TW202003007A - A composition containing a Rutaceae plant extract - Google Patents
A composition containing a Rutaceae plant extract Download PDFInfo
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- TW202003007A TW202003007A TW107118821A TW107118821A TW202003007A TW 202003007 A TW202003007 A TW 202003007A TW 107118821 A TW107118821 A TW 107118821A TW 107118821 A TW107118821 A TW 107118821A TW 202003007 A TW202003007 A TW 202003007A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Abstract
Description
本發明係有關一種含有芸香科植物萃取物的組成物。The present invention relates to a composition containing plant extracts of Rutaceae.
天然酸性潤滑液正常存在***中，及做愛時潤滑液會增量產生。由於一些原因，包括更年期時***減少、或卵巢摘除手術後，及放射線治療後，潤滑液可能減少，引起***組織成為乾燥及受刺激的。這可能導致做愛時疼痛及/或流血。口服避孕藥及某些藥物諸如，抗組織胺劑、抗憂鬱藥物、降血壓藥及心臟藥也會導致***乾燥。另外，心理狀況，包括壓力、勞累及焦慮可能阻礙天然潤滑液的產生。在分娩後，特別是媽媽親自哺乳時，荷爾蒙及心理因子的組合可能引發***暫時性乾燥。Natural acidic lubricating fluid is normally stored in the vagina, and the lubricating fluid will be produced in increments during sex. For some reasons, including decreased estrogen during menopause, or after ovarian removal surgery, and after radiation therapy, lubricating fluid may be reduced, causing vaginal tissue to become dry and irritated. This may cause pain and/or bleeding during sex. Oral contraceptives and certain medicines such as antihistamines, antidepressants, blood pressure lowering drugs, and heart medicines can also cause vaginal dryness. In addition, psychological conditions, including stress, fatigue and anxiety may hinder the production of natural lubricants. After childbirth, especially when the mother is breastfeeding herself, the combination of hormones and psychological factors may cause temporary vaginal dryness.
常見的人體潤滑劑或保養品和清潔用品，諸如矽酮及市售的K-Y膠及凡士林主要係基於諸如矽酮、石化原料的合成物質。於是，此種商業市售可得的酸性***潤滑劑並不推薦給想要懷孕的婦女，或是注重天然有機、預防保健的族群使用。Common human lubricants or care products and cleaning products, such as silicone and commercially available K-Y glue and petrolatum are mainly based on synthetic substances such as silicone and petrochemical raw materials. Therefore, this commercially available acidic vaginal lubricant is not recommended for women who want to become pregnant, or for groups that focus on natural organic and preventive health care.
本發明之一目的，在於提供一種含有芸香科植物萃取物的組成物，其不僅具有潤滑，保濕等保養效果，而且具有短時間抗菌、抗病毒、預防疾病傳染等功效。An object of the present invention is to provide a composition containing Rutaceae plant extracts, which not only has maintenance effects such as lubrication and moisturization, but also has short-term antibacterial, anti-viral, and prevention of disease and other effects.
為了達成上述之目的，本發明有關一種含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物、10-30 wt%C1-C4多元醇系統及60-70 wt%純水。於一態樣中，本發明的含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物、2-10 wt%C5-C8多元醇系統及60-70 wt%純水。於一態樣中，該芸香科植物萃取物係選自由橘、柑、甜橙、酸橙、苦橙、柚、葡萄柚、檸檬、萊姆、枸櫞、佛手柑及金橘所組成之任一族群的萃取物。該多元醇系統係選自由甘油、丙二醇、甲基丙二醇、丁二醇、戊二醇、己二醇、辛二醇、辛乙二醇及乙基己基甘油所組成之任一族群的組合物。In order to achieve the above object, the present invention relates to a composition containing Rutaceae plant extract, including 0.1-2 wt% Rutaceae plant extract, 10-30 wt% C1-C4 polyol system and 60-70 wt% pure water. In one aspect, the composition containing the Rutaceae plant extract of the present invention includes 0.1-2 wt% Rutaceae plant extract, 2-10 wt% C5-C8 polyol system and 60-70 wt% pure water . In one aspect, the Rutaceae plant extract is selected from the group consisting of tangerine, mandarin, sweet orange, lime, bitter orange, pomelo, grapefruit, lemon, lime, citron, bergamot and kumquat An extract of an ethnic group. The polyol system is a composition selected from any group consisting of glycerin, propylene glycol, methyl propylene glycol, butylene glycol, pentanediol, hexanediol, octanediol, octane glycol, and ethylhexylglycerin.
