SK283366B6 - Substituované heterocyklické benzocykloalkény, spôsob ich výroby a ich použitie ako analgetikum - Google Patents

Substituované heterocyklické benzocykloalkény, spôsob ich výroby a ich použitie ako analgetikum Download PDF

Info

Publication number: SK283366B6
Authority: SK; Slovakia
Prior art keywords: compound; formula; group; alkyl; carbon atoms
Prior art date: 1997-12-13

Application number

SK1699-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK169998A3 (en

Inventor

Oswald Zimmer

Wolfgang Strassburger

Claudia P�Tz

Werner Englberger

Babette-Yvonne Kgel

Original Assignee

Grnenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-13

Filing date

1998-12-10

Publication date

2003-06-03

1998-12-10 Application filed by Grnenthal Gmbh filed Critical Grnenthal Gmbh

1999-07-12 Publication of SK169998A3 publication Critical patent/SK169998A3/sk

2003-06-03 Publication of SK283366B6 publication Critical patent/SK283366B6/sk

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/08—Naphthothiopyrans; Hydrogenated naphthothiopyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyrane Compounds (AREA)

SK1699-98A 1997-12-13 1998-12-10 Substituované heterocyklické benzocykloalkény, spôsob ich výroby a ich použitie ako analgetikum SK283366B6 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19755480A DE19755480A1 (de)	1997-12-13	1997-12-13	Substituierte heterocyclische Benzocycloalkene und ihre Verwendung als analgetisch wirksame Substanzen

Publications (2)

Publication Number	Publication Date
SK169998A3 SK169998A3 (en)	1999-07-12
SK283366B6 true SK283366B6 (sk)	2003-06-03

Family

ID=7851818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1699-98A SK283366B6 (sk)	1997-12-13	1998-12-10	Substituované heterocyklické benzocykloalkény, spôsob ich výroby a ich použitie ako analgetikum

Country Status (29)

Country	Link
US (1)	US6013809A (fr)
EP (1)	EP0922703B1 (fr)
JP (1)	JPH11246547A (fr)
KR (1)	KR19990062982A (fr)
CN (1)	CN100376564C (fr)
AR (1)	AR017800A1 (fr)
AT (1)	ATE229016T1 (fr)
AU (1)	AU747979B2 (fr)
BR (1)	BR9805437A (fr)
CA (1)	CA2256007C (fr)
CO (1)	CO4990950A1 (fr)
CZ (1)	CZ294990B6 (fr)
DE (2)	DE19755480A1 (fr)
DK (1)	DK0922703T3 (fr)
ES (1)	ES2189072T3 (fr)
HK (1)	HK1020944A1 (fr)
HU (1)	HU226014B1 (fr)
IL (1)	IL127518A (fr)
MY (1)	MY133169A (fr)
NO (1)	NO985818L (fr)
NZ (1)	NZ332622A (fr)
PE (1)	PE133499A1 (fr)
PL (1)	PL194934B1 (fr)
PT (1)	PT922703E (fr)
RU (1)	RU2197484C2 (fr)
SI (1)	SI0922703T1 (fr)
SK (1)	SK283366B6 (fr)
UY (1)	UY25296A1 (fr)
ZA (1)	ZA9811346B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6077850A (en) *	1997-04-21	2000-06-20	G.D. Searle & Co.	Substituted benzopyran analogs for the treatment of inflammation
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
DE19830105C1 (de) *	1998-07-06	2000-02-17	Gruenenthal Gmbh	Acridinderivate
WO2000010965A2 (fr) *	1998-08-20	2000-03-02	Takeda Chemical Industries, Ltd.	Sels d'ammonium quaternaire et leur utilisation
DE10033459A1 (de) *	2000-07-10	2002-01-24	Gruenenthal Gmbh	Cyclische substituierte Aminomethylverbindungen und diese Verbindungen enthaltende Arzeimittel
US7289083B1 (en) *	2000-11-30	2007-10-30	Palm, Inc.	Multi-sided display for portable computer
CN102076654B (zh) *	2008-04-28	2014-07-23	詹森药业有限公司	苯并环庚烷及苯并噁庚英衍生物
MX354242B (es)	2011-10-28	2018-02-20	Lumena Pharmaceuticals Inc	Nhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas.
CN104844471B (zh) *	2015-04-21	2017-05-03	苏州远智医药科技有限公司	一种作为dor受体拮抗剂的化合物
CN109896991B (zh) *	2017-12-08	2020-11-20	苏州远智医药科技有限公司	一种δ阿片受体拮抗剂及其用途和药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3444176A (en) *	1967-04-28	1969-05-13	Mcneilab Inc	Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof
US4104280A (en) *	1977-02-04	1978-08-01	Syntex (U.S.A.) Inc.	Dibenzo [b.f]thiepin and dibenzo[b.f]oxepin derivatives
JPS61130286A (ja) *	1984-11-28	1986-06-18	Suntory Ltd	２，３−ジヒドロ−１−ベンズオキセピン誘導体
JP3042156B2 (ja) *	1992-02-20	2000-05-15	田辺製薬株式会社	ナフタレン誘導体、その製法及びその合成中間体
ATE161530T1 (de) *	1992-09-04	1998-01-15	Takeda Chemical Industries Ltd	Kondensierte heterozyklische verbindungen, deren herstellung und verwendung

