SK6162001A3 - Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis - Google Patents

Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis Download PDF

Info

Publication number: SK6162001A3
Authority: SK; Slovakia
Prior art keywords: carnitine; quercetin; propionyl; composition; acid
Prior art date: 1998-11-13

Application number

SK616-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Claudio Cavazza

Original Assignee

Sigma Tau Healthscience Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-13

Filing date

1999-11-05

Publication date

2001-10-08

1999-11-05 Application filed by Sigma Tau Healthscience Spa filed Critical Sigma Tau Healthscience Spa

2001-10-08 Publication of SK6162001A3 publication Critical patent/SK6162001A3/sk

Links

239000000203 mixture Substances 0.000 title claims abstract description 53
UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 title claims abstract description 50
229930003935 flavonoid Natural products 0.000 title claims abstract description 11
235000017173 flavonoids Nutrition 0.000 title claims abstract description 11
150000002215 flavonoids Chemical class 0.000 title claims abstract description 10
239000003963 antioxidant agent Substances 0.000 title claims 2
201000001320 Atherosclerosis Diseases 0.000 title description 4
230000003078 antioxidant effect Effects 0.000 title description 4
208000007536 Thrombosis Diseases 0.000 title 1
REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims abstract description 155
ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims abstract description 79
HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims abstract description 79
MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims abstract description 79
235000005875 quercetin Nutrition 0.000 claims abstract description 79
229960001285 quercetin Drugs 0.000 claims abstract description 79
239000003814 drug Substances 0.000 claims abstract description 12
235000015872 dietary supplement Nutrition 0.000 claims abstract description 10
230000005856 abnormality Effects 0.000 claims abstract description 8
230000003143 atherosclerotic effect Effects 0.000 claims abstract description 8
JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims abstract description 5
IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims abstract description 5
FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims abstract description 5
235000005493 rutin Nutrition 0.000 claims abstract description 5
IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims abstract description 5
ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims abstract description 5
229960004555 rutoside Drugs 0.000 claims abstract description 5
230000001732 thrombotic effect Effects 0.000 claims abstract description 5
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 29
229960004203 carnitine Drugs 0.000 claims description 18
239000002253 acid Substances 0.000 claims description 17
RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 12
IGQBPDJNUXPEMT-SNVBAGLBSA-N isovaleryl-L-carnitine Chemical compound CC(C)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C IGQBPDJNUXPEMT-SNVBAGLBSA-N 0.000 claims description 12
150000003839 salts Chemical class 0.000 claims description 11
208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 11
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 9
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
206010061218 Inflammation Diseases 0.000 claims description 5
230000004054 inflammatory process Effects 0.000 claims description 5
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 5
JNMKPXXKHWQWFB-UHFFFAOYSA-L 2-aminoacetate;manganese(2+) Chemical compound [Mn+2].NCC([O-])=O.NCC([O-])=O JNMKPXXKHWQWFB-UHFFFAOYSA-L 0.000 claims description 4
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 4
IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 claims description 4
229910019142 PO4 Inorganic materials 0.000 claims description 4
RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims description 4
RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
229930003268 Vitamin C Natural products 0.000 claims description 4
229930003427 Vitamin E Natural products 0.000 claims description 4
230000000172 allergic effect Effects 0.000 claims description 4
229940009098 aspartate Drugs 0.000 claims description 4
208000010668 atopic eczema Diseases 0.000 claims description 4
229940024455 beta carotene 5 mg Drugs 0.000 claims description 4
ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 4
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
229940004916 magnesium glycinate Drugs 0.000 claims description 4
AACACXATQSKRQG-UHFFFAOYSA-L magnesium;2-aminoacetate Chemical compound [Mg+2].NCC([O-])=O.NCC([O-])=O AACACXATQSKRQG-UHFFFAOYSA-L 0.000 claims description 4
PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 claims description 4
235000007743 myricetin Nutrition 0.000 claims description 4
229940116852 myricetin Drugs 0.000 claims description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
239000010452 phosphate Substances 0.000 claims description 4
229960002718 selenomethionine Drugs 0.000 claims description 4
235000019154 vitamin C Nutrition 0.000 claims description 4
239000011718 vitamin C Substances 0.000 claims description 4
235000019165 vitamin E Nutrition 0.000 claims description 4
229940046009 vitamin E Drugs 0.000 claims description 4
239000011709 vitamin E Substances 0.000 claims description 4
229940071566 zinc glycinate Drugs 0.000 claims description 4
UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 claims description 4
VSNFQQXVMPSASB-SNVBAGLBSA-N O-valeroyl-L-carnitine Chemical compound CCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VSNFQQXVMPSASB-SNVBAGLBSA-N 0.000 claims description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 3
229940079593 drug Drugs 0.000 claims description 3
DCYOADKBABEMIQ-OWMUPTOHSA-N myricitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=C(O)C=2)OC2=CC(O)=CC(O)=C2C1=O DCYOADKBABEMIQ-OWMUPTOHSA-N 0.000 claims description 3
DCYOADKBABEMIQ-FLCVNNLFSA-N myricitrin Natural products O([C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)C1=C(c2cc(O)c(O)c(O)c2)Oc2c(c(O)cc(O)c2)C1=O DCYOADKBABEMIQ-FLCVNNLFSA-N 0.000 claims description 3
235000016709 nutrition Nutrition 0.000 claims description 3
NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims description 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 2
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims description 2
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
201000010099 disease Diseases 0.000 claims description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 2
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 2
229940095064 tartrate Drugs 0.000 claims description 2
229940066528 trichloroacetate Drugs 0.000 claims description 2
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 2
239000002552 dosage form Substances 0.000 claims 6
239000007787 solid Substances 0.000 claims 4
239000002775 capsule Substances 0.000 claims 2
239000008187 granular material Substances 0.000 claims 2
239000007788 liquid Substances 0.000 claims 2
239000007937 lozenge Substances 0.000 claims 2
239000006187 pill Substances 0.000 claims 2
239000006188 syrup Substances 0.000 claims 2
235000020357 syrup Nutrition 0.000 claims 2
239000003826 tablet Substances 0.000 claims 2
235000006708 antioxidants Nutrition 0.000 claims 1
239000005515 coenzyme Substances 0.000 claims 1
230000006806 disease prevention Effects 0.000 claims 1
229910052500 inorganic mineral Inorganic materials 0.000 claims 1
239000011707 mineral Substances 0.000 claims 1
PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
239000000419 plant extract Substances 0.000 claims 1
229940088594 vitamin Drugs 0.000 claims 1
229930003231 vitamin Natural products 0.000 claims 1
239000011782 vitamin Substances 0.000 claims 1
235000013343 vitamin Nutrition 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 abstract description 3
239000004480 active ingredient Substances 0.000 abstract description 2
235000005911 diet Nutrition 0.000 abstract description 2
230000000378 dietary effect Effects 0.000 abstract description 2
230000001575 pathological effect Effects 0.000 abstract description 2
230000002265 prevention Effects 0.000 abstract description 2
230000004075 alteration Effects 0.000 abstract 1
238000012360 testing method Methods 0.000 description 21
241001465754 Metazoa Species 0.000 description 12
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 12
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 8
235000013305 food Nutrition 0.000 description 8
230000001681 protective effect Effects 0.000 description 7
230000002195 synergetic effect Effects 0.000 description 7
235000012000 cholesterol Nutrition 0.000 description 6
230000002401 inhibitory effect Effects 0.000 description 6
241000196324 Embryophyta Species 0.000 description 5
241000283973 Oryctolagus cuniculus Species 0.000 description 5
241000700159 Rattus Species 0.000 description 5
230000003110 anti-inflammatory effect Effects 0.000 description 5
235000010418 carrageenan Nutrition 0.000 description 5
229920001525 carrageenan Polymers 0.000 description 5
238000000034 method Methods 0.000 description 5
238000007254 oxidation reaction Methods 0.000 description 5
231100000331 toxic Toxicity 0.000 description 5
230000002588 toxic effect Effects 0.000 description 5
206010002199 Anaphylactic shock Diseases 0.000 description 4
208000003455 anaphylaxis Diseases 0.000 description 4
230000006378 damage Effects 0.000 description 4
230000000694 effects Effects 0.000 description 4
210000002216 heart Anatomy 0.000 description 4
230000000260 hypercholesteremic effect Effects 0.000 description 4
238000002347 injection Methods 0.000 description 4
239000007924 injection Substances 0.000 description 4
210000004185 liver Anatomy 0.000 description 4
229960004857 mitomycin Drugs 0.000 description 4
-1 polyphenol flavonoids Chemical class 0.000 description 4
235000013824 polyphenols Nutrition 0.000 description 4
150000003626 triacylglycerols Chemical class 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
102000004895 Lipoproteins Human genes 0.000 description 3
108090001030 Lipoproteins Proteins 0.000 description 3
241000699670 Mus sp. Species 0.000 description 3
206010030113 Oedema Diseases 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
239000008103 glucose Substances 0.000 description 3
229930182470 glycoside Natural products 0.000 description 3
150000002338 glycosides Chemical class 0.000 description 3
230000003902 lesion Effects 0.000 description 3
201000002364 leukopenia Diseases 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
230000002107 myocardial effect Effects 0.000 description 3
230000003647 oxidation Effects 0.000 description 3
230000000144 pharmacologic effect Effects 0.000 description 3
150000008442 polyphenolic compounds Chemical class 0.000 description 3
239000000047 product Substances 0.000 description 3
235000020095 red wine Nutrition 0.000 description 3
210000002966 serum Anatomy 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
235000013616 tea Nutrition 0.000 description 3
240000002234 Allium sativum Species 0.000 description 2
206010058892 Carnitine deficiency Diseases 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
244000269722 Thea sinensis Species 0.000 description 2
241000219094 Vitaceae Species 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
125000001589 carboacyl group Chemical group 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
230000002526 effect on cardiovascular system Effects 0.000 description 2
239000000284 extract Substances 0.000 description 2
239000003925 fat Substances 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
235000004611 garlic Nutrition 0.000 description 2
229930182478 glucoside Natural products 0.000 description 2
235000021021 grapes Nutrition 0.000 description 2
230000012010 growth Effects 0.000 description 2
230000001506 immunosuppresive effect Effects 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
210000000265 leukocyte Anatomy 0.000 description 2
231100001022 leukopenia Toxicity 0.000 description 2
230000002248 lipoperoxidative effect Effects 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
150000003254 radicals Chemical class 0.000 description 2
230000009467 reduction Effects 0.000 description 2
230000002829 reductive effect Effects 0.000 description 2
231100000161 signs of toxicity Toxicity 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
208000016505 systemic primary carnitine deficiency disease Diseases 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
