CN106511119A - Composition having preservative efficacy as well as preparation method and application of composition - Google Patents
Composition having preservative efficacy as well as preparation method and application of composition Download PDFInfo
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- CN106511119A CN106511119A CN201510566874.8A CN201510566874A CN106511119A CN 106511119 A CN106511119 A CN 106511119A CN 201510566874 A CN201510566874 A CN 201510566874A CN 106511119 A CN106511119 A CN 106511119A
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- composition
- preservative efficacy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a composition having a preservative efficacy as well as a preparation method and an application of the composition. The composition having the preservative efficacy consists of 0.5-10 parts by weight of carboxymethyl chitosan, 10-80 parts by weight of 1,2-pentanediol, 10-80 parts by weight of 1,2-octanediol, 10-80 parts by weight of 1,2-hexanediol, 1-30 parts by weight of 1,2-propanediol, 1-30 parts by weight of 1,3-butanediol and 1-30 parts by weight of propanetriol. According to the preparation method of the composition having the preservative efficacy, the composition is prepared by mixing the materials in accordance with the parts by weight, and uniformly stirring and dissolving an obtained mixture. The composition having the preservative efficacy can take a preservative effect in cosmetics, wherein the content of the composition having the preservative efficacy in the cosmetics is 0.1-5%. The composition having the preservative efficacy is free from any banned and restricted preservative components, and the composition can take a relatively ideal antibacterial effect and broad-spectrum antibacterial and preservative capacities on bacteria and fungi.
Description
Technical field
The present invention relates to cosmetics additive technical field, more particularly to it is a kind of without Form aldehyde release body, there are no the compositionss with preservative efficacy of strong reductant.
Background technology
Containing abundant nutrient substance in cosmetics, it is particularly suitable for the growth of microorganism, so needing to add preservative in cosmetics, the purpose for counting preservative in cosmetics is to suppress growth of microorganism and generating, it is to avoid cosmetics produce denaturalization phenomenon and maintain freshness and persistence.
At present, on market, almost each conventional antiseptic activity composition all has formaldehyde or Form aldehyde release body substantially.And the potential sensitization of the potential carcinogenecity of formaldehyde and Form aldehyde release body, organic halogen compound is discussed by everybody always.In the past two years, cause the public with regard to the association between Nipagin ester and hormone secretion and some particular cancers greatly to pay close attention to.Although up to the present having different disputes for these arguements also do not have the final conclusion of science in cosmetics industry.Therefore, cosmetic industry is attempting to look for new Preservative Technology for Personal Care.
The content of the invention
In order to solve the problems of the prior art, it is an object of the invention to provide a kind of contain carboxymethylchitosan and polyhydric alcohol, and the compositionss with preservative efficacy of formaldehyde and Form aldehyde release body are not contained.The compositionss that should have preservative efficacy do not contain any preservative ingredient for limiting, and with the Antimicrobial preservative ability to antibacterial and the comparatively ideal fungistatic effect of funguses and wide spectrum.
For achieving the above object, the present invention is employed the following technical solutions：The component and the weight portion of correspondence component that a kind of compositionss of the compositionss with preservative efficacy are included is as follows：
Carboxymethylchitosan
0.5-10 weight portions；
1,2- pentanediol
10-80 weight portions；
1,2- ethohexadiol
10-80 weight portions；
1,2- hexanediol
10-80 weight portions；
1,2-PD
1-30 weight portions；
1,3 butylene glycol
1-30 weight portions；
Glycerol
1-30 weight portions.
Another object of the present invention is to provide a kind of preparation method of the compositionss with preservative efficacy, and its preparation method is as follows：By the carboxymethylchitosan of 0.5-10 weight portions, 10-80 weight portions 1, the 1 of 2- pentanediols, 10-80 weight portions, the 1 of 2- ethohexadiols, 10-80 weight portions, the 1 of 2- hexanediol, 1-30 weight portions, 2- Propylene Glycol, the 1,3 butylene glycol of 1-30 weight portions, 1-30 weight portions glycerol mixing after stirring and dissolving uniformly can be prepared by.
The a further object of the present invention is to provide a kind of application in preparing cosmetics of the compositionss with preservative efficacy, the above-mentioned compositionss with preservative efficacy are used for into the anti-corrosion of cosmetics, wherein content of the compositionss with preservative efficacy in cosmetics is 0.1-5%.
