201235054 六、發明說明 【發明所屬之技術領域】 本發明係關於消臭劑。更詳細而言，本發明係提供含 有以多元醇，尤其1，3-丁二醇作爲有效成份之消臭劑，對 老年臭之原因物質之不飽和醛具有優異消臭效果之老年臭 抑制劑者。另外，本發明係關於摻混1，3-丁二醇、烏龍茶 萃取物及甜茶萃取物而成之組成物。 【先前技術】 近年來，受到追求更舒適的生活空間之消費者的價値 觀或需求升高，開發各種消臭劑、除臭劑或芳香劑。另 外，消費者對體臭之關心亦升高，對於具有除臭效果之製 品的要求於近年來升高。 體臭中，主要係中高年者所意識的臭味之所謂的「老 年臭」，已知係與辛烯醛或壬烯醛等之不飽和醛深切關 聯。詳細而言，已知中高年齡層之皮脂中增加的9-十六 碳烯酸（棕櫚烯酸）係因過氧化脂質而被氧化、分解，或因 皮膚常在菌而被分解，而使發生惡臭物質之壬烯醛（專利 文獻1)。 作爲去除老年臭之技術，揭示藉由香料遮蔽、包覆轉 換所發生的不飽和醛之方法（專利文獻1 )、以乙醇胺捕捉 的方法（專利文獻2)。另外，揭示抑制成爲老年臭發生原 因之皮脂中不飽和醛發生之抑制老年臭之方法。具體上’ 揭示以抗氧化劑之抑制氧化（專利文獻3)、以脂氧合酶 -5- 201235054 (1 i p 〇 x y g e n a s e)抑制劑抑制過氧化脂質生成（專利文獻4)、 以抗菌劑抑制參與脂肪酸生成之皮膚常在菌增殖（專利文 獻5)，抑制不飽和醛發生之方法。 另一方面’關於化妝材料’大多摻混多元醇，就供應 安定性之觀點，常使用甘油、丙二醇、二丙二醇、1，3 -丁 二醇。此等中’因爲1，3-丁二醇具有非揮發性、低毒性、 保濕性之性質’已知適用於化妝品用途。具體上，揭示具 有保濕作用（專利文獻6)、抗菌作用及防腐作用（專利文獻 7)。 [先前技術文獻] [專利文獻] [專利文獻1]特開平1 1 -286428號公報 [專利文獻2]特開2001-97838號公報 [專利文獻3]特開平1 1 -286423號公報 [專利文獻4]特開平1 1 -2 86424號公報 [專利文獻5 ]特開平1 1 - 2 8 6 4 2 5號公報 [專利文獻6]特開平8-25 943 3號公報（特許 3159622 號） [專利文獻7]特開2003-238328號公報 【發明內容】 發明所欲解決之課題 本發明係以提供消臭效果高，且安全性高之消臭劑或 組成物爲目的。 -6- 201235054 課題之解決手段 本發明者等重複努力硏究的結果，發現多元醇，尤其 1，3-丁二醇具有消臭效果。尤其，發現此等對老年臭之原 因物質不飽和醛具有明顯的消臭效果，達到完成本發明。 亦即，本發明係關於下述，但不受此限制。 (1) 含有以2價或3價之C2〜C6醇作爲有效成份之消 臭劑。 (2) 前述醇爲1，3-丁二醇之（1)記載之消臭劑。 (3) 老年臭之消臭用之（1)或（2)記載之消臭劑。 (4) 臭味成份爲不飽和醛之（1)〜（3)中任一項記載之消 臭劑。 (5) 不飽和醛爲壬烯醛或辛烯醛之（4)記載之消臭劑。 (6) 摻混（1)〜（5)中任一項記載之消臭劑而成之消臭用 組成物。 (7) 皮膚外用劑之（6)記載之消臭用組成物。 (8) 摻混1,3-丁二醇、烏龍茶萃取物及甜茶萃取物而 成之組成物。 發明之功效 本發明係提供含有以多元醇，尤其U3-丁二醇作爲有 效成份，具有優異效果之消臭劑者。本發明之消臭劑，尤 其對老年臭原因物質，具有抑制效果，所以可摻混於以消 臭抑制爲目的之消臭用組成物。其中可摻混於以抑制老年 201235054 臭爲目的之消臭用組成物》另外，於本發明之其他型態， 可提供摻混1,3-丁二醇、烏龍茶萃取物及甜茶萃取物之具 有優異消臭效果之組成物。 用以實施發明之最佳型態 <消臭劑> 本發明之消臭劑係含有以多元醇，具體上2價或3價 之C2〜C6醇作爲有效成份爲特徵。 本發明之消臭劑係作爲以對各種臭味成份消臭爲目 的，其中以年老伴隨之體臭之老年臭的消臭爲目的，特別 是提供作爲對老年臭原因物質之不飽和醛（壬烯醛、辛烯 醛等）之消臭劑。 後述係詳細地說明本發明之實施型態。 消臭劑之有效成份 本發明之消臭劑之有效成份爲多元醇，具體上爲2價 或3價之C2〜C6醇。作爲2價或3價之C2〜C6醇，可 舉例如甘油、乙二醇、丙二醇、1,4-丁二醇、二乙二醇、 二丙二醇、1,3-丁二醇、戊二醇、己二醇等。此等中，以 2價的C2〜C6醇爲宜，以1，3-丁二醇尤佳。 消臭劑中之前述有效成份的量並無特別限制，雖可爲 有效成份100重量％，但爲0.01〜99重量％，以1〜50重 量％爲宜，以5〜30重量％尤佳。 201235054 消臭效果 本發明之消臭劑係對各種臭味具有效 臭（腋臭、腳臭、汗臭、頭皮臭、口臭等） 所臭味、廚房臭味、冰箱臭味、魚或蔬菜 臭味、衣服臭味、鞋子臭味等。 因此，本發明之消臭劑係可作爲例如 體臭用消臭劑、寵物用消臭劑、家畜用消 臭劑、廁所用消臭劑、室內用消臭劑、生 內用消臭劑、工業用消臭劑等使用。 另外，本發明之消臭劑特別對於體臭 效果。作爲老年臭係只要包含於老年臭之 限定，尤其對於壬烯醛或辛烯醛等之不飽 本發明之消臭劑亦可保持於載體後使 可舉例如寒天、明膠、鹿角菜膠、*** 乙烯醇、聚丙烯醯胺等之凝膠、各種纖維 石、多孔質玻璃、陶瓷、活性碳、二氧化 多孔性材料等。 <消臭用組成物〉 本發明之消臭用組成物係可摻混前述 消臭用組成物中之消臭劑之摻混量並 爲前述有效成份之100重量％，但爲0.01 1〜50重量％爲宜’以5〜30重量％尤佳。 可單獨摻混本發明之消臭劑，亦可組 摻混。可倂用之消臭成份並無特別限制， 果。可舉例如體 、寵物臭味、廁 等食品臭味、菸 口臭用消臭劑、 臭劑、廚房用消 活用消臭劑、車 中之老年臭具有 臭味，並無特別 和醛具有效果。 用。作爲載體， 膠等之膠類、聚 素等之纖維、沸 矽、矽酸鹽等之 消臭劑而調製。 無特別限定，可 〜9 9重量％，以 合其他消臭成份 可舉例如已知之 -9 - 201235054 遮蔽劑、吸附劑或多孔質材料等。另外’爲更加提高抑制 老年臭的效果，可倂用已知對老年臭之消臭劑’例如抗氧 化劑、脂氧合酶抑制劑、抗菌劑、遮蔽及包覆轉換香料、 乙醇胺等。另外’可添加烏龍茶、甜茶、綠茶、紅柿果 實、黃芩、月見草、甘蔗之植物成份之萃取物或粉碎物。 其中可適合使用對老年臭之消臭效果佳之烏龍茶或甜茶之 萃取物或粉碎物。 作爲消臭組成物之型態，以皮膚外用劑使用爲宜。可 舉例如洗面乳、香皂、口腔內護理製品（漱口水、牙膏 等）、洗髮精、潤絲精、護髮液、髮霜、整髮劑、養髮 液、長毛髮及育毛髮劑、化妝水、乳液、乳霜等。 另外，於不損及本發明效果之範圍內，本發明之消臭 用組成物係可摻混其他成份或添加劑。作爲此等成份或添 加劑，可列舉植物油等之油脂類、羊毛脂或蜂蠟等之蠟 類、烴類、脂肪酸、高級醇類、酯類、各種界面活性劑、 保濕劑、美白劑、色素、著色劑、顔料、甘味料、營養強 化劑、香料、維生素類、胺基酸、植物及動物萃取成份、 紫外線吸收劑、抗氧化劑、防腐及殺菌劑等。 <組成物> 本發明之一種型態中之組成物係含有1，3-丁二醇、烏 龍茶萃取物及甜茶萃取物。另外’本發明之組成物係可再 摻混綠茶萃取物及/或紅柿果實萃取物，亦可摻混其他成 份。尤其使用組成物作爲消臭用組成物爲宜。 調製烏龍茶萃取物、甜茶萃取物、綠茶萃取物及紅柿 -10- 201235054 果實萃取物係可依據相關業者已知的任一種方法進行。另 外，此等萃取物爲固體，亦可爲液體，亦包含葉或果實之 粉碎品。另外，只要包含來自烏龍茶、甜茶、綠茶及紅柿 果實的有效成份之型態，萃取步驟並不是必要的。 本發明之組成物中之1，3 - 丁二醇之含量並無特別限 定’爲0.01〜99重量％，以1〜70重量％爲宜，以5〜60 重量°/。尤佳。另外’組成物中之烏龍茶萃取物及甜茶萃取 物之合計摻混量，或於組成物中再加入綠茶萃取物及/或 紅柿果實萃取物之總萃取物之合計摻混量亦無特別限定， 但以乾燥重量換算，爲0.0001〜90重量％，以0.005〜50 重量％爲宜，以0.0 0 1〜1 0重量％尤佳》 各萃取物之摻混量雖亦無特別限定，但例如使用烏龍 茶萃取物及甜茶萃取物2種，或於此等中加入綠茶萃取物 及/或紅柿果實萃取物之3種或4種萃取物時，各組合中 萃取物之摻混比雖無特別限制，但以量最少的萃取物之乾 燥重量爲基準，可分別摻混以使其他萃取物之乾燥重量成 爲1〜10倍量’以1〜5倍量爲宜，以1〜2倍量更好。 本發明之組成物中所摻混之烏龍茶萃取物及甜茶萃取 物所含成份，或再摻混綠茶萃取物及/或紅柿果實萃取物 所含成份並無特別限定，作爲此等萃取物之主要成份，可 舉多酚。所謂多酚係1個分子內具有複數個酚性羥基之化 合物之總稱，並非特別限定者，由烏龍茶、甜茶、綠茶等 茶葉、紅柿果實等所萃取之鞣酸、類黃酮、兒茶酸類等。 本發明之一種型態中之組成物係以作爲皮膚外用劑使 -11 - 201235054 用爲宜。可舉例如洗面乳、香皂、口腔內護理製品（漱口 水、牙脊等）、洗髮精、潤絲精、護髮液、髮霜、整髮 劑、養髮液、長毛髮及育毛髮劑、化妝水、乳液、乳霜 等。 另外，本發明之一種型態之組成物係於不損及本發明 效果之範圍內，可摻混其他成份或添加劑。作爲此等成份 或添加劑，可列舉由黃芩、月見草、甘蔗等之植物原料所 得之萃取物或粉碎物、羊毛脂或蜂蠟等之蠟類、烴類、脂 肪酸、高級醇類、酯類、各種界面活性劑、保濕劑、美白 劑、色素、著色劑、顏料、甘味料、營養強化劑、香料、 維生素類、胺基酸、植物及動物萃取成份、紫外線吸收 劑、抗氧化劑、防腐及殺菌劑等。另外，對於可倂用之消 臭成份並無特別限制，可舉例如已知之遮蔽劑、吸附劑或 多孔質材料等。另外，可倂用已知之對老年臭之消臭劑， 例如抗氧化劑、脂氧合酶抑制劑、抗菌劑、遮蔽及包覆轉 換香料、乙醇胺等。 【實施方式】 實施例 後述係基於實施例詳細地說明本發明，但本發明並非 局限於此等者。 [實施例1]對不飽和醛之消臭效果試驗U官能評估）： 放入20ml之1 %之1，3-丁二醇水溶液於各管形瓶中。 -12- 201235054 添加0.5ml之0.5%之壬烯醛（將trans-2-壬烯醛（一級，和 光純藥工業股份有限公司）以橄欖角鯊烷（NIKKOL精製橄 欖角鯊烷，日光Chemicals(股）製）稀釋者）於其中，迅速地 封上橡膠塞。於40°C之條件下靜置1 〇分鐘後，進行官能 評估。 [結果] 如後述表1所示，1，3-丁二醇與無添加進行比較，顯 示對壬烯醛臭味之消臭效果佳。 [表1] 評估樣品_壬烯醛臭味_ 1，3-丁二醇_〇_201235054 VI. Description of the Invention [Technical Field of the Invention] The present invention relates to a deodorant. More specifically, the present invention provides an aged odor inhibitor having an excellent deodorizing effect on an unsaturated aldehyde which is a causative substance of an old odor, containing a deodorant which is a polyhydric alcohol, particularly 1,3-butylene glycol as an active ingredient. By. Further, the present invention relates to a composition obtained by blending 1,3-butanediol, oolong tea extract and sweet tea extract. [Prior Art] In recent years, various deodorants, deodorants, or fragrances have been developed by consumers who are pursuing a more comfortable living space with an increase in price or demand. In addition, consumers' interest in body odor has also increased, and the demand for products having deodorizing effects has increased in recent years. Among the body odors, the so-called "aging odor" which is mainly caused by the odor of the middle-aged people is known to be deeply related to the unsaturated aldehyde such as octenal or decenal. In detail, it is known that 9-hexadecenoic acid (palmitoic acid) which is increased in sebum of the middle and high age layers is oxidized, decomposed by peroxidized lipids, or is decomposed by the skin often causing bacteria to occur. Terpene aldehyde of malodorous substance (Patent Document 1). As a technique for removing old-age odor, a method of masking and coating the unsaturated aldehyde generated by the coating (Patent Document 1) and a method of capturing with ethanolamine (Patent Document 2) are disclosed. Further, it is disclosed that the inhibition of the odor of the old odor caused by the unsaturated aldehyde in the sebum which is the cause of the sensation of the elderly is revealed. Specifically, it discloses that inhibition of oxidation by an antioxidant (Patent Document 3), inhibition of lipid peroxidation by a lipoxygenase-5-201235054 (1 ip 〇xygenase) inhibitor (Patent Document 4), and inhibition of participating fatty acids by an antibacterial agent The produced skin is often proliferated (Patent Document 5), and a method of suppressing the occurrence of unsaturated aldehydes. On the other hand, the "cosmet material" is often blended with a polyhydric alcohol, and glycerin, propylene glycol, dipropylene glycol, and 1,3-butanediol are often used from the viewpoint of supplying stability. These are known to be suitable for cosmetic use because of the non-volatile, low toxicity, moisture retention properties of 1,3-butanediol. Specifically, it is disclosed that it has a moisturizing action (Patent Document 6), an antibacterial action, and an antiseptic effect (Patent Document 7). [PRIOR ART DOCUMENT] [Patent Document 1] Japanese Laid-Open Patent Publication No. JP-A No. 2001-97838 [Patent Document 5] Japanese Patent Laid-Open Publication No. Hei No. Hei 1 1 - 2 8 6 4 2 5 [Patent Document 6] Japanese Patent Publication No. 8-25 943 (No. 3,159,622) [Patent [Problem to be Solved by the Invention] The present invention has an object of providing a deodorant or a composition having a high deodorizing effect and high safety. -6- 201235054 Solution to the problem As a result of repeated efforts by the inventors, it was found that a polyol, particularly 1,3-butanediol, has a deodorizing effect. In particular, it has been found that these materials have a significant deodorizing effect on the unsaturation aldehyde of the original odor, and the present invention has been completed. That is, the present invention relates to the following, but is not limited thereto. (1) A deodorant containing a C2 to C6 alcohol having a divalent or trivalent value as an active ingredient. (2) The alcohol is a deodorant described in (1) of 1,3-butanediol. (3) The deodorant described in (1) or (2) for the deodorization of old-aged odor. (4) The odor component is the deodorant described in any one of (1) to (3). (5) The unsaturated aldehyde is a deodorant described in (4) of nonenal or octenal. (6) A deodorant composition comprising the deodorant according to any one of (1) to (5). (7) The composition for deodorization described in (6) of the external preparation for skin. (8) A composition obtained by blending 1,3-butanediol, oolong tea extract and sweet tea extract. EFFECTS OF THE INVENTION The present invention provides a deodorant containing a polyhydric alcohol, particularly U3-butanediol, as an effective component and having an excellent effect. The deodorant of the present invention has an inhibitory effect on an old-age odor-causing substance, and therefore can be blended in a deodorizing composition for the purpose of suppressing odor. In addition, in other forms of the present invention, blending of 1,3-butanediol, oolong tea extract, and sweet tea extract may be provided in addition to the composition for deodorizing for the purpose of suppressing odor of aged 201235054. A composition that is excellent in deodorizing effect. BEST MODE FOR