TR200400611T4 - Sitalopramın preparasyon metodu - Google Patents

Sitalopramın preparasyon metodu

Info

Publication number
TR200400611T4
TR200400611T4 TR2004/00611T TR200400611T TR200400611T4 TR 200400611 T4 TR200400611 T4 TR 200400611T4 TR 2004/00611 T TR2004/00611 T TR 2004/00611T TR 200400611 T TR200400611 T TR 200400611T TR 200400611 T4 TR200400611 T4 TR 200400611T4
Authority
TR
Turkey
Prior art keywords
group
cyano
converting
cor
alkyl
Prior art date
Application number
TR2004/00611T
Other languages
English (en)
Inventor
Petersen Hans
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of TR200400611T4 publication Critical patent/TR200400611T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Bulus, herhangi bir sirayla, Y'nin bir siyano grubu veya bir siyano grubuna dönüstürülebilen bir grup oldugu, R'nin hidrojen, -O-R1, NH2, NHCH3 veya -N(CH3)2(R1, hidrojen, alkil, alkenil, alkinil ve istege göre alkille ikame edilen aril veya aralkilden seçilir) oldugu bir formül (III) bilesiginin, i) -CH=CH-COR formülünün yan zincirinde çifli bag indirgemesine tabi tutulmasini; ii) -COR grubunun veya bunun indirgenmis bir formunun, bir dimetilaminemetil grubuna dönüstürülmesini; ve iii) Y'nin siyano olmamasi durumunda Y grubunun bir siyano grubuna dönüstürülmesini; bunu takiben sitalopram bazinin veya bunun farmasötik açidan kabul gören asit ilaveli bir tuzunun izole edilmesini kapsayan bir preparasyon metodu ile ilgilidir.
TR2004/00611T 2000-03-14 2001-03-09 Sitalopramın preparasyon metodu TR200400611T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200000415 2000-03-14

Publications (1)

Publication Number Publication Date
TR200400611T4 true TR200400611T4 (tr) 2004-04-21

Family

ID=8159331

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2004/00611T TR200400611T4 (tr) 2000-03-14 2001-03-09 Sitalopramın preparasyon metodu
TR2002/02155T TR200202155T2 (tr) 2000-03-14 2001-03-09 Sitalopramin preparasyon metodu

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2002/02155T TR200202155T2 (tr) 2000-03-14 2001-03-09 Sitalopramin preparasyon metodu

Country Status (26)

Country Link
US (1) US6806376B2 (tr)
EP (1) EP1265882B1 (tr)
JP (1) JP2003527386A (tr)
KR (1) KR20020080476A (tr)
CN (1) CN1418205A (tr)
AT (1) ATE257832T1 (tr)
AU (1) AU2001239213A1 (tr)
BG (1) BG107051A (tr)
BR (1) BR0109268A (tr)
CA (1) CA2402557A1 (tr)
DE (1) DE60101786T2 (tr)
DK (1) DK1265882T3 (tr)
EA (1) EA005094B1 (tr)
ES (1) ES2214400T3 (tr)
HR (1) HRP20020740A2 (tr)
HU (1) HUP0300178A2 (tr)
IL (1) IL151488A0 (tr)
IS (1) IS6527A (tr)
MX (1) MXPA02008653A (tr)
NO (1) NO20024198D0 (tr)
PL (1) PL360107A1 (tr)
PT (1) PT1265882E (tr)
SK (1) SK14512002A3 (tr)
TR (2) TR200400611T4 (tr)
WO (1) WO2001068630A1 (tr)
ZA (1) ZA200206897B (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
NZ521201A (en) 2000-03-13 2004-02-27 H Method for the preparation of citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (tr) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
PT1015416E (pt) 1997-07-08 2002-03-28 Lundbeck & Co As H Metodo para a producao de citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
HU228576B1 (en) 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
EA005134B1 (ru) 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NZ521201A (en) 2000-03-13 2004-02-27 H Method for the preparation of citalopram
WO2001068632A1 (en) 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
WO2002004435A1 (en) 2000-07-06 2002-01-17 H. Lundbeck A/S Method for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
EP1265882A1 (en) 2002-12-18
CN1418205A (zh) 2003-05-14
NO20024198L (no) 2002-09-03
DE60101786D1 (de) 2004-02-19
PL360107A1 (en) 2004-09-06
ATE257832T1 (de) 2004-01-15
BR0109268A (pt) 2002-12-03
MXPA02008653A (es) 2003-02-24
ES2214400T3 (es) 2004-09-16
IL151488A0 (en) 2003-04-10
SK14512002A3 (sk) 2003-03-04
IS6527A (is) 2002-08-27
DE60101786T2 (de) 2004-07-15
BG107051A (en) 2003-05-30
EP1265882B1 (en) 2004-01-14
ZA200206897B (en) 2003-08-28
US20030050484A1 (en) 2003-03-13
US6806376B2 (en) 2004-10-19
HUP0300178A2 (en) 2003-05-28
JP2003527386A (ja) 2003-09-16
NO20024198D0 (no) 2002-09-03
WO2001068630A1 (en) 2001-09-20
TR200202155T2 (tr) 2002-12-23
PT1265882E (pt) 2004-06-30
HRP20020740A2 (en) 2004-12-31
CA2402557A1 (en) 2001-09-20
EA005094B1 (ru) 2004-10-28
AU2001239213A1 (en) 2001-09-24
DK1265882T3 (da) 2004-06-01
EA200200970A1 (ru) 2003-02-27
KR20020080476A (ko) 2002-10-23

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