Preferred technical scheme, content of the compositionss with preservative efficacy in cosmetics are 0.1-4%.
Chitosan (CS) is unique cationic polysaccharide in nature, with good biocompatibility, adhesion, degradability, biocidal property and plasticity, can promote wound healing and tissue regeneration.
Carboxymethylchitosan CAS No.: 83512-85-0 ；INCI： CARBOXYMETHYL
CHITOSAN, carboxymethylchitosan have certain fungistatic effect, and especially to mycete effect is significant, its antifungal mechanism is which can be dissolved each other with bacteria cell wall generation, reaches effect.But experiment shows that the fungistatic effect of single carboxymethyl chitosan is unable to reach antibacterial requirement in cosmetics, it has been investigated that carboxymethyl chitosan is used as macromolecular polysaccharide class product, it is impossible to high-effective penetrating bacteria cell wall.
1,2- pentanediol, CAS No.：5343-92-0, molecular weight：104.15, INCI titles：Penty1enG1yco, with excellent performance of keeping humidity, can help moisturizing and infiltration.Additionally, also have antibacterial and solubilized effect, addition within the specific limits, with antiseptic effect.
1,2- ethohexadiol（Caprylyl glycol）, CAS NO.：1117-86-8, molecular weight：146.23, INCI titles：Capry1y1G1yco1, can improve the skin moistening function of skin-protection product, also with excellent antimicrobial acivity, with the carbon chain lengths that membrane structure can be promoted to explain（C8）, contribute to strengthening protective system effect.
1,2- hexanediol, CAS NO.：6920-22-5, molecular weight：118.17, INCI titles：1,2-Hexanediol, the skin moistening performance of skin-protection product can be improved, effectively suppresses the activity of microorganism, so as to strengthen effect of protective system.
1,2-PD is as wetting agent and antifreezing agent, to increase the coordinative role of whole protective system.
The features such as 1.3- butanediols have the reactivity of dihydroxylic alcohols, odorless, low toxicity, good water solubility, to humidification and the emollescence of whole protective system.
Glycerol is without the sweet clear and bright thick liquid of color and taste.Its odorless, has warm sweet taste, is commonly called as glycerol.When using it for skin is carried out moistening, in addition to moisturizing, humectation function, also with high activity, antioxidation, promote the special efficacies such as alcoholization.
According to above-mentioned substance characteristic, after carboxymethyl chitosan is mixed by the present invention with polyhydric alcohol, by both synergism, the osmosiss of polyhydric alcohol are played so that fungistatic effect is increased substantially in geometric index mode.
In sum, the compositionss with preservative efficacy of the invention are safe and free of toxic and side effects, non-stimulated；Bacteriostasis are good.The compounded combination can bring synergism to the preservative compositions of compositionss, especially have obvious action to the growth inhibited of antibacterial and funguses, have the antibacterial activity of wide spectrum, can effectively suppress gram negative bacteria, positive bacteria, yeast and mycete.
The antiseptic composition of the present invention does not contain any limiting and uses preservative ingredient, formaldehydeless releaser yet, without strong reductant.The compound system of " no added preservative " concept is supported, property is gentle, and zest is low, safe.
Specific embodiment
Embodiment 1, a kind of preparation method of the compositionss with preservative efficacy are as follows：By 0.5 gram of carboxymethylchitosan, 10 grams 1,2- pentanediols, the 1 of 10 grams, 2- ethohexadiols, the 1 of 10 grams, 2- hexanediol, the 1 of 1 gram, 2- Propylene Glycol, 1 gram of 1,3 butylene glycol, stirring and dissolving uniformly can be prepared by 33.5 grams of compositionss with preservative efficacy after 1 gram of glycerol mixing.
By the multiple batches of experiment carried out on animal and clinical verification, compositionss with preservative efficacy of the present invention effect harmless to the human body.
The compositionss that 33.5 grams obtained above have preservative efficacy are used for into the anti-corrosion of cosmetics, wherein content of the compositionss with preservative efficacy in cosmetics is 0.1-5%.The i.e. 33.5 grams compositionss with preservative efficacy can be used for the cosmetics that gross weight is 670 grams to 33500 grams carries out anti-corrosion.The content of the compositionss in cosmetics wherein with preservative efficacy is 0.1-4%, namely 33.5 grams should the compositionss with preservative efficacy most preferably carry out anti-corrosion for the cosmetics that gross weight is 837.5 grams to 33500 grams.