CARRYING OUT THE INVENTION <Deodorant> The deodorant of the present invention is characterized by containing a polyhydric alcohol, specifically a divalent or trivalent C2 to C6 alcohol as an active ingredient. The deodorant of the present invention is for the purpose of deodorizing various odor components, and is intended to provide deodorization of the aged odor accompanying the body odor of the elderly, and in particular to provide an unsaturated aldehyde as a substance for the elderly odor ( Deodorant of nonenal, octenal, etc.). Hereinafter, the embodiment of the present invention will be described in detail. Active ingredient of deodorant The active ingredient of the deodorant of the present invention is a polyhydric alcohol, specifically a divalent or trivalent C2 to C6 alcohol. Examples of the divalent or trivalent C2 to C6 alcohols include glycerin, ethylene glycol, propylene glycol, 1,4-butanediol, diethylene glycol, dipropylene glycol, 1,3-butylene glycol, and pentanediol. , hexanediol, etc. Among these, a divalent C2 to C6 alcohol is preferred, and 1,3-butanediol is particularly preferred. The amount of the above-mentioned effective ingredient in the deodorant is not particularly limited, and may be from 0.01 to 99% by weight, preferably from 1 to 50% by weight, particularly preferably from 5 to 30% by weight, based on 100% by weight of the active ingredient. 201235054 Deodorizing effect The deodorizing agent of the present invention has an odor against various odors (odor, foot odor, sweat odor, scalp odor, bad breath, etc.), odor, kitchen odor, refrigerator odor, fish or vegetable odor. , clothing smell, shoe smell, etc. Therefore, the deodorant of the present invention can be used, for example, as a deodorant for body odor, a deodorant for pets, a deodorant for livestock, a deodorant for toilets, a deodorant for indoor use, a deodorant for internal use, Industrial deodorant and the like. Further, the deodorant of the present invention is particularly effective for body odor. As the old odor system, as long as it is included in the definition of the old-age odor, especially for the non-salenal or octenal, the deodorant of the present invention may be retained in the carrier, such as cold weather, gelatin, carrageenan, and arabic. Gels such as vinyl alcohol and polypropylene decylamine, various fiber stones, porous glass, ceramics, activated carbon, and porous porous materials. <Deodorizing composition> The deodorizing composition of the present invention may be blended with the deodorant in the deodorant composition and is 100% by weight of the above-mentioned effective component, but is 0.011% 50% by weight is preferably '5 to 30% by weight. The deodorant of the present invention may be blended alone or in combination. There are no particular restrictions on the deodorizing ingredients that can be used. For example, a food odor such as a body, a pet odor, a toilet, a deodorant for a odor, a odor, a deodorant for a kitchen, and an odor of an old odor in a vehicle may be used, and there is no particular effect with an aldehyde. use. The carrier is prepared by using a gel such as glue, a fiber such as a polymer, or a deodorant such as boiling bismuth or bismuth citrate. It is not particularly limited, and may be 9% by weight, and other deodorizing components may be, for example, known as -9 - 201235054, a shielding agent, an adsorbent or a porous material. Further, in order to further enhance the effect of suppressing the sensation of the elderly, a deodorant known to be used for the elderly, such as an antioxidant, a lipoxygenase inhibitor, an antibacterial agent, a masking and coating conversion flavor, an ethanolamine or the like can be used. In addition, an extract or pulverized material of olean tea, sweet tea, green tea, red persimmon fruit, scutellaria, evening primrose, and sugar cane may be added. Among them, it is suitable to use an extract or pulverized material of oolong tea or sweet tea which has a good deodorizing effect on the aged odor. As a form of the deodorizing composition, it is preferably used as a skin external preparation. Examples thereof include facial cleansers, soaps, oral care products (mouthwashes, toothpastes, etc.), shampoos, conditioners, hair conditioners, hair creams, hair styling agents, hair growth liquids, long hairs, and hair growth agents. Lotions, lotions, creams, etc. Further, the deodorant composition of the present invention may be blended with other components or additives within the range not impairing the effects of the present invention. Examples of such components or additives include oils and fats such as vegetable oils, waxes such as lanolin or beeswax, hydrocarbons, fatty