為了達成上述之目的，本發明有關另外一種含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物；10-30 wt% C1-C4多元醇系統；1-4 wt%天然防腐劑；0.5-2 wt%天然增稠劑及60-70 wt%純水。於一態樣中，本發明有關另外一種含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物；2-10 wt% C5-C8多元醇系統；1-4 wt%天然防腐劑；1-3 wt%天然增稠劑及60-70 wt%純水。In order to achieve the above object, the present invention relates to another composition containing Rutaceae plant extract, including 0.1-2 wt% Rutaceae plant extract; 10-30 wt% C1-C4 polyol system; 1-4 wt% Natural preservative; 0.5-2 wt% natural thickener and 60-70 wt% pure water. In one aspect, the present invention relates to another composition containing Rutaceae plant extract, including 0.1-2 wt% Rutaceae plant extract; 2-10 wt% C5-C8 polyol system; 1-4 wt% Natural preservative; 1-3 wt% natural thickener and 60-70 wt% pure water.
於一態樣中，該芸香科植物萃取物係選自由橘、柑、甜橙、酸橙、苦橙、柚、葡萄柚、檸檬、萊姆、枸櫞、佛手柑及金橘所組成之任一族群的萃取物。In one aspect, the Rutaceae plant extract is selected from the group consisting of tangerine, mandarin, sweet orange, lime, bitter orange, pomelo, grapefruit, lemon, lime, citron, bergamot and kumquat An extract of an ethnic group.
該C1-C4多元醇系統係選自由甘油、丙二醇、甲基丙二醇及丁二醇所組成之任一族群的組合物。該C5-C8多元醇系統係選自由戊二醇、己二醇、辛二醇及辛乙二醇所組成之任一族群的組合物。該天然增稠劑係選自由三仙膠、瓜爾豆膠、海藻酸鈉及***樹膠所組成之任一族群的組合物。依照使用目的，非天然增稠劑亦可使用。The C1-C4 polyol system is a composition selected from any group consisting of glycerin, propylene glycol, methyl propylene glycol and butylene glycol. The C5-C8 polyol system is a composition selected from any group consisting of pentanediol, hexanediol, octanediol and octanediol. The natural thickening agent is a composition selected from any group consisting of ginseng gum, guar gum, sodium alginate and gum arabic. Depending on the purpose of use, non-natural thickeners can also be used.
該防腐劑係例如茴香酸鈉及乙醯丙酸鈉；辛醯氧肟酸及乳酸；或甘油辛酸酯及甘油十一碳烯酸酯。本發明之適合的防腐劑可以是酸類防腐劑，例如己二烯酸、去水醋酸、苯甲酸、對羥基苯甲酸或水楊酸。或者，本發明之防腐劑可以是對羥基苯甲酸酯類防腐劑，例如對羥基苯甲酸甲酯、對羥基苯甲酸乙酯、對羥基苯甲酸丙酯、對羥基苯甲酸丁酯、對羥基苯甲酸異丙酯、對羥基苯甲酸異丁酯或對羥基苯甲酸第二丁酯。另外，本發明之防腐劑可以是甲基異噻唑啉酮、甲基氯異塞唑晽酮、碘代丙炔基丁基氨基甲酸酯、苯氧乙醇、氯苯甘醚、三氯沙、四級銨鹽類或陽離子表面活性劑。The preservatives are, for example, sodium aniseate and sodium acetopropionate; octyl hydroxamic acid and lactic acid; or glyceryl caprylate and glyceryl undecylenate. Suitable preservatives of the present invention may be acid preservatives, such as adipic acid, dehydrated acetic acid, benzoic acid, p-hydroxybenzoic acid or salicylic acid. Alternatively, the preservative of the present invention may be a paraben-based preservative, such as methyl paraben, ethyl paraben, propyl paraben, butyl paraben, paraben Isopropyl formate, isobutyl paraben or second butyl paraben. In addition, the preservative of the present invention may be methyl isothiazolinone, methyl chloroisoselazolone, iodopropynyl butyl carbamate, phenoxyethanol, chlorphenesin, triclosan, Quaternary ammonium salts or cationic surfactants.
