SU609466A3 - Способ получени производных оксазола - Google Patents

Способ получени производных оксазола

Info

Publication number
SU609466A3
SU609466A3 SU752189818A SU2189818A SU609466A3 SU 609466 A3 SU609466 A3 SU 609466A3 SU 752189818 A SU752189818 A SU 752189818A SU 2189818 A SU2189818 A SU 2189818A SU 609466 A3 SU609466 A3 SU 609466A3
Authority
SU
USSR - Soviet Union
Prior art keywords
oxazole derivatives
obtaining
general formula
derivatives
synthesis
Prior art date
Application number
SU752189818A
Other languages
English (en)
Inventor
Чарльз Невилл Мартин
Помфрет Вердж Джон
Original Assignee
Лилли Индастриз Лимитед (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лилли Индастриз Лимитед (Фирма) filed Critical Лилли Индастриз Лимитед (Фирма)
Application granted granted Critical
Publication of SU609466A3 publication Critical patent/SU609466A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Description

Изобретение относитс  к синтезу новых производных оксазола, которые могут найти применение в медицине. Известен способ получени  лактамов из соответствующих аминов путем ацилировани  их «)-галоидацилгалоге нидами с последующей циклизацией под действием дегидрогалогенируюцих агентов fl . Целью изобретени   вл етс  синтез новых производных оксазола, обладающих ценными фармакологическими свойствами . Поставленна  цель достйгаетс  ойн сываемым способом получени  производных оксазола общей формулы (1)/ И 11 O- N-CCHOn где К, и R,могут быть одинаковы ил различны и означают водород или Cj-С -алкил; - целое число от 3 до 5; заключающийс  в том, что 2-аминооксазол общей формулы (п) л RI О Ж , где RI и Rj имеют указанные вьлце значени ; подвергают взаимодействию с ш галоидацилгалогенкдом общей формулы (ш) й«1-(сн,Ь-с Ш1 / где п имеет вышеуказанные значени ; в присутствии основани , при температуре кипени  реакционной массы, с последуицей циклизацией полученного W)-галоидациламинооксазола в инертном растворителе при комнатной температуре в присутствии дегидрогалогенирующего средства. Приведенные ниже примеры иллюстри руют насто щее изобретение. Там, где в примерах делаетс  ссылка на точку кипени , как температуру воздушной, бани, это означает, что соединени  перегон ют на перегонном аппарате Кюгельрора и указанна  .температура
SU752189818A 1973-12-17 1975-11-18 Способ получени производных оксазола SU609466A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB58351/73A GB1497536A (en) 1973-12-17 1973-12-17 2-acylaminooxazoles methods for their preparation and their use

Publications (1)

Publication Number Publication Date
SU609466A3 true SU609466A3 (ru) 1978-05-30

Family

ID=10481393

Family Applications (3)

Application Number Title Priority Date Filing Date
SU2087389A SU552029A3 (ru) 1973-12-17 1974-12-16 Способ получени производных оксазола
SU752189818A SU609466A3 (ru) 1973-12-17 1975-11-18 Способ получени производных оксазола
SU752189819A SU623518A3 (ru) 1973-12-17 1975-11-18 Способ получени производных оксазола

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU2087389A SU552029A3 (ru) 1973-12-17 1974-12-16 Способ получени производных оксазола

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU752189819A SU623518A3 (ru) 1973-12-17 1975-11-18 Способ получени производных оксазола

Country Status (29)

