SK44399A3 - Reconstituted human anti-hm1.24 antibody - Google Patents
Reconstituted human anti-hm1.24 antibody Download PDFInfo
- Publication number
- SK44399A3 SK44399A3 SK443-99A SK44399A SK44399A3 SK 44399 A3 SK44399 A3 SK 44399A3 SK 44399 A SK44399 A SK 44399A SK 44399 A3 SK44399 A3 SK 44399A3
- Authority
- SK
- Slovakia
- Prior art keywords
- chain
- region
- antibody
- human
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26475696 | 1996-10-04 | ||
PCT/JP1997/003553 WO1998014580A1 (fr) | 1996-10-04 | 1997-10-03 | Anticorps anti-hm1.24 humain reconstitue |
Publications (1)
Publication Number | Publication Date |
---|---|
SK44399A3 true SK44399A3 (en) | 2000-05-16 |
Family
ID=17407753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK443-99A SK44399A3 (en) | 1996-10-04 | 1997-10-03 | Reconstituted human anti-hm1.24 antibody |
Country Status (20)
Country | Link |
---|---|
US (2) | US6699974B2 (zh) |
EP (1) | EP0960936B1 (zh) |
KR (1) | KR100388256B1 (zh) |
CN (2) | CN1271205C (zh) |
AT (1) | ATE512224T1 (zh) |
AU (1) | AU715156B2 (zh) |
BR (1) | BR9712488A (zh) |
CA (1) | CA2267072C (zh) |
CZ (1) | CZ296790B6 (zh) |
HK (1) | HK1024261A1 (zh) |
IL (1) | IL129286A0 (zh) |
NO (1) | NO325178B1 (zh) |
PL (1) | PL187642B1 (zh) |
RU (1) | RU2184147C2 (zh) |
SK (1) | SK44399A3 (zh) |
TR (1) | TR199900722T2 (zh) |
TW (1) | TW530064B (zh) |
UA (1) | UA76934C2 (zh) |
WO (1) | WO1998014580A1 (zh) |
ZA (1) | ZA978865B (zh) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2280875C (en) * | 1997-02-12 | 2005-07-05 | Chugai Seiyaku Kabushiki Kaisha | Remedies for lymphocytic tumors |
WO1998037913A1 (fr) * | 1997-02-28 | 1998-09-03 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteurs d'activation de lymphocytes |
WO1999018997A1 (fr) * | 1997-10-14 | 1999-04-22 | Chugai Seiyaku Kabushiki Kaisha | Potentialisateur pour anticorps anti-tumeur lymphoide |
WO1999043703A1 (fr) * | 1998-02-25 | 1999-09-02 | Chugai Seiyaku Kabushiki Kaisha | Technique de dosage immunochimique de l'anticorps anti-hm1.24 |
US6602663B1 (en) | 1998-09-18 | 2003-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method for detection or measuring plasmocytoma cells |
EP1176194B1 (en) * | 1999-05-10 | 2005-07-20 | Chugai Seiyaku Kabushiki Kaisha | Method of cell cultivation |
WO2001013940A1 (fr) | 1999-08-23 | 2001-03-01 | Chugai Seiyaku Kabushiki Kaisha | Potentialisateurs d'expression de l'antigene hm1.24 |
WO2001077362A1 (fr) * | 2000-04-06 | 2001-10-18 | Chugai Seiyaku Kabushiki Kaisha | Dosage immunologique d'anticorps anti hm1 . 24 |
ES2477996T3 (es) | 2000-08-11 | 2014-07-18 | Chugai Seiyaku Kabushiki Kaisha | Preparaciones estabilizadas que contienen un anticuerpo |
JP4450555B2 (ja) * | 2000-12-28 | 2010-04-14 | 協和発酵キリン株式会社 | 新規モノクローナル抗体 |
US7931897B2 (en) | 2001-02-07 | 2011-04-26 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for hematopoietic tumors |
US7332289B2 (en) | 2001-03-09 | 2008-02-19 | Chugai Seiyaku Kabushiki Kaisha | Method of purifying protein |
WO2002076499A2 (en) * | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
EP1378752A4 (en) * | 2001-04-13 | 2004-08-04 | Chugai Pharmaceutical Co Ltd | METHOD FOR QUANTIFYING ANTIGEN EXPRESSION |
US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
AU2002315857B2 (en) * | 2001-06-22 | 2007-07-26 | Kaisha, Chugai Seiyaku Kabushiki | Cell proliferation inhibitors containing anti-glypican 3 antibody |
KR20040049830A (ko) * | 2001-07-09 | 2004-06-12 | 애프톤 코포레이션 | 간, 폐 및 식도의 암 및 전암 상태의 치료 및 예방 |
MXPA04007924A (es) * | 2002-02-14 | 2005-05-17 | Chugai Pharmaceutical Co Ltd | Formulaciones en solucion que contienen anticuerpo. |