Embodiment 2, a kind of preparation method of the compositionss with preservative efficacy are as follows：By 10 grams of carboxymethylchitosan, 80 grams 1,2- pentanediols, the 1 of 80 grams, 2- ethohexadiols, the 1 of 80 grams, 2- hexanediol, the 1 of 30 grams, 2- Propylene Glycol, 30 grams of 1,3 butylene glycol, stirring and dissolving uniformly can be prepared by 340 grams of compositionss with preservative efficacy after 30 grams of glycerol mixing.
Embodiment 3, a kind of preparation method of the compositionss with preservative efficacy are as follows：By 5.25 grams of carboxymethylchitosan, 45 grams 1,2- pentanediols, the 1 of 45 grams, the 1 of 45 grams of 2- ethohexadiols, 2- hexanediol, the 1 of 15.5 grams, 2- Propylene Glycol, 15.5 grams of 1,3 butylene glycol, stirring and dissolving uniformly can be prepared by 186.75 grams of compositionss with preservative efficacy after 15.5 grams of glycerol mixing.
The carboxymethyl chitosan used in the present invention and polyhydric alcohol（Pentanediol example）Compounding fungistatic effect experimental data is as shown in table 1 below.
| 1 | 2 | 3 | |
| Carboxymethyl chitosan | 0% | 0.15% | 0.15% |
| Pentanediol | 2% | 0% | 2% |
| Escherichia coli bacteria liquid | up to 100% | up to 100% | up to % |
| 1st day（Clump count cfu/g） | 58,000 | 52,000 | 52,800 |
| 6th day（Clump count cfu/g） | 280,000 | 9,050 | 10,000 |
| 13rd day（Clump count cfu/g） | Can not count more | 72,500 | 100 |
| 17th day（Clump count cfu/g） | Can not count more | Can not count more | ＜ 10 |
Table 1
A kind of compositionss with preservative efficacy of the present invention are as shown in table 2 below:
| Title | English name (English name) | Content | Effect |
| EDTA-2Na | EDTA-2Na | 0.05% | Chelating agen |
| SYMSAVE H | SYMSAVE H | 0.3% | Antioxidant |
| Glycerol | Glycerine | 5% | Wetting agent |
| HANSHENGJIAO T | Keltrol T | 0.05% | Thickening agent |
| Cosmdia SPL | Cosmdia SPL | 0.2% | Thickening stabilizing agent |
| Aqueous soluble ginseng's Saponin | Ginsenoside | 0.1% | Extract |
| Anhydrous betaine | Betaine Anhydrous | 0.5% | Surfactant |
| 1,3 butylene glycol | 1, 3-butylene glycol | 0.3% | Wetting agent, penetrating agent |
| 1,2 pentanediols | 1,2-Pentanediol | 0.1% | Wetting agent, penetrating agent |
| Hexanediol | 1,6-Hexanediol | 0.4% | Wetting agent, penetrating agent |
| Carboxymethylchitosan | CARBOXYMETHYL CHITOSAN | 0.15% | Anti-corrosion |
Table 2
In table 2, the inhibitor effectiveness test data of corrosion preventive compound is as shown in table 3 below:
Table 3
Another kind of compositionss with preservative efficacy of the invention are as shown in table 4 below:
| Trade name | English name（English name） | Content | Effect |
| Dimethicone (200cs) | Silicone PMX-200 | 2.00% | Skin sense regulator |
| Sad certain herbaceous plants with big flowers acid triglyceride | GTCC(Caprylic/ Capric Triglyceride) | 2.00% | Stabilizer |
| Ethylhexyl palmitate | 2-Ethylhexyl Palmitate | 2.00% | Skin sense regulator |
| Dicaprylyl carbonate | Dioctyl carbonate | 2.00% | Softening agent, skin sense regulator |
| Olivem1000 | Ceterayl Olivate | 2.00% | Emulsifying agent |
| White oil | White mineral oil | 2.00% | Basic grease |
| Emulsifying agent A-165 | Cithrol GMS A/S | 1.00% | Emulsifying agent |
| Octadecanol | Stearyl alcohol | 1.00% | Basic grease |
| Deionized water | DI water | 77.55% | Solvent |
| Glycerol | Glycerine | 5.00% | Wetting agent |
| SEPIPLUS 265 | Sepiplus 265 | 0.80% | Thickening agent |
| Pentanediol | 1,2-PENTANEDIOL | 2.00% | Penetrating agent |
| Hexanediol | 1,6-Hexanediol | 0.50% | Penetrating agent |
| Carboxymethylchitosan | CARBOXYMETHYL CHITOSAN | 0.15% | Anti-corrosion |
Table 4
In table 4, the inhibitor effectiveness test data of corrosion preventive compound is as shown in table 5 below:
Table 5.