230000004614 tumor growth Effects 0.000 description 2
235000014101 wine Nutrition 0.000 description 2
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
108010029190 1-Phosphatidylinositol 4-Kinase Proteins 0.000 description 1
102000001556 1-Phosphatidylinositol 4-Kinase Human genes 0.000 description 1
108010052341 1-phosphatidylinositol-4-phosphate 5-kinase Proteins 0.000 description 1
ZNHVWPKMFKADKW-UHFFFAOYSA-N 12-HETE Chemical compound CCCCCC=CCC(O)C=CC=CCC=CCCCC(O)=O ZNHVWPKMFKADKW-UHFFFAOYSA-N 0.000 description 1
ZNHVWPKMFKADKW-ZYBDYUKJSA-N 12-HETE Natural products CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O ZNHVWPKMFKADKW-ZYBDYUKJSA-N 0.000 description 1
230000002407 ATP formation Effects 0.000 description 1
TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 description 1
PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
208000009079 Bronchial Spasm Diseases 0.000 description 1
208000014181 Bronchial disease Diseases 0.000 description 1
206010006482 Bronchospasm Diseases 0.000 description 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
241000700198 Cavia Species 0.000 description 1
241000723382 Corylus Species 0.000 description 1
235000007466 Corylus avellana Nutrition 0.000 description 1
101710111837 Cyclic phosphodiesterase Proteins 0.000 description 1
102000004127 Cytokines Human genes 0.000 description 1
108090000695 Cytokines Proteins 0.000 description 1
DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
244000141359 Malus pumila Species 0.000 description 1
235000001412 Mediterranean diet Nutrition 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
102000014418 Phosphatidylinositol-4-phosphate 5-kinases Human genes 0.000 description 1
102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
229940124639 Selective inhibitor Drugs 0.000 description 1
229940100514 Syk tyrosine kinase inhibitor Drugs 0.000 description 1
108090000190 Thrombin Proteins 0.000 description 1
LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
MMWCIQZXVOZEGG-HOZKJCLWSA-N [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-HOZKJCLWSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000004931 aggregating effect Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000000489 anti-atherogenic effect Effects 0.000 description 1
230000000879 anti-atherosclerotic effect Effects 0.000 description 1
230000003501 anti-edematous effect Effects 0.000 description 1
230000002137 anti-vascular effect Effects 0.000 description 1
210000000709 aorta Anatomy 0.000 description 1
235000021016 apples Nutrition 0.000 description 1
150000008209 arabinosides Chemical class 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
238000003556 assay Methods 0.000 description 1
235000013361 beverage Nutrition 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
238000004820 blood count Methods 0.000 description 1
238000009534 blood test Methods 0.000 description 1
230000037396 body weight Effects 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
150000005693 branched-chain amino acids Chemical class 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
230000003293 cardioprotective effect Effects 0.000 description 1
ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
235000005487 catechin Nutrition 0.000 description 1
150000001765 catechin Chemical class 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000001120 cytoprotective effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
150000002066 eicosanoids Chemical class 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 1
229960001123 epoprostenol Drugs 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
229960003399 estrone Drugs 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
150000008195 galaktosides Chemical class 0.000 description 1
150000002303 glucose derivatives Chemical class 0.000 description 1
150000008131 glucosides Chemical class 0.000 description 1
PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 description 1
230000003308 immunostimulating effect Effects 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000031891 intestinal absorption Effects 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
230000000302 ischemic effect Effects 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
150000004668 long chain fatty acids Chemical class 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
208000037841 lung tumor Diseases 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
210000001589 microsome Anatomy 0.000 description 1
210000001700 mitochondrial membrane Anatomy 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000035764 nutrition Effects 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000004792 oxidative damage Effects 0.000 description 1
229940094443 oxytocics prostaglandins Drugs 0.000 description 1
230000008506 pathogenesis Effects 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
QAQREVBBADEHPA-IEXPHMLFSA-N propionyl-CoA Chemical class O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QAQREVBBADEHPA-IEXPHMLFSA-N 0.000 description 1
150000003180 prostaglandins Chemical class 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
150000003244 quercetin derivatives Chemical class 0.000 description 1
230000010410 reperfusion Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
235000021283 resveratrol Nutrition 0.000 description 1
229940016667 resveratrol Drugs 0.000 description 1
150000008265 rhamnosides Chemical class 0.000 description 1
210000000518 sarcolemma Anatomy 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
210000002027 skeletal muscle Anatomy 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000000243 solution Substances 0.000 description 1
230000003319 supportive effect Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
230000002883 vasorelaxation effect Effects 0.000 description 1
235000021030 vegetable-rich-diet Nutrition 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
150000008216 xylosides Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Polymers & Plastics (AREA)
Mycology (AREA)
Food Science & Technology (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Inorganic Chemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Immunology (AREA)
Botany (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

