TR200401209T4 - Kaspazların aktivatörleri ve apoptoz endüserleri olarak yer değiştiren 4H-kromen ve analogları ile bunların kullanımı - Google Patents
Kaspazların aktivatörleri ve apoptoz endüserleri olarak yer değiştiren 4H-kromen ve analogları ile bunların kullanımıInfo
- Publication number
- TR200401209T4 TR200401209T4 TR2004/01209T TR200401209T TR200401209T4 TR 200401209 T4 TR200401209 T4 TR 200401209T4 TR 2004/01209 T TR2004/01209 T TR 2004/01209T TR 200401209 T TR200401209 T TR 200401209T TR 200401209 T4 TR200401209 T4 TR 200401209T4
- Authority
- TR
- Turkey
- Prior art keywords
- caspases
- activators
- chromene
- analogs
- inducers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
Bu bulus genel formül (I) ile gösterilen yer degistirmis 4H-kromen ve analoglariyla ilgili olup, burada A,B,X,Y,Z ve R5 tanimlanmaktadir. Bu bulus ayrica formül (I)'e sahip olan bilesiklerin kaspaz aktivatörleri ve apoptoz endüserleri oldugunun kesfedilmesiyle ilgilidir. Bu nedenle, bu bulustaki kaspaz aktivatörleri ve adoptoz endüserleri hücrelerin kontrolsüz büyümesinin ve anormal yayilmasinin meydana geldigi çesitli klinik kosullarda hücre ölümüne yol açmak için kullanilabilir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16358499P | 1999-11-05 | 1999-11-05 | |
US18521100P | 2000-02-24 | 2000-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200401209T4 true TR200401209T4 (tr) | 2004-07-21 |
Family
ID=26859774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/01209T TR200401209T4 (tr) | 1999-11-05 | 2000-11-03 | Kaspazların aktivatörleri ve apoptoz endüserleri olarak yer değiştiren 4H-kromen ve analogları ile bunların kullanımı |
Country Status (13)
Country | Link |
---|---|
US (2) | US6906203B1 (tr) |
EP (1) | EP1230232B1 (tr) |
JP (1) | JP2003513967A (tr) |
AT (1) | ATE260269T1 (tr) |
AU (1) | AU781986B2 (tr) |
CA (1) | CA2390164C (tr) |
DE (1) | DE60008574T2 (tr) |
DK (1) | DK1230232T3 (tr) |
ES (1) | ES2216987T3 (tr) |
PT (1) | PT1230232E (tr) |
SI (1) | SI1230232T1 (tr) |
TR (1) | TR200401209T4 (tr) |
WO (1) | WO2001034591A2 (tr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE260269T1 (de) * | 1999-11-05 | 2004-03-15 | Cytovia Inc | Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung |
EP1392683B1 (en) * | 2001-05-16 | 2009-12-02 | Cytovia, Inc. | Substituted 4h-chromenes and analogs as activators of caspases and inducers of apoptosis and their use as anticancer agents |
WO2002092083A1 (en) * | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | 7,8-fused 4$i(h)-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1392283A4 (en) * | 2001-05-16 | 2004-10-20 | Cytovia Inc | COUMARINS AND SUBSTITUTED QUINOLINES USED AS CASPASE ACTIVATORS |
US6858607B1 (en) | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US20050165053A1 (en) * | 2001-06-04 | 2005-07-28 | Cytovia, Inc. | Substituted4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1463505A2 (en) * | 2001-12-13 | 2004-10-06 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
EP1513515A2 (en) | 2002-05-16 | 2005-03-16 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1509515A4 (en) * | 2002-05-16 | 2006-07-05 | Cytovia Inc | SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H | CHROMENES AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THEIR USE |
CA2522700A1 (en) | 2003-04-18 | 2004-11-04 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
AU2005294430A1 (en) * | 2004-10-07 | 2006-04-20 | Cytovia, Inc. | Substituted N-aryl-1H-pyrazolo[3,4-b]quinolin-4-amines and analogs as activators of caspases and inducers of apoptosis |
CA2600797A1 (en) * | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Michigan | Chromen-4-one inhibitors of anti-apoptotic bcl-2 family members and the uses thereof |
CA2938241A1 (en) | 2006-07-06 | 2008-01-10 | Cytovia, Inc. | Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof |
US20080090234A1 (en) * | 2006-10-13 | 2008-04-17 | Kejian Zhang | Diagnostic assay for autoimmune lymphoproliferative syndrome (ALPS) and genetically related disorders |
US8263775B2 (en) * | 2007-11-19 | 2012-09-11 | Howard Florey Institute | Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof |
US8349864B2 (en) * | 2008-03-25 | 2013-01-08 | New Mexico Technical Research Foundation | Pyrano [3,2-C] pyridones and related heterocyclic compounds as pharmaceutical agents for treating disorders responsive to apoptosis, antiproliferation or vascular disruption, and the use thereof |
ES2331451B1 (es) | 2008-06-30 | 2010-10-21 | Consejo Superior De Investigaciones Cientificas (Csic) | Inmunosupresor basado en la interrupcion de la interaccion tcr-nck. |
CN102171215B (zh) * | 2008-11-05 | 2014-06-18 | 沈阳中海药业有限公司 | 7H-咪唑并[1,2-a]吡喃并[2,3-c]吡啶类衍生物及其应用 |
WO2012062901A2 (en) * | 2010-11-12 | 2012-05-18 | Deutsches Krebsforschungszentrum (Dkfz) | Chromene derivatives and their analoga as wnt pathway antagonists |
WO2013070998A1 (en) * | 2011-11-10 | 2013-05-16 | Memorial Sloan-Kettering Cancer Center | TREATMENT OF OVARIAN CANCER WITH 2-AMINO-4H-NAPHTHO[1,2-b]PYRAN-3-CARBONITRILES |
ES2534336B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno como inhibidores de la interacción TCR-Nck |
ES2534318B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck |
CN108358880A (zh) * | 2017-12-29 | 2018-08-03 | 五邑大学 | 一种4H-苯并[b]吡喃类化合物的合成方法 |
CN108191806A (zh) * | 2017-12-29 | 2018-06-22 | 五邑大学 | 一种联苯型4H-苯并[b]吡喃类化合物的合成方法 |
IL301120A (en) | 2018-02-27 | 2023-05-01 | Artax Biopharma Inc | A history of novel chromium as TCR–NCK interaction inhibitors |
RU2674987C1 (ru) * | 2018-04-17 | 2018-12-14 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | 2-Аминия-7-(диэтиламино)-4-(4-метоксибензо[d][1,3]диоксол-5-ил)-4Н-хромен-3-карбонитрила N-ацетиламиноэтаноат, проявляющий противоопухолевую активность |
RU2704262C1 (ru) * | 2018-12-27 | 2019-10-25 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | Производные 2-аминохроменов проявляющие противоопухолевую активность. Фармацевтические композиции |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8402047D0 (en) * | 1984-01-26 | 1984-02-29 | Fisons Plc | Nitrogen heterocycles |
US5284868A (en) | 1991-10-09 | 1994-02-08 | Eli Lilly And Company | Pharmaceutical compounds |
US5281619A (en) | 1992-09-25 | 1994-01-25 | Eli Lilly And Company | Therapy for diabetic complications |
EP0599514A3 (en) | 1992-11-18 | 1994-07-06 | Lilly Industries Ltd | Pyranoquinoline derivatives as inhibitors of cell proliferation. |
GB9306062D0 (en) | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
EP0619314A1 (en) | 1993-04-09 | 1994-10-12 | Eli Lilly And Company | 4-Phenyl-4H- naphtho(2,1-b)pyran derivatives and their pharmaceutical use |
US6087160A (en) | 1993-06-24 | 2000-07-11 | The General Hospital Corporation | Programmed cell death genes and proteins |
US5637589A (en) | 1993-10-29 | 1997-06-10 | University Of North Carolina At Chapel Hill | Suksdorfin, analogs, compositions thereof, and methods for making and using thereof |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
WO1999018856A1 (en) | 1997-10-10 | 1999-04-22 | Cytovia, Inc. | Novel fluorescent reporter molecules and their applications including assays for caspases |
KR20010042804A (ko) | 1998-04-17 | 2001-05-25 | 파커 휴우즈 인스티튜트 | 비티케이 억제제와 그들의 동정 방법 및 용도 |
US6303652B1 (en) | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
CA2338328A1 (en) | 1998-07-21 | 2000-02-03 | Thomas Jefferson University | Small molecule inhibitors of bcl-2 proteins |
TR200201297T2 (tr) | 1999-02-11 | 2002-06-21 | Pfizer Products Inc. | Antikanser maddeleri olarak faydalı heteroaril-ikame edilmiş kinolin-2-on türevleri. |
ATE260269T1 (de) * | 1999-11-05 | 2004-03-15 | Cytovia Inc | Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung |
WO2002092083A1 (en) | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | 7,8-fused 4$i(h)-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1392683B1 (en) | 2001-05-16 | 2009-12-02 | Cytovia, Inc. | Substituted 4h-chromenes and analogs as activators of caspases and inducers of apoptosis and their use as anticancer agents |
US6858607B1 (en) * | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1392283A4 (en) | 2001-05-16 | 2004-10-20 | Cytovia Inc | COUMARINS AND SUBSTITUTED QUINOLINES USED AS CASPASE ACTIVATORS |
EP1509515A4 (en) | 2002-05-16 | 2006-07-05 | Cytovia Inc | SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H | CHROMENES AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THEIR USE |
EP1513515A2 (en) | 2002-05-16 | 2005-03-16 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
-
2000
