TNSN07167A1 - Indoles substitues, compositions les contenant, procede de fabrication et utilisation - Google Patents
Indoles substitues, compositions les contenant, procede de fabrication et utilisationInfo
- Publication number
- TNSN07167A1 TNSN07167A1 TNP2007000167A TNSN07167A TNSN07167A1 TN SN07167 A1 TNSN07167 A1 TN SN07167A1 TN P2007000167 A TNP2007000167 A TN P2007000167A TN SN07167 A TNSN07167 A TN SN07167A TN SN07167 A1 TNSN07167 A1 TN SN07167A1
- Authority
- TN
- Tunisia
- Prior art keywords
- compositions containing
- manufacture
- substituted indoles
- containing same
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne notamment la préparation d'indoles substitués, des compositions les contenant, leur procédé de préparation, et leur utilisation comme médicament, en particulier en tant qu'agents anticancéreux.Formule (I)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0412966A FR2878849B1 (fr) | 2004-12-06 | 2004-12-06 | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
PCT/FR2005/003003 WO2006061493A1 (fr) | 2004-12-06 | 2005-12-02 | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN07167A1 true TNSN07167A1 (fr) | 2008-11-21 |
Family
ID=34954266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2007000167A TNSN07167A1 (fr) | 2004-12-06 | 2007-05-04 | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
Country Status (14)
Country | Link |
---|---|
US (1) | US7566736B2 (fr) |
EP (1) | EP1841762A1 (fr) |
CN (1) | CN101098868A (fr) |
AR (1) | AR052257A1 (fr) |
AU (1) | AU2005313253A1 (fr) |
CA (1) | CA2586991A1 (fr) |
FR (1) | FR2878849B1 (fr) |
GT (1) | GT200500357A (fr) |
PA (1) | PA8654701A1 (fr) |
SV (1) | SV2006002319A (fr) |
TN (1) | TNSN07167A1 (fr) |
TW (1) | TW200634007A (fr) |
UY (1) | UY29248A1 (fr) |
WO (1) | WO2006061493A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2884821B1 (fr) * | 2005-04-26 | 2007-07-06 | Aventis Pharma Sa | Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation |
DE102005037499A1 (de) * | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
JP2009525350A (ja) * | 2006-02-01 | 2009-07-09 | スミスクライン ビーチャム コーポレーション | Rafキナーゼ阻害薬として有用なピロロ[2,3,b]ピリジン誘導体 |
US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
EP2134685B1 (fr) * | 2007-04-16 | 2015-09-02 | AbbVie Inc. | Derivés d'indole non-substitués en position 7 en tant qu'inhibiteurs de mcl-1 |
CN102532042A (zh) * | 2010-12-30 | 2012-07-04 | 上海医药工业研究院 | 一种芳基脲类化合物、其中间体及其应用 |
UY34893A (es) | 2012-07-10 | 2014-02-28 | Takeda Pharmaceutical | Derivados de azaindol |
EP2970119B1 (fr) * | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques |
GB201310460D0 (en) * | 2013-06-12 | 2013-07-24 | Lytix Biopharma As | Compounds |
CA2916615A1 (fr) * | 2013-07-01 | 2015-01-08 | Bristol-Myers Squibb Company | Inhibiteurs de l'ido |
UY35945A (es) | 2014-01-09 | 2015-08-31 | Takeda Pharmaceutical | Derivados de azaindol |
WO2020142559A1 (fr) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Inhibiteurs de l'interaction ménine-mll |
CN114040760A (zh) | 2018-12-31 | 2022-02-11 | 拜欧米富士恩公司 | Menin-mll相互作用的不可逆抑制剂 |
CA3229150A1 (fr) | 2021-08-20 | 2023-02-23 | Biomea Fusion, Inc. | Formes cristallines de n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidine-6-yl]phenyl]-4-[[3(r)-[(1-oxo-2-propene-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, un inhibiteur irreversible de menine-mll pour le traitement du cance |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376529B1 (en) * | 1995-06-07 | 2002-04-23 | Peng Cho Tang | Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof |
BR9609353A (pt) * | 1995-06-07 | 1999-05-11 | Sugen Inc | Composição farmacêutica conveniente para administração em humanos processo para melhorar sintomas de uma desordem proliferativa celular e compostos |
US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
GB0115393D0 (en) | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
AP2003002929A0 (en) * | 2001-06-23 | 2003-12-31 | Aventis Pharma Inc | Pyrrolopyrimidines as protein kinase inhibitors |
MXPA04003758A (es) * | 2001-10-22 | 2005-06-20 | Univ New York State Res Found | Inhibidores de proteina - cinasas y proteina-fosfatasas, metodos para disenarlos y metodos para usarlos. |
AU2003243709B2 (en) * | 2002-06-24 | 2007-01-18 | Schering Corporation | Indole derivatives useful as histamine H3 antagonists |
FR2842526B1 (fr) * | 2002-07-16 | 2007-07-13 | Aventis Pharma Sa | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments |
JP2004149429A (ja) * | 2002-10-29 | 2004-05-27 | Takeda Chem Ind Ltd | インドール化合物およびその用途 |
US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
GB0500492D0 (en) | 2005-01-11 | 2005-02-16 | Cyclacel Ltd | Compound |
WO2007010964A1 (fr) | 2005-07-22 | 2007-01-25 | Shionogi & Co., Ltd. | Dérivé d'indole ayant une activité antagoniste vis-à-vis du récepteur de la pgd2 |
-
2004
- 2004-12-06 FR FR0412966A patent/FR2878849B1/fr not_active Expired - Fee Related
-
2005
- 2005-12-02 EP EP05824445A patent/EP1841762A1/fr not_active Withdrawn
- 2005-12-02 AU AU2005313253A patent/AU2005313253A1/en not_active Withdrawn
- 2005-12-02 CA CA002586991A patent/CA2586991A1/fr not_active Abandoned
- 2005-12-02 CN CNA2005800461740A patent/CN101098868A/zh active Pending
- 2005-12-02 WO PCT/FR2005/003003 patent/WO2006061493A1/fr active Application Filing
- 2005-12-05 AR ARP050105076A patent/AR052257A1/es unknown
- 2005-12-05 TW TW094142712A patent/TW200634007A/zh unknown
- 2005-12-06 GT GT200500357A patent/GT200500357A/es unknown
- 2005-12-06 UY UY29248A patent/UY29248A1/es not_active Application Discontinuation
- 2005-12-06 PA PA20058654701A patent/PA8654701A1/es unknown
- 2005-12-06 SV SV2005002319A patent/SV2006002319A/es unknown
-
2007
- 2007-05-04 TN TNP2007000167A patent/TNSN07167A1/fr unknown
- 2007-06-04 US US11/757,613 patent/US7566736B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PA8654701A1 (es) | 2006-07-03 |
UY29248A1 (es) | 2006-06-30 |
US7566736B2 (en) | 2009-07-28 |
EP1841762A1 (fr) | 2007-10-10 |
US20070259910A1 (en) | 2007-11-08 |
AU2005313253A1 (en) | 2006-06-15 |
FR2878849B1 (fr) | 2008-09-12 |
GT200500357A (es) | 2007-01-09 |
CA2586991A1 (fr) | 2006-06-15 |
TW200634007A (en) | 2006-10-01 |
FR2878849A1 (fr) | 2006-06-09 |
SV2006002319A (es) | 2006-07-07 |
AR052257A1 (es) | 2007-03-07 |
WO2006061493A1 (fr) | 2006-06-15 |
CN101098868A (zh) | 2008-01-02 |
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