Country Link
US (1) US4122183A (ru)
JP (1) JPS5093968A (ru)
AR (4) AR214714A1 (ru)
AT (1) AT341521B (ru)
BE (1) BE823424A (ru)
BG (3) BG26669A4 (ru)
CA (1) CA1060440A (ru)
CH (3) CH605862A5 (ru)
DD (1) DD115676A5 (ru)
DE (1) DE2459380A1 (ru)
DK (1) DK655074A (ru)
EG (1) EG11873A (ru)
ES (2) ES433018A1 (ru)
FI (1) FI363374A (ru)
FR (1) FR2254338B1 (ru)
GB (1) GB1497536A (ru)
HU (1) HU170454B (ru)
IE (1) IE40308B1 (ru)
IL (2) IL46250A (ru)
LU (1) LU71499A1 (ru)
NL (1) NL7416389A (ru)
NO (1) NO142303C (ru)
OA (1) OA04946A (ru)
PH (1) PH13466A (ru)
PL (2) PL97985B1 (ru)
RO (1) RO70772A (ru)
SE (1) SE420604B (ru)
SU (3) SU552029A3 (ru)
ZA (1) ZA748013B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150143A (en) 1973-12-17 1979-04-17 Lilly Industries Limited N-Substituted-acylamino-oxazoles as antiasthma agents
GB1497536A (en) * 1973-12-17 1978-01-12 Lilly Industries Ltd 2-acylaminooxazoles methods for their preparation and their use
GB1547564A (en) 1975-06-05 1979-06-20 Lilly Industries Ltd Acylated amino-heteroaryl compounds
GB1552125A (en) * 1975-06-07 1979-09-05 Lilly Industries Ltd 2-acylamino oxazoles
IT1099996B (it) * 1978-10-17 1985-09-28 Anic Spa Derivati del 4,5-difenil-ossazolo 2-ammino o 2-tio sostituiti e procedimento per il loro ottenimento
CH655312A5 (de) * 1982-02-09 1986-04-15 Sandoz Ag Chloracetamide.
US4666502A (en) * 1982-02-09 1987-05-19 Sandoz Ltd. Herbicidal N-thienyl-chloroacetamides
GB2127816B (en) * 1982-09-30 1986-05-08 Lilly Co Eli Herbicidal 1-heterocyclic-2-pyrrolidinone derivatives
US4500343A (en) * 1982-09-30 1985-02-19 Eli Lilly And Company Oxazolyl and thiazolyl amides as herbicides
US6228871B1 (en) 1995-07-10 2001-05-08 Merck & Co., Inc. Angiogenesis inhibitors
WO2000002871A1 (en) * 1998-07-10 2000-01-20 Merck & Co., Inc. Novel angiogenesis inhibitors
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
US20130231340A1 (en) 2012-03-02 2013-09-05 Sareum Limited Pharmaceutical compounds
WO2015032423A1 (en) * 2013-09-03 2015-03-12 Sareum Limited Pharmaceutical compounds
GB201617871D0 (en) 2016-10-21 2016-12-07 Sareum Limited Pharmaceutical compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2401522A (en) * 1942-04-17 1946-06-04 Firm Sandoz Ltd Aromatic carboxylic acid amides and a process for their manufacture
US3152136A (en) * 1958-10-30 1964-10-06 Dow Chemical Co Dinitroaroyl-nu-pyridyl amides
US3682954A (en) * 1970-02-04 1972-08-08 Upjohn Co Bis (3-pyrazolidone) compounds
DE2045049A1 (de) * 1970-09-11 1972-03-23 Dr Karl Thomae GmbH, 7950 Biberach Neue Nitrofurandenvate und Ver fahren zu ihrer Herstellung
GB1264258A (ru) * 1970-10-10 1972-02-16
BE791087A (fr) * 1971-11-15 1973-03-01 Lepetit Spa Oxazoles 2,4,5-trisubstitues et leur preparation
GB1497536A (en) * 1973-12-17 1978-01-12 Lilly Industries Ltd 2-acylaminooxazoles methods for their preparation and their use

