200303761 玖、發明說明 【發明所屬之技術領域】 本發明係關於一種液狀化粧料，其即使在水溶性抗壞 血酸衍生物存在下，仍能使軟化劑安定的分散，更詳細的 說，係關於一種液狀化粧料，其保溼效果良好且使用時無 黏腻感（sticy、tacky、viscous)，使用感良好且外觀經時不會 變化。 【先前技術】 一直以來，水溶性L-抗壞血酸衍生物在美白效果上良 好並被配合於許多之化粧料中。但，若化粧料中含有多量 水溶性維生素C衍生物則會伴隨有獨特之黏腻感或皮膜感 ，使得很難得到良好使用感。爲了滿足使用感，有使用配 合水溶性高分子或蠟、粉末等高分子量之物質以對抗黏腻 感之方法、或配合油等軟化劑以抑制黏腻感之方法等。但 該種方法要在液狀化粧料上實現其技術上有困難。 再者，在液狀化粧料若水溶性抗壞血酸衍生物中以所 須之充足量配合軟化劑時，一面要保持液狀又要確保作爲 化粧料之安定性是有困難的。將軟化劑配合於液狀化粧料 之技術比如有日本專利特開2000-229812、特公平6-1876或 特公平6-99271或特公平8-16047等，但任一者若應用在水 溶性抗壞血酸衍生物水溶液中則都不能得到充分的效果。 【發明內容】 發明所欲解決之課題 本發明係鑒於這種現況所產生的，即，本發明係關於 200303761 一種液狀化粧料，其含有水溶性抗壞血酸衍生物且使用感 與經時安定性良好。 用以解決課顆之丰段 本發明者爲解決上述課題，專心硏究的結果，發現含 有水溶性L-抗壞血酸衍生物之液狀化粧料中，若含有特定 之聚環氧乙院固醇（sterol)衍生物及軟化劑，則可具有良好 使用感及經時安定性，並完成本發明。 即，本發明係關於一*種液狀化粧料’其含以下所示成 分（a)〜(c)爲必要成分， (a) 環氧乙烷之平均加成莫耳數爲2〜30莫耳之聚環氧乙 烷固醇衍生物； (b) 軟化劑； (c) 水溶性L-抗壞血酸衍生物； 又，特徵爲成分⑷與成分（b)含有質量比爲20:1〜1:20。 再者，係關於含有成分（d)陰離子界面活性劑之液狀化粧料 ，且成分(b)軟化劑之分散滴平均粒徑爲〇.5μιη以下。 以下，說明本發明之構成。 本發明所使用之成分（a)聚環氧乙烷固醇衍生物係爲用 以使成分（b)軟化劑能安定分散所含有之界面活性劑，其親 水基上帶有聚環氧乙烷鏈，親油基上帶有固醇骨架。固醇 骨架具體上，比如有，膽固醇、植物甾醇、膽巢烷醇、二 氫膽固醇等，不論由動植物中萃取到或者以化學合成得到 者皆可使用。構成親水基聚環氧乙烷鏈之環氧乙烷其平均 加成莫耳數每一莫耳固醇骨架需要2〜30莫耳來保持液狀化 200303761 粧料之安定，但由有效提高安定性之觀點上，以5〜20莫耳 爲較佳。若具體例示，比如，聚環氧乙烷（5〜30莫耳）膽固 醇醚、聚環氧乙烷（5〜30莫耳）植物甾醇醚、聚環氧乙烷 (5〜30莫耳）二氫膽固醇醚、聚環氧乙烷（5〜30莫耳）膽巢烷 醇醚等。該等市售品，膽固醇衍生物有貝魯波魯C-10(吉川 製油）、EMALEX 08-5，10，15,20,24,30(以上佐佐木化學、日 本艾馬魯遜）；膽巢烷醇衍生物有貝魯波魯DCH-30(吉川製 油）、NIKKOL DHC-20、DHC-30O以上日本開米卡路司）；植 物甾醇衍生物有NIKKOL BPS-10(日本開米卡路司他）、許奈 洛魯122E5，122E10，122E16，122E25(佐佐木化學）等。該等聚 環氧乙烷固醇衍生物可依需要使用1種或組合2種以上。 本發明中所使用成分（a)之含量較佳爲對液狀化粧料總 質量爲0.001〜10質量％(以下，單以「％」表示，又，在本 說明書中，「質量％」與「重量％」爲同義），更佳爲 0.01〜3%。若在此範圍內，可得到使用感及經時安定性良好 之液狀化粧料。 本發明所使用之成分（b)軟化劑係用於化粧料中以賦予 皮膚或毛髮滋潤並保持柔軟之成分，故在本申請案中使用 油性成分。該等可爲由天然物中所萃取者亦可爲化學合成 者。常溫下不論性狀爲固態、糊狀、液狀都可以，但常溫 下以糊狀〜液狀，可期待更好的使用感，故較佳。 該油性成分若具體例示，比如，液體石蠟、加氫聚異 丁烯、異石蠟、石蠘、精製地蠟、凡士林、微晶鱲等碳氫 化合物油。異壬酸異壬酯、異壬酸異三癸酯、肉豆蔻酸異 200303761 丙酯、辛酸鯨蠘酯、肉豆蔻酸辛基十二烷酯、棕櫚酸異丙 酯、硬脂酸丁酯、月桂酸己酯、肉豆蔻酸肉豆蔻酯、肉豆 寇酸-2-己基癸酯、棕櫚酸-2-己基癸酯、棕櫚酸-2-乙基己酯 、油酸癸酯、油酸油酯、棕櫚酸-2-庚酯、辛酸己基癸酯、 硬脂酸異丙酯、硬脂酸異鯨蠘酯、異硬脂酸異鯨蠟酯、異 硬脂酸異硬脂酯、二_2_乙基己酸乙二酯、二_2_乙基己酸新 戊二酯、二癸酸新戊二酯、蘋果酸二異硬脂酯、三-2-乙基 己酸甘油酯、三（癸基癸）酸甘油酯、三肉豆蔻酸甘油酯、三 -2-庚基十一碳酸甘油酯、三異棕櫚酸甘油酯、三-2-乙基己 酸三羥甲基丙烷、三異硬脂酸三羥甲基丙烷、四-2-乙基己 酸季戊四酯、篦麻油脂肪酸甲酯、己二酸二異丁酯、N-月 桂醯基_L-谷胺酸-2-辛基十二酯、己二酸二-2-庚基十一酯、 癸二酸二-2-乙基己酯、己二酸-2-己基癸酯、琥珀酸-2-乙基 己酯、二-2_乙基己酸丙二酯、二癸酸丙二酯、碳酸二烷酯（ 烷基碳數14，15)、乳酸鯨蠟酯、乳酸肉豆蔻酯、醋酸含水 羊毛酯、12-羥基硬酯酸膽固醇酯、異硬脂酸膽固醇酯、12-羥基硬酯酸植物笛醇酯、異硬脂酸植物甾醇酯等以化學合 成得到之酯油或三酸甘油脂油。 小麥胚芽油、米胚芽油、池花好油（Meadowfoam Seed Oil)、迷迭香油、橄欖油、篦麻油、荷荷巴油、夏威夷火山 豆（Macademia Nuts)油、葵花油等植物油；含水羊毛脂、 絲油、角鯊烷、角鯊烯、十八碳烷、紐西蘭紅魚（0range Roughy)油等動物油及魚油。 甲基聚矽氧烷、甲基苯基聚矽氧烷、甲基環聚矽氧烷 200303761 、烷基變性矽酮、聚醚變性矽酮等矽酮油。 月桂醇、鯨蠘醇、硬脂醇、辣木子醇、肉豆蔻醇、油 烯醇、鯨蠟硬脂醇、2-癸基四癸醇、含水羊毛醇、己基十 二烷醇、異硬脂醇、辛基十二烷醇等高級醇類、月桂酸、 肉豆蔻酸、棕櫚酸、硬脂酸、辣木子油酸、油酸、十一碳 烯酸、妥爾酸、異硬脂酸、亞油酸、亞油烯酸、二十碳五 烯酸（EPA)、二十六碳六烯酸（DHA)等高級脂肪酸類。 維生素E及其衍生物、維生素A及其衍生物、油溶性 維生素C等油溶性維生素類、油溶性甘草萃取物、油溶性 甘菊萃取物、油溶性迷迭香萃取物、三萜類等油溶性美容 成分等；單硬脂基甘油醚（鯊肝醇）、醯基鞘氨醇及其衍生物 、膽固醇、植物甾醇等固醇類等油性成分。 該等中較佳軟化劑以溶解在乙醇95度（換算爲約 92.9〜93.6質量％ 15°C)之成分看，比如有異壬基壬酯、異壬 酸異三癸酯、三-2-乙基己酸甘油酯、2-乙基己酸棕櫚酯、 三（癸基癸）酸甘油酯、四-2-乙基己酸季戊四酯、三異硬脂 酸三羥甲基丙烷、二癸酸新戊二酯、二癸酸丙二酯、甲基 苯基聚矽氧烷等。該等可依須要使用一種或者組合兩種以 上。 該等成分（b)之含量較佳爲對液狀化粧料總質量爲 0.01〜5%。若在此範圍內則可得到軟化劑效果良好且使用感 效果良好之液狀化粧料。 再者，若上述成分⑷與成分（b)之含有質量比（a):(b)在 1:20〜20:1之範圍內，則黏腻感可降低。又，更佳爲在 200303761 1:10〜10:1之範圍內，可使本發明的效果更加顯著（又，在本 說明書中，「質量比」與「重量比」爲同義）。 本發明中所使用之成分（c)水溶性L-抗壞血酸衍生物係 只要具有美白效果且水溶性者則不特別限定。若具體例示 ，比如有L-抗壞血酸鈉、L-抗壞血酸鉀、L-抗壞血酸鎂、 L-抗壞血酸磷酸鈉、L-抗壞血酸磷酸鎂、L-抗壞血酸磷酸鈣 、L-抗壞血酸硫酸鈉、L-抗壞血酸硫酸鎂、L_抗壞血酸硫酸 鈣等。其中以L-抗壞血酸磷酸鎂、L-抗壞血酸磷酸鈉、L-抗壞血酸硫酸鈉較佳。該等可依需求使用1種或組合2種 以上使用。 本發明中所使用成分（c)之含量較佳爲對液狀化粧料總 質量爲0.01〜5質量％，更佳爲0.1〜3%。若在此範圍內，則 可得到美白效果良好、無黏腻感且安定的液狀化粧料。 再者，若上述成分（b)與成分（c)之含有質量比（b):(c)在 1:300〜300:1之範圍內，則黏腻感可更被抑制。又更佳爲在 1:30〜30:1之範圍內，可使本發明之效果更爲顯著。 本發明中若添加成分（d)陰離子界面活性劑則可期待經 時安定性更加提高。陰離子界面活性劑比如有月桂基硫酸 鈉、月桂基硫酸鉀等烷基硫酸酯鹽、聚環氧乙烷（以下單以 「POE」表示）月桂基硫酸三乙醇胺、P〇E月桂基硫酸鈉等 POE烷基醚硫酸酯鹽、月桂醯基肌胺酸鈉等N-醯基肌胺酸 鹽、N-硬脂基-N-甲基牛磺酸鈉、N-棕櫚醯基-N-甲基牛磺酸 鈉、N-肉豆蔻醯基甲基牛磺酸鈉、椰子油脂肪酸甲基牛 磺酸鈉、月桂基甲基牛磺酸鈉等尚級脂肪酸胺基磺酸鹽、 200303761 P〇E月桂基醚磷酸鈉、POE肉豆蔻基醚磷酸鈉、POE棕櫚 基醚磷酸鈉、P0E油基醚磷酸鈉、P0E硬脂基醚磷酸鈉等 P〇E烷基醚磷酸酯鹽；二-2-乙基己基硫代琥珀酸鈉、單月桂 醯基單乙醇醯胺P0E硫代琥珀酸鈉、月桂基聚丙二醇硫代 琥珀酸鈉等硫代琥珀酸鹽；十二烷基苯磺酸鉀、十二烷基苯 磺酸三乙醇胺等烷基苯磺酸鹽;N-月桂醯基單谷胺酸單鈉、 N-硬脂醯基谷胺酸二鈉、N-肉豆蔻基-L-谷胺酸鈉等N-醯基 谷胺酸鹽；硬化椰子油脂肪酸甘油硫酸鈉等高級脂肪酸酯硫 酸酯鹽;P0E烷基醚羧酸、P0E烷基烯丙基醚羧酸鹽、α-烯 磺酸鹽、高級脂肪酸酯磺酸鹽、二級醇硫酸酯鹽、高級脂 肪酸烷醯基胺基磺酸酯鹽、月桂醯基單乙醇胺基琥珀酸鈉 、Ν-棕櫚醯基天冬胺酸二三乙醇胺、酪蛋白鈉等。 。 其中比如Ν-硬脂基-Ν-甲基牛磺酸鈉、Ν-棕櫚醯基-Ν-甲基牛磺酸鈉、Ν-肉豆蔻醯基-Ν-甲基牛磺酸鈉、椰子油脂 肪酸甲基牛磺酸鈉、月桂基甲基牛磺酸鈉等高級脂肪酸胺 基磺酸鹽、Ρ0Ε月桂基醚磷酸鈉、Ρ0Ε肉豆蔻基醚磷酸鈉 、Ρ0Ε棕櫚基醚磷酸鈉、Ρ0Ε油基醚磷酸鈉、Ρ0Ε硬脂基 醚磷酸鈉等Ρ0Ε烷基醚磷酸酯鹽；二-2-乙基己基硫代琥珀酸 鈉、單月桂醯基單乙醇醯胺Ρ0Ε硫代琥珀酸鈉等因爲可期 待更提高經時安定性，故較佳。該等可依須要使用一種或 者組合兩種以上。 該等成分（d)之含量較佳爲對液狀化粧料總質量爲 0.001〜5質量％，更佳爲0.01〜3%。若在此範圍內，則可期 待安定性更加提高。 11 200303761 本發明之液狀化粧料因含有上述成分（a)〜(c)而變得安 定，但若成分（b)軟化劑之分散滴之平均粒子徑在0.5μιη以 下，較佳爲在0.05〜0.3μιη以下，則更可期待經時安定性提 高。該種微細分散滴可利用下示之凝縮法得到，但再以高 壓均質機處理，則可得到更均一之微細分散滴。又，分散 滴之平均粒子徑係使用COULTER NS-4型（COULTER公司製 )所測定。 又，本發明之液狀化粧料其液狀在一般狀態下使用時 爲有流動性，在20°C下之黏度値爲5〜40000mPa· s之範圍 內。若較佳爲在10〜20000mPa · s之範圍，更佳爲在 10〜5000mPa · s之範圍，則可期待成爲使用感更好的液狀化 粧料。 