SU513622A3 - Method for preparing 4-hydroxymethyl-1,2-dihydro-1-phthalazone - Google Patents

Method for preparing 4-hydroxymethyl-1,2-dihydro-1-phthalazone

Info

Publication number
SU513622A3
SU513622A3 SU1814854A SU1814854A SU513622A3 SU 513622 A3 SU513622 A3 SU 513622A3 SU 1814854 A SU1814854 A SU 1814854A SU 1814854 A SU1814854 A SU 1814854A SU 513622 A3 SU513622 A3 SU 513622A3
Authority
SU
USSR - Soviet Union
Prior art keywords
dihydro
phthalazone
hydroxymethyl
preparing
yield
Prior art date
Application number
SU1814854A
Other languages
Russian (ru)
Inventor
Йнойе Митихиро
Исикава Масаюки
Цутийя Такаси
Симамото Такио
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Application granted granted Critical
Publication of SU513622A3 publication Critical patent/SU513622A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)

Description

i HaoepeTeHF касаетс  нового способа получени  4-оксиметил-1,2-дигидро- 1-фталазона формулы СНоОН I который может найти применение в медицине .. Известен способ получени  4-оксиметил-1 ,2-дигидро- 1-фталазоноБ взаимодействием нзохроман-1,4-диона с производными гидра . айна с последующим превращением образо-. вавшихс  4-гидразонизохроман-1-онов под действием щелочи в- 4-оксиметш1-1,2-дигидро-1-фтапазоны . Недостатками такого способа  вл ютс  : многостадийность и низкий выход целевого продукта. С целью упрощени  технологии получэ- j ни  и повышени  выхода целевого продук- та по предлагаемому способу 4-окснметнл-: -1,2-Дигидро-1-фталазон получают с высоким выходом в одну стадию взаимодейст- ; вием доступных производных 1,2-дигидро- . -1-фталазон-4-карбоновой кислоты обшей формулы - СОЕ где Ь - алкоксигруппа, имеюща  от 1 дд 5 атомов углерода, или атом галогена, . , боргидридом щелочного металла в среде органических растворителей и выдел ют целевой продукт или превращают в соль обычными приемами. В качестве растворител  можно использовать воду, алифатический спирт, имеюi HaoepeTeHF concerns a new method for the preparation of 4-hydroxymethyl-1,2-dihydro-1-phthalazone of the formula SNOOH I, which can be used in medicine. , 4-dione with hydra derivatives. Ainu with the subsequent transformation of the image. 4-hydrazonisochroman-1-ones under the action of alkali in 4-hydroxyme1-1,2-dihydro-1-phtapazones. The disadvantages of this method are: multi-stage and low yield of the target product. In order to simplify the technology of production and increase the yield of the target product according to the proposed method, 4-oxnemethyl-: -1,2-Dihydro-1-phthalazone is obtained with a high yield in one stage of interaction; available derivatives of 1,2-dihydro-. -1-phthalazone-4-carboxylic acid of the general formula: SOY, where b is an alkoxy group having from 1 dd 5 carbon atoms, or a halogen atom,. , with an alkali metal borohydride in an organic solvent medium and isolate the desired product or salt it by conventional methods. As a solvent, you can use water, aliphatic alcohol, I have

SU1814854A 1971-08-05 1972-08-04 Method for preparing 4-hydroxymethyl-1,2-dihydro-1-phthalazone SU513622A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP46058643A JPS5116430B2 (en) 1971-08-05 1971-08-05

Publications (1)

Publication Number Publication Date
SU513622A3 true SU513622A3 (en) 1976-05-05

Family

ID=13090247

Family Applications (2)

Application Number Title Priority Date Filing Date
SU7201817033A SU577986A3 (en) 1971-08-05 1972-08-03 Method of preparing phthalazone derivatives or salts thereof
SU1814854A SU513622A3 (en) 1971-08-05 1972-08-04 Method for preparing 4-hydroxymethyl-1,2-dihydro-1-phthalazone

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU7201817033A SU577986A3 (en) 1971-08-05 1972-08-03 Method of preparing phthalazone derivatives or salts thereof

Country Status (23)

