201244651 六、發明說明： 【發明所屬之技術領域】 本發明係關於不會隨著點火產生煙之非燃燒吸入型菸 草製品。 【先前技術】 該種非燃燒吸入型菸草製品係含有中空之吸入支架與 配置於該吸入支架内，將菸草原料粒狀化所得之菸草粒充 填物，其約40至約80mmHg之通氣阻抗（參照專利文獻1)。 根據專利文獻1，使用時，即使用者吸入時，菸草特 有成份之一的尼古丁會與吸入空氣一同送出至使用者口腔 内。 [先前技術文獻] (專利文獻） 專利文獻1 :國際公開第2010/095659號小冊 【發明内容】 (發明欲解決的課題） 專利文獻1之情形，來自菸草粒之尼古丁的釋出量， 即尼古丁至使用者口腔内的送出量，係隨著吸吐（puff)次 數增加比較迅速地減少。此係代表隨著吸吐次數之增加， 使用者所吸入之尼古丁會有很大變化，因此吸入使用時， 不僅會讓使用者感到不適Μ吏用者也會覺得可使用期間（吸 吐次數）較期待為短（少）。 本發明係基於上述情事基而研究者，其目的為提供一 種非燃燒吸入型菸草製品，其中菸草特有成份之一之尼古 324139 3 201244651 丁的送出量係長期間地維持安定，並可使使用者滿足之吸 吐次數大幅地增加。 (解決課題之手段） 上述目的可藉由本發明之非燃燒吸入型菸草製品而達 成，該非燃燒吸入型菸草製品係含有將菸草原料裁^或粉 碎而得之菸草粒狀體、與使由粒狀體之尼古丁的送出安定 的至少1種安定劑，該安定劑具有與尼古丁之溶解性參數 間距為17以下、且在25t蒸氣壓為immHg以下之特性。 上述之安定劑對於尼古丁之溶解性優異且其蒸氣壓 低，可安定並維持尼古丁，使尼古丁對於使用者之送出量 長期間地安定。 例如，安定劑係由丙二醇、苄醇或具有酯基之化合物 所選擇’此處之化合物係選自中鏈脂肪酸三酸甘油酯、捧 檬酸三酯（檸檬酸三乙酯、檸檬酸三丁酯等）、苯曱酸节醋 (benzyl benzoate)及月桂酸乙酯。 安定劑係為了更為冀求尼古丁送出量的安定化，較佳 為具有溶解性參數間距為12以下、且在25°C之蒸氣壓為 0. l_Hg以下之特性。 再者，菸草粒狀體可復含***菸（snus)等嗅覺菸草製 品一般所使用之碳酸鹽及碳酸氫鹽中的至少一者所構成之 添加劑。 另一方面，非燃燒吸入型菸草製品可復具備用以加熱 菸草粒狀體之加熱源。此時’安定劑具有溶解性參數間距 為17以下、且於菸草粒狀體加熱溫度的蒸氣壓為ImmHg 324139 4 201244651 以下之特性。 再者’相對於產生源之 ——々，人旦 5重量％至2〇重 “，女疋劑含量較佳為 則無法獲得所要求之°尼二時’^^劑含量少於5重量％， 量多於20重量^女疋化，相反地若安定劑含 粒狀體之操作，g 1使*⑽凝集微粒狀體’使得终草 (發明之效果）“會變得困難。 安定燒吸入型於草製品係在終草粒狀體含有 ::==r草粒狀一草特有成 【實施方式】 ^1圖所示-實施例之非燃燒吸人型 有轴線A、沿著該狀上游構件2、0 I游構㈣及❹構件12。該等構件2、6鲁12係藉 由複數之連結插銷•螺帽14而—體地結合。 例如’上游構件2係不麵所構成之厚度_之薄片， 該中央區域具有開口領域16。該開口領域16具有23 ^開口率。具體來說，開口領域16係藉由同樣地分布之 直C 1 πππ之小孔而形成。 终草卡g 6係含有不錄鋼所構成之厚度—之框構件 18，該框構件18係在該中央具有内經26mm之開π部。在 “肩4中收、、，内有終草粒狀體2〇，該粒狀體別 通氣性。 节 由第1圖可明顯得知，於草卡匿6復含通氣性之不織 324139 201244651 =4’8該等不織布4,8係夾著柊草卡匣6之框構件18， 、阻止菸草粒狀體2。由框構件18脱落。 另外，有關菸草粒狀體20係於後說明。 之下游構件10係與上游構件2同樣地為由不鏽鋼所構成 厚度1mm之溥片’該中央域具有内徑18mm之開口部22。 、、人方面，吸口構件12係由鐵氟龍（註冊商標）所形 並含有吸口端24。該吸口端24係由與下游構件10相 及口構件12的面而突出，並具有6_之内徑。另外， 位於下游構件10側之吸口構件12的開口部具有20賴之内 徑。 根據上述於草製品1，使用者由吸口構件12之吸口端 24吸入’藉此使外部空氣由上游構件2之開口領域16，經 過不織布4、菸草粒狀體20、不織布8、下游構件1〇之開 口。P 22及吸口構件12而流入使用者口腔内。此時，空氣 通過於草粒狀體2〇時，由菸草粒狀體2〇所釋出之尼古丁 含於空氣中’因此使用者會吸入含有尼古丁之空氣。 接著詳述菸草粒狀體20。 终草粒狀體20係含有將日本產之白肋種（burley)菸 草葉所構成之於草原料裁切或粉碎，之後進行加濕及加熱 處理所得之粒狀體；與例如碳酸鹽及碳酸氫鹽之至少一方 所構成之添加劑’具體來說為含有碳酸鉀之混合物所構 成’在於草粒狀體2〇中含有乾物重量為3〇〇mg之粒狀體。 該實施例之情形’混合物係相對於菸草原料之乾物重 量而含有12重量％之添加劑’接著調整使粒狀體所含之菸 324139 6 201244651 草特有成份之一的尼古丁為乾物重量之2. 3重量％、粒狀 體所含揮發成份為粒狀體重量之12重量％。 另外，尼古丁含量係在200mg±2. 5mg之粒狀體加入11 重量％氫氧化鈉水溶液7. 5m 1及己烧1 Om 1，一邊以銘箔遮 光一邊在室溫搖晃60分間中並進行萃取處理，之後將己烷 相以氣相層析質譜分析儀進行分析而得。 此外，揮發成分含量係將200mg±2mg之粒狀體以80°C 乾燥處理3小時間，之後由粒狀體之重量減少而求出。 再者，乾物重量係由粒狀體之重量減去以如上述方式 求得之揮發成份量的值係表示。 再者，本實施例之情形，菸草粒狀體20除了上述混合 物以外，並含有使前述尼古丁對於使用者之送出量安定的 至少1種安定劑，該安定劑具有與尼古丁之溶解性參數間 距為17以下、較佳為12以下，且25°C之蒸氣壓為1匪Hg 以下、較佳為0. ImmHg以下之特性。 詳細來說，溶解性參數間距係表示溶質對於溶媒之溶 解性的指標，一般以Ra(MPa1/2)表示，Ra係以下式求出。 Ra=[4*((5(i，2-(5d，l：T2+((5p，2-5p，l：T2+(<5h，2-5h，1) Hl/2) 在此，<5d、（5p、（5h係定義如下。 (5 d =溶解性參數之分散力 (5 p =溶解性參數之偶極相互作用 5 h =溶解性參數之氫鍵 具體來說，安定劑係由丙二醇、苄醇或具有酯基之化 324139 7 201244651 合物所選擇，在此之化合物可舉出中鏈脂肪酸三酸甘油 酉曰檸檬酸二酯（#檬酸三乙酯、檸檬酸三丁酯等）、苯甲 酸苄酯及月桂酸乙酯。 以下表1中也同時表示甘油（A)，而分別表示上述安定 劑之溶解性參數間距Ra及25。(：的蒸氣壓。 [表1 ] 安定劑 Ra (MPa丨/2 於 25。「、 蒸氣壓 (mmHg 於 25°C ) A (甘油） 23.0 0. 0002 B (丙二醇） 16.4 0. 2 C (中鏈脂肪酸三酸 甘油脂） 11. 7 0.0000000002 D (檸檬酸三乙酯） 5.7 0. 0002 E (苯曱酸苄酯） 1. 3 0. 0003 F (苄醇） 6. 6 0. 2 G (月桂酸乙酯） 9.0 0.00744 Η (檸檬酸三乙酯） 8.6 0.0000001 -------- 另外Ul C係以辛酸三酸甘油g旨為主成份之令鍵脂 肪酸三酸甘油酯.，具體來說為花王股份公司製之C0C0NARD MT。 