本發明之液狀化粧料其調製方法不特別限定，可依化 粧料之處方特性適當選擇。作爲例示，比如有將界面活性 劑、油劑等溶解於醇所得之物分散於水系中以調製之凝縮 法、使用高壓均質機等機械力以調製之方法等。 本發明之液狀化粧料除化粧料，亦可利用於準醫藥品 、外用醫藥品等。化粧料比如可作成化粧水、美容液、芳 香用組成物等各種液狀製劑。再者，本液狀化粧料亦可用 周知之方法作成噴劑、慕斯等製劑，又，亦可含浸於不織 布等，製成片狀製劑。 本發明之液狀化粧料中只要在不損害本發明效果之範 圍內可含有普通化粧料或準醫藥品、外用醫藥品等領域所 含有之成分。比如有成分（a)以外之非離子性界面活性劑、 12 200303761 保濕劑、高分子類、紫外線吸收劑、多價螫合劑、中和劑 、pH調整劑、抗氧化劑、抗菌劑、防腐劑、色素、粉體、 顏料、香料、藥效劑等，可依需要適當使用。 【實施方式】 (實施例） 以下舉實施例更詳細說明本發明，但並不因此而限定 本發明。 (實施例1〜15及比較例1〜7;化粧水） 製造表1及表2(皆爲實施例）及表3(比較例）所示組成 之化粧水，並對於經時安定性、使用感及乳化滴之平均粒 子徑進行評價。 表1 成分 實施例(％) 1 2 3 4 5 6 7 8 9 1 聚環氧乙院(5)膽固醇醚 1 1 1 1 1 0.5 0.1 0.05 0.05 2 單油酸聚環氧乙院(20)山梨糖醇酐 3 倍半油酸山梨糖醇酐 4 聚環氧乙烷(5)硬化篦麻油 5 三·2·乙基己酸甘油酯 0.05 0.1 0.5 1 5 0.1 0.1 0.1 1 6 乙醇 10 10 10 10 10 10 10 10 10 7 甘油 5 5 5 5 5 5 5 5 5 8 聚環氧乙烷(8)烷基(C12-18)醚磷酸鈉 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 9 L-抗壞血酸磷酸鎂 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 10 檸檬酸鈉 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 11 純水 殘量 殘量 殘量 殘量 殘量 殘量 殘量 殘量 殘量 成分⑻/成分⑼比 20/1 10/1 2/1 1/1 1/5 5/1 1/1 1/2 1/20 成分(b)/成分⑹比 1/12 1/6 5/6 10/6 50/6 1/6 1/6 1/6 10/6 判定 平均粒子徑 ◎ ◎ ◎ 〇 〇 ◎ 〇 ◎ 〇 使用感 〇 ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 經時安定性 ◎ ◎ ◎ 〇 〇 ◎ ◎ 〇 ◎ 13 200303761 表2 成分 實施佩％) 10 11 12 13 14 15 1 聚環氧乙烷(5)膽固醇醚 1 1 1 1 1 1 2 單油酸聚環氧乙院(20)山梨糖醇酐 - - - - 麵 晒 3 倍半油酸山梨糖醇酐 - - 瞒 - - - 4 聚環氧乙烷(5)硬化篦麻油 - - - - - - 5 三-2-乙基己酸甘油酯 0.1 0.1 0.5 0.5 0.1 0.5 6 乙醇 10 10 10 10 10 10 7 甘油 5 5 5 5 5 5 8 聚環氧乙傲8)院基(C12-18·磷酸鈉 0.02 0.02 0.02 0.02 - - 9 L·抗壞血酸磷酸鎂 1 3 1 3 0.5 0.5 10 檸檬酸鈉 0.1 0.1 0.1 0.1 0.1 0.1 11 純水 殘量 殘量 殘量1 殘量 殘量 殘量 成分⑻/成分⑼比 10/1 10/1 2/1 1/1 10/1 2/1 成分(b)/成分⑹比 1/11 1/31 5/11 5/31 1/11 5/11 判定 平均粒子徑 ◎ ◎ ◎ 〇 〇 ◎ 使用感 〇1 ◎ ◎ ◎ ◎ ◎ 經時安定性 ◎ ◎ 0 〇 ◎ 表3200303761 发明 Description of the invention [Technical field to which the invention belongs] The present invention relates to a liquid cosmetic material, which can stably disperse a softener even in the presence of a water-soluble ascorbic acid derivative. More specifically, it relates to a Liquid cosmetic materials have good moisturizing effect and no sticky feeling (sticy, tacky, viscous) during use, good use feeling and appearance will not change over time. [Prior art] Conventionally, water-soluble L-ascorbic acid derivatives have good whitening effect and are incorporated into many cosmetic materials. However, if the cosmetic contains a large amount of water-soluble vitamin C derivatives, it will be accompanied by a unique sticky feeling or film feeling, making it difficult to obtain a good feeling of use. In order to satisfy the feeling of use, there are methods of using a water-soluble polymer or a high molecular weight substance such as wax or powder to prevent stickiness, or adding a softener such as oil to suppress the feeling of stickiness. However, this method has technical difficulties in realizing liquid cosmetics. In addition, if a softener is added to the liquid cosmetic in a sufficient amount in a water-soluble ascorbic acid derivative, it is difficult to maintain the liquid state while ensuring stability as a cosmetic. Techniques for blending a softener with a liquid cosmetic material include, for example, Japanese Patent Laid-Open No. 2000-229812, Japanese Patent No. 6-1876, Japanese Patent No. 6-99271, Japanese Patent No. 8-16047, and the like. In the derivative aqueous solution, sufficient effects were not obtained. [Summary of the Invention] Problem to be Solved by the Invention The present invention is made in view of such a situation, that is, the present invention relates to 200303761, a liquid cosmetic material which contains a water-soluble ascorbic acid derivative and has a good feeling of use and stability over time. . In order to solve the above problem, the present inventor focused on solving the above-mentioned problems, and found that the liquid cosmetic containing the water-soluble L-ascorbic acid derivative contains a specific polyethylene oxide sterol ( A sterol) derivative and a softener can have a good feeling of use and stability over time, and complete the present invention. That is, the present invention relates to a * liquid cosmetic material which contains the following components (a) to (c) as essential components, and (a) the average addition mole number of ethylene oxide is 2 to 30 moles. Ear polyethylene oxide sterol derivative; (b) softener; (c) water-soluble L-ascorbic acid derivative; and characterized in that the mass ratio of component VII to component (b) is 20: 1 ~ 1: 20. Furthermore, it relates to a liquid cosmetic material containing the component (d) anionic surfactant, and the average particle diameter of the dispersed droplets of the component (b) softener is 0.5 μm or less. The structure of the present invention will be described