本發明之含有芸香科植物萃取物的組成物，視需求可額外添加玻尿酸粉、蘆薈萃取物、精油或香精及其他抗老或美白等功能性原料。本發明之含有芸香科植物萃取物的組成物能短時間抗菌、抗病毒，並具有潤滑、保濕的效果，而且衛生、安全；使用效果好。The composition containing the Rutaceae plant extract of the present invention can additionally add hyaluronic acid powder, aloe extract, essential oil or essence, and other functional raw materials such as anti-aging or whitening as needed. The composition containing the Rutaceae plant extract of the present invention can be antibacterial and antiviral in a short time, and has the effects of lubrication and moisturization, and is hygienic and safe; and the use effect is good.
本發明之一具體例係有關一種含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物、10-30 wt% C1-C4多元醇系統及60-70 wt%純水。於另一具體例中，含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物、2-10 wt% C5-C8多元醇系統及60-70 wt%純水。於一具體例中，該芸香科植物萃取物係選自由橘、柑、甜橙、酸橙、苦橙、柚、葡萄柚、檸檬、萊姆、枸櫞、佛手柑及金橘所組成之任一族群的萃取物。該芸香科植物萃取物能使細菌的細胞膜打開，讓其他物質進去，可增強殺菌。另外，該芸香科植物萃取物也具有抗病毒效果。該芸香科植物萃取物亦具有抗菌、抗病毒的效果。A specific example of the present invention relates to a composition containing Rutaceae plant extract, including 0.1-2 wt% Rutaceae plant extract, 10-30 wt% C1-C4 polyol system and 60-70 wt% pure water . In another specific example, the composition containing the Rutaceae plant extract includes 0.1-2 wt% Rutaceae plant extract, 2-10 wt% C5-C8 polyol system, and 60-70 wt% pure water. In a specific example, the Rutaceae plant extract is selected from the group consisting of tangerine, mandarin, sweet orange, lime, bitter orange, pomelo, grapefruit, lemon, lime, citron, bergamot and kumquat An extract of an ethnic group. The Rutaceae plant extract can open the bacterial cell membrane and allow other substances to enter, which can enhance sterilization. In addition, the Rutaceae plant extract also has antiviral effects. The Rutaceae plant extract also has antibacterial and antiviral effects.
該C1-C4多元醇系統係選自由甘油、丙二醇、甲基丙二醇及丁二醇所組成之任一族群的組合物。該C5-C8多元醇系統係選自由戊二醇、己二醇、辛二醇及辛乙二醇所組成之任一族群的組合物。上述多元醇例如丙二醇具有潤滑的效果。上述的甘油可以吸取空氣中的水份給皮膚保濕，也能將皮膚中的水份鎖住，不讓它流失，具有保濕的功效。另外，該些多元醇皆具有「自防腐」的功效，可以增加抗菌力，強化消毒效果。The C1-C4 polyol system is a composition selected from any group consisting of glycerin, propylene glycol, methyl propylene glycol and butylene glycol. The C5-C8 polyol system is a composition selected from any group consisting of pentanediol, hexanediol, octanediol and octanediol. The above-mentioned polyols such as propylene glycol have a lubricating effect. The above-mentioned glycerin can absorb the moisture in the air to moisturize the skin, and can also lock the moisture in the skin to prevent it from being lost, and has a moisturizing effect. In addition, these polyols have the effect of "self-preservation", which can increase the antibacterial power and strengthen the disinfection effect.