此外，表1中之溶解性參數間距Ra係使用M〇lecular 324139 8 201244651201244651 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION The present invention relates to a non-combustion inhaled tobacco product that does not generate smoke with ignition. [Prior Art] The non-combustion inhalation type tobacco product comprises a hollow inhalation stent and a tobacco grain filler which is disposed in the inhalation holder and granulates the tobacco material, and has a ventilation resistance of about 40 to about 80 mmHg (refer to Patent Document 1). According to Patent Document 1, nicotine, which is one of the tobacco-specific components, is delivered to the user's mouth together with the inhaled air when inhaled by the user. [Prior Art Document] (Patent Document) Patent Document 1: International Publication No. 2010/095659 (Convention) [Problem to be Solved by the Invention] In the case of Patent Document 1, the amount of nicotine released from tobacco particles, that is, The amount of nicotine delivered to the user's mouth is rapidly reduced as the number of puffs increases. This means that as the number of times of vomiting increases, the nicotine inhaled by the user will change greatly. Therefore, when inhaled, it will not only make the user feel uncomfortable, but also the user will feel the usable period (sucking times). Expected to be shorter (less). The present invention is based on the above-mentioned circumstances, and the object of the present invention is to provide a non-combustion inhaled type tobacco product in which the delivery amount of Niko 324139 3 201244651, one of the tobacco-specific ingredients, is maintained for a long period of time and can be made to the user. The number of breaths that are satisfied is greatly increased. (Means for Solving the Problem) The above object can be attained by the non-combustion inhalation type tobacco product of the present invention, which comprises a tobacco granule obtained by cutting or pulverizing a tobacco material, and is made of granules The nicotine of the body is provided with at least one stabilizer which is stable, and the stabilizer has a solubility parameter of 17 or less with respect to nicotine and a vapor pressure of 25 m or less at 25 t. The stabilizer described above is excellent in solubility to nicotine and has a low vapor pressure, so that nicotine can be stabilized and maintained, and the amount of nicotine delivered to the user can be stabilized for a long period of time. For example, the stabilizer is selected from propylene glycol, benzyl alcohol or a compound having an ester group. The compound herein is selected from the group consisting of medium chain fatty acid triglycerides, citric acid triesters (triethyl citrate, tributyl citrate). Ester, etc.), benzyl benzoate and ethyl laurate. The stabilizer is preferably a property having a solubility parameter spacing of 12 or less and a vapor pressure of 25 ° C of not more than 0.1 l_Hg in order to further stabilize the amount of nicotine. Further, the tobacco granules may contain an additive comprising at least one of a carbonate and a hydrogencarbonate generally used in olfactory tobacco products such as snus. Alternatively, the non-combustion inhaled tobacco product may have a heating source for heating the tobacco granules. At this time, the stabilizer has a solubility parameter pitch of 17 or less and a vapor pressure at the heating temperature of the tobacco granules of 1 mmHg 324139 4 201244651 or less. In addition, 'relative to the source of production - 々, human dan 5% to 2 〇 heavy", the female bismuth agent content is better can not obtain the required ° Ni 2 when the ^ ^ agent content is less than 5% by weight The