below. The component (a) polyethylene oxide sterol derivative used in the present invention is a surfactant contained in the component (b) for stabilizing and dispersing the component (b) softener, and has polyethylene oxide on the hydrophilic group. Chain, lipophilic group with a sterol backbone. Specific examples of sterol skeletons include cholesterol, phytosterols, cholestanol, and dihydrocholesterol, which can be used regardless of whether they are extracted from plants or animals or obtained by chemical synthesis. The average addition mole number of the ethylene oxide constituting the hydrophilic polyethylene oxide chain is 2 to 30 moles per mole of the sterol skeleton to maintain the liquefaction. 200303761 The stability of the makeup is improved by effective From a sexual point of view, 5 to 20 moles is preferred. If specifically exemplified, for example, polyethylene oxide (5 to 30 moles) cholesterol ether, polyethylene oxide (5 to 30 moles) phytosterol ether, polyethylene oxide (5 to 30 moles) two Hydrocholesteryl ether, polyethylene oxide (5 ~ 30 mol) choline alkanol ether, etc. Among these commercially available products, cholesterol derivatives include Belupolu C-10 (Yoshikawa Oil), EMALEX 08-5, 10, 15, 20, 24, 30 (above Sasaki Chemical Co., Ltd., and Japan ’s Emerson); Alkanol derivatives include Belupolu DCH-30 (Yoshikawa Oil), NIKKOL DHC-20, and Japan Kaimikalusi of DHC-30 and above; phytosterol derivatives are NIKKOL BPS-10 (Japan Kaimikalusi) He), Xu Nalulu 122E5, 122E10, 122E16, 122E25 (Sasaki Chemical) and so on. These polyethylene oxide sterol derivatives may be used singly or in combination of two or more kinds. The content of the component (a) used in the present invention is preferably 0.001 to 10% by mass based on the total mass of the liquid cosmetic material (hereinafter, simply expressed as "%". In this specification, "mass%" and " "% By weight" is synonymous), more preferably 0.01 to 3%. If it is within this range, a liquid cosmetic material with good usability and stability over time can be obtained. The component (b) softener used in the present invention is a component used in cosmetics to impart moisturization to the skin or hair and maintain softness, and therefore an oily component is used in the present application. These may be extracted from natural materials or chemically synthesized. It does not matter whether the properties are solid, pasty, or liquid at normal temperature, but it is preferably paste-to-liquid at normal temperature, and a better feeling of use can be expected. Specific examples of the oily component include hydrocarbon oils such as liquid paraffin, hydrogenated polyisobutylene, isoparaffin, paraffin, refined ceresin, vaseline and microcrystalline arsenic. Isononyl isononanoate, isotridecyl isononanoate, iso200303761 propyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, laurel Hexyl ester, Myristyl myristate, 2-hexyldecanoate myristate, 2-hexyldecanoate palmitate, 2-ethylhexyl palmitate, decyl oleate, oleate oleate , 2-heptyl palmitate, hexyldecyl octanoate, isopropyl stearate, isocetyl stearate, isocetyl isostearate, isostearyl isostearate, di_2 _Ethylhexanoate, di-2-Ethylhexanoate neoglutarate, neodecyl didecanoate, diisostearyl malate, tri-2-ethylhexanoate glyceride, tris Glyceryl (decyldecanoate), glyceryl trimyristate, glyceryl tri-2-heptyl undecanoate, glyceryl triisopalmitate, trimethyl ethylpropanoate trimethylolpropane, tris Trimethylolpropane isostearate, pentaerythritol tetra-2-ethylhexanoate, fatty acid methyl esters of ramie oil, diisobutyl adipate, N-lauroyl_L-glutamine-2 -Octyldodecyl, di-2-heptylundecyl adipate, sebacic acid di 2-ethylhexyl ester, 2-hexyldecyl adipate, 2-ethylhexyl succinate, propylene di-2-ethylhexanoate, propylene didecanoate, dioxane carbonate Esters (alkyl carbon number 14, 15), cetyl lactate, myristyl lactate, lanolin acetate, 12-hydroxystearate, cholesterol isostearate, 12-hydroxystearate plant flute Alcohol esters, isostearate phytosterol esters, etc. are chemically synthesized ester oils or triglyceride oils. Wheat germ oil, rice germ oil, Meadowfoam Seed Oil, rosemary oil, olive oil, ramie oil, jojoba oil, Hawaiian volcano bean (Macademia Nuts) oil, sunflower oil and other vegetable oils; water-containing lanolin , Silk oil, squalane, squalene, octadecane, New Zealand Redfish (0range Roughy) oil and other animal oils and fish oil. Silicone oils such as methyl polysiloxane, methyl phenyl polysiloxane, methyl cyclopolysiloxane 200303761, alkyl modified silicone, polyether modified silicone. Lauryl alcohol, cetyl alcohol, stearyl alcohol, moringadiol, myristyl alcohol, oleyl alcohol, cetylstearyl alcohol, 