SK616-2001A 1998-11-13 1999-11-05 Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis SK6162001A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998RM000706A IT1302863B1 (it)	1998-11-13	1998-11-13	Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un
PCT/IT1999/000351 WO2000028986A1 (en)	1998-11-13	1999-11-05	Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis

Publications (1)

Publication Number	Publication Date
SK6162001A3 true SK6162001A3 (en)	2001-10-08

Family

ID=11406214

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK616-2001A SK6162001A3 (en)	1998-11-13	1999-11-05	Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis

Country Status (19)

Country	Link
EP (1)	EP1128822B1 (da)
AR (1)	AR021089A1 (da)
AT (1)	ATE306258T1 (da)
AU (1)	AU766402B2 (da)
CA (1)	CA2350220C (da)
CZ (1)	CZ20011609A3 (da)
DE (1)	DE69927701T2 (da)
DK (1)	DK1128822T3 (da)
ES (1)	ES2249039T3 (da)
HU (1)	HU229061B1 (da)
IL (1)	IL143001A0 (da)
IT (1)	IT1302863B1 (da)
MA (1)	MA25592A1 (da)
NO (1)	NO20012338L (da)
PL (1)	PL201896B1 (da)
SK (1)	SK6162001A3 (da)
TN (1)	TNSN99212A1 (da)
TR (1)	TR200101344T2 (da)
WO (1)	WO2000028986A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1316998B1 (it) *	2000-03-02	2003-05-26	Sigma Tau Healthscience Spa	Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori.
IT1317035B1 (it) *	2000-05-30	2003-05-26	Sigma Tau Healthscience Spa	Integratore ad attivita' antiossidante comprendente unaalcanoilcarnitina ed una associazione di polifenoli estratti dal
US7338971B2 (en) *	2001-08-30	2008-03-04	El-Naggar Mawaheb M	Treatment of inflammatory, cancer, and thrombosis disorders
US6923960B2 (en)	2001-10-03	2005-08-02	Vsl Pharmaceuticals Inc.	Antioxidant combination composition and use thereof
GB0819960D0 (en) *	2008-10-31	2008-12-10	Provexis Natural Products Ltd	Therapeutic composition
EP2353596A1 (en) *	2010-02-02	2011-08-10	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	Combination composition, comprising as active ingredients L-carnitine or propionyl L-carnitine, for the prevention or treatment of chronic venous insufficiency
KR101758949B1 (ko) *	2010-04-09	2017-07-17	시구마-토우인더스트리에파아마슈우티히리유니트에스.피이.에이.	활성 성분으로 ｌ-카르니틴 또는 프로피오닐 ｌ-카르니틴을 포함하는, 만성 정맥 기능부전의 예방 또는 치료용 복합 조성물
US10391096B2 (en) *	2011-10-13	2019-08-27	Quercegen Pharmaceuticals Llc	Method for treating thrombotic disorders using quercetin-containing compositions
CA3121235A1 (en)	2018-11-30	2020-06-04	Beth Israel Deaconess Medical Center, Inc.	Compositions and methods for reducing major thrombotic events in cancer patients