1997
- 1997-12-13 DE DE19755480A patent/DE19755480A1/de not_active Ceased
1998
- 1998-11-03 MY MYPI98004994A patent/MY133169A/en unknown
- 1998-11-03 NZ NZ332622A patent/NZ332622A/xx unknown
- 1998-11-17 PE PE1998001116A patent/PE133499A1/es not_active Application Discontinuation
- 1998-11-23 DE DE59806523T patent/DE59806523D1/de not_active Expired - Fee Related
- 1998-11-23 EP EP98122218A patent/EP0922703B1/fr not_active Expired - Lifetime
- 1998-11-23 ES ES98122218T patent/ES2189072T3/es not_active Expired - Lifetime
- 1998-11-23 SI SI9830350T patent/SI0922703T1/xx unknown
- 1998-11-23 DK DK98122218T patent/DK0922703T3/da active
- 1998-11-23 PT PT98122218T patent/PT922703E/pt unknown
- 1998-11-23 AT AT98122218T patent/ATE229016T1/de not_active IP Right Cessation
- 1998-12-03 AR ARP980106155A patent/AR017800A1/es unknown
- 1998-12-09 BR BR9805437-6A patent/BR9805437A/pt not_active IP Right Cessation
- 1998-12-10 UY UY25296A patent/UY25296A1/es not_active Application Discontinuation
- 1998-12-10 CZ CZ19984076A patent/CZ294990B6/cs not_active IP Right Cessation
- 1998-12-10 ZA ZA9811346A patent/ZA9811346B/xx unknown
- 1998-12-10 SK SK1699-98A patent/SK283366B6/sk not_active IP Right Cessation
- 1998-12-10 CO CO98073439A patent/CO4990950A1/es unknown
- 1998-12-11 AU AU97073/98A patent/AU747979B2/en not_active Ceased
- 1998-12-11 JP JP10353219A patent/JPH11246547A/ja active Pending
- 1998-12-11 CA CA002256007A patent/CA2256007C/fr not_active Expired - Fee Related
- 1998-12-11 NO NO985818A patent/NO985818L/no not_active Application Discontinuation
- 1998-12-11 CN CNB981253180A patent/CN100376564C/zh not_active Expired - Fee Related
- 1998-12-11 PL PL330257A patent/PL194934B1/pl not_active IP Right Cessation
- 1998-12-11 IL IL12751898A patent/IL127518A/xx not_active IP Right Cessation
- 1998-12-11 US US09/208,990 patent/US6013809A/en not_active Expired - Fee Related
- 1998-12-11 KR KR1019980054315A patent/KR19990062982A/ko not_active Application Discontinuation
- 1998-12-11 HU HU9802886A patent/HU226014B1/hu not_active IP Right Cessation
- 1998-12-15 RU RU98122335/04A patent/RU2197484C2/ru not_active IP Right Cessation
1999
- 1999-11-26 HK HK99105471A patent/HK1020944A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2189072T3 (es)	2003-07-01
ZA9811346B (en)	1999-06-14
NO985818D0 (no)	1998-12-11
BR9805437A (pt)	2000-05-02
HK1020944A1 (en)	2000-05-26
CZ294990B6 (cs)	2005-04-13
EP0922703B1 (fr)	2002-12-04
IL127518A (en)	2003-05-29
IL127518A0 (en)	1999-10-28
DE59806523D1 (de)	2003-01-16
JPH11246547A (ja)	1999-09-14
MY133169A (en)	2007-10-31
CZ407698A3 (cs)	1999-06-16
ATE229016T1 (de)	2002-12-15
PL330257A1 (en)	1999-06-21
NZ332622A (en)	2000-03-27
HU9802886D0 (en)	1999-02-01
PT922703E (pt)	2003-04-30
DK0922703T3 (da)	2003-03-17
SI0922703T1 (en)	2003-04-30
AR017800A1 (es)	2001-10-24
HUP9802886A2 (hu)	2001-04-28
AU9707398A (en)	1999-07-01
NO985818L (no)	1999-06-14
KR19990062982A (ko)	1999-07-26
EP0922703A1 (fr)	1999-06-16
PL194934B1 (pl)	2007-07-31
CN1221743A (zh)	1999-07-07
US6013809A (en)	2000-01-11
RU2197484C2 (ru)	2003-01-27
HUP9802886A3 (en)	2001-09-28
DE19755480A1 (de)	1999-06-24
SK169998A3 (en)	1999-07-12
CN100376564C (zh)	2008-03-26
HU226014B1 (en)	2008-02-28
PE133499A1 (es)	2000-02-02
UY25296A1 (es)	2001-05-31
CA2256007A1 (fr)	1999-06-13
AU747979B2 (en)	2002-05-30
CO4990950A1 (es)	2000-12-26
CA2256007C (fr)	2009-04-14