本發明之另一具體例係有關一種含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物；10-30 wt%C1-C4多元醇系統；1~4 wt%防腐劑；0.5~2 wt%天然增稠劑及60-70 wt%純水。於另一具體例中，本發明之含有芸香科植物萃取物的組成物，包括0.1-2 wt%芸香科植物萃取物；2-10 wt%C5-C8多元醇系統；1~4 wt%防腐劑；1~3 wt%天然增稠劑及60-70 wt%純水。於一具體例中，該芸香科植物萃取物係選自由橘、柑、甜橙、酸橙、苦橙、柚、葡萄柚、檸檬、萊姆、枸櫞、佛手柑及金橘所組成之任一族群的萃取物。該芸香科植物萃取物能使細菌的細胞膜打開，讓其他物質進去，可增強殺菌。另外，該芸香科植物萃取物也具有抗病毒效果。Another specific example of the present invention relates to a composition containing Rutaceae plant extract, including 0.1-2 wt% Rutaceae plant extract; 10-30 wt% C1-C4 polyol system; 1~4 wt% preservative Agent; 0.5~2 wt% natural thickener and 60-70 wt% pure water. In another specific example, the composition of the present invention containing rutaceae plant extracts includes 0.1-2 wt% rutaceae plant extracts; 2-10 wt% C5-C8 polyol system; 1 to 4 wt% preservatives Agent; 1~3 wt% natural thickener and 60-70 wt% pure water. In a specific example, the Rutaceae plant extract is selected from the group consisting of tangerine, mandarin, sweet orange, lime, bitter orange, pomelo, grapefruit, lemon, lime, citron, bergamot and kumquat An extract of an ethnic group. The Rutaceae plant extract can open the bacterial cell membrane and allow other substances to enter, which can enhance sterilization. In addition, the Rutaceae plant extract also has antiviral effects.
該C1-C4多元醇系統係選自由甘油、丙二醇、甲基丙二醇及丁二醇所組成之任一族群的組合物。該C5-C8多元醇系統係選自由戊二醇、己二醇、辛二醇及辛乙二醇所組成之任一族群的組合物。上述多元醇例如丙二醇具有潤滑的效果。上述甘油可以吸取空氣中的水份給皮膚保濕，也能將皮膚中的水份鎖住，不讓它流失，具有保濕的功效。另外，該些多元醇皆具有「自防腐」的功效，可以增加抗菌力，強化消毒效果。The C1-C4 polyol system is a composition selected from any group consisting of glycerin, propylene glycol, methyl propylene glycol and butylene glycol. The C5-C8 polyol system is a composition selected from any group consisting of pentanediol, hexanediol, octanediol and octanediol. The above-mentioned polyols such as propylene glycol have a lubricating effect. The above-mentioned glycerin can absorb the moisture in the air to moisturize the skin, and can also lock the moisture in the skin to prevent it from being lost, and has a moisturizing effect. In addition, these polyols have the effect of "self-preservation", which can increase the antibacterial power and strengthen the disinfection effect.
該天然增稠劑係選自由三仙膠、瓜爾豆膠、海藻酸鈉及***樹膠所組成之任一族群的組合物。依照使用目的，非天然增稠劑亦可使用。The natural thickening agent is a composition selected from any group consisting of ginseng gum, guar gum, sodium alginate and gum arabic. Depending on the purpose of use, non-natural thickeners can also be used.