Claims (4)
1. a kind of compositionss with preservative efficacy, it is characterised in that：The component and the weight portion of correspondence component that the compositionss with preservative efficacy are included is as follows：
Carboxymethylchitosan
0.5-10 weight portions；
1,2- pentanediol
10-80 weight portions；
1,2- ethohexadiol
10-80 weight portions；
1,2- hexanediol
10-80 weight portions；
1,2-PD
1-30 weight portions；
1,3 butylene glycol
1-30 weight portions；
Glycerol
1-30 weight portions.
2. a kind of preparation method of the compositionss with preservative efficacy, it is characterised in that：By the carboxymethylchitosan of 0.5-10 weight portions, 10-80 weight portions 1, the 1 of 2- pentanediols, 10-80 weight portions, the 1 of 2- ethohexadiols, 10-80 weight portions, the 1 of 2- hexanediol, 1-30 weight portions, 2- Propylene Glycol, the 1,3 butylene glycol of 1-30 weight portions, 1-30 weight portions glycerol mixing after stirring and dissolving uniformly can be prepared by.
3. the application in preparing cosmetics of a kind of compositionss with preservative efficacy according to claim 1, it is characterised in that：Contain the above-mentioned compositionss with preservative efficacy in cosmetics, wherein content of the compositionss with preservative efficacy in cosmetics is 0.1-5%.
4. the application in preparing cosmetics of a kind of compositionss with preservative efficacy according to claim 3, it is characterised in that：Content of the compositionss with preservative efficacy in cosmetics is 0.1-4%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510566874.8A CN106511119A (en) | 2015-09-09 | 2015-09-09 | Composition having preservative efficacy as well as preparation method and application of composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510566874.8A CN106511119A (en) | 2015-09-09 | 2015-09-09 | Composition having preservative efficacy as well as preparation method and application of composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511119A true CN106511119A (en) | 2017-03-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510566874.8A Withdrawn CN106511119A (en) | 2015-09-09 | 2015-09-09 | Composition having preservative efficacy as well as preparation method and application of composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511120A (en) * | 2015-09-10 | 2017-03-22 | 上海春露生物化学有限公司 | Composition having corrosion preventing function as well as preparation and application of composition |
| CN107308018A (en) * | 2017-06-26 | 2017-11-03 | 上海新高姿化妆品有限公司 | A kind of antiseptic composition prepared for emulsified body and its application in corresponding skin care item |
| CN112679561A (en) * | 2020-12-28 | 2021-04-20 | 中国科学院青岛生物能源与过程研究所 | Preparation method of glycerol glucoside crystal |
| WO2021198285A1 (en) * | 2020-03-31 | 2021-10-07 | Minasolve Sas | Homogeneous liquid composition comprising 1,2-octanediol and use thereof |
-
2015
- 2015-09-09 CN CN201510566874.8A patent/CN106511119A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511120A (en) * | 2015-09-10 | 2017-03-22 | 上海春露生物化学有限公司 | Composition having corrosion preventing function as well as preparation and application of composition |
| CN107308018A (en) * | 2017-06-26 | 2017-11-03 | 上海新高姿化妆品有限公司 | A kind of antiseptic composition prepared for emulsified body and its application in corresponding skin care item |
| WO2021198285A1 (en) * | 2020-03-31 | 2021-10-07 | Minasolve Sas | Homogeneous liquid composition comprising 1,2-octanediol and use thereof |
| CN112679561A (en) * | 2020-12-28 | 2021-04-20 | 中国科学院青岛生物能源与过程研究所 | Preparation method of glycerol glucoside crystal |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170322 |
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| WW01 | Invention patent application withdrawn after publication |