_巯基葡萄聚糖、麴酸、麴酸衍生 物、維生素C .、維生素C之衍生物、氫醌酮、谷胱甘肽 •本料尺以財570810 A B c D 六、申請專利範圍 、半胱胺酸、桑椹萃取物、甘草汁萃取物及其衍生物及 .其等之混合物。 7· —種含有熊果萃取物之皮膚美白組成物,該熊果萃取物 係萃取自]咐0伽;^/仍且係一被標準化至每毫升 > 5 0酥氨基酸氧化酵素抑制單位的乙二醇萃取物,♦其 改良包含一能有效增加該熊果萃取物之皮膚美白功效 之含量之還原劑。 8· 種增加含有衍生自々ctos1啤/^/os臟Z-,S7·熊果萃取物之 皮膚美白組成物之皮膚美白功效之方法,該方法包含添 加有效量之0.001至99重量百分之還原劑,該還原劑為 一提供甲醛之化合物。 9·如申請專利範圍第8項之方法,其中該提供.甲醛之化合 物係選自甲醛、2-溴-2-氡基丙烷-1,3-二醇、戊二醛、 四級鹽-1 5、聚曱氧基雙環噁唑烷、DM乙内醯脲、MDM 乙内酿脲、DMDM乙内醯脲及尿囊素-甲醛縮合產物及 其混合物。 1〇·如申請專利範圍第8項之方法,其中該組成物包含約 0.001重量%至約99重量%之熊果萃取物。
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US09/195,577 US5980904A (en) | 1998-11-18 | 1998-11-18 | Skin whitening composition containing bearberry extract and a reducing agent |
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-
1998
- 1998-11-18 US US09/195,577 patent/US5980904A/en not_active Expired - Lifetime
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1999
- 1999-11-11 KR KR10-1999-0049823A patent/KR100402976B1/ko not_active IP Right Cessation
- 1999-11-15 ID IDP991057D patent/ID25773A/id unknown
- 1999-11-17 DE DE69918775T patent/DE69918775T2/de not_active Expired - Fee Related
- 1999-11-17 EP EP99309155A patent/EP1002526B1/en not_active Expired - Lifetime
- 1999-11-17 AT AT99309155T patent/ATE271374T1/de not_active IP Right Cessation
- 1999-11-17 MY MYPI99005004A patent/MY121824A/en unknown
- 1999-11-18 CN CN99127716A patent/CN1256914A/zh active Pending
- 1999-11-18 JP JP11327781A patent/JP2000154136A/ja active Pending
- 1999-12-04 TW TW088120050A patent/TW570810B/zh active
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EP1002526B1 (en) | 2004-07-21 |
DE69918775D1 (de) | 2004-08-26 |
ID25773A (id) | 2000-11-02 |
US5980904A (en) | 1999-11-09 |
JP2000154136A (ja) | 2000-06-06 |
KR100402976B1 (ko) | 2003-10-24 |
MY121824A (en) | 2006-02-28 |
KR20000035398A (ko) | 2000-06-26 |
EP1002526A1 (en) | 2000-05-24 |
CN1256914A (zh) | 2000-06-21 |
ATE271374T1 (de) | 2004-08-15 |
DE69918775T2 (de) | 2005-08-25 |
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