amount is more than 20% by weight, and conversely, if the stabilizer contains the operation of the granules, g 1 causes *(10) to aggregate the particulate matter 'to make the final grass (the effect of the invention) "it becomes difficult. The non-combustion type has a certain axis A, and the non-combustion type of the embodiment has an axis A, The (4) and the ❹ member 12 are moved along the upstream member 2, 0 I. The members 2, 6 and 12 are integrally joined by a plurality of connecting pins and nuts 14. For example, the 'upstream member 2 is a sheet having a thickness constituting no surface, and the central portion has an opening area 16. The open field 16 has a 23^ aperture ratio. Specifically, the opening region 16 is formed by a small hole of a straight C 1 πππ which is equally distributed. The final grass card g 6 is a frame member 18 having a thickness which is not composed of steel, and the frame member 18 has an open π portion of 26 mm in the center. In the "shoulder 4, the end of the grass, the granules are 2 〇, the granulated body is ventilated. The section can be clearly seen from the first picture, in the grass card 6 complex with air permeability of 324139 201244651=4'8 These non-woven fabrics 4, 8 are sandwiched by the frame member 18 of the weed card 6 to prevent the tobacco granular body 2. The frame member 18 is detached. Further, the tobacco granules 20 are described later. Similarly to the upstream member 2, the downstream member 10 is a slab having a thickness of 1 mm made of stainless steel. The central portion has an opening 22 having an inner diameter of 18 mm. In other words, the mouthpiece member 12 is made of Teflon (registered). The trademark is shaped and includes a mouth end 24. The mouth end 24 is protruded from the face of the downstream member 10 and the mouth member 12, and has an inner diameter of 6 mm. In addition, the mouthpiece member 12 on the side of the downstream member 10 The opening has an inner diameter of 20. According to the above-described straw product 1, the user is sucked by the mouth end 24 of the mouthpiece member 12, thereby causing outside air to pass through the open field 16 of the upstream member 2, through the nonwoven fabric 4, and the tobacco granules. 20. Non-woven fabric 8, opening of the downstream member 1〇. P 22 and the suction member 12 flow in In the user's mouth. At this time, when the air passes through the grass granules, the nicotine released by the tobacco granules is contained in the air. Therefore, the user inhales the air containing nicotine. Granular body 20. The final grass granules 20 are granules obtained by cutting or pulverizing grass raw materials composed of Japanese burley tobacco leaves, followed by humidification and heat treatment; For example, an additive composed of at least one of a carbonate and a hydrogencarbonate, specifically, a mixture containing potassium carbonate, is a granular material having a dry matter weight of 3 〇〇mg in the grass granule 2 。.重量重量。 The weight of the dry weight of the granules of the granules of the granules of the granules of the granules of the granules of the granules of the granules of the granules of the granules of the granules of the granules of the granules. The granules are contained in an amount of 12% by weight of the granules. The nicotine content is added to the granules of 200 mg ± 2. 5 mg of 11% by weight aqueous sodium hydroxide solution 7. 