Also Published As

Publication number Publication date
SE7415778L (ru) 1975-06-18
ES451058A1 (es) 1977-11-16
HU170454B (ru) 1977-06-28
GB1497536A (en) 1978-01-12
PH13466A (en) 1980-05-15
NO142303B (no) 1980-04-21
BG25992A3 (ru) 1979-01-12
AR209919A1 (es) 1977-06-15
EG11873A (en) 1977-11-30
FR2254338A1 (ru) 1975-07-11
IL52719A0 (en) 1977-10-31
ATA1000074A (de) 1977-06-15
AT341521B (de) 1978-02-10
IE40308L (en) 1975-06-17
AR214714A1 (es) 1979-07-31
OA04946A (fr) 1980-10-31
CH605862A5 (ru) 1978-10-13
IE40308B1 (en) 1979-04-25
SU623518A3 (ru) 1978-09-05
RO70772A (ro) 1981-09-24
AR212547A1 (es) 1978-07-31
FR2254338B1 (ru) 1982-02-12
SE420604B (sv) 1981-10-19
SU552029A3 (ru) 1977-03-25
NO744532L (ru) 1975-07-14
PL94117B1 (ru) 1977-07-30
DE2459380A1 (de) 1975-06-19
ES433018A1 (es) 1977-05-16
DD115676A5 (ru) 1975-10-12
AR215640A1 (es) 1979-10-31
FI363374A (ru) 1975-06-18
CH605861A5 (ru) 1978-10-13
CA1060440A (en) 1979-08-14
AU7648274A (en) 1976-06-17
PL97985B1 (pl) 1978-04-29
BG26530A4 (ru) 1979-04-12
BG26669A4 (ru) 1979-05-15
LU71499A1 (ru) 1976-11-11
DK655074A (ru) 1975-08-25
US4122183A (en) 1978-10-24
ZA748013B (en) 1976-08-25
JPS5093968A (ru) 1975-07-26
BE823424A (fr) 1975-06-16
CH605931A5 (ru) 1978-10-13
NO142303C (no) 1980-07-30
IL46250A0 (en) 1975-03-13
NL7416389A (nl) 1975-06-19
IL46250A (en) 1978-09-29

Similar Documents

Publication Publication Date Title
SU609466A3 (ru) Способ получени производных оксазола
FR2380283A1 (fr) Molybdates d'amines, procede d'obtention et application
FR2357528A1 (fr) Halogenures de 3-(n'-(3-halopropyl)-n'-methylamino)-n,n,n-trimethyl-1-propanaminium et procede pour leur preparation
FR2384765A1 (fr) Derives amino-substitues du furanne et procede pour leur preparation
GB948888A (en) Novel benzodiazepine derivatives
FR2374307A1 (fr) Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant
DE3767993D1 (de) Verfahren zur herstellung von thienylaethylaminen, und mittels des verfahrens hergestellte dithienylaethylamine.
FR2445328A1 (fr) Derives du 14-oxo-e-homo-eburnane, leur procede de preparation et leur utilisation comme medicament
FR2392999A1 (fr) Nouveaux derives de l'acide 6-((aminosulfonyl)-phenyl)-1,2-dihydro-2-oxonicotinique utile comme medicament
FR2397411A1 (fr) Composes tricycliques derives du norbornane, leur utilisation et procede pour leur preparation
FR2436144A1 (fr) Nouveaux derives d'aurones, leur procede de preparation et leur utilisation comme produits pharmaceutiques
ATE38515T1 (de) Spiro-2-aza-alkan-3-carbonitrile, verfahren zu ihrer herstellung und ihre verwendung.
ATE37365T1 (de) (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamine, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
FR2384770A1 (fr) Nouveaux derives de quinazoline utiles comme medicaments
ES466245A1 (es) Procedimiento para preparar derivados de isoquinolina
FR2398736A1 (fr) Derives a-halogenomethyles d'aminoacides, leur procede de preparation et leur utilisation comme antiallergiques
DE1445409B2 (de) Verfahren zur herstellung von 3- phenyl-5-amino-1,2,4-oxadiazolderivaten
US3254121A (en) Bromination of salicylanilide
SU565913A1 (ru) Способ получени хлорнитроимидазолов
FR2366261A1 (fr) Nouveaux derives d'ammonium quaternaire, leur procede de preparation et leur application
DE1445409C3 (ru)
US2185219A (en) Furfuryl n-morpholine alkyl halide medicinal preparation
AT350547B (de) Verfahren zur herstellung von einem neuen benzofuranderivat und den saeureadditionssalzen hievon
SU735593A1 (ru) Способ получени 2-оксо-з-арил-карбамоилтиозолидино-(3,2-а)-1,2-дигидропиридинов
FI61889B (fi) Foerfarande foer framstaellning av ny 2-((p-metoxibensoyl)-hydrazonoformyl)-kinoxalin-1,4-dioxid med antibakterisk verkan