SU510148A3 - Способ получени производныхизоиндолина или их солей - Google Patents

Способ получени производныхизоиндолина или их солей

Info

Publication number: SU510148A3
Authority: SU; USSR - Soviet Union
Prior art keywords: salts; isoindoline; obtaining derivatives; derivatives; preparation
Prior art date: 1971-05-04

Application number

SU1958514A

Other languages

English (en)

Inventor

Котрель Клод

Жанмар Клод

Наум Мессер Майер

Original Assignee

Рон-Пуленк С.А. (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-05-04

Filing date

1973-09-26

Publication date

1976-04-05

1973-09-26 Application filed by Рон-Пуленк С.А. (Фирма) filed Critical Рон-Пуленк С.А. (Фирма)

1976-04-05 Application granted granted Critical

1976-04-05 Publication of SU510148A3 publication Critical patent/SU510148A3/ru

Links

238000000034 method Methods 0.000 title description 5
GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical class C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title description 4
150000003839 salts Chemical class 0.000 title description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
229910052799 carbon Inorganic materials 0.000 description 2
-1 - alkylthio Chemical group 0.000 description 1
PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
MFSIEROJJKUHBQ-UHFFFAOYSA-N O.[Cl] Chemical class O.[Cl] MFSIEROJJKUHBQ-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
150000001244 carboxylic acid anhydrides Chemical class 0.000 description 1
125000004663 dialkyl amino group Chemical group 0.000 description 1
150000003948 formamides Chemical class 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
238000002955 isolation Methods 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
238000009938 salting Methods 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
239000000126 substance Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ИЗОИНДОЛИНА ИЛИ их СОЛЕЙ

1

Изобретение относитс к способу получени новых производных изоиндолина, которые обладают биологической активностью и могут найти применение в фармацевтической практике.

Основанный на известной реакции взаимодействи вторичных аминов с ангидридами карбоновых кислот с образованием амидов, предлагаемый способ получени производных изоиндолина общей формулы

или их солей заключаетс в том, что смешанный карбонат общей формулы

10O-00-O Ar

- О О-СО

он.

где Т - одинаковые или различные, водоС ,-С, С , - С.

род, галоид,

- алкил.

алкоксил, - алкилтиогруппа, диалкиламиногруппа , в которой алкил содержит 1-4 атома углерода, или феноксигруппа;

где Т имеет вышеуказанные значени ; Аг- замещенный фенил; обрабатывают 1-метилпиперазином в среде органического растворител , например ацетонитрила, с последующим выделением целевого продукта в виде основани или переведением его в соль известным способом.

Реакцию обычно провод т при комнатной температуре.

Дл очистки целевых продуктов используют известные физические и химические методы.

Дл получени солей, напрвп «ер хлор- гидратов, сульфатов, нитратов, фосфатов.

SU1958514A 1971-05-04 1973-09-26 Способ получени производныхизоиндолина или их солей SU510148A3 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7116074A FR2135066B1 (ru)	1971-05-04	1971-05-04
FR7206108A FR2172822B2 (ru)	1971-05-04	1972-02-23

Publications (1)

Publication Number	Publication Date
SU510148A3 true SU510148A3 (ru)	1976-04-05

Family

ID=26216373

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SU1771264A SU457215A3 (ru)	1971-05-04	1972-04-18	Способ получени производных изоиндолина или их солей
SU1958514A SU510148A3 (ru)	1971-05-04	1973-09-26	Способ получени производныхизоиндолина или их солей

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SU1771264A SU457215A3 (ru)	1971-05-04	1972-04-18	Способ получени производных изоиндолина или их солей

Country Status (26)

Country	Link
US (1)	US3879390A (ru)
JP (1)	JPS5512028B1 (ru)
AR (1)	AR192506A1 (ru)
AT (2)	AT315189B (ru)
BE (1)	BE782983A (ru)
CA (1)	CA961042A (ru)
CH (2)	CH541569A (ru)
CS (2)	CS180597B2 (ru)
DD (1)	DD97421A5 (ru)
DE (1)	DE2221939C3 (ru)
DK (1)	DK129715B (ru)
ES (1)	ES402365A1 (ru)
FI (1)	FI54305C (ru)
FR (2)	FR2135066B1 (ru)
GB (1)	GB1335808A (ru)
HU (1)	HU163610B (ru)
IE (1)	IE36345B1 (ru)
IL (1)	IL39337A (ru)
LU (1)	LU65290A1 (ru)
NL (1)	NL177311C (ru)
NO (1)	NO133142C (ru)
OA (1)	OA04084A (ru)
PH (1)	PH9441A (ru)
PL (2)	PL88999B1 (ru)
SE (1)	SE386898B (ru)
SU (2)	SU457215A3 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2205318A2 (en) *	1972-11-09	1974-05-31	Rhone Poulenc Sa	6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls
FR2208651A1 (en) *	1972-12-04	1974-06-28	Rhone Poulenc Sa	Piperazinyl carbonyloxy-dithiino pyrrols as tranquillisers - anticonvulsants and spasmolytics from aryloxycarbonates of dithiinopyrrols and piperazines
JPH01124068U (ru) *	1988-02-13	1989-08-23