5 m 1 and hexane 1 Om 1, one side The product was shaken for 60 minutes at room temperature and subjected to extraction treatment, and then the hexane phase was analyzed by a gas chromatography mass spectrometer. Further, the volatile component content was 200 mg ± 2 mg of the granular material. The drying treatment was carried out at 80 ° C for 3 hours, and then the weight of the granules was reduced. Further, the dry weight was expressed by subtracting the amount of the volatile component obtained as described above from the weight of the granules. Furthermore, in the case of the present embodiment, the tobacco granule 20 contains, in addition to the above mixture, at least one stabilizer which stabilizes the amount of nicotine delivered to the user, and the stabilizer has a solubility parameter spacing with nicotine. ImmHg or less. 17 or less, preferably 12 or less, and a vapor pressure of 25 ° C is 1 匪 Hg or less, preferably 0. ImmHg or less. Specifically, the solubility parameter spacing is an index indicating the solubility of the solute to the solvent, and is generally expressed by Ra (MPa 1/2), and Ra is determined by the following formula. Ra=[4*((5(i,2-(5d,l:T2+((5p,2-5p,l:T2+(<5h,2-5h,1) Hl/2) Here, < 5d, (5p, (5h is defined as follows. (5 d = dispersive force of solubility parameter (5 p = dipole interaction of solubility parameter 5 h = hydrogen bond of solubility parameter) Propylene glycol, benzyl alcohol or a compound having an ester group of 324139 7 201244651, wherein the compound may be a medium chain fatty acid triglyceride citrate diester (# triethyl citrate, tributyl citrate) Etc.), benzyl benzoate and ethyl laurate. The following Table 1 also shows glycerin (A), and shows the solubility parameter spacing Ra of the above stabilizers and 25. (: vapor pressure. [Table 1] Stabilizer Ra (MPa丨/2 at 25. ", Vapor pressure (mmHg at 25 ° C) A (glycerol) 23.0 0. 0002 B (propylene glycol) 16.4 0. 2 C (medium chain fatty acid triglyceride) 11. 7 0.0000000002 D (triethyl citrate) 5.7 0. 0002 E (benzyl benzoate) 1. 3 0. 0003 F (benzyl alcohol) 6. 6 0. 2 G (ethyl laurate) 9.0 0.00744 Η ( Triethyl citrate) 8.6 0.0000001 ------- - In addition, Ul C is a key fatty acid triglyceride based on caprylic acid triglyceride g. Specifically, it is C0C0NARD MT manufactured by Kao Co., Ltd. In addition, the solubility parameter spacing Ra in Table 1 is used. M〇lecular 324139 8 201244651
Modeling Pr。VersiQn 6 Q1 之計算結果。 為了驗也女疋劑B至η之效果，而使用第2圖所示之 測定裝置，該測定裝置係測定使用者在吸入上述於草製品 1時’由該路草製品1供給於使用者之終草特有之尼古丁 的送出量。 詳細來說，測定裝置係具有含有乙醇編之空氣採集 。（mpinger)26具體來說，空氣採集器使用木下理化 ▲業股司製木下式氣體吸收洗淨瓶（標準型5Gml)。空 j採集器26係於其内部具有過濾粒子〇⑽至測另 —方面分別具有由該内部導出之吸人管28及送出管30。 吸入管28可連接於驗證對象之於草製品卜另一方 送出& 30係經過電磁閥32、質流調控器（肌)34而連 ;吸入泵36。再者’電磁閥32與閥調控器（v〇38電氣 連接’且該閥調控n 38係調控電磁閥32之開閉動作。 具體來說’根據閥調控器38之開閉動作，藉此可重複 電磁閥32在吸入栗36與空氣採集器26間連接4秒鐘後， 將二氣採集器26解放至大氣η秒鐘之1吸入循環。另外， 質流調控器34之流量設定為3300cc/min。 作為驗證對象之菸草製品1，分別準備菸草粒狀體2〇 中不含有甘油（A)及任何安定劑B至Η之第1比較例之菸草 製品；菸草粒狀體20中含有甘油（Α)之比較例2之菸草製 品；接著是菸草粒狀體2〇中分別含有安定劑Β至η之實施 例之菸草製品。 在此’比較例2及各實施例之菸草製品中，相對於菸 324139 201244651 草粒狀體20之乾物重量，甘油（A)及安定劑B至F之含量 分別為15重量％(45mg)。 接著，在空氣採集器26之吸入管28連接比較例1、2 及實施例之菸草製品之一後，在室溫22°C、濕度60%之環 境下重複50次前述吸入循環，並將由菸草製品送出之尼古 丁捕集於空氣採集器26中之乙醇。 之後，由空氣採集器26取出捕集尼古丁之乙醇，將取 出之乙醇以氣相層析質譜分析儀分析，並測定由該於草製 品之每1吸入循環（1吸吐）中的菸草特有之尼古丁。 再者，重複實施上述捕集及分析測定至總吸入循環到 達預定次數為止，藉此而結束對於1個菸草製品之測定流 程。 對於各菸草製品實施該測定流程，該測定結果表示於 第3圖及第4圖。 在此，含有安定劑G，Η之實施例之菸草製品與其他實 施例比較時，有以下數個不同點。