acids, higher alcohols, esters, various surfactants, humectants, whitening agents, pigments, and coloring. Agents, pigments, sweeteners, nutritional supplements, spices, vitamins, amino acids, plant and animal extracts, UV absorbers, antioxidants, antiseptics and fungicides. <Composition> The composition of one form of the present invention contains 1,3-butanediol, oolong tea extract, and sweet tea extract. Further, the composition of the present invention may be further blended with green tea extract and/or red persimmon fruit extract, or may be blended with other ingredients. In particular, it is preferred to use a composition as a composition for deodorization. Preparation of oolong tea extract, sweet tea extract, green tea extract and red persimmon -10- 201235054 The fruit extract can be carried out according to any method known to the relevant industry. Further, the extracts are solids, liquids, and pulverized products of leaves or fruits. In addition, the extraction step is not necessary as long as it contains the form of the active ingredients from the oolong tea, sweet tea, green tea and red persimmon fruit. The content of 1,3-butanediol in the composition of the present invention is not particularly limited to 0.01 to 99% by weight, preferably 1 to 70% by weight, and preferably 5 to 60% by weight. Especially good. Further, the total blending amount of the oolong tea extract and the sweet tea extract in the composition, or the total blending amount of the green tea extract and/or the total extract of the red persimmon fruit extract added to the composition is not particularly limited. However, in terms of dry weight, it is 0.0001 to 90% by weight, preferably 0.005 to 50% by weight, and preferably 0.01 to 10% by weight. The blending amount of each extract is not particularly limited, but for example, When two kinds of oolong tea extract and sweet tea extract are used, or three or four kinds of extracts of green tea extract and/or red persimmon fruit extract are added thereto, the blending ratio of the extracts in each combination is not particularly special. Restriction, but based on the dry weight of the least amount of extract, can be blended separately so that the dry weight of other extracts is 1 to 10 times the amount is preferably 1 to 5 times, more preferably 1 to 2 times. it is good. The components contained in the oolong tea extract and the sweet tea extract blended in the composition of the present invention, or the blended green tea extract and/or the red persimmon fruit extract are not particularly limited, and as such extracts The main ingredients are polyphenols. The term "polyphenols" is a generic term for a compound having a plurality of phenolic hydroxyl groups in one molecule, and is not particularly limited, and is extracted from eucalyptus, flavonoids, catechins, etc., such as oolong tea, sweet tea, green tea, and the like. . The composition of one form of the present invention is preferably used as a skin external preparation -11 - 201235054. For example, facial cleanser, soap, oral care products (mouthwash, ridge, etc.), shampoo, moisturizing essence, hair lotion, hair cream, hair styling agent, hair growth liquid, long hair and hair growth agent , lotions, lotions, creams, etc. Further, a composition of one form of the present invention may be blended with other components or additives within a range not impairing the effects of the present invention. Examples of such components or additives include extracts or pulverized materials obtained from plant materials such as scutellaria, evening primrose, and sugar cane, waxes such as lanolin or beeswax, hydrocarbons, fatty acids, higher alcohols, esters, and various interfaces. Active agents, moisturizers, whitening agents, pigments, colorants, pigments, sweeteners, nutritional supplements, flavors, vitamins, amino acids, plant and animal extracts, UV absorbers, antioxidants, antiseptics and fungicides, etc. . Further, the deodorant component which can be used is not particularly limited, and examples thereof include known masking agents, adsorbents, and porous materials. Further, known deodorants for old-age odor, such as antioxidants, lipoxygenase inhibitors, antibacterial agents, masking and coating conversion perfumes, ethanolamine and the like can be used. [Embodiment] Embodiments Hereinafter, the present invention will be described in detail based on examples, but the present invention is not limited thereto. [Example 1] Deodorization effect test on unsaturated aldehydes U functional evaluation): 20 ml of a 1% aqueous solution of 1,3-butylene glycol was placed in each vial. -12- 201235054 Add 0.5ml of 0.5% terenal (trans-2-nonenal (Grade, Wako Pure Chemical Industries, Ltd.) to olive squalane (NIKKOL refined olive squalane, daylight Chemicals ( In the system), the dilute is quickly sealed with a rubber stopper. After standing at 40 ° C for 1 〇 minutes, the sensory evaluation was performed. [Results] As shown in Table 1 below, 1,3-butanediol showed a good deodorizing effect on the odor of decene aldehyde compared with no addition. [Table 1] Evaluation sample _ decene odor _ 1,3-butanediol _ 〇 _