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3198798A (en) *	1962-11-02	1965-08-03	Sterling Drug Inc	Phthalimido- and isoindolinyl-alkylpiperazines and their preparation
US3635976A (en) *	1967-12-20	1972-01-18	Pennwalt Corp	1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof

1971
- 1971-05-04 FR FR7116074A patent/FR2135066B1/fr not_active Expired
1972
- 1972-02-23 FR FR7206108A patent/FR2172822B2/fr not_active Expired
- 1972-04-18 SU SU1771264A patent/SU457215A3/ru active
- 1972-04-26 NL NLAANVRAGE7205656,A patent/NL177311C/xx not_active IP Right Cessation
- 1972-04-28 DD DD162638A patent/DD97421A5/xx unknown
- 1972-05-02 IL IL39337A patent/IL39337A/xx unknown
- 1972-05-02 JP JP4420172A patent/JPS5512028B1/ja active Pending
- 1972-05-02 US US249509A patent/US3879390A/en not_active Expired - Lifetime
- 1972-05-02 GB GB2036972A patent/GB1335808A/en not_active Expired
- 1972-05-02 HU HURO657A patent/HU163610B/hu unknown
- 1972-05-02 PL PL1972155106A patent/PL88999B1/pl unknown
- 1972-05-02 IE IE579/72A patent/IE36345B1/xx unknown
- 1972-05-02 PL PL1972179624A patent/PL92439B1/pl unknown
- 1972-05-02 PH PH13511*UA patent/PH9441A/en unknown
- 1972-05-03 CA CA141,249*7A patent/CA961042A/en not_active Expired
- 1972-05-03 CH CH657172A patent/CH541569A/fr not_active IP Right Cessation
- 1972-05-03 NO NO1558/72A patent/NO133142C/no unknown
- 1972-05-03 CH CH600773A patent/CH540919A/fr not_active IP Right Cessation
- 1972-05-03 BE BE782983A patent/BE782983A/xx not_active IP Right Cessation
- 1972-05-03 DK DK220372AA patent/DK129715B/da not_active IP Right Cessation
- 1972-05-03 SE SE7205838A patent/SE386898B/xx unknown
- 1972-05-03 LU LU65290A patent/LU65290A1/xx unknown
- 1972-05-04 AT AT474673A patent/AT315189B/de not_active IP Right Cessation
- 1972-05-04 CS CS7600004993A patent/CS180597B2/cs unknown
- 1972-05-04 CS CS7200003018A patent/CS180581B2/cs unknown
- 1972-05-04 FI FI1272/72A patent/FI54305C/fi active
- 1972-05-04 AT AT388872A patent/AT314554B/de not_active IP Right Cessation
- 1972-05-04 ES ES402365A patent/ES402365A1/es not_active Expired
- 1972-05-04 DE DE2221939A patent/DE2221939C3/de not_active Expired
- 1972-05-05 OA OA54561A patent/OA04084A/xx unknown
- 1972-11-20 AR AR245232A patent/AR192506A1/es active
1973
- 1973-09-26 SU SU1958514A patent/SU510148A3/ru active