含有安定劑G，Η之實施 例之情形，粒狀體所含尼古丁係菸草原料中之乾燥重量的 1. 6重量％，粒狀體所含揮發成份係粒狀體重量的10重量 %。 由第3圖及第4圖可明顯得知，與比較例1之菸草製 品（無安定劑）相比，含安定劑Β至Η之實施例之菸草製品 會抑制隨著吸吐次數增加之尼古丁之送出量降低，可知安 定劑Β至Η對於長期間安定之尼古丁送出量為有效的。 另一方面，與比較例1之菸草製品（無安定劑）相比， 324139 10 201244651 比較例2之終草製品（甘油A)之情形下，隨著吸吐次數增 加之尼古丁送出量降低幾乎沒有變化，可知甘油A對於^ 求尼古丁送出量之安定化為無效的。 認為該起因如下：安定劑B至Η皆具有π以下之溶解 參數間距Ra、及25°C為lnmHg以下之蒸氣壓枝特性，對此， 甘油A其溶解參數間距Ra為23. 0之大的值。 田另外，含有安定劑F之菸草製品之情形，尼古丁之送 出量並不拘限於該吸吐次數而較比較 這是因藉由安定劑F(铸）之尼古丁之捕捉效安 定劑B至E、G、Η高。 因此認為使用安定劑F時，若安定劑F之含量較安定 劑B至E、G、Η之含量少’則含有安定劑？之菸草製品係 可與其他實施例之终草製品同樣地送出尼古丁。另外，由 關於此點，由後述第5圖之測定結果之説明可更為明瞭。 另一方面，含有安定劑F之實施例之菸草製品之情形 中，由第3圖可明顯得知，隨著吸吐次數增加之尼古丁送 出量也,4示有增大之傾向。認為如此傾向會造成使用者有 不適感並對於使用者而言為不佳者時，如安定劑F類之溶 解參數間距Ra為12以下之安定劑，係認為其在25°C之蒸 氣壓過高，因此較佳為選擇在饥之蒸氣壓為〇1咖 下之安定劑。 义另一方面，著眼於安定劑D,準備該安定劑D含量與 前述情形不同之實施例之於草製品，對於該等终草製品實 施與前述同樣的測定流程後，將測定結果與無安定劑之測 324139 11 201244651 定結果並列表示。 曰由第4圖可明顯得知，隨著安定劑D之含量增加為5 重罝％(15mg)、1〇 重量％(30mg)、15 重量％(45mg) 尼古丁送出量，且該變化在長期間内是少的。 認為此情形也同樣地適用於其他安定劑b、c、e、f 至Η’故可知安定劑之含量為5重量％至2()重 在此’雜含量少於5重量％，料影響尼古丁送 $ =並無法得韻求之妓化絲，相反地若多於2〇 重安定劑會凝祕草粒狀體2g，使祕草粒狀體 川之細作，即該製造變得困難。 此外，使用前述安定劑"寺，苦安定劑f之含量 他安定劑之含量少，則含有安定密丨 其 倍“有劑F之菸草製品，係可期 待產生與3有安定劑B至E、G、卩 尼古丁送出量。 於草製品相同程度之 再者，非燃燒吸入型終草贺α 狀體2。之加熱源。例如，如含有用以加熱於草粒 游構件2係、内藏電加熱器4()。 不般，於草製品之上 之使用中’透過上游構件2、不:織；‘、:器40係於菸草製品 草粒狀體20加熱至所求产。螂布4及框構件Μ而將菸 此時，於草粒狀體 人 a 2〇之加熱溫度的蒸氣壓:之在菸草粒狀體 數間距Ra為17以下。g且與尼古丁之溶解性參 埶溫声厭& λ 為由具有在菸草粒狀體20之加 324139 12 201244651 以下表2係分別表示25°C、70°C及100°C之甘油（A) 與上述安定劑的蒸氣壓。 [表2] 安定劑 蒸氣壓 (mmHg 於 25°C ) 蒸氣壓 (mmHg 於 70°C) 蒸氣壓 (mmHg 於 100〇C) A (甘油） 0. 0002 0.00517 0. 0292 B (丙二醇） 0.2 2.7 10.0 C (中鏈脂肪酸三酸甘 油脂） 〇.〇〇〇〇〇〇〇002 〇.〇〇〇〇〇〇01 0.0000001 D (檸檬酸三乙酯） 0. 0002 0.005 0. 03 E (苯甲酸苄酯） 0.0003 0.006 0.03 F (苄醇） 0.2 1.9 6.9 G (月桂酸乙酯） 0. 00744 0.103 0.429 Η (檸檬酸三乙酯） 0.0000001 0.000005 0. 00004 表2中，70°C及100°C之蒸氣壓係藉由以下之克勞修 斯-可拉貝隆（Clausius-Clapeyron)方程式而算出。 P=P0*e^(L/R)*(l/T0-l/T) 在此，上式中的記號係定義如下。 P :溫度T之蒸氣壓[mmHg ] P0 : 25°C 之蒸氣壓[mmHg] L :蒸發熱[J/mol] R :氣體常數[J/mol*K] 324139 13 201244651 TO ： 298[K](25°C) τ :溫度[κ] 由表2可明顯得知，例如菸草粒狀體20之加熱溫度為 70°C或100°C時，安定劑可選擇c、D、E、G、h。 本發明並不限制於上述一實施例，而可作各種變形。 例如只要為具有溶解參數間距Ra為Π以下、且25。(：之蒸 氣壓為IminHg以下之特性的安定劑，則不限於前述安定劑 B至Η ’此外可任意組合該等安定劑B炱Η，再者，終草製 品之構造本身也不限於第1圖所示者。 此外，若選擇具有在菸草粒狀體20之加熱溫度的蒸氣 壓為IminHg以下、且與尼古丁之溶解性參數間距Ra為17 以下之特性的安定劑，則不限於表2所例示之加熱溫度， 可以任意溫度加熱菸草粒狀體20。再者，菸草粒狀體2〇 之加熱方式也不限於第6圖所例示之方式。 【圖式簡單說明】 第1圖係一實施例之非燃燒吸入型菸草製品之截面 圖。 第2圖係表示用以驗證安定劑效果之測定裝置之概略 圖。 第3圖係表示將安定劑之種類作為參數，吸吐次數與 尼古丁送出量之關係圖。 ' 第4圖係表示將其他安定劑之種類作為參數，吸吐次 數與尼古丁送出量之關係圖。 第5圖係表示將安定劑之含量作為參數，吸吐次數與 324139 14 201244651 尼古丁送出量之關係圖。 第6圖係變形例之非燃燒吸入型菸草製品的截面圖。 【主要元件符號說明】 1 菸草製品 2 上游構件 4 不織布 6 菸草卡匣 8 不織布 10 下游構件 12 吸口構件 14 插銷•螺帽 16 開口領域 18 框構件 20 菸草粒狀體 22 開口部 24 吸口端 26 空氣採集器 28 吸入管 30 送出管 32 電磁閥 34 質流調控器 36 吸入泵 38 閥調控器 40 加熱器（加熱源） 324139 15Modeling Pr. VersiQn 6 Q1 calculation results. In order to examine the effect of the female licking agent B to η, the measuring device shown in Fig. 2 is used, and the measuring device measures the user's supply of the grass product 1 to the user when inhaling the grass product 1. The amount of nicotine that is unique to the end of the grass. In detail, the measuring device has an air collection containing ethanol. (mpinger) 26 Specifically, the air collector uses the wood physicochemical ▲ industry stock system wood-type gas absorption washing bottle (standard type 5Gml). The empty j collector 26 has a suction tube 28 and a delivery tube 30 derived from the inside, respectively, having filter particles 〇 (10) to the inside thereof. The suction pipe 28 can be connected to the verification object to