Legal Events

Date	Code	Title	Description
2010-09-07	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20091210

Publication	Publication Date	Title
DE19805370A1 (de)	1998-09-17	Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
EP0230270B1 (fr)	1990-08-01	Benzazépines condensées
SK283366B6 (sk)	2003-06-03	Substituované heterocyklické benzocykloalkény, spôsob ich výroby a ich použitie ako analgetikum
US4973586A (en)	1990-11-27	Fused benzazepines, compositions of, and medical use thereof
US4002632A (en)	1977-01-11	Tetracyclic piperidino derivatives
CA2047307A1 (fr)	1992-01-19	Derives du carbostyryle
Yamato et al.	1981	Synthesis and structure-activity relationship of spiro [isochromanpiperidine] analogs for inhibition of histamine release. 1
EP0050387B1 (fr)	1984-08-15	Benzo(4,5)pyrano(2,3-c)pyrroles, procédés pour leur préparation et compositions pharmaceutiques les contenant
US4826975A (en)	1989-05-02	Fused cycloaliphatic aminoalcohols
FR2558835A1 (fr)	1985-08-02	Derives d'hydantoine, leur procede de production et medicament les contenant
FI76075B (fi)	1988-05-31	Foerfarande foer framstaellning av farmaceutiskt vaerdefulla bensazepinderivat.
US6077845A (en)	2000-06-20	Acridin derivatives
US5302716A (en)	1994-04-12	Fused benzazepines
Chukhajian et al.	2003	A new intramolecular recyclization in water‐base cleavage reaction of 2, 2‐dialkyl‐4‐hydroxymethylbenz [f] iso indolinium bromides and chlorides
US6323369B1 (en)	2001-11-27	Substituted cycloheptenes, their preparation and use
WO1987002035A1 (fr)	1987-04-09	Aminoalcools cycloaliphatiques fusionnes
SK281867B6 (sk)	2001-08-06	Deriváty 3,3a,4,5-tetrahydro-1h-oxazolo[3,4-a]chinolin-1-ónu, spôsob ich prípravy, liečivo a farmaceutický prostriedok obsahujúce tieto deriváty
EP0302787A1 (fr)	1989-02-08	Dérivés de (pipéridinyl-4)méthyl-2 benzofuro[2,3-c]pyridines, leur préparation et leur application en thérapeutique
CA1070689A (fr)	1980-01-29	2-(2-hydroxyethyl) tetrahydro-1,4 oxazines et leurs sels quaternaires aidant a traiter les spasmes
MXPA98010483A (es)	2000-06-05	Benzocicloalquenos heterociclicos sustituidos y su empleo como sustancias analgesicamente activas