Also Published As

Publication number	Publication date
NL177311C (nl)	1985-09-02
FR2172822B2 (ru)	1975-03-14
LU65290A1 (ru)	1973-01-22
PL92439B1 (ru)	1977-04-30
FI54305C (fi)	1978-11-10
DD97421A5 (ru)	1973-05-05
FI54305B (fi)	1978-07-31
CH540919A (fr)	1973-10-15
AU4179972A (en)	1973-11-08
IE36345L (en)	1972-11-04
HU163610B (ru)	1973-09-27
IL39337A (en)	1974-12-31
ES402365A1 (es)	1975-04-01
OA04084A (fr)	1979-10-30
SU457215A3 (ru)	1975-01-15
BE782983A (fr)	1972-11-03
CA961042A (en)	1975-01-14
NL177311B (nl)	1985-04-01
NL7205656A (ru)	1972-11-07
DE2221939A1 (de)	1972-11-23
PL88999B1 (ru)	1976-10-30
FR2172822A2 (ru)	1973-10-05
AT315189B (de)	1974-05-10
CS180597B2 (en)	1978-01-31
NO133142B (ru)	1975-12-08
FR2135066B1 (ru)	1974-08-23
CH541569A (fr)	1973-09-15
FR2135066A1 (ru)	1972-12-15
SE386898B (sv)	1976-08-23
JPS5512028B1 (ru)	1980-03-29
NO133142C (ru)	1976-03-17
PH9441A (en)	1975-11-26
DE2221939B2 (de)	1981-03-12
AR192506A1 (es)	1973-02-21
IE36345B1 (en)	1976-10-13
IL39337A0 (en)	1972-07-26
CS180581B2 (en)	1978-01-31
DE2221939C3 (de)	1981-12-10
AT314554B (de)	1974-04-10
DK129715B (da)	1974-11-11
US3879390A (en)	1975-04-22
GB1335808A (en)	1973-10-31
DK129715C (ru)	1975-05-05

Publication	Publication Date	Title
GB1382782A (en)	1975-02-05	Alkylarylketones processes for their preparation and compositions incorporating them
SU510148A3 (ru)	1976-04-05	Способ получени производныхизоиндолина или их солей
SU505361A3 (ru)	1976-02-28	Способ получени 1-аминосульфонил-2аминобензимидазолов
FR2428025B1 (ru)	1983-11-10
GB1377275A (en)	1974-12-11	N-o-cyanophenyl-n,n,- disubstituted formamidines and their salts
ES8106530A1 (es)	1981-08-16	Un procedimiento para la preparacion de un derivado de iminohalogenuro
JPS5640616A (en)	1981-04-16	Decarboxylation of carboxylic acids
GB1036990A (en)	1966-07-20	Cyclohexylsulphamic acid and metal salts thereof
SU125248A1 (ru)	1959-11-30	Способ получени 1-алкокси-3-оксихлорфосфин-4-хлорбутадиенов-1,3
SU474979A3 (ru)	1975-06-25	Способ получени производных спиро (дибензо в,е) оксепин-11:2-(4- аминометилдиоксолана-1,3)
JPS5233676A (en)	1977-03-14	Process for preparation of pyridinedicarboxylic acid amides
SU943238A1 (ru)	1982-07-15	Способ получени 2-фенилимино-5-арил-2,3-дигидрофуран-3-онов
SU434080A1 (ru)	1974-06-30	СПОСОБ ПОЛУЧЕНИЯ 2-АЛКИЛ-4-ГАЛОИД- 2,4-ДИНИТРО-1-АЛКАНОЛОВВ ПТ БФПМП ^^tft^"^'f^^ H-ujSA и «и-Л:-.: ' '^;;
FR2282416A1 (fr)	1976-03-19	Procede de preparation de produits d'autocondensation
SU498296A1 (ru)	1976-01-05	Способ получени производных 4-оксипиперидина
SU438266A1 (ru)	1976-01-25	Способ получени производных -аминометилиндола
SU1483883A1 (ru)	1996-03-10	Хлористые соли (3-хлор-5-алкокси-2-пентен)ил-хинолиния как ингибиторы кислотной коррозии
JPS51128938A (en)	1976-11-10	Thereof and their uses carbonates and, process for preparing
SU1697395A1 (ru)	1998-04-10	Четвертичные соли 4-хинолилбензимидазола как ингибиторы коррозии стали в растворе соляной кислоты
ES476841A1 (es)	1979-06-16	Metodo para la apertura de anillos piranicos.
ES383496A1 (es)	1973-07-01	Un procedimiento para preparar un d 2-(6-sustituido-2- naftil)-propanal.
FR2328697A1 (fr)	1977-05-20	Procede pour preparer des sels de type chlorure de pyridinium
JPS5257163A (en)	1977-05-11	Process for preparing gamma-lactones
ES8402256A1 (es)	1984-01-16	Un procedimiento para preparar un derivado de acetofenona.
ES311604A1 (es)	1966-01-01	Un procedimiento para la preparacion de derivados de benzodiazepina.