the other side of the grass product, and the delivery unit 30 is connected via a solenoid valve 32 and a mass flow controller (muscle) 34; the suction pump 36. Furthermore, the solenoid valve 32 is electrically connected to the valve regulator (v〇38), and the valve regulating n 38 system controls the opening and closing operation of the solenoid valve 32. Specifically, the electromagnetic valve 32 can be repeatedly opened and closed according to the opening and closing operation of the valve regulator 38. The valve 32 is connected for 4 seconds between the suction pump 36 and the air collector 26, and then the second gas collector 26 is liberated to the atmosphere for 1 second of the suction cycle. Further, the flow rate of the mass flow controller 34 is set to 3300 cc/min. As the tobacco product 1 to be tested, tobacco products of the first comparative example in which the tobacco granules 2 不 do not contain glycerin (A) and any stabilizer B to bismuth are prepared, respectively; the tobacco granules 20 contain glycerin (Α) The tobacco product of Comparative Example 2; followed by the tobacco product of the embodiment in which the stabilizer Β to η are respectively contained in the tobacco granule 2 。. In the tobacco product of Comparative Example 2 and each example, relative to the smoke 324139 201244651 The dry weight of the grass granule 20, the content of the glycerin (A) and the stabilizers B to F were respectively 15% by weight (45 mg). Next, the suction pipe 28 of the air collector 26 was connected to Comparative Examples 1, 2 and implemented. After one of the tobacco products, at room temperature 22 ° C, humidity 6 The aforementioned inhalation cycle is repeated 50 times in a 0% environment, and the nicotine sent from the tobacco product is trapped in the ethanol in the air collector 26. Thereafter, the nicotine-trapped ethanol is taken out by the air collector 26, and the extracted ethanol is taken as a gas. The phase chromatography mass spectrometer analyzes and measures the nicotine specific to the tobacco in each of the inhalation cycles (1 vomiting) of the grass product. Furthermore, the above-mentioned capture and analysis are repeated until the total inhalation cycle reaches a predetermined number of times. In this way, the measurement procedure for one tobacco product is completed. The measurement procedure is carried out for each tobacco product, and the measurement results are shown in Fig. 3 and Fig. 4. Here, the stabilizer G is contained in the embodiment. 6重量百分比的粒状。 The weight of the dry weight of the nicotine-based tobacco raw material in the granules, 1.6% by weight, granular The volatile component contained in the body is 10% by weight based on the weight of the granules. It is apparent from Fig. 3 and Fig. 4 that the stabilizer containing hydrazine is compared with the tobacco product of Comparative Example 1 (without stabilizer). The tobacco product of the example inhibits the decrease in the amount of nicotine delivered as the number of times of suction is increased, and it is known that the stabilizer is effective for the long-term stable nicotine delivery. On the other hand, the tobacco product of Comparative Example 1 ( Compared with 924139 10 201244651 in the case of the final grass product (glycerol A) of Comparative Example 2, there was almost no change in the amount of nicotine delivered as the number of times of suction