該防腐劑係例如茴香酸鈉及乙醯丙酸鈉；辛醯氧肟酸及乳酸；或甘油辛酸酯及甘油十一碳烯酸酯。本發明之適合的防腐劑也可以是酸類防腐劑，例如己二烯酸、去水醋酸、苯甲酸、對羥基苯甲酸或水楊酸。或者，本發明之防腐劑也可以是對羥基苯甲酸酯類防腐劑，例如對羥基苯甲酸甲酯、對羥基苯甲酸乙酯、對羥基苯甲酸丙酯、對羥基苯甲酸丁酯、對羥基苯甲酸異丙酯、對羥基苯甲酸異丁酯或對羥基苯甲酸第二丁酯。另外，本發明之之適合的防腐劑也可以是甲基異噻唑啉酮、甲基氯異塞唑晽酮、碘代丙炔基丁基氨基甲酸酯、苯氧乙醇、氯苯甘醚、三氯沙、四級銨鹽類或陽離子表面活性劑。The preservatives are, for example, sodium aniseate and sodium acetopropionate; octyl hydroxamic acid and lactic acid; or glyceryl caprylate and glyceryl undecylenate. Suitable preservatives of the present invention may also be acid preservatives, such as adipic acid, dehydrated acetic acid, benzoic acid, p-hydroxybenzoic acid or salicylic acid. Alternatively, the preservatives of the present invention may also be paraben-based preservatives, such as methyl paraben, ethyl paraben, propyl paraben, butyl paraben, parahydroxy Isopropyl benzoate, isobutyl paraben, or second butyl paraben. In addition, suitable preservatives of the present invention may also be methyl isothiazolinone, methyl chloroisoselazolone, iodopropynyl butyl carbamate, phenoxyethanol, chlorphenesin, Triclosan, quaternary ammonium salts or cationic surfactants.
本發明之含有芸香科植物萃取物的組成物，視需求可額外添加玻尿酸粉、蘆薈萃取物或精油等其他輔助原料而不影響抗菌抗病毒效力。本發明之含有芸香科植物萃取物的組成物能短時間抗菌、抗病毒，並具有潤滑、保濕的效果，而且衛生、安全；使用效果好。According to the composition of the present invention containing Rutaceae plant extract, other auxiliary raw materials such as hyaluronic acid powder, aloe extract or essential oil can be added without affecting the antibacterial and antiviral efficacy. The composition containing the Rutaceae plant extract of the present invention can be antibacterial and antiviral in a short time, and has the effects of lubrication and moisturization, and is hygienic and safe; and the use effect is good.
實施例1：將芸香科植物萃取物配置成水溶液Example 1: The Rutaceae plant extract is formulated as an aqueous solution
本實施例使用三種不同濃度及pH值的芸香科植物萃取物水溶液進行抗菌力測試，0.5 v%和pH 2.5、1 v%和pH 4.4及1 v%和pH 5.2，檢測數據結果如表1所示。 表1
由表1所示檢測數據結果發現，具有0.5 v%和pH 2.5的芸香科植物萃取物水溶液有較佳的抗菌力，若提高濃度至1 v%但同時為了降低本發明含有芸香科植物萃取物的組成物對***的刺激或正常人體皮膚使用所需必須提高pH，結果發現抗菌力並無法有效提升。一般市售人體潤滑劑產品的pH值為5至7，由檢測數據來看，pH 5.2時之抗菌力是三條件中最差的，無法達到20分鐘以內抗菌99.9%的門檻。依人體潤滑劑正常塗抹及使用時間，一般設定20分鐘必須達到99.9%抗菌力。使用水稀釋後之芸香科植物萃取物，在0.5 v%、pH = 2.5可以有一般之抗菌力，但若pH在一般市售產品使用範圍(pH 4-6)，抗菌力明顯下降，即使濃度拉高至1 v%，抗菌力也只有30~40%。因此，使用芸香科植物萃取物水溶液，且pH於一般市售產品使用範圍(pH 4-6)，抗菌力明顯不足。From the test data results shown in Table 1, it is found that the aqueous solution of Rutaceae plant extract with 0.5 v% and pH 2.5 has better antibacterial activity, if the concentration is increased to 1 v% but at the same time, in order to reduce the present invention, the Rutaceae plant extract contains The composition must be used to stimulate the vagina or normal human skin. The pH must be increased. As a result, it has been found that the antibacterial power cannot be effectively improved. Generally, the pH value of commercially available human lubricant products is 5 to 7. From the test data, the antibacterial activity at pH 5.2 is the worst among the three conditions, and the threshold of antibacterial 99.9% within 20 minutes cannot be reached. According to the normal application and use time of human lubricant, it is generally set to achieve 99.9% antibacterial power in 20 minutes. The Rutaceae plant extract diluted with water can have general antibacterial activity at 0.5 v% and pH = 2.5, but if the pH is within the range of general commercial products (pH 4-6), the antibacterial activity drops significantly, even if the concentration Pulled up to 1 v%, the antibacterial power is only 30-40%. Therefore, the aqueous solution of Rutaceae plant extract is used, and the pH is in the range of general commercial products (pH 4-6), and the antibacterial effect is obviously insufficient.