無添加 X 〇：具有高消臭效果 X:幾乎無消臭效果 [實施例2]對不飽和醛之消臭效果試驗2 : 使用24%之1，3-丁二醇水溶液，依據後述方法進行對 不飽和醛之消臭效果試驗。另外，使用壬烯醛作爲不飽和 醛，以高效液相層析法分析評估該減少率。 <試驗方法> •試藥及器具 氣味袋（25cmx40cm)[Miyakovinyl力卩工所股份有限公 -13- 201235054 司] 壬烯醛氣體：使用發生自trans-2·壬烯醛（一級）[和光 純藥工業股份有限公司]的氣體。No addition X 〇: high deodorizing effect X: almost no deodorizing effect [Example 2] Deodorizing effect on unsaturated aldehyde Test 2: Using a 24% aqueous solution of 1,3-butanediol, according to the method described later Deodorization effect test on unsaturated aldehydes. Further, using a nonenal as an unsaturated aldehyde, the reduction rate was evaluated by high performance liquid chromatography. <Test method> • Test drug and appliance scent bag (25cmx40cm) [Miyakovinyl Power Plant Co., Ltd. -13-201235054 Division] Terpene gas: use occurs from trans-2·nonenal (Grade 1) [ Wako Pure Chemical Industry Co., Ltd.] gas.
DNPH-吸附管（DNPH-Cartridge) : GL-P ak mini AERO DNP H [GL Sciences股份有限公司] •評估樣品 使用作爲評估樣品之24%之1，3-丁二醇水溶液、對照 (水）。 •操作 分別放入評估樣品及對照（水）於氣味袋，施以熱封 後，封入4L空氣，添加壬烯醛氣體使成爲設定的氣體濃 度。將此靜置，每隔經過時間（〇、30、60、180分鐘後）， 捕集300ml袋內氣體於DNPH-吸附管。使5ml之乙腈通 過捕集氣體之DNPH-吸附管，使溶出DNPH衍生物，以高 效液相層析法測定此溶出液，算出袋內的氣體濃度》高效 液相層析儀之操作條件表示如下。 •高效液相層析儀之操作條件 機種：LC-2010AHT[島津製作所股份有限公司] 偵測器：紫外線吸光光度偵測器 管柱：RP-Amide， φ 4.6 m m χ 2 5 cm [ S i gm a - A1 d r i ch Japan股份有限公司]DNPH-adsorbent tube (DNPH-Cartridge): GL-P ak mini AERO DNP H [GL Sciences Co., Ltd.] • Evaluation sample A 24% aqueous solution of 1,3-butanediol as a sample for evaluation, control (water) was used. • Operation Place the evaluation sample and the control (water) in the scent bag separately, apply heat seal, enclose 4L of air, and add the decene gas to make the set gas concentration. The solution was allowed to stand, and the gas in the bag of 300 ml was collected in a DNPH-adsorbing tube every elapsed time (〇, 30, 60, and 180 minutes). 5 ml of acetonitrile was passed through a DNPH-adsorbing tube for trapping gas to dissolve the DNPH derivative, and the eluate was measured by high performance liquid chromatography to calculate the gas concentration in the bag. The operating conditions of the high performance liquid chromatograph are as follows: . • Operating conditions of high performance liquid chromatography: LC-2010AHT [Shimadzu Corporation] Detector: UV spectrophotometer column: RP-Amide, φ 4.6 mm χ 2 5 cm [ S i gm a - A1 dri ch Japan Co., Ltd.]
管柱溫度：4(TC 沖提液：乙腈及水之混合液（乙腈：水=80 : 20) 沖提液流量：1.5ml/min -14- 201235054 測定波長：360nm 注入量：4 0以1 •試驗條件 檢體使用量：5ml之評估樣品（24%之1,3-丁二醇水溶 液）、5ml之對照（水） 試驗對象氣體：壬烯醛（初期氣體濃度’· 22ppm) 室溫條件：室溫 <結果> 如下述表2所示，24%之1,3-丁二醇水溶液與對照比 較，不飽和醛之減少率大，顯示具有優異的消臭效果。 [表2] 評估樣品 減少莉％) 經過時間(分） 0 30 60 180 24%之1,3-丁二醇水溶液 0 30 40 55 對照(水） 0 20 25 40 ※減少率（％)= 100-[各經過時間（30、60、180分鐘後）之 壬烯醛濃度]/[經過時間（0分）之壬烯醛濃度]xl 00 [實施例3 ]對不飽和醛之消臭效果試驗3 : 使用1〇〇%之1，3-丁二醇水溶液，依據後述方法進行 對不飽和醛之消臭效果試驗。另外，使用壬烯醛作爲不飽 和醛，藉由高效液相層析法，以與實施例2相同的條件分 析而評估該減少率。 <試驗方法> -15- 201235054 使用1 ο 0 %之1，3 - 丁二醇（5 m 1)作爲評估樣品、及水 (5ml)作爲對照，試驗對象氣體壬烯醛之初期氣體濃度爲 1 8 ppm以外，以與實施例2相同的方法進行消臭評估試 驗。 <結果> 如後述表3所示，100%之1,3-丁二醇與實施例2之 2 4 %之1 , 3 - 丁二醇水溶液比較’不飽和醛之減少率更大， 具有明顯的消臭效果8 [表3] 減少率(〇/〇) 評估樣品 經過時間(分） 0 30 60 180 100%之 1,3-丁二醇 0 94 94 94 對照(水） 0 28 28 39 減少率（％)= 100-[各經過時間（30、60、180分鐘後）之壬 烯醛濃度]/[經過時間（〇分）之壬烯醛濃度]xl 00 [實施例4]對不飽和醛之消臭效果試驗4 : <試驗方法> •評估樣品 作爲烏龍茶萃取液係使用以烏龍茶萃取物爲主要成份 之市售化妝品原料（烏龍茶萃取液BG(九善製藥（股）製）： 5 0%之1，3-丁二醇溶液）。另外，作爲甜茶萃取液係使用以 甜茶萃取物爲主要成份之市售化妝品原料（甜茶萃取液 8〇\¥(九善製藥（股）製）：50%之1，3-丁二醇溶液）。進而， -16- 201235054 作爲綠茶萃取液係使用以綠茶萃取物爲主要成份之市售化 妝品原料（和ism綠茶（九善製藥（股）製）：50%之1，3-丁二 醇溶液），作爲紅柿果實萃取液係使用以紅柿果實萃取物 爲主要成份之市售化妝品原料（Pancil BA-210-1 ’ Rilis科 學工業（股）製）。 摻混前述烏龍茶萃取液（2.5ml)、甜茶萃取液 (2,5ml)，使萃取物份（含有主要成份多酚）成爲1重量％， 並且各萃取物份的量爲等量，調製1，3-丁二醇+ 2種混合 萃取物之評估樣品（5ml)。1,3-丁二醇之含量爲（50重量 °同樣地，摻混前述烏龍茶萃取液、甜茶萃取液及綠茶 萃取液，使萃取物份成爲1重量％，並且各萃取物份的量 爲等量，調製1，3-丁二醇+ 3種混合萃取物（1)之評估樣 品°進而，摻混前述烏龍茶萃取液、甜茶萃取液及紅柿果 實萃取液，使萃取物份成爲1重量％，並且各萃取物份的 量爲等量，調製1，3-丁二醇+ 3種混合萃取物（2)之評估樣 品。另外，摻混前述烏龍茶萃取液、甜茶萃取液、綠茶萃 取液及紅柿果實萃取液，使萃取物份成爲1重量％，並且 各萃取物份的量爲等量，調製1，3 -丁二醇+ 4種混合萃取 物之評估樣品。 •操作 除了使用前述含有1，3-丁二醇之混合萃取物作爲評估 樣品，及水（5ml)爲對照以外，以與前述實施例2相同的 方法，對1,3-丁二醇+ 2種混合萃取物及1，3-丁二醇+ 4 種混合萃取物、I，3·丁二醇+ 3種混合萃取物（1)、及ι，3- -17- 201235054 丁二醇+ 3種混合萃取物（2)之評估樣品’分別進行對不飽 和醛之消臭效果試驗。另外，使用壬烯醛作爲不飽和醛， 藉由高效液相層析法，以與實施例2相同的條件分析而評 估該減少率。另外，試驗對象氣體壬烯醛之初期氣體濃度 分別爲20PPm(前述2種、4種之樣品評估時）、20ppm(前 述3種之樣品評估時）。 <結果〉 如後述表所示，1，3-丁二醇+ 2種混合萃取物、3種 混合萃取物（1)及（2)、及4種混合萃取物中任一種與對照 比較’不飽和醛之減少率大，顯示消臭效果佳。 [表4] 評估樣品 經過時間(分） 0 30 60 180 1，3-丁二醇+ 2種混合萃取物 (烏龍茶、甜茶） 0 70 80 80 1，3-丁二醇+ 4種混合萃取物(烏龍茶、甜 茶、綠茶、紅柿果實） 0 60 85 85 對照(水） 0 25 25 35 1，3-丁二醇+3種混合萃取物(1) (烏龍茶、甜茶、綠茶） 0 72 72 78 1，3-丁二醇+ 3種混合萃取物⑺ (烏龍茶、甜茶、紅柿果實） 0 44 50 50 對照(水） 0 28 28 39 [製造例1]香皂 後述係表示摻混1，3-丁二醇之消臭用組成物之製造 例。 -18- 201235054 原料之摻混量如表5所示。混合攪拌香皂素材’之 後’加入1，3-丁二醇及各萃取物，混合均勻後，成型。 5」_______ 原料 使用量(雷景份) 香皂素材 99.8 99.8 99.7 1，3-丁二醇 0.1 0.1 0.1 烏龍茶萃取物 0.1 0.1 甜茶萃取物 0.1 0.1 總量 100.0 100.0 100.0 [製造例2]洗髮精 原料之摻混量如表6所示。 加入溶解於1，3 -丁二醇之防腐劑於精製水。攪拌均勻 後’加入月桂基硫酸鈉、椰油脂肪酸單乙醇醯胺，之後’ 加入色素、香料及剩餘的1,3-丁二醇後，混合攪拌均勻。 - [表 61 — —® 使用量(重量份）__ 月桂基硫酸鈉 16〇 椰油脂肪酸單乙醇醯胺 4〇 2.0 適量 78.0 100.0 1，3-丁二醇 防腐劑、色素、香料 精製水 總量 -19- 201235054 [製造例3]護髮液 原料之摻混量如表7所示》 (1) 加入十八烷基二甲基苯甲基氯化銨及食鹽於精製 水’加溫至8〇r溶解。 (2) 將棘蠟醇及單硬脂酸甘油脂，加溫至8 0 °C溶解》 (3) 以勻化器攪拌（1)下’添加（2)，添加後進行預備攪 拌5分鐘。 (4) 預備攪拌結束後，邊攪拌邊冷卻至50〇c，添加 1，3 -丁二醇’再攪拌冷卻至35它而調製。 [表7] 原料 使用量(重量份） 十八烷基二甲基苯甲基氯化銨 1.4 鯨蠟醇 0.6 單硬脂酸甘油脂 1.5 食鹽 0.1 1,3-丁二醇 0.1 精製水 96.3 總量 100.0 [製造例4]養髮液 原料之摻混量如表8所示。 加入水楊酸、溶解於乙醇之維生素E、L-薄荷醇於精 -20- 201235054 製水’再加入溶解於部份精製水之甘草酸，之後’加入 1，3-丁二醇，混合均勻而調製。 [表8] 原料 使用量(重量份） 乙醇 70.0 維生素E 0.4 L-薄荷醇 0.4 甘草酸 0.1 1，3-丁二醇 0.1 水楊酸 0.5 甘油 0.5 精製水 28.0 總量 100.0 [製造例5]噴霧 原料之摻混量如表9所示。 加入檸檬酸及檸檬酸鈉於精製水溶解。之後’加入溶 解於乙醇之防腐劑及聚山梨酸酯80。之後，加入1，3-丁 二醇後，均勻地攪拌而調製。 -21 - 201235054 [表9] 原料 使用量(重量份） 檸檬酸 0.01 檸檬酸鈉 0.09 防腐劑 適量 聚山梨酸酯80 0.05 乙醇 10.00 1，3-丁二醇 1.0 精製水 88.85 總量 100.0 [製造例6]化妝水 原料之摻混量如表1 〇所示。 加入檸檬酸及檸檬酸鈉於精製水溶解。接著，依序加 入甘油、1,3-丁二醇及乙二胺四乙酸三鈉，再加入溶解於 乙醇之聚氧乙烯（18)油醇醚、維生素E，攪拌至均句而調 製。 [表 10]_ 原料 使用量(重量份） 甘油 4.0 1，3-丁二醇 5.0 乙醇 7.0 聚氧乙烯(18)油醇醚 0.5 檸檬酸 0.05 檸檬酸鈉 0.1 乙二胺四乙酸三鈉 0.02 維生素E 0.50 對羥基苯甲酸甲酯 0.1 精製水 82.7 總量 100.0 -22- 201235054 [製造例7 ]乳液 原料之摻混量如表Η所示。 (1) 加溫硬脂酸、十六烷醇、肉豆蔻酸辛基十二烷基 酯及流動鏈烷烴至801溶解。 (2) 加入三乙醇胺、透明質酸鈉、甘油、丨，3-丁二醇及 乙二胺三乙酸鈉於精製水，加溫至8 〇。 ⑴以句化器攪拌⑴下’加入(2)，加入後進行預備攪 拌5分鐘。 (4)預備攪拌結束後，冷卻至5〇°C ’再冷卻至35它而 調製。 [表 11]_________ 原料 使用量(重量份） — 硬脂酸 1.5 十六烷醇 0.5 肉豆蔻酸辛基十二烷基酯 5.0 聚氧乙烯(10)單油酸酯 1.0 流動鏈烷烴 5.0 三乙醇胺 0.5 透明質酸鈉 0.01 甘油 7.0 1，3-丁二醇 4.0 乙二胺三乙酸鈉 0.01 精製水 75.48 總量 100.0 [製造例8]乳霜 -23- 201235054 原料之摻混量如表12所示。 (1) 加溫硬脂酸、單硬脂酸甘油酯、倍半硬脂酸山梨 糖醇酐、單硬脂酸聚氧乙烯山梨糖醇酐、倍半硬脂醇、流 動鏈烷烴、六（羥基硬脂酸/硬脂酸/玫瑰酸）二季戊四醇 酯、三2 -乙基己酸甘油酯及二甲聚矽氧烷至8〇t溶解。 (2) 加入甘油、1,3-丁二醇、氫氧化鈉及對羥基苯甲酸 甲酯於精製水，加溫至80°C溶解。 (3) 以勻化器攪拌（1)下’加入（2)’加入後進行預備擾 拌5分鐘。 (4) 預備攪拌結束後，冷卻至50°C，再冷卻至 調製。 [表 12] 原料 使用量(重量份） _ 硬脂酸 2.0 〜~~~ 單硬脂酸甘油酯 1.0 倍半硬脂酸山梨糖醇酐 0.4 單硬脂酸聚氧乙烯山梨糖醇酐 0.6 倍半硬脂醇 2 流動鏈烷烴 12.0 六瓣硬脂酸_旨酸 /¾瑰酸)二季戊四醇酯 2.0 三2-乙基己酸甘油酯 20.0 二甲聚矽氧烷 0.5 甘油 10 1，3-丁二醇 8.0 氫氧化鈉 0.1 對羥基苯甲酸甲酯 0.1 精製水 41.3 總量 100.0 -24-Column temperature: 4 (TC rinse: mixture of acetonitrile and water (acetonitrile: water = 80: 20) Flow rate: 1.5ml/min -14- 201235054 Measurement wavelength: 360nm Injection volume: 4 0 to 1 • Test conditions Sample usage: 5 ml of evaluation sample (24% 1,3-butanediol aqueous solution), 5 ml of control (water) Test object gas: nonenal (initial gas concentration '·22 ppm) Room temperature conditions : room temperature <Results> As shown in the following Table 2, the 24% 1,3-butanediol aqueous solution showed a large reduction rate of the unsaturated aldehyde as compared with the control, and showed an excellent deodorizing effect. [Table 2] Evaluate the sample to reduce the %) elapsed time (minutes) 0 30 60 180 24% 1,3-butanediol aqueous solution 0 30 40 55 control (water) 0 20 25 40 ※ reduction rate (%) = 100-[each passed Time (30, 60, 180 minutes) terpene concentration] / [elemental time (0 points) of decene concentration] xl 00 [Example 3] Deodorization effect on unsaturated aldehydes Test 3: Use 1 The 1,3-% butanediol aqueous solution of 〇〇% was subjected to a deodorizing effect test on unsaturated aldehyde according to the method described later. Further, the reduction rate was evaluated by high performance liquid chromatography using the same conditions as in Example 2 using nonenyl aldehyde as the unsaturated aldehyde. <Test method> -15- 201235054 Using 1 ο 0 % of 1,3 - butanediol (5 m 1 ) as an evaluation sample, and water (5 ml) as a control, the initial gas concentration of the test gas decene aldehyde A deodorization evaluation test was conducted in the same manner as in Example 2 except that it was 18 ppm. <Results> As shown in Table 3 below, 100% of 1,3-butanediol was more effective than the aqueous solution of 2% by weight of 3,4-butanediol of Example 2, and the rate of reduction of unsaturated aldehyde was larger. Has a significant deodorizing effect 8 [Table 3] Reduction rate (〇 / 〇) Evaluation of sample elapsed time (minutes) 0 30 60 180 100% 1,3-butanediol 0 94 94 94 Control (water) 0 28 28 39 reduction rate (%) = 100 - [perylene aldehyde concentration per elapsed time (after 30, 60, 180 minutes)] / [perylene aldehyde concentration after elapsed time] xl 00 [Example 4] Deodorization effect test of unsaturated aldehydes 4: <Test method> • Evaluation sample As an oolong tea extract, a