increased, and it was found that glycerol A was used to obtain the amount of nicotine delivered. The stability is considered to be ineffective. The cause is as follows: the stabilizer B to bismuth has a dissolution parameter spacing Ra of π or less, and a vapor pressure characteristic of 25 ° C of 1 nmHg or less. For this, the dissolution parameter spacing Ra of glycerin A is 23. The value of 0 is large. In addition, in the case of tobacco products containing stabilizer F, the amount of nicotine delivered is not limited to the number of times of suction, but it is due to the effect of stabilizers B to E, G of nicotine by stabilizer F (casting). High. Therefore, it is considered that when the stabilizer F is used, if the content of the stabilizer F is less than the content of the stabilizer B to E, G, and ’, the stabilizer is contained. The tobacco product can be sent out of nicotine in the same manner as the final grass products of the other examples. Further, from this point, the description of the measurement results in the fifth drawing to be described later can be made clearer. On the other hand, in the case of the tobacco product of the example containing the stabilizer F, it is apparent from Fig. 3 that the amount of nicotine delivered as the number of times of suction is increased, 4 tends to increase. When it is considered that such a tendency may cause discomfort to the user and is not good for the user, such as a stabilizer having a dissolution parameter spacing Ra of 12 or less of the stabilizer F, it is considered to be a vapor pressure at 25 ° C. High, so it is better to choose a stabilizer that is under the pressure of hunger. On the other hand, focusing on the stabilizer D, preparation of the embodiment in which the stabilizer D content is different from the above-described case, the grass product is subjected to the same measurement procedure as the above-mentioned final grass product, and the measurement result is not stabilized. Determination of the agent 324139 11 201244651 The results are shown side by side.曰 It can be clearly seen from Fig. 4 that as the content of stabilizer D increases by 5 罝% (15 mg), 1 〇 wt% (30 mg), 15 wt% (45 mg) of nicotine, and the change is long There are few during the period. It is considered that this case is equally applicable to other stabilizers b, c, e, f to Η', so that the content of the stabilizer is 5% by weight to 2%, and the amount of the impurity is less than 5% by weight, which affects nicotine. Sending $ = can not get the rhyme of the silk, on the contrary, if more than 2 〇 heavy stabilizer will condense the grass granules 2g, so that the secret grass granules of the fine, that is, the manufacturing becomes difficult. In addition, the use of the aforementioned stabilizers, "the temple, the content of the bitter stabilizer f, the content of his stabilizer is small, it contains the stability of the "times F" tobacco products, can be expected to produce with 3 stabilizers B to E , G, and nicotine delivery amount. For the same degree of grass products, the non-combustion inhalation type of the end of the grass is a heating source. For example, if it is used to heat the grass particles, the 2 series, built-in Electric heater 4 (). In general, in the use of grass products, 'through the upstream member 2, no: weaving; ',: 40 is attached to the tobacco product grass pellets 20 to the desired yield. 