US20080219974A1 (en) * | 2002-03-01 | 2008-09-11 | Bernett Matthew J | Optimized antibodies that target hm1.24 |
EP1513879B1 (en) * | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
US20060058511A1 (en) | 2002-08-27 | 2006-03-16 | Chugai Seiyaku Kabushiki Kaisha | Method for stabilizing protein solution preparation |
AU2003262087B2 (en) * | 2002-09-11 | 2010-11-11 | Chugai Seiyaku Kabushiki Kaisha | Protein purification method |
CN1781023A (zh) * | 2003-03-28 | 2006-05-31 | 埃弗顿有限公司 | 胃泌素激素免疫测定 |
CA2534055A1 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody cdr polypeptide sequences with restricted diversity |
EP1666501A4 (en) * | 2003-08-11 | 2008-12-24 | Chugai Pharmaceutical Co Ltd | ANTI-HM1.24 ANTIBODIES WITH MODIFIED SUGAR CHAIN |
EP1693069B1 (en) * | 2003-10-10 | 2013-07-24 | Chugai Seiyaku Kabushiki Kaisha | Remedy for solid tumor |
MXPA06004836A (es) * | 2003-11-05 | 2006-07-06 | Glycart Biotechnology Ag | Anticuerpos cd20 con funcion del efector y afinidad de enlace al receptor fc mejoradas. |
DK1716181T3 (da) * | 2004-02-19 | 2010-03-01 | Genentech Inc | CDR-reparerede antistoffer |
WO2005095459A2 (en) * | 2004-03-29 | 2005-10-13 | Receptor Biologix, Inc. | Monoclonal antibodies to gastrin hormone |
JP2008513536A (ja) * | 2004-09-22 | 2008-05-01 | レセプター バイオロジックス インコーポレイテッド | プロガストリンに対するモノクローナル抗体 |
TWI615407B (zh) * | 2005-08-26 | 2018-02-21 | 羅齊克雷雅公司 | 具有經改變細胞傳訊活性之改質抗原結合分子 |
AU2012216702B2 (en) * | 2005-08-26 | 2014-12-04 | Roche Glycart Ag | Modified antigen binding molecules with altered cell signaling activity |
US8679490B2 (en) | 2005-11-07 | 2014-03-25 | Genentech, Inc. | Binding polypeptides with diversified and consensus VH/VL hypervariable sequences |
WO2007064919A2 (en) * | 2005-12-02 | 2007-06-07 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
JP5231810B2 (ja) | 2005-12-28 | 2013-07-10 | 中外製薬株式会社 | 抗体含有安定化製剤 |
WO2008036688A2 (en) * | 2006-09-18 | 2008-03-27 | Xencor, Inc. | Optimized antibodies that target hm1.24 |
PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
JP6294585B2 (ja) | 2009-09-03 | 2018-03-20 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗gitr抗体 |
AR080428A1 (es) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
US9574005B2 (en) | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
CN103889555B (zh) | 2011-09-01 | 2018-10-26 | 中外制药株式会社 | 通过超滤制备包含高度浓缩的抗体的组合物的方法 |
EP3088411A4 (en) | 2013-12-27 | 2018-12-19 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying antibody having low isoelectric point |
JP6858559B2 (ja) | 2014-08-20 | 2021-04-14 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
KR20200015943A (ko) | 2017-06-15 | 2020-02-13 | 캔설 어드밴스 아이엔씨 | 종양 및 암에 대한 체액성 및 세포 면역을 유도하기 위한 조성물 및 방법 |
CN109748964B (zh) * | 2017-11-01 | 2020-11-17 | 深圳宾德生物技术有限公司 | CD317单链抗体317scFv、其编码序列及制备方法和应用 |
CA3096222A1 (en) | 2018-04-06 | 2019-10-10 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
KR20210010996A (ko) | 2018-05-21 | 2021-01-29 | 추가이 세이야쿠 가부시키가이샤 | 유리 용기에 봉입된 동결건조 제제 |
CN115636141A (zh) | 2018-05-28 | 2023-01-24 | 中外制药株式会社 | 填充喷嘴 |
CA3156803A1 (en) * | 2019-10-03 | 2021-04-08 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
AR127269A1 (es) | 2021-10-08 | 2024-01-03 | Chugai Pharmaceutical Co Ltd | Formulación de anticuerpo anti-hla-dq2.5 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO873164L (no) * | 1986-07-30 | 1988-02-01 | Teijin Ltd | Muse-humane kimaere antistoffer. |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9014932D0 (en) * | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