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1275434B (it) *	1995-05-19	1997-08-07	Farmila Farma Milano	Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante
DK0755633T3 (da) *	1995-07-28	2000-04-17	Herbert Schlachter	Tofasepræparat
AU6141498A (en) *	1997-02-04	1998-08-25	John V. Kosbab	Compositions and methods for prevention and treatment of vascular degenerative diseases
US5976568A (en) *	1997-02-21	1999-11-02	Medical Doctors' Research Institute, Inc.	Modular system of dietary supplement compositions for optimizing health benefits and methods
DE59809565D1 (de) *	1997-12-17	2003-10-16	Meta Handelsgesellschaft M B H	Trinkflüssigkeit
DE19806890A1 (de) *	1998-02-19	1999-08-26	Beiersdorf Ag	Kosmetische und dermatologische Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen, und mindestens einem Antioxidans sowie Zubereitungen mit einem Gehalt an solchen Wirkstoffkombinationen
EP0960572A1 (en) *	1998-05-12	1999-12-01	N.V. Nutricia	Nutritional composition for the treatment of pressure ulcers
IT1299191B1 (it) *	1998-06-23	2000-02-29	Sigma Tau Healthscience Spa	Composizione atta a prevenire e trattare l'osteoporosi e le alterazioni legate alla menopausa

1998
- 1998-11-13 IT IT1998RM000706A patent/IT1302863B1/it active IP Right Grant
1999
- 1999-11-04 AR ARP990105588A patent/AR021089A1/es unknown
- 1999-11-05 SK SK616-2001A patent/SK6162001A3/sk unknown
- 1999-11-05 HU HU0104347A patent/HU229061B1/hu not_active IP Right Cessation
- 1999-11-05 TR TR2001/01344T patent/TR200101344T2/xx unknown
- 1999-11-05 AU AU12941/00A patent/AU766402B2/en not_active Ceased
- 1999-11-05 PL PL348515A patent/PL201896B1/pl unknown
- 1999-11-05 IL IL14300199A patent/IL143001A0/xx unknown
- 1999-11-05 CZ CZ20011609A patent/CZ20011609A3/cs unknown
- 1999-11-05 EP EP99956311A patent/EP1128822B1/en not_active Expired - Lifetime
- 1999-11-05 AT AT99956311T patent/ATE306258T1/de active
- 1999-11-05 WO PCT/IT1999/000351 patent/WO2000028986A1/en active IP Right Grant
- 1999-11-05 DK DK99956311T patent/DK1128822T3/da active
- 1999-11-05 ES ES99956311T patent/ES2249039T3/es not_active Expired - Lifetime
- 1999-11-05 CA CA002350220A patent/CA2350220C/en not_active Expired - Fee Related
- 1999-11-05 DE DE69927701T patent/DE69927701T2/de not_active Expired - Lifetime
- 1999-11-09 MA MA25841A patent/MA25592A1/fr unknown
- 1999-11-11 TN TNTNSN99212A patent/TNSN99212A1/fr unknown
2001
- 2001-05-11 NO NO20012338A patent/NO20012338L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE69927701D1 (de)	2006-02-23
CZ20011609A3 (cs)	2002-01-16
DE69927701T2 (de)	2006-07-20
NO20012338D0 (no)	2001-05-11
PL201896B1 (pl)	2009-05-29
CA2350220A1 (en)	2000-05-25
HUP0104347A3 (en)	2003-01-28
AU1294100A (en)	2000-06-05
DK1128822T3 (da)	2006-02-06
ES2249039T3 (es)	2006-03-16
HU229061B1 (hu)	2013-07-29
TNSN99212A1 (fr)	2005-11-10
EP1128822A1 (en)	2001-09-05
IL143001A0 (en)	2002-04-21
TR200101344T2 (tr)	2001-10-22
CA2350220C (en)	2008-06-17
HUP0104347A2 (hu)	2002-04-29
IT1302863B1 (it)	2000-10-10
WO2000028986A1 (en)	2000-05-25
AU766402B2 (en)	2003-10-16
MA25592A1 (fr)	2002-12-31
EP1128822B1 (en)	2005-10-12
AR021089A1 (es)	2002-06-12
PL348515A1 (en)	2002-06-03
NO20012338L (no)	2001-05-11
ITRM980706A1 (it)	2000-05-13
ATE306258T1 (de)	2005-10-15
ITRM980706A0 (it)	1998-11-13