2-decyltetradecanol, hydrolanolin alcohol, hexyldodecanol, isostearyl alcohol Higher alcohols such as alcohol, octyldodecanol, lauric acid, myristic acid, palmitic acid, stearic acid, moringa oleic acid, oleic acid, undecylenic acid, tallic acid, isostearic acid, Higher fatty acids such as linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), and hexaosahexaenoic acid (DHA). Vitamin E and its derivatives, Vitamin A and its derivatives, oil-soluble vitamins such as oil-soluble vitamin C, oil-soluble licorice extract, oil-soluble camomile extract, oil-soluble rosemary extract, triterpenoids and other oils Soluble cosmetic ingredients, etc .; monostearyl glyceryl ether (squalol), sphingosine and its derivatives, cholesterol, phytosterols and other oily ingredients. Among these, the preferred softeners are components dissolved in 95 degrees of ethanol (equivalent to about 92.9 to 93.6 mass% at 15 ° C), such as isononyl nonyl, isotridecyl isononanoate, and tri-2- Glyceryl ethylhexanoate, palmitoyl 2-ethylhexanoate, glyceryl tris (decyldecanoate), pentaerythritol tetra-2-ethylhexanoate, trimethylolpropane triisostearate, Neopentyl didecanoate, propylene didecanoate, methylphenyl polysiloxane and the like. These can be used singly or in combination of two or more. The content of these ingredients (b) is preferably 0.01 to 5% for the total mass of the liquid cosmetic. Within this range, a liquid cosmetic material having a good softening effect and a good use feeling effect can be obtained. Furthermore, if the mass ratio (a) :( b) of the component ⑷ to the component (b) is in the range of 1:20 to 20: 1, the sticky feeling can be reduced. In addition, it is more preferable that it is in the range of 200303761 1:10 to 10: 1, so that the effect of the present invention can be more significant (also, in this specification, "mass ratio" and "weight ratio" are synonymous). The component (c) water-soluble L-ascorbic acid derivative used in the present invention is not particularly limited as long as it has a whitening effect and is water-soluble. If specifically exemplified, for example, there are L-ascorbate, L-ascorbate, L-ascorbate, L-ascorbate phosphate, L-ascorbate phosphate, L-ascorbate phosphate, L-ascorbate sodium, L-ascorbate sulfate , L_ascorbic acid calcium sulfate and so on. Among them, magnesium L-ascorbate phosphate, sodium L-ascorbate phosphate, and sodium L-ascorbate are preferred. These can be used as required or in combination of two or more. The content of the component (c) used in the present invention is preferably from 0.01 to 5% by mass, more preferably from 0.1 to 3%, based on the total mass of the liquid cosmetic. If it is within this range, a liquid cosmetic with good whitening effect, no stickiness, and stability can be obtained. In addition, if the mass ratio (b) :( c) of the component (b) to the component (c) is within a range of 1: 300 to 300: 1, the sticky feeling can be further suppressed. It is more preferably within the range of 1:30 to 30: 1, which can make the effect of the present invention more remarkable. When the component (d) anionic surfactant is added in the present invention, the stability over time can be expected to be further improved. Examples of anionic surfactants include alkyl sulfate salts such as sodium lauryl sulfate and potassium lauryl sulfate, polyethylene oxide (hereinafter referred to as "POE") triethanolamine lauryl sulfate, and POE sodium lauryl sulfate. POE alkyl ether sulfate, N-fluorenyl sarcosinate such as sodium lauryl sarcosinate, N-stearyl-N-methyl sodium taurine, N-palmitinyl-N-methyl Sodium taurine, N-myristyl methyl taurine, coconut oil fatty acid sodium methyl taurine, sodium lauryl methyl taurine and other high-grade fatty acid amine sulfonates, 200303761 POE POE alkyl ether phosphate salts such as sodium lauryl ether phosphate, POE myristyl ether sodium phosphate, POE palmityl ether sodium phosphate, POE sodium oleyl ether phosphate, and POE stearyl ether phosphate; di-2- Thiosuccinates such as ethylhexyl sodium thiosuccinate, monolaurylmonoethanolammonium amine POE sodium thiosuccinate, sodium lauryl polypropylene glycol sodium thiosuccinate; potassium dodecylbenzenesulfonate, ten Alkylbenzene sulfonates such as dialkylbenzenesulfonic acid triethanolamine; monosodium N-lauroyl monoglutamate, disodium N-stearyl glutamate, N-myristoyl-L -N-fluorenyl glutamate such as sodium glutamate; higher fatty acid ester sulfate salts such as hardened coconut oil fatty acid sodium sulfate glycerol; POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylate, α -Ene sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkyl sulfonate sulfonate, sodium lauryl monoethanolamine