JP3370324B2 (ja) | 1991-04-25 | 2003-01-27 | 中外製薬株式会社 | ヒトインターロイキン−6受容体に対する再構成ヒト抗体 |
ATE306930T1 (de) * | 1994-08-12 | 2005-11-15 | Immunomedics Inc | Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper |
CA2280875C (en) * | 1997-02-12 | 2005-07-05 | Chugai Seiyaku Kabushiki Kaisha | Remedies for lymphocytic tumors |
US20020034507A1 (en) * | 1997-02-28 | 2002-03-21 | Yasuo Koishihara | Inhibitor of lymphocyte activation |
RU2221809C2 (ru) * | 1997-10-03 | 2004-01-20 | Тугаи Сейяку Кабусики Кайся | Способ получения природного гуманизированного антитела |
WO1999018997A1 (fr) * | 1997-10-14 | 1999-04-22 | Chugai Seiyaku Kabushiki Kaisha | Potentialisateur pour anticorps anti-tumeur lymphoide |
JP2006512895A (ja) * | 2002-06-28 | 2006-04-20 | ドマンティス リミテッド | リガンド |
-
1997
- 1997-03-10 UA UA99042469A patent/UA76934C2/uk unknown
- 1997-10-03 CN CNB971992150A patent/CN1271205C/zh not_active Expired - Fee Related
- 1997-10-03 US US09/269,921 patent/US6699974B2/en not_active Expired - Lifetime
- 1997-10-03 EP EP97942246A patent/EP0960936B1/en not_active Expired - Lifetime
- 1997-10-03 CZ CZ0117399A patent/CZ296790B6/cs not_active IP Right Cessation
- 1997-10-03 AT AT97942246T patent/ATE512224T1/de not_active IP Right Cessation
- 1997-10-03 AU AU43992/97A patent/AU715156B2/en not_active Ceased
- 1997-10-03 BR BR9712488-5A patent/BR9712488A/pt not_active Application Discontinuation
- 1997-10-03 WO PCT/JP1997/003553 patent/WO1998014580A1/ja active IP Right Grant
- 1997-10-03 IL IL12928697A patent/IL129286A0/xx not_active IP Right Cessation
- 1997-10-03 KR KR10-1999-7002902A patent/KR100388256B1/ko not_active IP Right Cessation
- 1997-10-03 PL PL97332742A patent/PL187642B1/pl not_active IP Right Cessation
- 1997-10-03 TW TW086114474A patent/TW530064B/zh not_active IP Right Cessation
- 1997-10-03 TR TR1999/00722T patent/TR199900722T2/xx unknown
- 1997-10-03 ZA ZA9708865A patent/ZA978865B/xx unknown
- 1997-10-03 CN CNA2005100687876A patent/CN1765928A/zh active Pending
- 1997-10-03 CA CA002267072A patent/CA2267072C/en not_active Expired - Fee Related
- 1997-10-03 RU RU99109034/13A patent/RU2184147C2/ru not_active IP Right Cessation
- 1997-10-03 SK SK443-99A patent/SK44399A3/sk unknown
-
1999
- 1999-03-31 NO NO19991591A patent/NO325178B1/no unknown
-
2000
- 2000-03-23 HK HK00101791A patent/HK1024261A1/xx not_active IP Right Cessation
-
2002
- 2002-08-13 US US10/218,253 patent/US7892543B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO991591L (no) | 1999-06-01 |
UA76934C2 (en) | 2006-10-16 |
CZ117399A3 (cs) | 1999-09-15 |
EP0960936B1 (en) | 2011-06-08 |
TW530064B (en) | 2003-05-01 |
CN1765928A (zh) | 2006-05-03 |
PL187642B1 (pl) | 2004-08-31 |
CZ296790B6 (cs) | 2006-06-14 |
RU2184147C2 (ru) | 2002-06-27 |
EP0960936A1 (en) | 1999-12-01 |
US6699974B2 (en) | 2004-03-02 |
AU4399297A (en) | 1998-04-24 |
TR199900722T2 (xx) | 1999-12-21 |
BR9712488A (pt) | 1999-10-19 |
AU715156B2 (en) | 2000-01-20 |
ATE512224T1 (de) | 2011-06-15 |
KR20000048884A (ko) | 2000-07-25 |
US7892543B2 (en) | 2011-02-22 |
HK1024261A1 (en) | 2000-10-05 |
CN1235639A (zh) | 1999-11-17 |
NO325178B1 (no) | 2008-02-11 |
NO991591D0 (no) | 1999-03-31 |
CN1271205C (zh) | 2006-08-23 |
PL332742A1 (en) | 1999-10-11 |
KR100388256B1 (ko) | 2003-06-19 |
IL129286A0 (en) | 2000-02-17 |
EP0960936A4 (en) | 2005-01-19 |
CA2267072A1 (en) | 1998-04-09 |
US20030045691A1 (en) | 2003-03-06 |
WO1998014580A1 (fr) | 1998-04-09 |
CA2267072C (en) | 2004-11-30 |
ZA978865B (en) | 1998-04-20 |
US20030129185A1 (en) | 2003-07-10 |
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