commercially available cosmetic raw material containing oolong tea extract as a main component (Oolong tea extract BG (Jiushan Pharmaceutical Co., Ltd.) ): 50% 1,3-butanediol solution). In addition, as a sweet tea extract, a commercially available cosmetic raw material containing a sweet tea extract as a main component (sweet tea extract 8〇\¥(made by Jiuji Pharmaceutical Co., Ltd.): 50% 1,3-butanediol solution) is used. . Further, -16- 201235054 is a commercially available cosmetic raw material containing green tea extract as a main component of green tea extract (and ism green tea (made by Jiushan Pharmaceutical Co., Ltd.): 50% 1,3-butanediol solution) As a red persimmon fruit extract, a commercially available cosmetic material containing Panax persimmon fruit extract as a main component (Pancil BA-210-1 'Lilis Scientific Industries Co., Ltd.) was used. The oolong tea extract (2.5 ml) and the sweet tea extract (2, 5 ml) were blended so that the extract fraction (containing the main component polyphenol) became 1% by weight, and the amount of each extract fraction was equal, and the ratio was adjusted to 1. Evaluation sample (5 ml) of 3-butanediol + 2 mixed extracts. The content of 1,3-butanediol is (50% by weight, similarly, the oolong tea extract, the sweet tea extract, and the green tea extract are blended so that the extract fraction becomes 1% by weight, and the amount of each extract fraction is equal to To prepare an evaluation sample of 1,3-butanediol + three kinds of mixed extracts (1). Further, blending the aforementioned oolong tea extract, sweet tea extract and red persimmon fruit extract to make the extract fraction 1% by weight And the amount of each extract is equal, and the evaluation sample of 1,3-butanediol + 3 kinds of mixed extracts (2) is prepared. In addition, the aforementioned oolong tea extract, sweet tea extract, green tea extract and the like are blended. The persimmon fruit extract was made to have an extract fraction of 1% by weight, and the amount of each extract fraction was equal, and an evaluation sample of 1,3 - butanediol + 4 kinds of mixed extracts was prepared. A mixed extract of 1,3-butanediol was used as an evaluation sample, and water (5 ml) was used as a control. In the same manner as in the above Example 2, 1,3-butanediol + 2 kinds of mixed extracts and 1 , 3-butanediol + 4 kinds of mixed extracts, I, 3 · butanediol + 3 kinds of mixed extraction (1), and ι,3- -17- 201235054 Butanediol + 3 kinds of mixed extracts (2) Evaluation sample 'Test the deodorization effect of unsaturated aldehyde separately. In addition, use nonenal as the no The saturated aldehyde was evaluated by high performance liquid chromatography using the same conditions as in Example 2. The initial gas concentration of the test gas decene was 20 ppm (the above two types and four types). When the sample is evaluated, 20 ppm (at the time of evaluation of the above three kinds of samples). <Results> As shown in the following table, 1,3-butanediol + two kinds of mixed extracts, three kinds of mixed extracts (1) and 2), and any of the four mixed extracts compared with the control 'the rate of reduction of unsaturated aldehyde is large, showing good deodorizing effect. [Table 4] Evaluation of sample elapsed time (minutes) 0 30 60 180 1,3- Glycol + 2 kinds of mixed extracts (Oolong tea, sweet tea) 0 70 80 80 1,3-butanediol + 4 kinds of mixed extracts (Oolong tea, sweet tea, green tea, red persimmon fruit) 0 60 85 85 Control (water) 0 25 25 35 1,3-butanediol + 3 kinds of mixed extracts (1) (Oolong tea, sweet tea, green tea) 0 72 72 78 1,3-丁二+ 3 kinds of mixed extracts (7) (Oolong tea, sweet tea, red persimmon fruit) 0 44 50 50 Control (water) 0 28 28 39 [Production Example 1] The following description of the soap indicates the deodorization of the blended 1,3-butanediol Manufacture of the composition. -18- 201235054 The blending amount of the raw materials is shown in Table 5. After mixing and stirring the soap material, '1,3-butanediol and each extract are added, and the mixture is uniformly mixed and then molded. 