succinate, N-palmitinyl aspartate Ditriethanolamine, sodium caseinate, etc. . Among them, for example, N-stearyl-N-methyltaurine, N-palmitinyl-N-methyltaurine, N-myristoyl-N-methyltaurine, coconut oil Fatty acid methyl taurine, sodium lauryl methyl taurine and other higher fatty acid amine sulfonates, POE lauryl ether phosphate, POE myristyl ether phosphate, POE palmityl ether sodium phosphate, POE oil group POE alkyl ether phosphate salts, such as sodium ether phosphate, POE stearyl ether phosphate, and sodium di-2-ethylhexyl sodium thiosuccinate, monolauryl monoethanolamine sodium thiosulfate, etc. It is desirable to further improve stability over time. These can be used singly or in combination of two or more. The content of these ingredients (d) is preferably 0.001 to 5% by mass, and more preferably 0.01 to 3%, based on the total mass of the liquid cosmetic. If it is within this range, it can be expected that the stability will be further improved. 11 200303761 The liquid cosmetic of the present invention is stabilized by containing the above components (a) to (c), but if the average particle diameter of the dispersed droplets of the component (b) softener is 0.5 μm or less, preferably 0.05 When the thickness is less than 0.3 μm, the stability over time can be expected to improve. Such finely dispersed droplets can be obtained by the condensation method shown below, but then treated with a high-pressure homogenizer to obtain more uniform finely dispersed droplets. The average particle diameter of the dispersed droplets was measured using a COULTER NS-4 type (manufactured by COULTER). In addition, the liquid cosmetic of the present invention has liquidity when used in a general state, and its viscosity at 20 ° C is in a range of 5 to 40,000 mPa · s. If it is preferably in the range of 10 to 20,000 mPa · s, and more preferably in the range of 10 to 5000 mPa · s, it can be expected to be a liquid cosmetic material with better usability. The preparation method of the liquid cosmetic of the present invention is not particularly limited, and may be appropriately selected depending on the local characteristics of the cosmetic. As an example, there are a condensation method in which a substance obtained by dissolving a surfactant, an oil agent, and the like in an alcohol is dispersed in an aqueous system, and a method in which mechanical force such as a high-pressure homogenizer is used to prepare. In addition to cosmetics, the liquid cosmetic of the present invention can also be used in quasi-drugs, external medicines, and the like. Cosmetics can be formulated into various liquid preparations such as lotions, cosmetic liquids, and fragrance compositions. In addition, the liquid cosmetic material can be prepared into a spray, mousse, etc. by a known method, or it can be impregnated with a non-woven fabric or the like to form a sheet-like preparation. The liquid cosmetic of the present invention may contain ingredients contained in the fields of ordinary cosmetic, quasi-drugs, external medicines, and the like, as long as the effects of the present invention are not impaired. For example, non-ionic surfactants other than ingredient (a), 12 200303761 humectants, polymers, ultraviolet absorbers, polyvalent couplers, neutralizers, pH adjusters, antioxidants, antibacterial agents, preservatives, Pigments, powders, pigments, perfumes, medicinal agents, etc. can be used appropriately as required. [Embodiments] (Examples) The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. (Examples 1 to 15 and Comparative Examples 1 to 7; Lotion) Make-up lotions with the compositions shown in Tables 1 and 2 (both examples) and Table 3 (comparative examples) were manufactured, and were stable and used with time. The average particle diameter of the emulsion droplets was evaluated. Table 1 Composition examples (%) 1 2 3 4 5 6 7 8 9 1 Poly (ethylene oxide) (5) Cholesteryl ether 1 1 1 1 1 0.5 0.1 0.05 0.05 2 Poly (ethylene oxide) monooleate (20) Yamanashi Sugar alcohol anhydride 3 sesquioleic acid sorbitan 4 polyethylene oxide (5) hardened ramie oil 5 tri · 2 · ethylhexanoic acid glyceride 0.05 0.1 0.5 1 5 0.1 0.1 0.1 1 6 ethanol 10 10 10 10 10 10 10 10 10 7 Glycerol 5 5 5 5 5 5 5 5 5 8 Polyethylene oxide (8) alkyl (C12-18) ether sodium phosphate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 9 L-Ascorbyl magnesium phosphate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 10 Sodium citrate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 11 Pure water residual residual residual residual residual residual residual residual residual component ⑻ / component ⑼ ratio 20 / 1 10/1 2/1 1/1 1/5 5/1 1/1 1/2 1/20 component (b) / component