實施例2：於芸香科植物萃取物水溶液中添加天然增稠劑Example 2: Add natural thickener to the aqueous solution of Rutaceae plant extract
本實施例將1.55 wt%的芸香科植物萃取物水溶液與三仙膠(0.4 wt%)、瓜爾豆膠 (0.6wt%)、玻尿酸粉(0.05 wt%)、蘆薈萃取物(0.1 wt%)，植物甘油(9.5%)和純水混合成凝膠。上述除了甘油外，基本上皆是容易長菌的天然原料。檢測數據結果如表2所示。 表2
由表2所示檢測數據結果發現，抗菌力明顯下降或無抗菌力，顯示芸香科植物萃取物水溶液不僅無法當作凝膠類產品之抑菌防腐使用，更別說還要達到短時間殺菌殺病毒效果。因此，將芸香科植物萃取物水溶液和容易長菌及不易長期保存之天然增稠劑諸如三仙膠、瓜爾豆膠等混合調成凝膠，由檢測數據的結果可看出抗菌力明顯不足，甚至連抑菌防腐都有疑慮。According to the results of the test data shown in Table 2, it is found that the antibacterial ability is significantly reduced or no antibacterial ability, showing that the aqueous solution of Rutaceae plant extracts can not only be used as antibacterial and antiseptic for gel products, let alone to achieve a short period of time Virus effect. Therefore, the aqueous solution of Rutaceae plant extracts and natural thickeners that are easy to grow bacteria and are not easy to store for a long time, such as Sanxian gum and guar gum, are mixed into a gel. The results of the test data show that the antibacterial effect is obviously insufficient. Even doubts about bacteriostasis and antiseptic.
實施例3：在以改性矽油為基底之含有適量的水及多元醇中添加芸香科植物萃取物水溶液Example 3: Adding an aqueous solution of Rutaceae plant extract to a suitable amount of water and polyol based on modified silicone oil
本實施例於80 wt% Dow Corning 2501之改性矽油、9 wt%水和10 wt%甘油之混合物中添加1 wt%芸香科植物萃取物水溶液，配方的pH值為4.5，檢測數據結果如表3所示。 表3
由表3檢測數據發現，20分鐘可達到99.9%抗菌，此原因可能是多元醇類可以增強芸香科植物萃取物的效果，抑或是芸香科植物萃取物可以強化多元醇抗菌效果，兩者有協同作用；及芸香科植物萃取物在水為基底下無法達到抗菌99.9%，在改性矽油基底下卻可以，證明芸香科植物萃取物只要在不會長菌發霉的條件下，或是無微生物可利用之養分的環境下，可發揮其固有的消毒作用。According to the test data in Table 3, it can be found that 99.9% antibacterial can be achieved in 20 minutes. The reason may be that polyols can enhance the effect of Rutaceae plant extracts, or that Rutaceae plant extracts can enhance the antibacterial effect of polyols. Function; and the Rutaceae plant extract cannot achieve antibacterial 99.9% under the water base, but it can be used under the modified silicone oil base, which proves that the Rutaceae plant extract can be used as long as it does not grow mold or microorganisms. Under the environment of nutrients, it can exert its inherent disinfection effect.
由以上實施例得知，芸香科植物萃取物在水為基底可以達到一般的抗菌效果，在改性矽油為基底下卻能完全發揮消毒效果，因此要做成具有消毒效力的天然凝膠，不僅防腐效果要好，防腐劑和多元醇的比例也要調整到協同作用，才能達到短時間抗菌消毒。It is known from the above examples that Rutaceae plant extracts can achieve general antibacterial effect on water as a base, but can fully exert disinfection effect on modified silicone oil as a base. Therefore, to make a natural gel with disinfection effect, not only The antiseptic effect is better, and the ratio of preservatives and polyols must be adjusted to synergy to achieve short-term antibacterial disinfection.