5"_______ Raw material usage (Rayjing) Soap material 99.8 99.8 99.7 1,3-butanediol 0.1 0.1 0.1 Oolong tea extract 0.1 0.1 Sweet tea extract 0.1 0.1 Total amount 100.0 100.0 100.0 [Manufacturing example 2] Blending of shampoo raw materials The amount is shown in Table 6. A preservative dissolved in 1,3-butanediol is added to the purified water. After stirring uniformly, 'sodium lauryl sulfate, coconut fatty acid monoethanolamine was added, and then the pigment, the flavor and the remaining 1,3-butanediol were added, and the mixture was stirred well. - [Table 61 — —® Usage (parts by weight) __ Sodium lauryl sulfate 16 〇 coconut oil fatty acid monoethanol decylamine 4 〇 2.0 Appropriate amount 78.0 100.0 Total amount of 1,3-butanediol preservative, pigment, flavor refined water -19- 201235054 [Manufacturing Example 3] The blending amount of the hair conditioner raw material is as shown in Table 7 (1) Adding octadecyldimethylbenzylammonium chloride and salt in the purified water 'warm to 8 〇r dissolved. (2) Heat the parathyl alcohol and glyceryl monostearate to 80 °C. (3) Stir in the homogenizer (1) and then add (2). Add and stir for 5 minutes. (4) After the completion of the preliminary stirring, the mixture was cooled to 50 ° C with stirring, and 1,3 -butanediol was added thereto, and the mixture was cooled to 35 to prepare it. [Table 7] Raw material usage (parts by weight) Octadecyldimethylbenzyl ammonium chloride 1.4 Cetyl alcohol 0.6 Monostearic acid glyceride 1.5 Salt 0.1 1,3-butanediol 0.1 Refined water 96.3 Total Amount 100.0 [Production Example 4] The blending amount of the hair growth raw material is shown in Table 8. Add salicylic acid, vitamin E dissolved in ethanol, L-menthol in water -20- 201235054, add glycyrrhizic acid dissolved in partially purified water, then add 1,3-butanediol and mix well. And modulation. [Table 8] Raw material usage (parts by weight) Ethanol 70.0 Vitamin E 0.4 L-menthol 0.4 Glycyrrhizic acid 0.1 1,3-butanediol 0.1 Salicylic acid 0.5 Glycerol 0.5 Refined water 28.0 Total amount 100.0 [Production Example 5] Spray The blending amount of the raw materials is shown in Table 9. Citric acid and sodium citrate were added to dissolve in purified water. Thereafter, a preservative dissolved in ethanol and polysorbate 80 were added. Thereafter, 1,3-butanediol was added, and the mixture was uniformly stirred to prepare. -21 - 201235054 [Table 9] Raw material usage (parts by weight) Citric acid 0.01 Sodium citrate 0.09 Preservatives Polysorbate 80 0.05 Ethanol 10.00 1,3-Butanediol 1.0 Refined water 88.85 Total amount 100.0 [Production example 6] The blending amount of the lotion raw material is shown in Table 1. Citric acid and sodium citrate were added to dissolve in purified water. Next, glycerin, 1,3-butanediol, and trisodium ethylenediaminetetraacetate were added in this order, and then polyoxyethylene (18) oleyl ether and vitamin E dissolved in ethanol were added thereto, and the mixture was stirred and mixed. [Table 10]_ Raw material usage (parts by weight) Glycerin 4.0 1,3-butanediol 5.0 Ethanol 7.0 Polyoxyethylene (18) oleyl ether 0.5 Citric acid 0.05 Sodium citrate 0.1 Ethylenediaminetetraacetic acid trisodium 0.02 Vitamins E 0.50 methyl p-hydroxybenzoate 0.1 purified water 82.7 Total amount 100.0 -22- 201235054 [Production Example 7] The blending amount of the emulsion raw material is shown in Table 。. (1) Warming stearic acid, cetyl alcohol, octyldodecyl myristate and flowing paraffins to 801 are dissolved. (2) Add triethanolamine, sodium hyaluronate, glycerin, hydrazine, 3-butanediol and sodium edetate to purified water and heat to 8 〇. (1) Stir (1) and then add (2) with a synthesizer, and add and stir for 5 minutes. (4) After the completion of the preliminary stirring, it was cooled to 5 ° C and cooled to 35 to be prepared. [Table 11]_________ Raw material usage (parts by weight) — Stearic acid 1.5 Cetyl alcohol 0.5 Octyl lauryl myristate 5.0 Polyoxyethylene (10) monooleate 1.0 Mobile paraffin 5.0 Triethanolamine 0.5 Sodium hyaluronate 0.01 Glycerol 7.0 1,3-butanediol 4.0 Sodium ethylenediamine triacetate 0.01 Refined water 75.48 Total amount 100.0 [Manufacturing Example 8] Cream -23- 201235054 The blending amount of the raw materials is shown in Table 12. (1) Warming stearic acid, glyceryl monostearate, sorbitan sesquisitrate, polyoxyethylene sorbitan monostearate, sesquisteal, flow alkane, six ( Hydroxystearic acid/stearic acid/rosmarinic acid dipentaerythritol ester, tris-2-ethylhexanoic acid glyceride and dimethyl polyoxyalkylene to 8 〇t dissolved. (2) Glycerol, 1,3-butanediol, sodium hydroxide and methyl p-hydroxybenzoate were added to purified water, and the mixture was heated to 80 ° C to dissolve. (3) Stirring with a homogenizer (1) and then adding (2)' was carried out for 5 minutes. (4) After the preparatory stirring is completed, cool to 50 ° C and cool to adjust. [Table 12] Raw material usage (parts by weight) _ Stearic acid 2.0 〜~~~ glyceryl monostearate 1.0 sesquisitol succinate 0.4 bispolysuccinate polyoxyethylene sorbitan 0.6 times Semi-stearyl alcohol 2 mobile paraffin 12.0 six-petal stearic acid _ acid / 3⁄4 lye acid dipentaerythritol ester 2.0 triethyl 2-ethylhexanoate 20.0 dimethyl polyoxyl 0.5 glycerol 10 1,3- Glycol 8.0 Sodium hydroxide 0.1 Methylparaben 0.1 Refined water 41.3 Total 100.0 -24-