ratio 1/12 1/6 5/6 10/6 50/6 1 / 6 1/6 1/6 10/6 Judging the average particle diameter Table 2% of ingredients implemented 10 11 12 13 14 15 1 Polyethylene oxide (5) Cholesteryl ether 1 1 1 1 1 1 2 Polyoleic acid monooleate Polyethylene oxide (20) Sorbitol----Face exposure 3 times semi-oleic acid Sorbitol anhydride--Concealed---4 Polyethylene oxide (5) hardened ramie oil------5 Tri-2-ethylhexanoic acid glyceride 0.1 0.1 0.5 0.5 0.1 0.5 6 Ethanol 10 10 10 10 10 10 7 Glycerin 5 5 5 5 5 5 8 Polyethylene glycol 8) Hospital base (C12-18 · Sodium phosphate 0.02 0.02 0.02 0.02--9 L · Ascorbic acid magnesium phosphate 1 3 1 3 0.5 0.5 10 Sodium citrate 0.1 0.1 0.1 0.1 0.1 0.1 11 Pure water residual amount residual amount 1 residual amount residual amount Component 1 / component ⑼ ratio 10/1 10/1 2/1 1/1 10/1 2/1 Component (b) / Component ratio 1/11 1/31 5/11 5/31 1/11 5/11 Judging the average particle diameter table 3
成分 比較例 (%) 1 2 3 4 5 6 7 1 聚環氧乙烷(5)膽固醇醚 - - - 0.002 3 1 2 單油酸聚環氧乙院(20)山梨糖醇酐 謹 1 0.5 - - - - 3 倍半油酸山梨糖醇酐 - - 0.5 0.5 1 - - 4 聚環氧乙烷(5)硬化篦麻油 - - 0.5 - - - 5 三-2_乙基己酸甘油酯 0.1 0.1 0.1 0.1 0.1 0.1 - 6 乙醇 10 10 10 10 10 10 10 7 甘油 5 5 5 5 5 5 5 8 聚環氧乙垸⑻院基(C12-18)醚磷酸鈉 0.02 0.02 0.02 0.02 0.02 0.02 0.02 9 L·抗壞血酸磷酸鎂 0.5 0.5 0.5 0.5 0.5 0.5 0.5 10 檸檬酸鈉 0.1 0.1 0.1 0.1 0.1 0.1 0.1 11 純水 殘量 殘量 殘量 殘量 殘量 殘量 殘量 成分⑻/成分(b)比 - 麵 - - 1/50 30/1 - 成分(b)/成分⑹比 1/6 1/6 1/6 1/6 1/6 1/6 - 判 定 平均粒子徑 X ◎ ◎ X Δ 〇 ◎ 使用感 〇 Δ 〇 Δ 〇 X X 經時安定性 X X X X Δ ◎ ◎ 14 200303761 (製造方法） A:將成分1〜8於40°C下混合並溶解。 B:將成分9〜11於室溫下混合並溶解。 C:將A添加至B中並混合，以得到化粧水。 (評價方法1:經時安定性） 將所得到之化粧水放置於50°C之恆溫槽2週，再以目 視觀察是否有分離等外觀變化。 [評價] ◎:認爲外觀完全沒有變化 〇：認爲外觀大致沒有變化 △:認爲外觀有分離等變化 X:認爲外觀有分離等顯著變化 (評價方法2:使用感） 以10名專門之評價委員，對塗佈在皮膚時之使用性( 淸爽感、無黏腻感度）依下述評價基準進行5階段評價，再 由其平均點依下述判定基準作判定。 [評價] 5點:非常良好 4點:良好 3點:普通 2點:不良 1點:非常不良 [判定] ◎:平均點4.5點以上 15 200303761 〇：平均點3.5點以上未達4.5點 △:平均點2.5點以上未達3.5點 X:平均點不滿2.5點 (評價方法3:平均粒子徑）Comparison of ingredients (%) 1 2 3 4 5 6 7 1 Polyethylene oxide (5) Cholesteryl ether---0.002 3 1 2 Polyoleic acid monooleate (20) Sorbitol anhydride 1 0.5- ---3 sorbitan sesquioleate--0.5 0.5 1--4 polyethylene oxide (5) hardened ramie oil--0.5---5 tri-2-ethylhexanoic acid glyceride 0.1 0.1 0.1 0.1 0.1 0.1-6 Ethanol 10 10 10 10 10 10 10 7 Glycerol 5 5 5 5 5 5 5 8 Polyethylene oxide (C12-18) ether sodium phosphate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 9 L · Magnesium ascorbate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 10 Sodium citrate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 11 11 Pure water residual residual residual residual residual residual residual component ⑻ / component (b) ratio-noodles-- 1/50 30/1-component (b) / component ratio 1/6 1/6 1/6 1/6 1/6 1/6-judging the average particle diameter X ◎ ◎ X Δ 〇 ◎ feeling of use 〇 Δ 〇 Δ〇XX Stability over time XXXX Δ ◎ ◎ 14 200303761 (manufacturing method) A: Ingredients 1 to 8 are mixed and dissolved at 40 ° C. B: Components 9 to 11 are mixed and dissolved at room temperature. C: Add A to B and mix to get a lotion. (Evaluation method 1: stability over time) The obtained lotion was placed in a thermostatic bath at 50 ° C for 2 weeks, and then visually observed whether there were any appearance changes such as separation. [Evaluation] ◎: No change in appearance at all. 0: No change in appearance at all. △: Change in appearance at separation. X: Significant change in appearance at separation. (Evaluation method 2: feeling of use) The evaluation committee evaluated the usability (smoothness, non-stickiness) when applied to the skin in five stages according to the following evaluation criteria, and then determined its average point according to the following evaluation criteria. [Evaluation] 5 points: very good 4 points: good 3 points: normal 2 points: bad 1 point: very bad [judgment] ◎: average point 4.5 or more 15 200303761 〇: average point 3.5 or more and less than 4.5 points △: The average point is 2.5 points or more and less than 3.5 points X: The average point is less than 2.5 points (evaluation method 3: average particle diameter)