4 and the frame member Μ 将 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时 此时The anaesthesia & λ is the vapor pressure of glycerin (A) at 25 ° C, 70 ° C and 100 ° C, respectively, with the addition of 324139 12 201244651 in the tobacco granule 20, respectively. Table 2] Stabilizer vapor pressure (mmHg at 25 ° C) Vapor pressure (mmHg at 70 ° C) Vapor pressure (mmHg at 100 ° C) A (glycerol 0. 0002 0.00517 0. 0292 B (propylene glycol) 0.2 2.7 10.0 C (medium chain fatty acid triglyceride) 〇.〇〇〇〇〇〇〇002 〇.〇〇〇〇〇〇01 0.0000001 D (triethyl citrate) Ester) 0. 0002 0.005 0. 03 E (benzyl benzoate) 0.0003 0.006 0.03 F (benzyl alcohol) 0.2 1.9 6.9 G (ethyl laurate) 0. 00744 0.103 0.429 Η (triethyl citrate) 0.0000001 0.000005 0 00004 In Table 2, the vapor pressures at 70 ° C and 100 ° C are calculated by the following Clausius-Clapeyron equation. P = P0 * e ^ (L / R) *(l/T0-l/T) Here, the symbols in the above formula are defined as follows: P: vapor pressure of temperature T [mmHg] P0: vapor pressure of 25 °C [mmHg] L : heat of evaporation [J/ Mol] R : gas constant [J/mol*K] 324139 13 201244651 TO : 298 [K] (25 ° C) τ : temperature [κ] It is apparent from Table 2, for example, the heating temperature of the tobacco granule 20 When the temperature is 70 ° C or 100 ° C, the stabilizer may be selected from c, D, E, G, and h. The present invention is not limited to the above embodiment, and various modifications may be made. For example, as long as the dissolution parameter spacing Ra is ΠThe following, and 25. (The stabilizer which has a vapor pressure of not more than 1 minHg is not limited to the stabilizer B to Η', and the stabilizer B can be arbitrarily combined. Further, the structure of the final product itself is not limited to the first one. In addition, when the stabilizer having a vapor pressure of the heating temperature of the tobacco granule 20 of 1 minHg or less and a solubility parameter spacing Ra of nicotine of 17 or less is selected, it is not limited to Table 2. The exemplified heating temperature may heat the tobacco granules 20 at any temperature. Further, the heating method of the tobacco granules 2 is not limited to the one illustrated in Fig. 6. [Simplified illustration] Fig. 1 is an implementation A cross-sectional view of a non-combustion inhaled tobacco product. Fig. 2 is a schematic view showing a measuring device for verifying the effect of a stabilizer. Fig. 3 is a view showing the type of stabilizer used as a parameter, the number of times of suction and the amount of nicotine delivered. The relationship diagram. 'Fig. 4 shows the relationship between the number of times of other stabilizers and the number of times of suction and the amount of nicotine delivered. Figure 5 shows the content of stabilizers as parameters, the number of times of suction and 324139 14 201244651 Diagram of the amount of nicotine delivered. Fig. 6 is a cross-sectional view of a non-combustion inhaled tobacco product according to a modification. [Description of main components] 1 Tobacco product 2 Upstream member 4 Non-woven fabric 6 Tobacco cassette 8 Non-woven fabric 10 Downstream member 12 Suction member 14 Pin • Nut 16 Open field 18 Frame member 20 Tobacco granular body 22 Opening 24 Suction end 26 Air collector 28 Suction tube 30 Delivery tube 32 Solenoid valve 34 Mass flow controller 36 Suction pump 38 Valve regulator 40 heater (heat source) 324139 15