TW200510531A - Cloning genes from streptomyces cyaneogriseus subsp. Noncyanogenus for biosynthesis of antibiotics and methods of use - Google Patents

Cloning genes from streptomyces cyaneogriseus subsp. Noncyanogenus for biosynthesis of antibiotics and methods of use

Info

Publication number
TW200510531A
TW200510531A TW093113580A TW93113580A TW200510531A TW 200510531 A TW200510531 A TW 200510531A TW 093113580 A TW093113580 A TW 093113580A TW 93113580 A TW93113580 A TW 93113580A TW 200510531 A TW200510531 A TW 200510531A
Authority
TW
Taiwan
Prior art keywords
biosynthetic pathway
isolated
biosynthesis
purified
nucleic acid
Prior art date
Application number
TW093113580A
Other languages
English (en)
Inventor
Chengjin Huang
Deborah Tardy Chaleff
Mark Edward Ruppen
Jerome Stephens
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of TW200510531A publication Critical patent/TW200510531A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW093113580A 2003-05-16 2004-05-14 Cloning genes from streptomyces cyaneogriseus subsp. Noncyanogenus for biosynthesis of antibiotics and methods of use TW200510531A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47125603P 2003-05-16 2003-05-16

Publications (1)

Publication Number Publication Date
TW200510531A true TW200510531A (en) 2005-03-16

Family

ID=33030127

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093113580A TW200510531A (en) 2003-05-16 2004-05-14 Cloning genes from streptomyces cyaneogriseus subsp. Noncyanogenus for biosynthesis of antibiotics and methods of use

Country Status (6)

Country Link
US (2) US7396660B2 (zh)
EP (1) EP1477563A3 (zh)
JP (1) JP2004337169A (zh)
KR (1) KR20040099138A (zh)
CN (1) CN1676607A (zh)
TW (1) TW200510531A (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4310750B2 (ja) * 2003-06-11 2009-08-12 学校法人北里研究所 ストレプトマイセス属に属するネマデクチン生産能を有する菌株、該菌株を用いるネマデクチンの製造法
CN101061437A (zh) 2004-11-22 2007-10-24 保土谷化学工业株式会社 电子照相感光体
AU2006100665B4 (en) * 2006-07-06 2006-09-07 Wyeth Biocatalytic oxidation process and use thereof
CN101363022B (zh) * 2008-04-18 2012-09-26 中国科学院上海有机化学研究所 替曲卡星a的生物合成基因簇及其应用
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
MX2015007201A (es) * 2015-06-05 2016-12-05 Centro De Investigación Y De Estudios Avanzados Del I P N Sistema genetico para la produccion de la leupeptina y su uso para su produccion y la de proteinas heterologas.
CN106916835B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN106916836B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
ES2921056T3 (es) 2016-04-12 2022-08-17 Warp Drive Bio Inc Composiciones y métodos para la producción de compuestos
CA3042231A1 (en) 2016-10-28 2018-05-03 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
AU2020379731A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
EP4055028A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
KR20230067635A (ko) 2020-09-15 2023-05-16 레볼루션 메디슨즈, 인크. 암의 치료에서 ras 억제제로서 인돌 유도체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106994A (en) * 1984-06-05 1992-04-21 American Cyanamid Company Agents and method of production thereof
US5169956A (en) * 1984-06-05 1992-12-08 American Cyanamid Company Macrolide antibiotic compounds
WO1987003907A1 (en) * 1985-12-17 1987-07-02 Lubrizol Genetics, Inc. Isolation of genes for biosynthesis of polyketide antibiotics
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
JP2000245457A (ja) * 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
CA2380639A1 (en) * 1999-07-30 2001-02-08 Merck & Co., Inc. Cloning of the <i>streptomyces avermitilis</i> genes for glycosylation of avermectin aglycones
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
US7416868B2 (en) * 2003-01-21 2008-08-26 Thallion Pharmaceuticals, Inc. Polyene polyketides, processes for their production and their use as a pharmaceutical

Also Published As

Publication number Publication date
US20090176969A1 (en) 2009-07-09
US7396660B2 (en) 2008-07-08
EP1477563A2 (en) 2004-11-17
EP1477563A3 (en) 2004-11-24
EP1477563A9 (en) 2005-09-21
KR20040099138A (ko) 2004-11-26
US20050003409A1 (en) 2005-01-06
EP1477563A8 (en) 2005-07-27
JP2004337169A (ja) 2004-12-02
CN1676607A (zh) 2005-10-05

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