Publication	Publication Date	Title
US20030206895A1 (en)	2003-11-06	Antioxidant composition comprising propionyl L-carnitine and a flavonoid against throm-bosis and atherosclerosis
US7786175B2 (en)	2010-08-31	Anti-atherosclerosis composition containing carotenoids and method for inhibiting LDL oxidation
KR20010079981A (ko)	2001-08-22	대뇌 및 노화 질환의 예방 또는 치료를 위한 카르니틴과레스베라트롤의 복합물
US20130165396A1 (en)	2013-06-27	Apple Skin Extracts for Treating Cardiovascular Disease
SK6162001A3 (en)	2001-10-08	Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis
CZ20021062A3 (cs)	2002-08-14	Přípravek k prevenci a/nebo léčbě oběhových potíľí obsahující deriváty L-karnitinu a výtaľky z Ginkgo biloba
EP3203853A1 (en)	2017-08-16	Marine lecithin preparations with enhanced oxidation resistance
US20100022464A1 (en)	2010-01-28	Functional food composition that is rich in phenolic compounds and use of said composition
EP2659892B1 (en)	2018-05-23	Concomitant drug for improving cognitive function
KR20010022449A (ko)	2001-03-15	Ｌ-카르니틴 또는 알카노일 ｌ-카르니틴 및 긴 사슬의알카놀을 함유하는 조성물
ES2197890T3 (es)	2004-01-16	Composicion para la prevencion y/o tratamiento de trastornos debidos a un metabolismo lipidico anormal que comprende propionil l-carnitina y quitosana.
US20110038813A2 (en)	2011-02-17	Novel Compositions Against Alkyl-Acyl GPC, The Derivatives And Products Thereof
CZ20024A3 (cs)	2002-06-12	Přípravek k prevenci a léčbě dysfunkcí onemocnění ledvin
AU2017347778A1 (en)	2019-05-16	Delaying latency to seizure by combinations of ketone supplements
MXPA01004752A (en)	2002-03-26	Antioxidant composition comprising propionyl l-carnitine and a flavonoid against thrombosis and atherosclerosis
WO2002040013A1 (en)	2002-05-23	Composition for stimulating the immune defence and iron metabolism, containing propionyl l-carnitine and lactoferrin
CZ20022759A3 (cs)	2003-02-12	Přípravek k prevenci a/nebo léčbě cytotoxických účinků vyvolaných používáním imunosupresivních látek
CZ20022758A3 (cs)	2003-02-12	Přípravek k prevenci a/nebo léčbě vaskulárních onemocnění obsahující propionyl-L-karnitin a koenzym Q10
KR100291143B1 (ko)	2001-05-15	나린진 또는 나린제닌을 포함하는 아실 코에이:콜레스테롤-오-아실트랜스퍼레이즈 저해제 조성물
MXPA01003569A (es)	2002-05-09	Combinacion de carnitinas y resveratrol para prevenir o tratar enfermedades cerebrales y del envejecimiento
KR19990034090A (ko)	1999-05-15	나린진 또는 나린제닌을 포함하는 아실 코에이: 콜레스테롤-오르토-아실트랜스퍼레이즈 저해제 조성물
MXPA01000874A (en)	2002-03-26	Antioxidant, antiproliferous composition, comprising a carnitine and a carotenoid