對岡!ί調製好的化粧水，以COULTER NS-4型（COULTER 公司製）測定乳化滴之平均粒子徑，並以下述評價基準評價 〇 ◎ :0.3μιη 以下 〇：超過0.3μπι0.5μιη以下 △:超過 0·5μπι5·0μιη 以下 X :超過 5·0μιη 依以上評價方法所得到之結果倂列於表1〜3。 如表1及表2之結果可了解，本發明之實施例1〜15之 化粧水即使配合水溶性L-抗壞血酸磷酸鎂仍然有良好之外 觀，且經時安定性、使用感良好。相對於此，表3之比較 例中，無法得到可滿足所有項目者。 實施例16:化粧水 ® (成分） （％) 1. 環氧乙烷（5)膽固醇醚 0.03 2. 環氧乙烷（10)膽固醇醚 〇·〇3 3. 環氧乙烷（6)烷基（C12-18)醚磷酸鈉 0.02 4. 四-2-乙基己酸季戊四酯 〇.〇5 5. 三-2-乙基己酸甘油酯 〇.〇5 6. 四-2-己基癸酸抗壞血酯 〇.〇1 16 200303761 7·維生素E乙酸酯 0.01 8·乙醇 5.0 9·1，3-丁二醇 10.0 10·1抗壞血酸磷酸鎂 3.0 Η·檸檬酸鈉 0.5 12·乙二胺四乙酸二鈉 〇.〇3 13·黃芩萃取物 〇.〇1 Η·人參萃取液 〇.〇1 15·甘草酸二鉀 〇.〇1 · 16·苯氧基乙醇 0.01 Π.薰衣草水 10.0 18. L-絲胺酸 〇.1 19. 防腐劑 適量 20. 純水 殘量 (製造方法） Α:將成分1〜8於40°C下混合並溶解。 B:將成分9〜20於室溫下混合並溶解。 · C:將A添加至B中並混合，以得到化粧水。 實施例16之化粧水其軟化劑之分散滴平均粒子徑在 0.3μιη以下，且少有水溶性L-抗壞血酸磷酸鎂之黏腻感， 爲經時安定性良好之化粧水。 實施例17:化粧水 (成分） （％) 1.環氧乙烷（10)植物甾醇醚 0.1 17 200303761 2. 環氧乙烷（20)硬化篦麻油 〇.05For the prepared lotion, the average particle diameter of the emulsified droplets was measured with a COULTER NS-4 type (manufactured by COULTER), and evaluated based on the following evaluation criteria: ○: 0.3 μm or less 〇: 0.3 μm or less 0.5 μm or less △ : More than 0.5 μm 5.0 to 0 μm η X: more than 5.0 μm η The results obtained according to the above evaluation methods are shown in Tables 1 to 3. As can be understood from the results of Tables 1 and 2, the lotions of Examples 1 to 15 of the present invention have good appearance even when water-soluble L-ascorbic acid magnesium phosphate is added, and they have good stability over time and a good feeling of use. On the other hand, in the comparative example in Table 3, those who can satisfy all items cannot be obtained. Example 16: Lotion® (ingredient) (%) 1. Ethylene oxide (5) cholesterol ether 0.03 2. Ethylene oxide (10) cholesterol ether 0.03 3. Ethylene oxide (6) alkane (C12-18) ether sodium phosphate 0.02 4. Pentaerythritol tetra-2-ethylhexanoate 0.05. Triglyceryl tri-2-ethylhexanoate 0.05. Tetra-2- Hexyldecanoic acid ascorbate 〇01 16 200303761 7. Vitamin E acetate 0.01 8 · ethanol 5.0 9 · 1, 3-butanediol 10.0 10 · 1 magnesium ascorbyl phosphate 3.0 Η · sodium citrate 0.5 12 · Disodium ethylenediamine tetraacetate 0.03 13. Scutellaria baicalensis extract 0.001 Η Ginseng extract 0.011 15. Dipotassium glycyrrhizin 0.001 16. 16 phenoxyethanol 0.01 Π. Lavender Water 10.0 18. L-serine 0.1. 19. Appropriate amount of preservative 20. Residual amount of pure water (manufacturing method) Α: Mix and dissolve ingredients 1 to 8 at 40 ° C. B: Ingredients 9-20 are mixed and dissolved at room temperature. C: Add A to B and mix to get a lotion. The lotion of Example 16 has an average particle diameter of the dispersed droplets of the softening agent of 0.3 μm or less, and has little stickiness of water-soluble L-ascorbic acid magnesium phosphate, which is a lotion with good stability over time. Example 17: Lotion (Composition) (%) 1. Ethylene oxide (10) Phytosterol ether 0.1 17 200303761 2. Ethylene oxide (20) hardened ramie oil 0.05
3. 環氧乙烷（6)烷基（C12-18)醚磷酸鈉 （U 4. 荷荷巴油 0.2 5. 二癸酸新戊二酯 0.2 6. 油溶性迷迭香精 〇.〇1 7. 維生素E菸鹼酸 0.01 8. 乙醇 10.0 9. 甘油 10.03. Ethylene oxide (6) alkyl (C12-18) ether phosphate (U 4. Jojoba oil 0.2 5. Neopentyl didecanoate 0.2 6. Oil-soluble rosemary extract 0.07 Vitamin E Niacin 0.01 8. Ethanol 10.0 9. Glycerin 10.0
10. 環氧乙烷（10)甲基葡萄糖 3.0 11. 檸檬酸鈉 0.5 12. 乙二胺四乙酸二鈉 〇.〇3 13. 薏苡仁萃取液 〇iQ1 14.2-羥基-4-甲氧基苯甲酮-5-磺酸鈉 〇.01 15. L-抗壞血酸磷酸鎂 1.〇 16. 對羥基苯甲酸甲酯 o.cn 17. 焦谷胺酸鈉 〇.210. Ethylene oxide (10) methyl glucose 3.0 11. Sodium citrate 0.5 12. Disodium ethylenediamine tetraacetate 0.03 13. Coix seed extract 〇iQ1 14.2-hydroxy-4-methoxybenzene Sodium methyl ketone-5-sulfonate 0.01. 15. L-ascorbic acid magnesium phosphate 1.0. 16. Methyl parahydroxybenzoate o.cn 17. Sodium pyroglutamate 0.2
18. 乳酸鈉 0.1 19. 透明質酸鈉水溶液（1%) 2.0 20. 純水 殘量 (製造方法） A:將成分1〜8於40°C下混合並溶解。 B:將成分9〜20於室溫下混合並溶解。 C:將A添加至B中並混合，以得到化粧水。 實施例17之化粧水其軟化劑之分散滴平均粒子徑在 18 200303761 0.3μιη以下，且少有水溶性L-抗壞血酸磷酸鎂之黏腻感， 具有足夠之柔軟感，爲經時安定性良好之化粧水。 實施例18:美容液 (成分） (%) 1.環氧乙烷（5)二氫膽固醇醚 1.0 2.環氧乙烷（30)二氫膽固醇醚 0.03 3加氫大豆磷脂質 0.5 4.醯基鞘氨醇III 0.01 5.三_2-乙基己酸甘油酯 0.05 6.油溶性甘草精 0.01 7.維生素A棕櫚酸酯 0.01 8.二丙二醇 5.0 9.純水 20.0 10. L-抗壞血酸硫酸鈉 0.3 11.檸檬酸鈉 0.05 12.檸檬酸 0.01 13.羧基乙烯基聚合物1%水溶液 15.0 14.聚乙二醇400 1.0 15.二甘油 5.0 16.咕噸膠1%水溶液 3.0 Π.胺基甲基丙醇 0.3 18.球狀尼龍粉末 0.1 19.防腐劑 適量 20.純水 殘量 200303761 (製造方法） A:將成分1〜8於85°C下混合並溶解。 B:將成分9加熱至85X：並在充分攪拌下加入A。 C:將成分B冷卻並以高壓均質機使微粒子化。 D:將成分10〜20於室溫下混合並溶解。 E:將C添加至D中並混合，以得到美容液。 實施例18之美容液其軟化劑之分散滴平均粒子徑在 0.3μπι以下，且少有水溶性L-抗壞血酸磷酸鎂之黏腻感， 具有足夠之柔軟感，爲經時安定性良好並具適度黏度之美 容液。 實施例19:美容液 (成分） （％) 1. 環氧乙烷（10)膽固醇醚 0.05 2. 環氧乙烷（10)異硬脂基醚 〇.〇5 3. 環氧乙烷（6)烷基（C12-18)醚磷酸鈉 0.1 4. 四-2_乙基己酸季戊四酯 〇·〇5 5. 甲基苯基聚矽氧烷 0.5 6. 十甲基環戊矽氧烷 〇·1 7. 天然維生素Ε 〇.〇1 8. 乙醇 5.0 9. 甘油 1〇·〇 10丄-抗壞血酸磷酸鎂 〇·5 11. 乳酸鈉 〇·5 12. 乳酸 〇·〇3 200303761 13. 甘菊萃取物 0.01 14. 烏龍茶萃取液 0.01 15. 甲基纖維素1%水溶液 10.0 16. 溫梓子萃取液 20.0 17. 聚丙烯醯胺 0.02 18. 聚乙二醇 20000 0.5 19. 防腐劑 適量 20. 純水 殘量 (製造方法） A:將成分1〜8於40°C下混合並溶解。 B:將成分9〜20於室溫下混合並溶解。 C:將A添加至B中並混合，以得到美容液。 實施例19之美容液其軟化劑之分散滴平均粒子徑在 0.5μηι以下，且少有水溶性L-抗壞血酸磷酸鎂之黏腻感， 具有足夠之柔軟感，爲經時安定性良好之美容液。18. Sodium lactate 0.1 19. Sodium hyaluronate aqueous solution (1%) 2.0 20. Pure water Residual amount (manufacturing method) A: Mix ingredients 1 to 8 and dissolve them at 40 ° C. B: Ingredients 9-20 are mixed and dissolved at room temperature. C: Add A to B and mix to get a lotion. The average particle diameter of the dispersed droplets of the softener of Example 17 is 18 200303761 0.3 μιη or less, and there is little sticky feeling of water-soluble L-ascorbic acid magnesium phosphate. It has sufficient softness and is stable over time. Lotion. Example 18: Beauty liquid (ingredient) (%) 1. Ethylene oxide (5) dihydrocholesteryl ether 1.0 2. Ethylene oxide (30) dihydrocholesteryl ether 0.03 3 Hydrogenated soybean phospholipid 0.5 4. 