Country Link
US (1) US3864343A (en)
JP (1) JPS5116430B2 (en)
AR (3) AR197089A1 (en)
AT (2) AT317233B (en)
AU (2) AU461281B2 (en)
BE (2) BE787139A (en)
CA (2) CA966489A (en)
CH (2) CH580081A5 (en)
CS (2) CS180587B2 (en)
DE (2) DE2237832A1 (en)
DK (2) DK131857C (en)
ES (2) ES405456A1 (en)
FR (2) FR2150735B1 (en)
GB (2) GB1404367A (en)
HU (2) HU165815B (en)
IE (2) IE36598B1 (en)
LU (2) LU65856A1 (en)
NL (2) NL7210369A (en)
NO (1) NO134113C (en)
SE (2) SE408177B (en)
SU (2) SU577986A3 (en)
YU (1) YU35245B (en)
ZA (2) ZA725203B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205004A1 (en) * 1973-10-30 1976-03-31 Ishikawa M PROCEDURE TO PREPARE 6,8-DIALKYL-7-ALCOXY-CARBONYL-4-HYDROXIMETHYL-1-PHTHALAZONE AND 7,8-LACTONE DERIVATIVES
NL7702763A (en) * 1976-03-18 1977-09-20 Takio Shimamoto En Masayuki Is PROCESS FOR THE PREPARATION OF THROMBOXAN ANTAGONISTS AND OF PREPARATIONS CONTAINING THESE SUBSTANCES.
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4293553A (en) * 1978-08-11 1981-10-06 Masayuki Ishikawa 1-Phthalazone derivatives, and use thereof
US4861778A (en) * 1986-06-16 1989-08-29 Research Corporation 2,3-dihydrophthalazine-1,4-diones
CH683965A5 (en) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Ftalidrazidici compounds of the class as an active substance in anti-inflammatory agents and anti-toxic.
DE102005011822A1 (en) * 2005-03-15 2006-09-21 Merck Patent Gmbh phthalazinones

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE687916A (en) * 1965-10-12 1967-03-16

Also Published As

Publication number Publication date
HU163726B (en) 1973-10-27
IE36597B1 (en) 1976-12-08
AU461018B2 (en) 1975-05-15
CH580081A5 (en) 1976-09-30
NL7210369A (en) 1973-02-07
BE787138A (en) 1972-12-01
SE408177B (en) 1979-05-21
DK143159B (en) 1981-07-06
FR2150735A1 (en) 1973-04-13
AU4494072A (en) 1974-01-31
ZA725203B (en) 1973-04-25
AR197089A1 (en) 1974-03-15
AU461281B2 (en) 1975-05-22
IE36597L (en) 1973-02-05
GB1404368A (en) 1975-08-28
NL151261B (en) 1976-11-15
HU165815B (en) 1974-11-28
ES405555A1 (en) 1975-07-01
IE36598B1 (en) 1976-12-08
SE406587B (en) 1979-02-19
NO134113C (en) 1976-08-18
FR2150736B1 (en) 1976-04-16
AR197156A1 (en) 1974-03-15
DK131857B (en) 1975-09-15
AT320658B (en) 1975-02-25
AT317233B (en) 1974-08-26
JPS4826781A (en) 1973-04-09
DK143159C (en) 1981-11-16
JPS5116430B2 (en) 1976-05-24
GB1404367A (en) 1975-08-28
AR194123A1 (en) 1973-06-22
CH577980A5 (en) 1976-07-30
ZA725202B (en) 1973-04-25
LU65856A1 (en) 1973-01-15
IE36598L (en) 1973-02-05
DK131857C (en) 1976-02-16
BE787139A (en) 1972-12-01
CA966489A (en) 1975-04-22
FR2150735B1 (en) 1976-04-16
YU201372A (en) 1980-04-30
DE2238566A1 (en) 1973-02-15
SU577986A3 (en) 1977-10-25
CS180587B2 (en) 1978-01-31
NO134113B (en) 1976-05-10
ES405456A1 (en) 1975-07-16
YU35245B (en) 1980-10-31
DE2237832A1 (en) 1973-02-15
NL7210370A (en) 1973-02-07
AU4484372A (en) 1974-01-24
CA999236A (en) 1976-11-02
CS180588B2 (en) 1978-01-31
US3864343A (en) 1975-02-04
FR2150736A1 (en) 1973-04-13
LU65855A1 (en) 1973-01-15

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