實施例4：在以水為基底之含有天然多元醇、天然增稠劑、天然防腐劑中添加芸香科植物萃取物水溶液Example 4: Add aqueous solution of Rutaceae plant extract to water-based natural polyol, natural thickener and natural preservative
本實施例在以水為基底之含有多元醇、天然增稠劑、防腐劑中添加芸香科植物萃取物水溶液之成分和比例如表4所示，抗菌力檢測數據結果如表5所示。 表4
由表5數據看出，實施例4之配方於20分鐘內，對於大腸桿菌、金黃色葡萄球菌、綠膿桿菌及白色念珠菌之四種菌的抑菌率皆至少可達99.9%。It can be seen from the data in Table 5 that the formulation of Example 4 has an antibacterial rate of at least 99.9% against the four bacteria of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans within 20 minutes.
以下說明實施例4之配方的抗HIV-1病毒測試。圖1顯示單純1.35 wt%芸香科植物萃取物水溶液（樣品1）；多元醇系統、防腐劑和天然增稠劑（樣品2）；以及芸香科植物萃取物水溶液、多元醇系統、防腐劑和天然增稠劑（樣品3）抗HIV-1病毒測試的比較。由圖1看出，樣品3比樣品1或樣品2更能抗菌、防腐和抗病毒的作用。The anti-HIV-1 virus test of the formulation of Example 4 is described below. Figure 1 shows a pure 1.35 wt% aqueous solution of Rutaceae plant extract (Sample 1); polyol system, preservative and natural thickener (Sample 2); and aqueous solution of Rutaceae plant extract, polyol system, preservative and natural Comparison of anti-HIV-1 virus test of thickener (sample 3). It can be seen from Figure 1 that Sample 3 is more antibacterial, antiseptic and antiviral than Sample 1 or Sample 2.
圖2係利用80倍稀釋之單純1.35 wt%芸香科植物萃取物水溶液（樣品1）；多元醇系統、防腐劑和天然增稠劑（樣品2）；以及芸香科植物萃取物水溶液、多元醇系統、防腐劑和天然增稠劑（樣品3）抑制HIV-1感染JLTRG CD4+細胞之能力的比較。由圖2看出，樣品3比樣品1或樣品2更能抗菌、防腐和抗病毒的作用，已達到八成作為陽性對照藥物的疊氮胸苷（AZT）之效果。Figure 2 is a simple 1.35 wt% aqueous solution of Rutaceae plant extract (sample 1) diluted 80 times; polyol system, preservative and natural thickener (sample 2); and aqueous solution of Rutaceae plant extract and polyol system , Preservatives and natural thickeners (sample 3) to compare the ability of HIV-1 to infect JLTRG CD4+ cells. It can be seen from Figure 2 that Sample 3 is more antibacterial, antiseptic, and antiviral than Sample 1 or Sample 2, and has achieved the effect of 80% of the azide thymidine (AZT) as a positive control drug.