醯Sphingosine III 0.01 5. Tris-2-ethylhexanoic acid glyceride 0.05 6. Oil-soluble glycyrrhizin 0.01 7. Vitamin A palmitate 0.01 8. Dipropylene glycol 5.0 9. Pure water 20.0 10. L-ascorbic acid sulfuric acid Sodium 0.3 11. Sodium citrate 0.05 12. Citric acid 0.01 13. Carboxyvinyl polymer 1% aqueous solution 15.0 14. Polyethylene glycol 400 1.0 15. Diglycerol 5.0 16. Gutton gum 1% aqueous solution 3.0 Π. Amine group Methylpropanol 0.3 18. Spherical nylon powder 0.1 19. Appropriate amount of preservative 20. Pure water residue 200303761 (manufacturing method) A: Ingredients 1 to 8 are mixed and dissolved at 85 ° C. B: Heat component 9 to 85X: and add A with sufficient stirring. C: The component B is cooled and fine particles are formed in a high-pressure homogenizer. D: Ingredients 10 to 20 are mixed and dissolved at room temperature. E: Add C to D and mix to get a beauty lotion. The average particle diameter of the dispersed droplets of the softening agent of the cosmetic liquid of Example 18 is less than 0.3 μm, and there is little stickiness of water-soluble L-ascorbic acid magnesium phosphate, and it has sufficient softness, good stability over time, and moderate Viscosity beauty liquid. Example 19: Cosmetic liquid (ingredient) (%) 1. Ethylene oxide (10) cholesterol ether 0.05 2. Ethylene oxide (10) isostearyl ether 0.05. Ethylene oxide (6 ) Alkyl (C12-18) ether sodium phosphate 0.1 4. Pentaerythritol tetra-2-ethylhexanoate 005. 5. Methylphenyl polysiloxane 0.5 6. Decamethylcyclopentylsiloxane Alkanes 0 · 1 7. Natural vitamin E 0.〇1 8. Ethanol 5.0 9. Glycerol 10.0 · 10 丄 -magnesium ascorbyl phosphate 0.5 · 11. Sodium lactate 0.5 · Lactic acid 0.3032003 13. 13. Gan Chrysanthemum extract 0.01 14. Oolong tea extract 0.01 15. Methyl cellulose 1% aqueous solution 10.0 16. Warm zizi extract 20.0 17. Polyacrylamide 0.02 18. Polyethylene glycol 20000 0.5 19. Preservative amount 20. Pure water Residual amount (manufacturing method) A: Ingredients 1 to 8 are mixed and dissolved at 40 ° C. B: Ingredients 9-20 are mixed and dissolved at room temperature. C: A is added to B and mixed to obtain a beauty lotion. The beauty liquid of Example 19 had an average particle diameter of the dispersed droplets of the softener of 0.5 μm or less, and had little stickiness of water-soluble L-ascorbyl magnesium phosphate. .
實施例20:淸潔化粧水 I (成分） （％) 1. 環氧乙烷（5)膽固醇醚 0.03 2. 環氧乙烷（20)硬化篦麻油 0.03 3. 環氧乙烷（8)烷基（C12-18)醚磷酸鈉 0.02 4. 四-2-乙基己酸季戊四酯 0.1 5. 對甲氧基桂皮酸辛酯 0.05 6. 環氧乙烷（5)月桂基二乙醇醯胺 0.02 7. 甘草酸硬脂酯 0.01 21 200303761 8·無水乙醇 丨5.〇 9·丙二醇 2.0 10. L-抗壞血酸磷酸鈉 2.0 11. 檸檬酸鈉 〇.5 12·乙二胺四乙酸二鈉 〇.〇3 13.磷酸氫二鈉 0.01 14·金縷梅萃取液 0.01 15.結晶纖維素粉末 0.05 16·咼嶺土 0.01 17. 矢車菊水 10.0 18. 乙醯基谷胺酸 〇」 19. 防腐劑 適量 20. 純水 殘量 (製造方法） Α:將成分1〜8於40°C下混合並溶解。 B:將成分9〜20於室溫下混合並溶解。 C··將A添加至B中並混合，以得到淸潔化粧水。 本發明品平均粒徑在0·3μιη以下，且少有水溶性L-抗 壞血酸磷酸鈉之黏腻感，爲經時安定性良好之淸潔化粧水 發明效果 如以上所詳述，本發明之液狀化粧料可一面活用水溶 性抗壞血酸衍生物之美白作用，且即使在水溶性L-抗壞 血酸衍生物存在下，經時安定性及使用感依然良好。 22Example 20: Cleansing Lotion I (ingredients) (%) 1. Ethylene oxide (5) cholesterol ether 0.03 2. Ethylene oxide (20) hardened ramie oil 0.03 3. Ethylene oxide (8) alkane (C12-18) sodium ether phosphate 0.02 4. Pentaerythritol tetra-2-ethylhexanoate 0.1 5. Octyl p-methoxycinnamate 0.05 6. Ethylene oxide (5) lauryl diethanolamine 0.02 7. Stearyl Glycyrrhizin 0.01 21 200303761 8. Anhydrous alcohol 丨 5.09. Propanediol 2.0 10. L-ascorbic acid sodium phosphate 2.0 11. Sodium citrate 0.5 12. Disodium ethylenediamine tetraacetate 0.0. 〇3 13. Disodium hydrogen phosphate 0.01 14 Witch hazel extract 0.01 15. Crystalline cellulose powder 0.05 16 Moolin 0.01 17. Cornflower water 10.0 18. Ethyl glutamic acid 〇 19. Preservative amount 20. Pure water residue (manufacturing method) Α: Mix and dissolve ingredients 1 to 8 at 40 ° C. B: Ingredients 9-20 are mixed and dissolved at room temperature. C ... Add A to B and mix to get a cleansing lotion. The average particle diameter of the product of the present invention is below 0.3 μm, and there is little stickiness of water-soluble L-ascorbic acid sodium phosphate. It is a cleansing lotion with good stability over time. The effect of the invention is as detailed above. The liquid of the present invention The cosmetic can make use of the whitening effect of the water-soluble ascorbic acid derivative at the same time, and even in the presence of the water-soluble L-ascorbic acid derivative, the stability over time and the use feeling are still good. twenty two