SK282428B6 - Spôsob výroby enantiomérne čistých fenylsubstituovaných derivátov kyseliny 1,4-dihydropyridín-3,5-dikarboxylovej a medziprodukty na túto výrobu - Google Patents

Spôsob výroby enantiomérne čistých fenylsubstituovaných derivátov kyseliny 1,4-dihydropyridín-3,5-dikarboxylovej a medziprodukty na túto výrobu Download PDF

Info

Publication number
SK282428B6
SK282428B6 SK1526-95A SK152695A SK282428B6 SK 282428 B6 SK282428 B6 SK 282428B6 SK 152695 A SK152695 A SK 152695A SK 282428 B6 SK282428 B6 SK 282428B6
Authority
SK
Slovakia
Prior art keywords
formula
carbon atoms
straight
enantiomerically pure
compounds
Prior art date
Application number
SK1526-95A
Other languages
English (en)
Slovak (sk)
Other versions
SK152695A3 (en
Inventor
Joachim Mittendorf
Peter Fey
Bodo Junge
Johannes Kaulen
Laak Kai Van
Heinrich Meier
Rudolf Schohe-Loop
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of SK152695A3 publication Critical patent/SK152695A3/sk
Publication of SK282428B6 publication Critical patent/SK282428B6/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/402,5-Pyrrolidine-diones
    • C07D207/4162,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK1526-95A 1994-12-05 1995-12-04 Spôsob výroby enantiomérne čistých fenylsubstituovaných derivátov kyseliny 1,4-dihydropyridín-3,5-dikarboxylovej a medziprodukty na túto výrobu SK282428B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4443168A DE4443168A1 (de) 1994-12-05 1994-12-05 Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten

Publications (2)

Publication Number Publication Date
SK152695A3 SK152695A3 (en) 1996-06-05
SK282428B6 true SK282428B6 (sk) 2002-01-07

Family

ID=6534908

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1526-95A SK282428B6 (sk) 1994-12-05 1995-12-04 Spôsob výroby enantiomérne čistých fenylsubstituovaných derivátov kyseliny 1,4-dihydropyridín-3,5-dikarboxylovej a medziprodukty na túto výrobu

Country Status (27)

Country Link
US (4) US5700948A (pl)
EP (2) EP0716081B1 (pl)
JP (1) JP3891500B2 (pl)
KR (1) KR100396011B1 (pl)
CN (5) CN1079793C (pl)
AT (1) ATE322482T1 (pl)
AU (1) AU702274B2 (pl)
CA (1) CA2164276C (pl)
CZ (1) CZ296438B6 (pl)
DE (2) DE4443168A1 (pl)
DK (1) DK0716081T3 (pl)
ES (1) ES2262138T3 (pl)
FI (1) FI115908B (pl)
HU (1) HU214683B (pl)
IL (1) IL116225A (pl)
MX (1) MX9504954A (pl)
MY (1) MY112938A (pl)
NO (1) NO312832B1 (pl)
NZ (1) NZ280578A (pl)
PL (1) PL183604B1 (pl)
PT (1) PT716081E (pl)
RU (1) RU2155752C2 (pl)
SG (1) SG73352A1 (pl)
SI (1) SI0716081T1 (pl)
SK (1) SK282428B6 (pl)
TW (1) TW310324B (pl)
ZA (1) ZA9510263B (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102533154B1 (ko) 2022-09-22 2023-05-17 임태형 안전계단 난간대

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
JPS6058239B2 (ja) * 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
DE2911029C2 (de) * 1979-03-21 1985-03-14 Kombi-Lift Montage- Und Handelsgesellschaft Mbh, 5650 Solingen Vorrichtung zum Haltern der Führungsrollen für die Lastseile eines Fassadenseilaufzuges in einem oben am Gebäude fest angeordneten Gehäuse
GR850872B (pl) * 1984-04-16 1985-11-25 Yamanouchi Pharma Co Ltd
US4539302A (en) * 1984-04-30 1985-09-03 E. I. Du Pont De Nemours And Company Recovery of zerovalent nickel complexes
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine

Also Published As

Publication number Publication date
SG73352A1 (en) 2000-06-20
PT716081E (pt) 2006-08-31
PL311539A1 (en) 1996-06-10
US5910593A (en) 1999-06-08
JP3891500B2 (ja) 2007-03-14
EP1443043A2 (de) 2004-08-04
HU9503438D0 (en) 1996-01-29
HUT74292A (en) 1996-11-28
MY112938A (en) 2001-10-31
DE4443168A1 (de) 1996-06-13
NZ280578A (en) 1996-10-28
CN1216054C (zh) 2005-08-24
HU214683B (hu) 1998-04-28
AU702274B2 (en) 1999-02-18
FI115908B (fi) 2005-08-15
CZ296438B6 (cs) 2006-03-15
US5700948A (en) 1997-12-23
DK0716081T3 (da) 2006-08-07
CA2164276A1 (en) 1996-06-06
CN1269358A (zh) 2000-10-11
NO954885D0 (no) 1995-12-01
NO312832B1 (no) 2002-07-08
IL116225A0 (en) 1996-03-31
CA2164276C (en) 2007-04-10
ATE322482T1 (de) 2006-04-15
NO954885L (no) 1996-06-06
ES2262138T3 (es) 2006-11-16
CN1269362A (zh) 2000-10-11
RU2155752C2 (ru) 2000-09-10
EP1443043A3 (de) 2005-02-02
SK152695A3 (en) 1996-06-05
KR100396011B1 (ko) 2003-11-10
USRE36607E (en) 2000-03-07
CN1269357A (zh) 2000-10-11
KR960022463A (ko) 1996-07-18
CN1079793C (zh) 2002-02-27
CN1094926C (zh) 2002-11-27
PL183604B1 (pl) 2002-06-28
US5849924A (en) 1998-12-15
EP0716081A1 (de) 1996-06-12
ZA9510263B (en) 1996-06-12
CN1131664A (zh) 1996-09-25
FI955825A (fi) 1996-06-06
TW310324B (pl) 1997-07-11
JPH08225529A (ja) 1996-09-03
CZ320595A3 (en) 1996-06-12
AU3915095A (en) 1996-06-13
FI955825A0 (fi) 1995-12-04
CN1269359A (zh) 2000-10-11
MX9504954A (es) 1997-01-31
CN1105102C (zh) 2003-04-09
IL116225A (en) 2000-06-29
DE59511043D1 (de) 2006-05-18
EP0716081B1 (de) 2006-04-05
SI0716081T1 (sl) 2006-06-30
CN1094486C (zh) 2002-11-20

Similar Documents

Publication Publication Date Title
DK170891B1 (da) 1,4-dihydropyridin-3,5-dicarboxylsyrederivater og fremgangsmåde til fremstilling deraf samt farmaceutisk middel indeholdende dem
EP1125924B1 (en) Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization
AU2005310406B2 (en) Optical resolution method of amlodipine
AU596382B2 (en) Flavone derivatives
KR100646670B1 (ko) 레르카니디핀 염화수소의 개선된 제조방법
SK282428B6 (sk) Spôsob výroby enantiomérne čistých fenylsubstituovaných derivátov kyseliny 1,4-dihydropyridín-3,5-dikarboxylovej a medziprodukty na túto výrobu
EP0371492B1 (en) Process for the preparation of 1,4-dihydropyridine derivatives
CA2536608C (en) New highly selective process for the preparation of enantiomerically pure phenyl-substituted 1,4-dihydropyridine-3,5-dicarboxylic acid derivatives
KR100374405B1 (ko) 암로디핀 베실레이트의 제조방법
KR100354806B1 (ko) 암로디핀 베실레이트의 신규 중간체 및 그의 제조방법
KR100469030B1 (ko) 시사프라이드의 합성방법
FI94242B (fi) Menetelmä heterosyklisten johdannaisten valmistamiseksi
HU223138B1 (hu) Új eljárás racém alkil-4,6,7,8,9,9a-hexahidro-2H, 3H-pirido-[1,2-a] pirazin-1-on-7-karbonsavészterek előállítására
JP2966004B2 (ja) 3―アミノクロトン酸エステル
EP0109049A2 (en) Process for preparation of substituted dihydropyridines and intermediates therefor
JPH07196612A (ja) 1,4−ジヒドロピリジン誘導体及びそれを用いる1,4−ジヒドロピリジンカルボン酸誘導体の製造方法

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20111204