表6係以樣品3的稀釋倍數顯示樣品3之抗HIV-1感染之50%抑制濃度。 表6
前述實施例顯示芸香科植物萃取物水溶液、多元醇系統、防腐劑和增稠劑之組成物的抗菌效果比單純芸香科植物萃取物水溶液或於芸香科植物萃取物水溶液中添加天然增稠劑之組成物皆較佳，可達99.9%的抑菌率。另外，以HIV-1檢測為例，芸香科植物萃取物水溶液、多元醇系統、防腐劑和天然增稠劑之組成物（樣品3）的抗病毒效果比單純芸香科植物萃取物水溶液（樣品1）或多元醇系統、防腐劑和天然增稠劑（樣品2）之組成物皆較佳，可達大約80%的陽性對照藥物AZT之抗病毒能力，且實驗條件為樣品稀釋80倍的情況下。因此，推估於不稀釋的條件下，樣品3具有非常顯著之抗菌抗病毒效力達99.9%。The foregoing examples show that the composition of the Rutaceae plant extract aqueous solution, polyol system, preservative and thickener is more effective than the pure Rutaceae plant extract aqueous solution or the natural thickener added to the Rutaceae plant extract aqueous solution. The composition is better, with a bacteriostatic rate of 99.9%. In addition, taking the HIV-1 test as an example, the antiviral effect of the composition of the Rutaceae plant extract aqueous solution, polyol system, preservative and natural thickener (Sample 3) is higher than the simple Rutaceae plant extract aqueous solution (Sample 1) ) Or the polyol system, preservatives and natural thickener (sample 2) are all preferred, up to about 80% of the antiviral ability of the positive control drug AZT, and the experimental conditions are when the sample is diluted 80 times . Therefore, it is estimated that under the condition of no dilution, Sample 3 has a very significant antibacterial and antiviral efficacy of 99.9%.
實施例5：在以水為基底之含有多元醇、天然增稠劑、防腐劑中添加芸香科植物萃取物水溶液Example 5: Add aqueous solution of Rutaceae plant extract to water-based polyols, natural thickeners and preservatives
實施例5在以水為基底之含有多元醇、天然增稠劑、防腐劑中添加芸香科植物萃取物水溶液之成分和比例如表7所示。實施例5與實施例4之差異在於其使用不同的多元醇，可以用不同比例達到同樣等級的抗菌效果。 表7
本發明之含有芸香科植物萃取物的組成物適用於各式劑型，不像許多消毒劑只能做成水溶液，或是大部分的陽離子殺菌劑無法與大部分天然增稠劑（多數是陰離子）搭配，例如市售的水神噴霧、白因子及黃金盾等產品都是水溶液型式，不適合做成凝膠或乳霜類產品。The composition of the present invention containing Rutaceae plant extracts is suitable for various dosage forms, unlike many disinfectants that can only be made into aqueous solutions, or most cationic fungicides cannot be combined with most natural thickeners (most are anionic) Matching, for example, the commercially available products such as water god spray, white factor and golden shield are all aqueous solutions and are not suitable for gel or cream products.
本發明之實施例及具體例的描述應視為例示性，而非限制如申請專利範圍界定的本發明。將輕易理解大量以上記載的特徵之變化及組合可被利用而不背離如記載在申請專利範圍的本發明。如此的變化意圖包括在以下申請專利範圍之範圍內。The description of the embodiments and specific examples of the present invention should be regarded as illustrative, rather than limiting the present invention as defined by the scope of the patent application. It will be easily understood that a large number of variations and combinations of the above-described features can be utilized without departing from the invention as described in the patent application. Such changes are intended to be included within the scope of the following patent applications.
圖1顯示單純芸香科植物萃取物水溶液(樣品1)；多元醇系統、防腐劑和天然增稠劑(樣品2)；以及芸香科植物萃取物水溶液、多元醇系統、防腐劑和天然增稠劑(樣品3)，分別抗HIV-1病毒測試的比較。Figure 1 shows the aqueous solution of pure Rutaceae plant extract (Sample 1); polyol system, preservative and natural thickener (Sample 2); and the aqueous solution of Rutaceae plant extract, polyol system, preservative and natural thickener (Sample 3) Comparison of anti-HIV-1 virus tests respectively.
圖2係利用80倍稀釋之單純芸香科植物萃取物水溶液(樣品1)；多元醇系統、防腐劑和天然增稠劑(樣品2)；以及芸香科植物萃取物水溶液、多元醇系統、防腐劑和天然增稠劑(樣品3)，分別抑制HIV-1感染JLTRG CD4+細胞之能力的比較。Figure 2 is an aqueous solution of pure Rutaceae plant extract (sample 1) diluted 80 times; polyol system, preservative and natural thickener (sample 2); and aqueous solution of Rutaceae plant extract, polyol system and preservative Compared with natural thickener (Sample 3), the ability to inhibit HIV-1 infection of JLTRG CD4+ cells, respectively.
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