- 2000-11-03 AT AT00976912T patent/ATE260269T1/de not_active IP Right Cessation
- 2000-11-03 DE DE60008574T patent/DE60008574T2/de not_active Expired - Lifetime
- 2000-11-03 AU AU14619/01A patent/AU781986B2/en not_active Ceased
- 2000-11-03 ES ES00976912T patent/ES2216987T3/es not_active Expired - Lifetime
- 2000-11-03 WO PCT/US2000/030374 patent/WO2001034591A2/en active IP Right Grant
- 2000-11-03 TR TR2004/01209T patent/TR200401209T4/tr unknown
- 2000-11-03 DK DK00976912T patent/DK1230232T3/da active
- 2000-11-03 EP EP00976912A patent/EP1230232B1/en not_active Expired - Lifetime
- 2000-11-03 CA CA2390164A patent/CA2390164C/en not_active Expired - Fee Related
- 2000-11-03 SI SI200030376T patent/SI1230232T1/xx unknown
- 2000-11-03 JP JP2001536538A patent/JP2003513967A/ja active Pending
- 2000-11-03 PT PT00976912T patent/PT1230232E/pt unknown
- 2000-11-06 US US09/705,840 patent/US6906203B1/en not_active Expired - Fee Related
-
2005
- 2005-03-07 US US11/072,499 patent/US7507762B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK1230232T3 (da) | 2004-06-28 |
SI1230232T1 (en) | 2004-08-31 |
EP1230232A2 (en) | 2002-08-14 |
WO2001034591A2 (en) | 2001-05-17 |
US20050154015A1 (en) | 2005-07-14 |
WO2001034591A3 (en) | 2001-09-20 |
CA2390164A1 (en) | 2001-05-17 |
ES2216987T3 (es) | 2004-11-01 |
US6906203B1 (en) | 2005-06-14 |
AU781986B2 (en) | 2005-06-23 |
DE60008574D1 (de) | 2004-04-01 |
EP1230232B1 (en) | 2004-02-25 |
JP2003513967A (ja) | 2003-04-15 |
ATE260269T1 (de) | 2004-03-15 |
AU1461901A (en) | 2001-06-06 |
US7507762B2 (en) | 2009-03-24 |
CA2390164C (en) | 2011-03-29 |
DE60008574T2 (de) | 2009-10-01 |
PT1230232E (pt) | 2004-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200401209T4 (tr) | Kaspazların aktivatörleri ve apoptoz endüserleri olarak yer değiştiren 4H-kromen ve analogları ile bunların kullanımı | |
WO2002100826A3 (en) | Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs | |
EP1392683A4 (en) | CHROMENES SUBTITUES 4 i H / i AND THEIR ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS, AND THEIR USE | |
WO2003096982A3 (en) | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2001079187A3 (en) | Substituted 1,4-thiazepine and analogs and their use as activators of caspases | |
DE60035037D1 (de) | Caspase inhibitoren und ihre verwendung | |
ATE336480T1 (de) | Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung | |
ATE295177T1 (de) | Dipeptid kaspase inhibitoren und deren verwendung | |
EA200200301A1 (ru) | ЗАМЕЩЕННЫЕ α-ГИДРОКСИКИСЛОТЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ КЛЕТОЧНОЙ ГИБЕЛИ НА КЛЕТОЧНОМ ИЛИ ТКАНЕВОМ УРОВНЕ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ОБЛЕГЧЕНИЯ СОСТОЯНИЯ ПРИ ГИБЕЛИ КЛЕТОК У ЖИВОТНОГО, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАЗЛИЧНЫХ БОЛЕЗНЕЙ | |
WO2007056208A3 (en) | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
ATE301122T1 (de) | Kernerweiterte perylenbisimide und ihre verwendung als fluoreszenzfarbstoffe | |
CO4940451A1 (es) | Derivados de acido barbiturico con actividad antimetastica y antitumoral | |
WO2006041900A9 (en) | SUBSTITUTED QUINOLIN-4-AMINOUS <I> N </ I> -ARYL-1 <I> H </ I> -PYRAZOLO [3,4- <I> B </ I>] QUINOLIN-4-AMINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | |
WO2004002428A3 (en) | Derivatives of gambogic acid and induce apoptosis | |
WO2006039356A8 (en) | Substituted n-aryl-9-oxo-9h-fluorene-1-carboxamides and analogs as activators of caspases and inducers of apoptosis | |
WO2002089745A3 (en) | Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2008021456A3 (en) | N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2005060663A3 (en) | Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis | |
WO2003097806A3 (en) | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2004055163A3 (en) | Substituted 1-benzoyl-3-cyano-pyrrolo[1,2-a]quinolines | |
ATE247660T1 (de) | Furopyridinderivate und ihre therapeutische verwendung | |
EP1180991A4 (en) | GAMBOGIC ACID, ANALOG AND DERIVATIVE AS CASPASENACTIVATORS AND APOPTOSIS INDUCTIONS | |
WO2005037196A3 (en) | Substituted 2-arylmethylene-n-aryl-n'-aryl-malonamides and analogs as activators of caspases and inducers of apoptosis | |
WO2002072544A3 (en) | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
DE59809344D1 (de) | Disubstituierte biphenyloxazoline |